{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:54:19Z","timestamp":1784555659157,"version":"3.55.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":68,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019179","name":"\"la Caixa\" Foundation","doi-asserted-by":"publisher","award":["ID 100010434"],"award-info":[{"award-number":["ID 100010434"]}],"id":[{"id":"10.13039\/501100019179","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019179","name":"\"la Caixa\" Foundation","doi-asserted-by":"publisher","award":["LCF\/PR\/GN17\/50300004"],"award-info":[{"award-number":["LCF\/PR\/GN17\/50300004"]}],"id":[{"id":"10.13039\/501100019179","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019179","name":"\"la Caixa\" Foundation","doi-asserted-by":"publisher","award":["SLT002\/16\/00201"],"award-info":[{"award-number":["SLT002\/16\/00201"]}],"id":[{"id":"10.13039\/501100019179","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019179","name":"\"la Caixa\" Foundation","doi-asserted-by":"publisher","award":["TriBEKa-17-519007"],"award-info":[{"award-number":["TriBEKa-17-519007"]}],"id":[{"id":"10.13039\/501100019179","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019179","name":"\"la Caixa\" Foundation","doi-asserted-by":"publisher","award":["ID 100010434"],"award-info":[{"award-number":["ID 100010434"]}],"id":[{"id":"10.13039\/501100019179","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019179","name":"\"la Caixa\" Foundation","doi-asserted-by":"publisher","award":["847648"],"award-info":[{"award-number":["847648"]}],"id":[{"id":"10.13039\/501100019179","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019179","name":"\"la Caixa\" Foundation","doi-asserted-by":"publisher","award":["LCF\/BQ\/PR21\/11840004"],"award-info":[{"award-number":["LCF\/BQ\/PR21\/11840004"]}],"id":[{"id":"10.13039\/501100019179","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Universities and Research Secretariat"},{"name":"Ministry of Business and Knowledge of the Catalan Government","award":["2021 SGR 00913"],"award-info":[{"award-number":["2021 SGR 00913"]}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["#2023-00356"],"award-info":[{"award-number":["#2023-00356"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["#2022-01018"],"award-info":[{"award-number":["#2022-01018"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["#2019-02397"],"award-info":[{"award-number":["#2019-02397"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["101053962"],"award-info":[{"award-number":["101053962"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["#ALFGBG-71320"],"award-info":[{"award-number":["#ALFGBG-71320"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["#201809-2016862"],"award-info":[{"award-number":["#201809-2016862"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["#ADSF-21-831376-C"],"award-info":[{"award-number":["#ADSF-21-831376-C"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["#ADSF-21-831381-C"],"award-info":[{"award-number":["#ADSF-21-831381-C"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["#ADSF-21-831377-C"],"award-info":[{"award-number":["#ADSF-21-831377-C"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["#ADSF-24-1284328-C"],"award-info":[{"award-number":["#ADSF-24-1284328-C"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["#22HLT07"],"award-info":[{"award-number":["#22HLT07"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["#FO2022-0270"],"award-info":[{"award-number":["#FO2022-0270"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["860197"],"award-info":[{"award-number":["860197"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["JPND2021-00694"],"award-info":[{"award-number":["JPND2021-00694"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["#2017-00915"],"award-info":[{"award-number":["#2017-00915"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["#2022-00732"],"award-info":[{"award-number":["#2022-00732"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["#AF-930351"],"award-info":[{"award-number":["#AF-930351"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["#AF-939721"],"award-info":[{"award-number":["#AF-939721"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["#AF-968270"],"award-info":[{"award-number":["#AF-968270"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["#AF-994551"],"award-info":[{"award-number":["#AF-994551"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["#FO2017-0243"],"award-info":[{"award-number":["#FO2017-0243"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["#ALZ2022-0006"],"award-info":[{"award-number":["#ALZ2022-0006"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["#ALFGBG-715986"],"award-info":[{"award-number":["#ALFGBG-715986"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["#ALFGBG-965240"],"award-info":[{"award-number":["#ALFGBG-965240"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["JPND2019-466-236"],"award-info":[{"award-number":["JPND2019-466-236"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["ZEN-21-848495"],"award-info":[{"award-number":["ZEN-21-848495"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["SG-23-1038904 QC"],"award-info":[{"award-number":["SG-23-1038904 QC"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["948677"],"award-info":[{"award-number":["948677"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["PI19\/00155"],"award-info":[{"award-number":["PI19\/00155"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["PI22\/00456"],"award-info":[{"award-number":["PI22\/00456"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre"},{"DOI":"10.13039\/501100017510","name":"UK Dementia Research Institute","doi-asserted-by":"publisher","award":["UKDRI-1003"],"award-info":[{"award-number":["UKDRI-1003"]}],"id":[{"id":"10.13039\/501100017510","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017510","name":"UK Dementia Research Institute","doi-asserted-by":"publisher","award":["2019-AARF-644568"],"award-info":[{"award-number":["2019-AARF-644568"]}],"id":[{"id":"10.13039\/501100017510","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Spanish Ministry of Science, Innovation and Universities","award":["IJC2020-043417-I"],"award-info":[{"award-number":["IJC2020-043417-I"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In the preclinical stages of Alzheimer\u2019s disease, increased brain volume has been associated with amyloid-beta pathology, particularly in regions that undergo volume reductions as the disease progresses. Glial reactivity and water diffusion alterations have been linked to such macroscopic volumetric changes. Brain volume reductions have also been reported following amyloid-beta removal with anti-amyloid therapies with beneficial clinical effects, but it remains unclear whether these changes result from resolving amyloid-triggered neuroinflammation or neurodegeneration. Intravoxel incoherent motion modelling based on multi-shell diffusion-weighted imaging may provide a better understanding of the processes underlying these paradoxical changes. This study used intravoxel incoherent motion diffusion MRI to examine how alterations in cerebral water pools contribute to increased brain volume linked to amyloid-beta deposition and neuroinflammation in cognitively unimpaired individuals. We developed a three-compartment diffusion MRI model with four parameters of cerebral water diffusion: slow diffusion coefficient, fast diffusion coefficient, slow signal portion, and perfusion fraction. We computed these diffusion parameters in 297 cognitively unimpaired late middle-aged adults, 35% of whom showed evidence of amyloid deposition. We examined their correlation with demographic factors (age, sex, apolipoprotein E status), markers of Alzheimer\u2019s disease pathology, neurodegeneration, neuroinflammation, and mean diffusivity. Then, we identified regions showing grey matter volume increases related to amyloid burden and examined the association between grey matter volume and diffusion parameters within these regions. We did not find evidence of associations between diffusion parameters and amyloid-related biomarkers, whether assessed by PET or cerebrospinal fluid measures. In contrast, the four diffusion parameters showed strong and widespread associations with biomarkers of neuroinflammation and neurodegeneration, particularly in frontoparietal and cingulate regions. Additionally, in grey matter regions where volume increases were related to amyloid levels, volumes were negatively correlated with the slow diffusion coefficient (P = 0.001), perfusion fraction (P = 0.036) and mean diffusivity (P = 0.047). These findings indicate that diffusion-derived measures are more sensitive to neuroinflammatory and neurodegenerative processes than to amyloid pathology in cognitively unimpaired individuals. Furthermore, the observed negative association between grey matter volume and slow diffusion coefficient in amyloid-related regions may reflect increased cellular complexity rather than intracellular water accumulation. This interpretation suggests that glial remodelling or microstructural changes could underlie brain volume increases in amyloid-positive individuals without overt neurodegeneration. These results underscore the value of intravoxel incoherent motion-derived metrics for gaining deeper insights into the pathophysiological mechanisms of Alzheimer\u2019s disease, influencing brain volume changes as well as those resulting from the response to anti-amyloid therapies.<\/jats:p>","DOI":"10.1093\/braincomms\/fcag075","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T12:25:30Z","timestamp":1773059130000},"source":"Crossref","is-referenced-by-count":1,"title":["Intracellular fluid accumulation underlies brain volume increases in early Alzheimer\u2019s disease"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4312-4401","authenticated-orcid":false,"given":"Michalis","family":"Kassinopoulos","sequence":"first","affiliation":[{"name":"Barcelona\u03b2eta Brain Research Center (BBRC), Pasqual Maragall Foundation , Barcelona 08005 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Montesinos","sequence":"additional","affiliation":[{"name":"Philips Healthcare Iberia , Madrid 28050 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carles","family":"Falcon","sequence":"additional","affiliation":[{"name":"Barcelona\u03b2eta Brain Research Center (BBRC), Pasqual Maragall Foundation , Barcelona 08005 ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), Instituto de Salud Carlos III , Madrid 28029 ,","place":["Spain"]},{"name":"Hospital del Mar Research Institute , Barcelona 08003 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Huguet","sequence":"additional","affiliation":[{"name":"Barcelona\u03b2eta Brain Research Center (BBRC), Pasqual Maragall Foundation , Barcelona 08005 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Minguillon","sequence":"additional","affiliation":[{"name":"Barcelona\u03b2eta Brain Research Center (BBRC), Pasqual Maragall Foundation , Barcelona 08005 ,","place":["Spain"]},{"name":"Hospital del Mar Research Institute , Barcelona 08003 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Fauria","sequence":"additional","affiliation":[{"name":"Barcelona\u03b2eta Brain Research Center (BBRC), Pasqual Maragall Foundation , Barcelona 08005 ,","place":["Spain"]},{"name":"Hospital del Mar Research Institute , Barcelona 08003 ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III , Madrid 28029 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwendlyn","family":"Kollmorgen","sequence":"additional","affiliation":[{"name":"Roche Diagnostics GmbH , Penzberg 82377 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Quijano-Rubio","sequence":"additional","affiliation":[{"name":"Roche Diagnostics International Ltd , Rotkreuz 6343 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Molinuevo","sequence":"additional","affiliation":[{"name":"Barcelona\u03b2eta Brain Research Center (BBRC), Pasqual Maragall Foundation , Barcelona 08005 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4730-5341","authenticated-orcid":false,"given":"Oriol","family":"Grau-Rivera","sequence":"additional","affiliation":[{"name":"Barcelona\u03b2eta Brain Research Center (BBRC), Pasqual Maragall Foundation , Barcelona 08005 ,","place":["Spain"]},{"name":"Hospital del Mar Research Institute , Barcelona 08003 ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III , Madrid 28029 ,","place":["Spain"]},{"name":"Servei de Neurologia, Hospital del Mar , Barcelona 08003 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3930-4354","authenticated-orcid":false,"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital , M\u00f6lndal 431 80 ,","place":["Sweden"]},{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg , M\u00f6lndal 431 80 ,","place":["Sweden"]},{"name":"UK Dementia Research Institute at University College London (UCL) , London WC1N 3BG ,","place":["UK"]},{"name":"Department of Neurodegenerative Disease, UCL Institute of Neurology , London WC1M 3BG ,","place":["UK"]},{"name":"Hong Kong Center for Neurodegenerative Diseases , Hong Kong ,","place":["China"]},{"name":"Wisconsin Alzheimer\u2019s Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison , Madison 53705, WI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[{"name":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital , M\u00f6lndal 431 80 ,","place":["Sweden"]},{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg , M\u00f6lndal 431 80 ,","place":["Sweden"]},{"name":"Paris Brain Institute, ICM, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Sorbonne University , Paris 75013 ,","place":["France"]},{"name":"Neurodegenerative Disorder Research Center, Division of Life Sciences and Medicine, and Department of Neurology, Institute on Aging and Brain Disorders, University of Science and Technology of China and First Affiliated Hospital of USTC , Hefei 230001 ,","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Su\u00e1rez-Calvet","sequence":"additional","affiliation":[{"name":"Barcelona\u03b2eta Brain Research Center (BBRC), Pasqual Maragall Foundation , Barcelona 08005 ,","place":["Spain"]},{"name":"Hospital del Mar Research Institute , Barcelona 08003 ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III , Madrid 28029 ,","place":["Spain"]},{"name":"Servei de Neurologia, Hospital del Mar , Barcelona 08003 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Sanchez-Gonzalez","sequence":"additional","affiliation":[{"name":"Philips Healthcare Iberia , Madrid 28050 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Domingo","family":"Gispert","sequence":"additional","affiliation":[{"name":"Barcelona\u03b2eta Brain Research Center (BBRC), Pasqual Maragall Foundation , Barcelona 08005 ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), Instituto de Salud Carlos III , Madrid 28029 ,","place":["Spain"]},{"name":"Hospital del Mar Research Institute , Barcelona 08003 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"ALFA study","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00fcge","family":"Akinci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Anastasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabella","family":"Beteta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Cacciaglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Canals","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Ca\u00f1as","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carme","family":"Deulofeu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Emilio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Cumplido-Mayoral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"del Campo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carme","family":"Deulofeu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Dominguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Emilio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherezade","family":"Fuentes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gema","family":"Huesa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Iglesias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"L\u00f3pez-Martos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Marne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Mench\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Ortiz-Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Palpatzis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiesje","family":"Pelkmans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albina","family":"Polo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Pradas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahnaz","family":"Shekari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Llu\u00eds","family":"Solsona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Soteras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria","family":"Tort-Colet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Vilanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia Vilor","family":"Tejedor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"issue":"10284","key":"2026041703580562700_fcag075-B1","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","article-title":"Alzheimer\u2019s disease","volume":"397","author":"Scheltens","year":"2021","journal-title":"Lancet"},{"issue":"4","key":"2026041703580562700_fcag075-B2","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer\u2019s disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol"},{"issue":"3","key":"2026041703580562700_fcag075-B3","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.jalz.2017.09.013","article-title":"Cortical microstructural changes along the Alzheimer\u2019s disease continuum","volume":"14","author":"Montal","year":"2018","journal-title":"Alzheimers Dement"},{"key":"2026041703580562700_fcag075-B4","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/s41380-023-02387-3","article-title":"Different inflammatory signatures based on CSF biomarkers relate to preserved or diminished brain structure and cognition","volume":"29","author":"Hayek","year":"2024","journal-title":"Mol Psychiatry"},{"key":"2026041703580562700_fcag075-B5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.neurobiolaging.2015.10.022","article-title":"CSF YKL-40 and pTau181 are related to different cerebral morphometric patterns in early AD","volume":"38","author":"Gispert","year":"2016","journal-title":"Neurobiol Aging"},{"key":"2026041703580562700_fcag075-B6","doi-asserted-by":"crossref","first-page":"101801","DOI":"10.1016\/j.nicl.2019.101801","article-title":"CSF glial biomarkers YKL40 and sTREM2 are associated with longitudinal volume and diffusivity changes in cognitively unimpaired individuals","volume":"23","author":"Falcon","year":"2019","journal-title":"Neuroimage Clin"},{"issue":"3","key":"2026041703580562700_fcag075-B7","doi-asserted-by":"crossref","first-page":"fcac134","DOI":"10.1093\/braincomms\/fcac134","article-title":"Brain alterations in the early Alzheimer\u2019s continuum with amyloid-\u03b2, tau, glial and neurodegeneration CSF markers","volume":"4","author":"Salvad\u00f3","year":"2022","journal-title":"Brain Commun"},{"issue":"12","key":"2026041703580562700_fcag075-B8","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.jalz.2016.06.005","article-title":"Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer\u2019s disease","volume":"12","author":"Gispert","year":"2016","journal-title":"Alzheimers Dement"},{"issue":"1","key":"2026041703580562700_fcag075-B9","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJMoa2212948","article-title":"Lecanemab in early Alzheimer\u2019s disease","volume":"388","author":"van Dyck","year":"2023","journal-title":"N Engl J Med"},{"issue":"6","key":"2026041703580562700_fcag075-B10","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1001\/jama.2023.13239","article-title":"Donanemab in early symptomatic Alzheimer disease: The TRAILBLAZER-ALZ 2 randomized clinical trial","volume":"330","author":"Sims","year":"2023","journal-title":"JAMA"},{"issue":"20","key":"2026041703580562700_fcag075-B11","doi-asserted-by":"crossref","first-page":"e2114","DOI":"10.1212\/WNL.0000000000207156","article-title":"Accelerated brain volume loss caused by anti\u2013\u03b2-amyloid drugs","volume":"100","author":"Alves","year":"2023","journal-title":"Neurology"},{"issue":"9","key":"2026041703580562700_fcag075-B12","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1212\/01.WNL.0000159743.08996.99","article-title":"Effects of A\u03b2 immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease","volume":"64","author":"Fox","year":"2005","journal-title":"Neurology"},{"issue":"10","key":"2026041703580562700_fcag075-B13","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/S1474-4422(24)00335-1","article-title":"Brain volume change following anti-amyloid \u03b2 immunotherapy for Alzheimer\u2019s disease: Amyloid-removal-related pseudo-atrophy","volume":"23","author":"Belder","year":"2024","journal-title":"Lancet Neurol"},{"issue":"1","key":"2026041703580562700_fcag075-B14","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/jmri.25519","article-title":"Intravoxel incoherent motion modeling in the kidneys: Comparison of mono-, bi-, and triexponential fit","volume":"46","author":"van Baalen","year":"2017","journal-title":"J Magn Reson Imaging"},{"issue":"3","key":"2026041703580562700_fcag075-B15","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jalz.2016.08.005","article-title":"Defining imaging biomarker cut points for brain aging and Alzheimer\u2019s disease","volume":"13","author":"Jack","year":"2017","journal-title":"Alzheimers Dement"},{"key":"2026041703580562700_fcag075-B16","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.nicl.2016.05.017","article-title":"A large-scale comparison of cortical thickness and volume methods for measuring Alzheimer\u2019s disease severity","volume":"11","author":"Schwarz","year":"2016","journal-title":"Neuroimage Clin"},{"issue":"2","key":"2026041703580562700_fcag075-B17","first-page":"82","article-title":"The ALFA project: A research platform to identify early pathophysiological features of Alzheimer\u2019s disease","volume":"2","author":"Molinuevo","year":"2016","journal-title":"Alzheimers Dement"},{"issue":"8","key":"2026041703580562700_fcag075-B18","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1001\/jamaneurol.2014.803","article-title":"The preclinical Alzheimer cognitive composite: Measuring amyloid-related decline","volume":"71","author":"Donohue","year":"2014","journal-title":"JAMA Neurol"},{"key":"2026041703580562700_fcag075-B19","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.neurobiolaging.2021.02.026","article-title":"Amyloid-\u03b2 positive individuals with subjective cognitive decline present increased CSF neurofilament light levels that relate to lower hippocampal volume","volume":"104","author":"S\u00e1nchez-Benavides","year":"2021","journal-title":"Neurobiol Aging"},{"issue":"12","key":"2026041703580562700_fcag075-B20","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.3174\/ajnr.A4929","article-title":"A simplified model for intravoxel incoherent motion perfusion imaging of the brain","volume":"37","author":"Conklin","year":"2016","journal-title":"AJNR Am J Neuroradiol"},{"issue":"2","key":"2026041703580562700_fcag075-B21","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.neuroimage.2011.09.015","article-title":"FSL","volume":"62","author":"Jenkinson","year":"2012","journal-title":"Neuroimage"},{"issue":"10","key":"2026041703580562700_fcag075-B22","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1002\/alz.12131","article-title":"Amyloid beta, tau, synaptic, neurodegeneration, and glial biomarkers in the preclinical stage of the Alzheimer\u2019s continuum","volume":"16","author":"Mil\u00e0-Alom\u00e0","year":"2020","journal-title":"Alzheimers Dement"},{"key":"2026041703580562700_fcag075-B23","first-page":"3676","article-title":"Cerebrospinal fluid reference proteins increase accuracy and interpretability of biomarkers for brain diseases","volume":"15","author":"Karlsson","year":"2024","journal-title":"Neuroscience"},{"issue":"1","key":"2026041703580562700_fcag075-B24","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/s41380-020-0721-9","article-title":"Biomarkers for Alzheimer\u2019s disease\u2014preparing for a new era of disease-modifying therapies","volume":"26","author":"Zetterberg","year":"2021","journal-title":"Mol Psychiatry"},{"issue":"20","key":"2026041703580562700_fcag075-B25","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1212\/WNL.0000000000207268","article-title":"Brain shrinkage in anti-\u03b2-amyloid Alzheimer trials: Neurodegeneration or pseudoatrophy?","volume":"100","author":"Barkhof","year":"2023","journal-title":"Neurology"},{"issue":"6","key":"2026041703580562700_fcag075-B26","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1002\/jmri.27272","article-title":"Preliminary assessment of intravoxel incoherent motion diffusion-weighted MRI (IVIM-DWI) metrics in Alzheimer\u2019s disease","volume":"52","author":"Bergamino","year":"2020","journal-title":"J Magn Reson Imaging"},{"issue":"1","key":"2026041703580562700_fcag075-B27","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/alz.12364","article-title":"Interaction of amyloid and tau on cortical microstructure in cognitively unimpaired adults","volume":"18","author":"Vogt","year":"2022","journal-title":"Alzheimers Dement"},{"issue":"3","key":"2026041703580562700_fcag075-B28","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00234-012-1129-2","article-title":"The use of multi b values diffusion-weighted imaging in patients with acute stroke","volume":"55","author":"Liu","year":"2013","journal-title":"Neuroradiology"},{"issue":"3","key":"2026041703580562700_fcag075-B29","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1177\/1747493019873515","article-title":"Comparison of MRI IVIM and MR perfusion imaging in acute ischemic stroke due to large vessel occlusion","volume":"15","author":"Zhu","year":"2020","journal-title":"Int J Stroke"},{"issue":"9","key":"2026041703580562700_fcag075-B30","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1002\/acn3.50836","article-title":"Probing axons using multi-compartmental diffusion in multiple sclerosis","volume":"6","author":"Bagnato","year":"2019","journal-title":"Ann Clin Transl Neurol"},{"issue":"6","key":"2026041703580562700_fcag075-B31","doi-asserted-by":"crossref","first-page":"e63869","DOI":"10.1371\/journal.pone.0063869","article-title":"Analysis of multiple B-value diffusion-weighted imaging in pediatric acute encephalopathy","volume":"8","author":"Tachibana","year":"2013","journal-title":"PLoS One"},{"key":"2026041703580562700_fcag075-B32","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neurobiolaging.2021.06.017","article-title":"Associations of increased interstitial fluid with vascular and neurodegenerative abnormalities in a memory clinic sample","volume":"106","author":"van der Thiel","year":"2021","journal-title":"Neurobiol Aging"},{"issue":"2","key":"2026041703580562700_fcag075-B33","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s11682-021-00538-0","article-title":"Intravoxel incoherent motion diffusion-weighted imaging in the characterization of Alzheimer\u2019s disease","volume":"16","author":"Xia","year":"2022","journal-title":"Brain Imaging Behav"},{"key":"2026041703580562700_fcag075-B34","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3389\/fnins.2018.00102","article-title":"A modified tri-exponential model for multi-b-value diffusion-weighted imaging: A method to detect the strictly diffusion-limited compartment in brain","volume":"12","author":"Zeng","year":"2018","journal-title":"Front Neurosci"},{"key":"2026041703580562700_fcag075-B35","doi-asserted-by":"crossref","first-page":"116228","DOI":"10.1016\/j.neuroimage.2019.116228","article-title":"Effect of intravoxel incoherent motion on diffusion parameters in normal brain","volume":"204","author":"Vieni","year":"2020","journal-title":"NeuroImage"},{"issue":"6","key":"2026041703580562700_fcag075-B36","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1007\/s11682-021-00548-y","article-title":"Age and sex effects on advanced white matter microstructure measures in 15,628 older adults: A UK biobank study","volume":"15","author":"Lawrence","year":"2021","journal-title":"Brain Imaging Behav"},{"issue":"3","key":"2026041703580562700_fcag075-B37","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1093\/brain\/awad428","article-title":"Diffusion MRI tracks cortical microstructural changes during the early stages of Alzheimer\u2019s disease","volume":"147","author":"Spotorno","year":"2024","journal-title":"Brain"},{"issue":"1","key":"2026041703580562700_fcag075-B38","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s13195-020-00679-2","article-title":"Measuring cortical mean diffusivity to assess early microstructural cortical change in presymptomatic familial Alzheimer\u2019s disease","volume":"12","author":"Weston","year":"2020","journal-title":"Alz Res Therapy"},{"issue":"12","key":"2026041703580562700_fcag075-B39","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1001\/jamaneurol.2022.3392","article-title":"Association of donanemab treatment with exploratory plasma biomarkers in early symptomatic Alzheimer disease: A secondary analysis of the TRAILBLAZER-ALZ randomized clinical trial","volume":"79","author":"Pontecorvo","year":"2022","journal-title":"JAMA Neurol"},{"key":"2026041703580562700_fcag075-B40","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.neuroimage.2016.08.016","article-title":"Denoising of diffusion MRI using random matrix theory","volume":"142","author":"Veraart","year":"2016","journal-title":"NeuroImage"}],"container-title":["Brain Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/braincomms\/advance-article-pdf\/doi\/10.1093\/braincomms\/fcag075\/67289682\/fcag075.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/8\/2\/fcag075\/68100979\/fcag075.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/8\/2\/fcag075\/68100979\/fcag075.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T08:00:02Z","timestamp":1776412802000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/braincomms\/article\/doi\/10.1093\/braincomms\/fcag075\/8513135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3,3]]}},"URL":"https:\/\/doi.org\/10.1093\/braincomms\/fcag075","relation":{},"ISSN":["2632-1297"],"issn-type":[{"value":"2632-1297","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026]]},"published":{"date-parts":[[2026]]},"article-number":"fcag075"}}