{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T03:58:31Z","timestamp":1781582311105,"version":"3.54.5"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Alzheimer\u2019s disease (AD) is a significant global health issue, impacting 50 million individuals with dementia worldwide, a number projected to triple by 2050. Although research has been conducted for decades, there is no effective prevention, treatment, or early diagnostic method for AD. Research on AD in Latin America (LatAm) faces unique challenges compared to developed countries due to socioeconomic, cultural, and infrastructural factors. While the prevalence of dementia is rapidly increasing in LatAm due to demographic shifts, the region is underrepresented in research, diagnostics and care. The informed consent process, a critical aspect of research, becomes particularly complex with individuals who have cognitive impairments. It requires a balance between protecting vulnerable individuals and advancing research for their benefit. By developing and implementing best practices, ethical research can be conducted with this population, ensuring they receive appropriate care. This review provides an update on informed consent for AD research in Chile.<\/jats:p>","DOI":"10.1093\/braincomms\/fcag011","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T12:28:02Z","timestamp":1768307282000},"source":"Crossref","is-referenced-by-count":1,"title":["Biomedical research in Alzheimer\u2019s disease in a Latin American developing country: challenges in the informed consent process"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8700-8520","authenticated-orcid":false,"given":"Natalia","family":"Salvadores","sequence":"first","affiliation":[{"name":"Neurodegenerative Diseases Laboratory, Center for Biomedicine, Universidad Mayor , Temuco 4780000 ,","place":["Chile"]},{"name":"Comit\u00e9 \u00c9tico Cient\u00edfico, Universidad Mayor , Temuco 4780000 ,","place":["Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"issue":"5","key":"2026021203270293600_fcag011-B1","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.1002\/alz.13809","article-title":"2024 Alzheimer\u2019s disease facts and figures","volume":"20","author":"Alzheimer, Association","year":"2024","journal-title":"Alzheimer\u2019s & Dementia"},{"issue":"10248","key":"2026021203270293600_fcag011-B2","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0140-6736(20)30367-6","article-title":"Dementia prevention, intervention, and care: 2020 report of the lancet commission","volume":"396","author":"Livingston","year":"2020","journal-title":"The Lancet"},{"issue":"6","key":"2026021203270293600_fcag011-B3","doi-asserted-by":"crossref","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease at 25 years","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol Med"},{"issue":"15","key":"2026021203270293600_fcag011-B4","first-page":"1471","article-title":"WHO: Need for global dementia care planning is urgent","volume":"326","author":"Kuehn","year":"2021","journal-title":"JAMA"},{"key":"2026021203270293600_fcag011-B5","doi-asserted-by":"crossref","first-page":"100093","DOI":"10.1016\/j.nbas.2023.100093","article-title":"Rethinking the detection and diagnosis of Alzheimer\u2019s disease: Outcomes of a European brain council project","volume":"4","author":"Dumas","year":"2023","journal-title":"Aging Brain"},{"issue":"3","key":"2026021203270293600_fcag011-B6","doi-asserted-by":"crossref","first-page":"e0172204","DOI":"10.1371\/journal.pone.0172204","article-title":"The cost of dementia in an unequal country: The case of Chile","volume":"12","author":"Hojman","year":"2017","journal-title":"PLoS One"},{"key":"2026021203270293600_fcag011-B7","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1016\/j.jns.2015.08.112","article-title":"The cost of dementia: The case of Chile. 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