{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:55:43Z","timestamp":1787666143509,"version":"build-2736575974"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"vor","delay-in-days":297,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Epilepsy Research United Kingdom","award":["P1904"],"award-info":[{"award-number":["P1904"]}]},{"DOI":"10.13039\/100015572","name":"National Imaging Facility","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015572","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Collaborative Research Infrastructure Strategy"},{"DOI":"10.13039\/501100001801","name":"University of Western Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001801","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute for Health"},{"name":"Care Research Biomedical Research Centre"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Temporal lobe epilepsy (TLE) is associated with progressive neocortical thinning that may be prevented by resective surgery, but little knowledge exists on dynamic changes in the hippocampus. Here, we assessed progressive morphological changes of the hippocampus before and after TLE surgery. In this longitudinal case-control neuroimaging study, we included patients with unilateral drug-resistant TLE before (main cohort n = 23; replication cohort n = 81) or after (n = 54) anterior temporal lobe resection and healthy volunteers (n = 120) matched for age and sex. We compared hippocampal volumes and surface shape morphology on paired scans between groups using linear mixed effects models. We did not find accelerated atrophy of the ipsilateral hippocampus in chronic presurgical TLE (\u22122.1\u2005\u00b5l\/year) compared to normal aging (\u22123.6\u2005\u00b5l\/year, P = 0.78). In contrast, there was progressive hypertrophy of the contralateral hippocampus before epilepsy surgery (+1.4\u2005\u00b5l\/year) compared to normal aging (\u22124.1\u2005\u00b5l\/year), which was further accelerated after surgery (+4.0\u2005\u00b5l\/year, P = 0.01). We validated these findings in the replication cohort (n = 81). Factors contributing to contralateral hippocampal hypertrophy included left-sided epilepsy lateralization, ipsilateral hippocampal sclerosis, and visual memory encoding deficits before or after surgery. Conversely, a history of focal to bilateral tonic clonic seizures was associated with accelerated pre- and postsurgical atrophy of the contralateral hippocampus. Refractory TLE is associated with progressive hypertrophy of the contralateral hippocampus before and after resective surgery. These contralateral changes may represent compensatory plasticity that is related to pre- and postoperative disturbances in cognition, mainly affecting visual memory. In contrast to progressive cortical thinning, the ipsilateral hippocampus does not show additional atrophy in chronic TLE.<\/jats:p>","DOI":"10.1093\/braincomms\/fcaf416","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T11:52:59Z","timestamp":1761133979000},"source":"Crossref","is-referenced-by-count":5,"title":["Longitudinal changes in hippocampal morphology before and after temporal lobe epilepsy surgery"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7711-8250","authenticated-orcid":false,"given":"Matus","family":"Velicky Buecheler","sequence":"first","affiliation":[{"name":"Department of Neurology, Clinical Neuroscience Centre, University Hospital and University of Zurich , Zurich 8091 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Zubal","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Inselspital, Bern University Hospital and University of Bern , Bern 3010 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Terziev","sequence":"additional","affiliation":[{"name":"Department of Neurology, Clinical Neuroscience Centre, University Hospital and University of Zurich , Zurich 8091 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew W","family":"McEvoy","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology , London, London WC1N 3BG ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"de Tisi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology , London, London WC1N 3BG ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Miserocchi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology , London, London WC1N 3BG ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sjoerd B","family":"Vos","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology , London, London WC1N 3BG ,","place":["United Kingdom"]},{"name":"Department of Computer Science, Centre for Medical Image Computing, University College London , London NW1 2AE ,","place":["United Kingdom"]},{"name":"Western Australia National Imaging Facility Node, The University of Western Australia , Nedlands 6009 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1438-7544","authenticated-orcid":false,"given":"Kai Michael","family":"Schubert","sequence":"additional","affiliation":[{"name":"Department of Neurology, Clinical Neuroscience Centre, University Hospital and University of Zurich , Zurich 8091 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3417-1978","authenticated-orcid":false,"given":"Christian R","family":"Baumann","sequence":"additional","affiliation":[{"name":"Department of Neurology, Clinical Neuroscience Centre, University Hospital and University of Zurich , Zurich 8091 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1373-0681","authenticated-orcid":false,"given":"John S","family":"Duncan","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology , London, London WC1N 3BG ,","place":["United Kingdom"]},{"name":"MRI Unit, Epilepsy Society, Chalfont St Peter , Buckinghamshire SL9 0RJ ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias J","family":"Koepp","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology , London, London WC1N 3BG ,","place":["United Kingdom"]},{"name":"MRI Unit, Epilepsy Society, Chalfont St Peter , Buckinghamshire SL9 0RJ ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2307-071X","authenticated-orcid":false,"given":"Marian","family":"Galovic","sequence":"additional","affiliation":[{"name":"Department of Neurology, Clinical Neuroscience Centre, University Hospital and University of Zurich , Zurich 8091 ,","place":["Switzerland"]},{"name":"Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology , London, London WC1N 3BG ,","place":["United Kingdom"]},{"name":"MRI Unit, Epilepsy Society, Chalfont St Peter , Buckinghamshire SL9 0RJ ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,10,24]]},"reference":[{"issue":"1","key":"2025112901531451200_fcaf416-B1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0920-1211(96)00043-5","article-title":"Introduction to temporal lobe epilepsy","volume":"26","author":"Engel","year":"1995","journal-title":"Epilepsy Res"},{"issue":"3","key":"2025112901531451200_fcaf416-B2","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/brain\/89.3.499","article-title":"Epilepsy and the temporal lobes: A clinical, electroencephalographic and neuropathological study of the brain in epilepsy, with particular reference 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