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However, the in vivo contribution of vitamin D to epileptogenesis remains unclear. In this study, we observed a significant increase in vitamin D receptor (VDR) mRNA level at 6\u201312\u2005h after seizure onset in four distinct classic epilepsy models. Vitamin D receptor protein expression also increased following pilocarpine-induced seizures, particularly in the hippocampal granule cell layer. Subsequently, we found that aberrant vitamin D dietary levels could accelerate kindling development. To our surprise, excessive vitamin D intake reduced the frequency of spontaneous seizures in the pilocarpine model, whereas vitamin D deficiency decreased mossy fibre sprouting\u2014a hallmark of epileptogenesis. These findings provide new insights into the mechanisms underlying limbic epileptogenesis.<\/jats:p>","DOI":"10.1093\/braincomms\/fcag049","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T12:41:34Z","timestamp":1770986494000},"source":"Crossref","is-referenced-by-count":1,"title":["Vitamin D is involved in regulating limbic epileptogenesis"],"prefix":"10.1093","volume":"8","author":[{"given":"Shuya","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Human Anatomy, Institute of Neuroscience and Guangxi Key Laboratory of Brain Science, School of Basic Medical Sciences, Guangxi Medical University , Nanning, Guangxi 530021 ,","place":["China"]},{"name":"Key Laboratory of Longevity and Aging-Related Diseases of Chinese Ministry of Education , Guangxi Medical University, Nanning, Guangxi 530021 ,","place":["China"]},{"name":"Health Commission Key Laboratory of Basic Research on Brain Function and Disease, Key Laboratory of Human Development and Disease Research by Education Department of Guangxi Zhuang Autonomous Region , Nanning, Guangxi 530021 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyue","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, Institute of Neuroscience and Guangxi Key Laboratory of Brain Science, School of Basic Medical Sciences, Guangxi Medical University , Nanning, Guangxi 530021 ,","place":["China"]},{"name":"Key Laboratory of Longevity and Aging-Related Diseases of Chinese Ministry of Education , Guangxi Medical University, Nanning, Guangxi 530021 ,","place":["China"]},{"name":"Health Commission Key Laboratory of Basic Research on Brain Function and Disease, Key Laboratory of Human Development and Disease Research by Education Department of Guangxi Zhuang Autonomous Region , Nanning, Guangxi 530021 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Key Laboratory of Brain Science, School of Basic Medical Sciences, Guangxi Medical University , Nanning, Guangxi 530021 ,","place":["China"]},{"name":"Health Commission Key Laboratory of Basic Research on Brain Function and Disease, Key Laboratory of Human Development and Disease Research by Education Department of Guangxi Zhuang Autonomous Region , Nanning, Guangxi 530021 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohe","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, Institute of Neuroscience and Guangxi Key Laboratory of Brain Science, School of Basic Medical Sciences, Guangxi Medical University , Nanning, Guangxi 530021 ,","place":["China"]},{"name":"Key Laboratory of Longevity and Aging-Related Diseases of Chinese Ministry of Education , Guangxi Medical University, Nanning, Guangxi 530021 ,","place":["China"]},{"name":"Health Commission Key Laboratory of Basic Research on Brain Function and 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