{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T13:30:12Z","timestamp":1769261412839,"version":"3.49.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["209933838"],"award-info":[{"award-number":["209933838"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015754","name":"Foundation of German Business","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015754","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The regulation of appetite by pharmaceuticals has gained significant interest for the treatment of obesity and cachexia. The melanocortin 4 receptor (MC4R) and the ghrelin receptor (GhrR) are known to play a crucial role in the regulation of energy homeostasis. Thus, peptide ligands, which modulate these receptors, have become attractive therapeutic lead structures. A key challenge is the efficient delivery of such peptides to the targeted receptors, which are expressed in the hypothalamus. Therefore, direct nose-to-brain delivery is a compelling strategy. Here, we report on food intake that is modulated by using intranasal applied peptides. We synthesized fluorescently labelled variants of the MC4R agonist setmelanotide, the GhrR agonist ghrelin (Ghr) and the GhrR inverse agonist KbFwLL-NH2 [\u03b2-(3-benzothienyl)-D-alanine (b)] and assessed their receptor activity. Further, we measured the permeability and stability of these peptides on Calu-3 cells as a model system for the nasal mucosa. Next, the uptake of peptides after intranasal application was analysed in vivo by quantification of fluorescent signals in the olfactory bulb, cortex and hypothalamus. In addition, we monitored the effects of the two most promising peptides on food intake in vivo. Although no significant changes in body weight were observed, we detected differences in the daily change in food intake: this parameter was reduced for mice treated with setmelanotide variants and increased for mice treated with GhrR agonists compared to a control group. Taken together, our findings clearly underline the high potential of intranasal peptide administration for modulating food intake.<\/jats:p>","DOI":"10.1093\/braincomms\/fcaf450","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:37:58Z","timestamp":1768567078000},"source":"Crossref","is-referenced-by-count":0,"title":["Modulating food intake by nasal application of peptides targeting melanocortin 4 receptor and ghrelin receptor systems"],"prefix":"10.1093","volume":"8","author":[{"given":"Benginur","family":"\u00d6zbay","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Institute of Anatomy, University of Leipzig , Leipzig 04103 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva-Maria","family":"J\u00fclke","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences, Institute of Biochemistry, University of Leipzig , Leipzig 04103 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moritz","family":"List","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences, Institute of Biochemistry, University of Leipzig , Leipzig 04103 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcin","family":"Nowicki","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Anatomy, University of Leipzig , Leipzig 04103 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvia","family":"Els-Heindl","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences, Institute of Biochemistry, University of Leipzig , Leipzig 04103 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Immig","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Anatomy, University of Leipzig , Leipzig 04103 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