{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T19:14:39Z","timestamp":1784402079519,"version":"3.55.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":296,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002283","name":"Alzheimer\u2019s Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002283","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"name":"College London Hospitals Biomedical Research Centre"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1RF1MH123195"],"award-info":[{"award-number":["1RF1MH123195"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01AG070988"],"award-info":[{"award-number":["1R01AG070988"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1UM1MH130981"],"award-info":[{"award-number":["1UM1MH130981"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1RF1AG080371"],"award-info":[{"award-number":["1RF1AG080371"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R21NS138995"],"award-info":[{"award-number":["1R21NS138995"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Welcome Trust","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Cambridge University Centre"},{"DOI":"10.13039\/501100007155","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_UU_00030\/14"],"award-info":[{"award-number":["MC_UU_00030\/14"]}],"id":[{"id":"10.13039\/501100007155","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018956","name":"National Institute for Health Research Cambridge Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000320","name":"Alzheimer's Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000320","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research University College London","award":["10510032120002"],"award-info":[{"award-number":["10510032120002"]}]},{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health","doi-asserted-by":"publisher","award":["733051042"],"award-info":[{"award-number":["733051042"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012479","name":"Weston Brain Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008914","name":"Ontario Brain Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008914","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hospitals Biomedical Research Centre","award":["MR\/M008525\/1"],"award-info":[{"award-number":["MR\/M008525\/1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Thalamic subregions are commonly, but variably, affected by different forms of frontotemporal dementia. We aimed to better characterize thalamic subregional involvement in genetic frontotemporal dementia with a recently published thalamus segmentation tool that utilizes structural and diffusion MRI, offering additional assessment of mean diffusivity and a more fine-grained analysis of the pulvinar specifically compared to previous studies. Using this tool, we performed thalamus segmentations in MRI scans from C9orf72, GRN and MAPT mutation carriers and mutation non-carriers with suitable 3-Tesla MRI cross-sectional data from the GENetic Frontotemporal dementia Initiative. Mutation carriers were divided according to their genetic group and Clinical Dementia Rating\u00ae Dementia Staging Instrument plus National Alzheimer\u2019s Coordinating Center Behaviour and Language Domains global score (0 or 0.5: presymptomatic\/prodromal stage, 1 or higher: symptomatic stage). Following stringent quality control and harmonization across sites and scanners, we compared volumes and mean diffusivity values of thalamic subregions in C9orf72 (47 presymptomatic, 10 symptomatic), GRN (57 presymptomatic, 11 symptomatic) and MAPT (31 presymptomatic, 12 symptomatic) mutation carriers to those in 109 mutation non-carriers with analyses of covariance including age and sex (and total intracranial volume for volumetric comparisons) as covariates. Presymptomatic C9orf72 expansion carriers showed smaller volumes (3\u20138% difference from non-carriers) and higher mean diffusivity (2\u20135% difference from non-carriers) for several thalamic subregions, including all pulvinar subdivisions. We found subtly larger volumes of the ventral anterior subregion and the non-medial pulvinar (3% difference from non-carriers for both) in presymptomatic GRN mutation carriers, and of the anteroventral subregion (5% difference from non-carriers) in presymptomatic MAPT mutation carriers. Symptomatic mutation carriers in all three genetic groups showed significantly smaller volumes and widespread higher mean diffusivity of thalamic subregions compared with non-carriers, which were overall most prominent in subregions involved in associative and limbic functions (the midline, medial pulvinar, anteroventral, mediodorsal, laterodorsal and lateral posterior subregions). Notably smaller volume (12\u201323% difference from non-carriers) and higher mean diffusivity (16\u201323% difference from non-carriers) of the most medial part of the medial pulvinar was a shared feature across the three genetic groups at the symptomatic stage. Overall, our study confirms that thalamic subregions are affected in genetic frontotemporal dementia and identifies prominent involvement of the most medial part of the medial pulvinar as a potential unifying feature in the variable pattern of thalamic subregional involvement across the main genetic groups.<\/jats:p>","DOI":"10.1093\/braincomms\/fcaf420","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T12:26:03Z","timestamp":1761222363000},"source":"Crossref","is-referenced-by-count":5,"title":["Thalamus involvement in genetic frontotemporal dementia assessed using structural and diffusion MRI: a GENFI study"],"prefix":"10.1093","volume":"7","author":[{"given":"Sonja","family":"Soskic","sequence":"first","affiliation":[{"name":"Department of Medical Physics and Biomedical Engineering, UCL Hawkes Institute, University College London , London WC1V 6LJ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry F J","family":"Tregidgo","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Biomedical Engineering, UCL Hawkes Institute, University College London , London WC1V 6LJ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1551-5691","authenticated-orcid":false,"given":"Emily G","family":"Todd","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Disease, Dementia Research Centre, UCL Queen Square Institute of Neurology , London WC1N 3BG ,","place":["UK"]},{"name":"Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, University of Cambridge , Cambridge CB2 1TN ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0267-8590","authenticated-orcid":false,"given":"Arabella","family":"Bouzigues","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Disease, Dementia Research Centre, UCL Queen Square Institute of Neurology , London WC1N 3BG ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7833-616X","authenticated-orcid":false,"given":"David M","family":"Cash","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Disease, Dementia Research Centre, UCL Queen Square Institute of Neurology , London WC1N 3BG ,","place":["UK"]},{"name":"UK Dementia Research Institute at University College London , London WC1N 3BG ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy L","family":"Russell","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Disease, Dementia Research Centre, UCL Queen Square Institute of Neurology , London WC1N 3BG ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L","family":"Thomas","sequence":"additional","affiliation":[{"name":"Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology , Queen Square, University College London, London WC1N 3BG ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7512-7856","authenticated-orcid":false,"given":"Ian B","family":"Malone","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Disease, Dementia Research Centre, UCL Queen Square Institute of Neurology , London WC1N 3BG ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phoebe H","family":"Foster","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Disease, Dementia Research Centre, UCL Queen Square Institute of Neurology , London WC1N 3BG ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eve","family":"Ferry-Bolder","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Disease, Dementia Research Centre, UCL Queen Square Institute of Neurology , London WC1N 3BG ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C","family":"van Swieten","sequence":"additional","affiliation":[{"name":"Department of Neurology, Erasmus Medical Centre , Rotterdam 2040 3000 ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1120-1858","authenticated-orcid":false,"given":"Lize C","family":"Jiskoot","sequence":"additional","affiliation":[{"name":"Department of Neurology, Erasmus Medical Centre , Rotterdam 2040 3000 ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1989-7527","authenticated-orcid":false,"given":"Harro","family":"Seelaar","sequence":"additional","affiliation":[{"name":"Department of Neurology, Erasmus Medical Centre , Rotterdam 2040 3000 ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7750-896X","authenticated-orcid":false,"given":"Raquel","family":"Sanchez-Valle","sequence":"additional","affiliation":[{"name":"Alzheimer\u2019s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Cl\u00ednic, Institut d\u2019Investigaci\u00f3ns Biom\u00e8diques August Pi I Sunyer, University of Barcelona , Barcelona 08036 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Laforce","sequence":"additional","affiliation":[{"name":"Clinique Interdisciplinaire de M\u00e9moire, D\u00e9partement des Sciences Neurologiques, CHU de Qu\u00e9bec, and Facult\u00e9 de M\u00e9decine, Universit\u00e9 Laval , Qu\u00e9bec City, QC G1V 0A6 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9949-2951","authenticated-orcid":false,"given":"Caroline","family":"Graff","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Bioclinicum, Karolinska Institutet , Solna 17177 ,","place":["Sweden"]},{"name":"Unit for Hereditary Dementias, Theme Inflammation and Aging, Karolinska University Hospital , Solna 17177 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Galimberti","sequence":"additional","affiliation":[{"name":"Fondazione Ca\u2019 Granda, IRCCS Ospedale Policlinico , Milan 20122 ,","place":["Italy"]},{"name":"Centro Dino Ferrari , University of Milan, Milan 20122 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6237-2502","authenticated-orcid":false,"given":"Rik","family":"Vandenberghe","sequence":"additional","affiliation":[{"name":"Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven , Leuven 3000 ,","place":["Belgium"]},{"name":"Neurology Service, University Hospitals Leuven , Leuven 3000 ,","place":["Belgium"]},{"name":"Leuven Brain Institute, KU Leuven , Leuven 3000 ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"de Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Lisbon , Lisbon 1649-004 ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Tiraboschi","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Istituto Neurologico Carlo Besta , Milano 20133 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Santana","sequence":"additional","affiliation":[{"name":"Neurology Service, Faculty of Medicine, University Hospital of Coimbra (HUC), University of Coimbra , Coimbra 3000-214 ,","place":["Portugal"]},{"name":"Center for Neuroscience and Cell Biology, Faculty of Medicine, University of Coimbra , Coimbra 3000-214 ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8071-6062","authenticated-orcid":false,"given":"Alexander","family":"Gerhard","sequence":"additional","affiliation":[{"name":"Division of Psychology Communication and Human Neuroscience, Wolfson Molecular Imaging Centre, University of Manchester , Manchester M13 9GB ,","place":["UK"]},{"name":"Department of Nuclear Medicine, Center for Translational Neuro- and Behavioral Sciences, University Medicine Essen , Essen 47057 ,","place":["Germany"]},{"name":"Department of Geriatric Medicine, Klinikum Hochsauerland , Arnsberg 59759 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5092-4306","authenticated-orcid":false,"given":"Johannes","family":"Levin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ludwig-Maximilians Universit\u00e4t M\u00fcnchen , Munich 80539 ,","place":["Germany"]},{"name":"German Center for Neurodegenerative Diseases (DZNE) , Munich 81377 ,","place":["Germany"]},{"name":"Munich Cluster of Systems Neurology (SyNergy) , Munich 81377 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Nacmias","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence , Florence 50139 ,","place":["Italy"]},{"name":"IRCCS Fondazione Don Carlo Gnocchi , Florence 50143 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Otto","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Ulm , Ulm 89081 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5283-503X","authenticated-orcid":false,"given":"Maxime","family":"Bertoux","sequence":"additional","affiliation":[{"name":"Lille Neuroscience & Cognition U1172, University of Lille, Inserm, CHU Lille , Lille 59000 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibaud","family":"Lebouvier","sequence":"additional","affiliation":[{"name":"Lille Neuroscience & Cognition U1172, University of Lille, Inserm, CHU Lille , Lille 59000 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7309-1113","authenticated-orcid":false,"given":"Simon","family":"Ducharme","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Douglas Mental Health University Institute, McGill University , Montreal, Qu\u00e9bec H3H 2R9 ,","place":["Canada"]},{"name":"McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University , Montreal, Qu\u00e9bec H3H 2R9 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7502-9284","authenticated-orcid":false,"given":"Christopher R","family":"Butler","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences, Medical Sciences Division, University of Oxford , Oxford OX1 4BH ,","place":["UK"]},{"name":"Department of Brain Sciences, Imperial College London , London SW7 2BX ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Le Ber","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Neurologie, AP-HP\u2014H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Centre de r\u00e9f\u00e9rence des d\u00e9mences rares ou pr\u00e9coces, IM2A , Paris 5783 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4461-7427","authenticated-orcid":false,"given":"Elizabeth C","family":"Finger","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurological Sciences, University of Western Ontario , London, ON N6A 5A5 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Carmela","family":"Tartaglia","sequence":"additional","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto , Toronto, ON M4N 3M5 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Masellis","sequence":"additional","affiliation":[{"name":"Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, University of Toronto , Toronto M4N 3M5 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B","family":"Rowe","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, University of Cambridge , Cambridge CB2 1TN ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2280-7273","authenticated-orcid":false,"given":"Matthis","family":"Synofzik","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and Center of Neurology, University of T\u00fcbingen , T\u00fcbingen 72074 ,","place":["Germany"]},{"name":"Center for Neurodegenerative Diseases (DZNE) , T\u00fcbingen 72076 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fermin","family":"Moreno","sequence":"additional","affiliation":[{"name":"Cognitive Disorders Unit, Department of Neurology, Hospital Universitario Donostia , San Sebastian 20014 ,","place":["Spain"]},{"name":"Neurosciences Area, Group of Neurodegenerative Diseases, Biogipuzkoa Health Research Institute , San Sebastian 20014 ,","place":["Spain"]},{"name":"Center for Biomedical Research in Neurodegenerative Disease (CIBERNED), Carlos III Health Institute , Madrid 28029 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9340-9814","authenticated-orcid":false,"given":"Barbara","family":"Borroni","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia , Brescia 25123 ,","place":["Italy"]},{"name":"Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli , Brescia 25125 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel C","family":"Alexander","sequence":"additional","affiliation":[{"name":"Department of Computer Science, UCL Hawkes Institute, University College London , London WC1V 6LJ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Eugenio","family":"Iglesias","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Biomedical Engineering, UCL Hawkes Institute, University College London , London WC1V 6LJ ,","place":["UK"]},{"name":"Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School , Boston, MA 02114 ,","place":["USA"]},{"name":"Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology , Cambridge, MA 02139 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D","family":"Rohrer","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Disease, Dementia Research Centre, UCL Queen Square Institute of Neurology , London WC1N 3BG ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1814-5024","authenticated-orcid":false,"given":"Martina","family":"Bocchetta","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Disease, Dementia Research Centre, UCL Queen Square Institute of Neurology , London WC1N 3BG ,","place":["UK"]},{"name":"Centre for Cognitive and Clinical Neuroscience, Division of Psychology, Department of Life Sciences, College of Health, Medicine and Life Sciences, Brunel University London , London UB8 3PH ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"GENetic Frontotemporal dementia Initiative (GENFI)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhian","family":"Convery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Goldsmith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Samra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Cope","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura","family":"Malpetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Alberici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Premi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Gasparotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Buratti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Cantoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Arighi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Fenoglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittoria","family":"Borracci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Serpente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Carandini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Rotondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomina","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Giaccone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Di Fede","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Caroppo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Prioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Redaelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Tang-Wai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Rogaeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Kr\u00fcger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Castelo-Branco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morris","family":"Freedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Keren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Black","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christen","family":"Shoesmith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robart","family":"Bartha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Rademakers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackie","family":"Poos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janne M","family":"Papma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Giannini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liset","family":"de Boer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"de Houwer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick","family":"van Minkelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolande","family":"Pijnenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Polito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Lombardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Bessi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Fainardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Chiti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattias","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Viklund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa Taheri","family":"Rydell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesna","family":"Jelic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbe","family":"Ullgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Langheinrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Llad\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Antonell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"Olives","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mircea","family":"Balasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Bargall\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergi","family":"Borrego-Ecija","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Verdelho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Maruta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago","family":"Costa-Coelho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Miltenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederico","family":"Sim\u00f5es do Couto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alazne","family":"Gabilondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana","family":"Croitoru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikel","family":"Tainta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Barandiaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Bender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Mengel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Graf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annick","family":"Vogels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Vandenbulcke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Van Damme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose","family":"Bruffaerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen","family":"Poesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Rosa-Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Montembault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Migliaccio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ninon","family":"Burgos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisy","family":"Rinaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina","family":"Prix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Wlasich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Wagemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Sch\u00f6necker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander Maximilian","family":"Bernhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Stockbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolina","family":"Lombardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Anderl-Straub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeline","family":"Rollin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Kuchcinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Deramecourt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Dur\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jo\u00e3o","family":"Leit\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rosario","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"T\u00e1buas-Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f3nia","family":"Afonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Lemos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,10,24]]},"reference":[{"issue":"2","key":"2025112901525158600_fcaf420-B1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S1474-4422(19)30394-1","article-title":"Age at symptom onset and death and disease duration in genetic frontotemporal dementia: An international retrospective cohort study","volume":"19","author":"Moore","year":"2020","journal-title":"Lancet Neurol"},{"issue":"7","key":"2025112901525158600_fcaf420-B2","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1111\/nan.12250","article-title":"Review: An update on clinical, genetic and pathological aspects of frontotemporal lobar degenerations","volume":"41","author":"Lashley","year":"2015","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"S1","key":"2025112901525158600_fcaf420-B3","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/jnc.13654","article-title":"The clinical spectrum of sporadic and familial forms of frontotemporal dementia","volume":"138","author":"Woollacott","year":"2016","journal-title":"J Neurochem"},{"issue":"3","key":"2025112901525158600_fcaf420-B4","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S1474-4422(14)70324-2","article-title":"Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: A cross-sectional analysis","volume":"14","author":"Rohrer","year":"2015","journal-title":"Lancet Neurol"},{"key":"2025112901525158600_fcaf420-B5","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-540-34686-9","volume-title":"The human central nervous system","author":"Nieuwenhuys","year":"2008"},{"issue":"2","key":"2025112901525158600_fcaf420-B6","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1001\/jamaneurol.2017.4266","article-title":"Early cognitive, structural, and microstructural changes in presymptomatic C9orf72 carriers younger than 40 years","volume":"75","author":"Bertrand","year":"2018","journal-title":"JAMA Neurol"},{"key":"2025112901525158600_fcaf420-B7","doi-asserted-by":"crossref","first-page":"102646","DOI":"10.1016\/j.nicl.2021.102646","article-title":"Differential early subcortical involvement in genetic FTD within the GENFI cohort","volume":"30","author":"Bocchetta","year":"2021","journal-title":"Neuroimage Clin"},{"key":"2025112901525158600_fcaf420-B8","doi-asserted-by":"crossref","first-page":"120221","DOI":"10.1016\/j.jns.2022.120221","article-title":"Focal thalamus pathology in frontotemporal dementia: Phenotype-associated thalamic profiles","volume":"436","author":"McKenna","year":"2022","journal-title":"J Neurol Sci"},{"issue":"2","key":"2025112901525158600_fcaf420-B9","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcad061","article-title":"Structural MRI predicts clinical progression in presymptomatic genetic frontotemporal dementia: Findings from the GENetic Frontotemporal dementia initiative cohort","volume":"5","author":"Bocchetta","year":"2023","journal-title":"Brain Commun"},{"issue":"2","key":"2025112901525158600_fcaf420-B10","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/ana.27116","article-title":"Longitudinal magnetic resonance imaging in asymptomatic C9orf72 mutation carriers distinguishes phenoconverters to amyotrophic lateral sclerosis or amyotrophic lateral sclerosis with frontotemporal dementia","volume":"97","author":"van Veenhuijzen","year":"2024","journal-title":"Ann Neurol"},{"key":"2025112901525158600_fcaf420-B11","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.neuroimage.2018.08.012","article-title":"A probabilistic atlas of the human thalamic nuclei combining ex vivo MRI and histology","volume":"183","author":"Iglesias","year":"2018","journal-title":"Neuroimage"},{"key":"2025112901525158600_fcaf420-B12","doi-asserted-by":"crossref","first-page":"120129","DOI":"10.1016\/j.neuroimage.2023.120129","article-title":"Accurate Bayesian segmentation of thalamic nuclei using diffusion MRI and an improved histological atlas","volume":"274","author":"Tregidgo","year":"2023","journal-title":"Neuroimage"},{"issue":"12","key":"2025112901525158600_fcaf420-B13","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1093\/brain\/aww250","article-title":"Timing and significance of pathological features in C9orf72 expansion-associated frontotemporal dementia","volume":"139","author":"Vatsavayai","year":"2016","journal-title":"Brain"},{"key":"2025112901525158600_fcaf420-B14","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.nicl.2016.12.006","article-title":"Network degeneration and dysfunction in presymptomatic C9ORF72 expansion carriers","volume":"14","author":"Lee","year":"2017","journal-title":"Neuroimage Clin"},{"issue":"11","key":"2025112901525158600_fcaf420-B15","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1093\/brain\/awu248","article-title":"Altered network connectivity in frontotemporal dementia with C9orf72 hexanucleotide repeat expansion","volume":"137","author":"Lee","year":"2014","journal-title":"Brain"},{"issue":"6","key":"2025112901525158600_fcaf420-B16","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1109\/TMI.2010.2046908","article-title":"N4ITK: Improved N3 bias correction","volume":"29","author":"Tustison","year":"2010","journal-title":"IEEE Trans Med Imaging"},{"issue":"9","key":"2025112901525158600_fcaf420-B17","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1109\/TMI.2015.2418298","article-title":"Geodesic information flows: Spatially-variant graphs and their application to segmentation and fusion","volume":"34","author":"Cardoso","year":"2015","journal-title":"IEEE Trans Med Imaging"},{"issue":"9","key":"2025112901525158600_fcaf420-B18","doi-asserted-by":"crossref","first-page":"e2216399120","DOI":"10.1073\/pnas.2216399120","article-title":"Robust machine learning segmentation for large-scale analysis of heterogeneous clinical brain MRI datasets","volume":"120","author":"Billot","year":"2023","journal-title":"Proc Natl Acad Sci"},{"key":"2025112901525158600_fcaf420-B19","doi-asserted-by":"crossref","first-page":"102789","DOI":"10.1016\/j.media.2023.102789","article-title":"SynthSeg: Segmentation of brain MRI scans of any contrast and resolution without retraining","volume":"86","author":"Billot","year":"2023","journal-title":"Med Image Anal"},{"key":"2025112901525158600_fcaf420-B20","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.neuroimage.2015.10.019","article-title":"An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging","volume":"125","author":"Andersson","year":"2016","journal-title":"Neuroimage"},{"issue":"2","key":"2025112901525158600_fcaf420-B21","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.neuroimage.2011.09.015","article-title":"FSL","volume":"62","author":"Jenkinson","year":"2012","journal-title":"Neuroimage"},{"issue":"7","key":"2025112901525158600_fcaf420-B22","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.media.2014.06.008","article-title":"Susceptibility artefact correction using dynamic graph cuts: Application to neurosurgery","volume":"18","author":"Daga","year":"2014","journal-title":"Med Image Anal"},{"issue":"3","key":"2025112901525158600_fcaf420-B23","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s12021-016-9297-6","article-title":"NiftyFit: A software package for multi-parametric model-fitting of 4D magnetic resonance imaging data","volume":"14","author":"Melbourne","year":"2016","journal-title":"Neuroinformatics"},{"issue":"2","key":"2025112901525158600_fcaf420-B24","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1002\/mrm.20965","article-title":"Log-Euclidean metrics for fast and simple calculus on diffusion tensors","volume":"56","author":"Arsigny","year":"2006","journal-title":"Magn Reson Med"},{"key":"2025112901525158600_fcaf420-B25","first-page":"247","volume-title":"Medical image computing and computer assisted intervention\u2014MICCAI 2023","author":"Tregidgo","year":"2023"},{"issue":"4","key":"2025112901525158600_fcaf420-B26","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1002\/hbm.24856","article-title":"Thalamic nuclei in frontotemporal dementia: Mediodorsal nucleus involvement is universal but pulvinar atrophy is unique to C9orf72","volume":"41","author":"Bocchetta","year":"2020","journal-title":"Hum Brain Mapp"},{"key":"2025112901525158600_fcaf420-B27","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.neuroimage.2017.08.047","article-title":"Harmonization of multi-site diffusion tensor imaging data","volume":"161","author":"Fortin","year":"2017","journal-title":"Neuroimage"},{"key":"2025112901525158600_fcaf420-B28","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.neuroimage.2017.11.024","article-title":"Harmonization of cortical thickness measurements across scanners and sites","volume":"167","author":"Fortin","year":"2018","journal-title":"Neuroimage"},{"issue":"1","key":"2025112901525158600_fcaf420-B29","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/alz.12033","article-title":"Utility of the global CDR\u00ae plus NACC FTLD rating and development of scoring rules: Data from the ARTFL\/LEFFTDS consortium","volume":"16","author":"Miyagawa","year":"2020","journal-title":"Alzheimers Dement"},{"issue":"1","key":"2025112901525158600_fcaf420-B30","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: A practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Stat Soc Series B Stat Methodol"},{"issue":"3","key":"2025112901525158600_fcaf420-B31","doi-asserted-by":"crossref","first-page":"701","DOI":"10.3233\/JAD-170002","article-title":"von Economo neuron density and thalamus volumes in behavioral deficits in frontotemporal dementia cases with and without a C9ORF72 repeat expansion","volume":"58","author":"Yang","year":"2017","journal-title":"J Alzheimers Dis"},{"issue":"7","key":"2025112901525158600_fcaf420-B32","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1212\/WNL.0000000000001276","article-title":"Pulvinar","volume":"84","author":"Benarroch","year":"2015","journal-title":"Neurology"},{"key":"2025112901525158600_fcaf420-B33","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/B978-0-12-374236-0.10019-7","volume-title":"The human nervous system","author":"Mai","year":"2012","edition":"edn"},{"issue":"3","key":"2025112901525158600_fcaf420-B34","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/(SICI)1096-9861(19970317)379:3<313::AID-CNE1>3.0.CO;2-6","article-title":"Topographic organization of medial pulvinar connections with the prefrontal cortex in the rhesus monkey","volume":"379","author":"Romanski","year":"1997","journal-title":"J Comp Neurol"},{"issue":"1","key":"2025112901525158600_fcaf420-B35","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/0006-8993(76)90654-5","article-title":"A projection from the medial pulvinar to the amygdala in primates","volume":"104","author":"Jones","year":"1976","journal-title":"Brain Res"},{"issue":"1","key":"2025112901525158600_fcaf420-B36","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/cne.902270112","article-title":"Thalamic connections of the insula in the rhesus monkey and comments on the paralimbic connectivity of the medial pulvinar nucleus","volume":"227","author":"Mufson","year":"1984","journal-title":"J Comp Neurol."},{"issue":"8","key":"2025112901525158600_fcaf420-B37","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1016\/j.neuropsychologia.2006.09.017","article-title":"Emotion recognition following human pulvinar damage","volume":"45","author":"Ward","year":"2007","journal-title":"Neuropsychologia"},{"issue":"3","key":"2025112901525158600_fcaf420-B38","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/joa.12932","article-title":"The medial pulvinar: Function, origin and association with neurodevelopmental disorders","volume":"235","author":"Homman-Ludiye","year":"2019","journal-title":"J Anat"},{"key":"2025112901525158600_fcaf420-B39","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.cortex.2020.08.023","article-title":"Social cognition impairment in genetic frontotemporal dementia within the GENFI cohort","volume":"133","author":"Russell","year":"2020","journal-title":"Cortex"},{"issue":"2","key":"2025112901525158600_fcaf420-B40","doi-asserted-by":"crossref","first-page":"e2881","DOI":"10.1002\/brb3.2881","article-title":"Thalamic pathology in frontotemporal dementia: Predilection for specific nuclei, phenotype-specific signatures, clinical correlates, and practical relevance","volume":"13","author":"McKenna","year":"2023","journal-title":"Brain Behav"},{"issue":"9","key":"2025112901525158600_fcaf420-B41","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1161\/01.STR.0000087786.38997.9E","article-title":"Vascular syndromes of the thalamus","volume":"34","author":"Schmahmann","year":"2003","journal-title":"Stroke"},{"key":"2025112901525158600_fcaf420-B42","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/B978-0-12-396460-1.00011-1","volume-title":"Diffusion MRI","author":"Bodini","year":"2014","edition":"edn"},{"issue":"1","key":"2025112901525158600_fcaf420-B43","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s13195-020-00679-2","article-title":"Measuring cortical mean diffusivity to assess early microstructural cortical change in presymptomatic familial Alzheimer\u2019s disease","volume":"12","author":"Weston","year":"2020","journal-title":"Alzheimers Res Ther"},{"issue":"5","key":"2025112901525158600_fcaf420-B44","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1093\/brain\/awt065","article-title":"Magnetic resonance imaging evidence for presymptomatic change in thalamus and caudate in familial Alzheimer\u2019s disease","volume":"136","author":"Ryan","year":"2013","journal-title":"Brain"},{"issue":"1","key":"2025112901525158600_fcaf420-B45","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13195-015-0132-3","article-title":"Diffusion imaging changes in grey matter in Alzheimer\u2019s disease: A potential marker of early neurodegeneration","volume":"7","author":"Weston","year":"2015","journal-title":"Alzheimers Res Ther"},{"issue":"6","key":"2025112901525158600_fcaf420-B46","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1007\/s11682-022-00711-z","article-title":"Pre-symptomatic radiological changes in frontotemporal dementia: Propagation characteristics, predictive value and implications for clinical trials","volume":"16","author":"McKenna","year":"2022","journal-title":"Brain Imaging Behav"},{"issue":"9","key":"2025112901525158600_fcaf420-B47","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1002\/acn3.601","article-title":"Presymptomatic white matter integrity loss in familial frontotemporal dementia in the GENFI cohort: A cross-sectional diffusion tensor imaging study","volume":"5","author":"Jiskoot","year":"2018","journal-title":"Ann Clin Transl Neurol"},{"key":"2025112901525158600_fcaf420-B48","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neurobiolaging.2020.08.004","article-title":"Age- and memory- related differences in hippocampal gray matter integrity are better captured by NODDI compared to single-tensor diffusion imaging","volume":"96","author":"Venkatesh","year":"2020","journal-title":"Neurobiol Aging"},{"issue":"11","key":"2025112901525158600_fcaf420-B49","doi-asserted-by":"crossref","first-page":"e209944","DOI":"10.1212\/WNL.0000000000209944","article-title":"Association of initial side of brain atrophy with clinical features and disease progression in patients with GRN frontotemporal dementia","volume":"103","author":"Borrego-Ecija","year":"2024","journal-title":"Neurology"}],"container-title":["Brain Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/braincomms\/advance-article-pdf\/doi\/10.1093\/braincomms\/fcaf420\/64925314\/fcaf420.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/7\/6\/fcaf420\/64925314\/fcaf420.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/7\/6\/fcaf420\/64925314\/fcaf420.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T06:53:04Z","timestamp":1764399184000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/braincomms\/article\/doi\/10.1093\/braincomms\/fcaf420\/8301026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,10,30]]}},"URL":"https:\/\/doi.org\/10.1093\/braincomms\/fcaf420","relation":{},"ISSN":["2632-1297"],"issn-type":[{"value":"2632-1297","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025]]},"published":{"date-parts":[[2025]]},"article-number":"fcaf420"}}