{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T08:59:07Z","timestamp":1776416347908,"version":"3.51.2"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":82,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017962","name":"Elderly Health in Jiangsu Province","doi-asserted-by":"publisher","award":["LKM2023014"],"award-info":[{"award-number":["LKM2023014"]}],"id":[{"id":"10.13039\/100017962","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health Committee of Jiangsu Province","award":["H2023134"],"award-info":[{"award-number":["H2023134"]}]},{"DOI":"10.13039\/501100024892","name":"Paired Assistance Scientific Research Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012217","name":"Xuzhou Medical University","doi-asserted-by":"publisher","award":["SHJDBF2024216"],"award-info":[{"award-number":["SHJDBF2024216"]}],"id":[{"id":"10.13039\/501100012217","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012217","name":"Xuzhou Medical University","doi-asserted-by":"publisher","award":["PYJH2025205"],"award-info":[{"award-number":["PYJH2025205"]}],"id":[{"id":"10.13039\/501100012217","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Emerging evidence indicates that stroke may impair glymphatic function by disrupting cerebrospinal fluid clearance. The coupling between global blood-oxygen-level-dependent signals and cerebrospinal fluid flow has been proposed as a non-invasive biomarker of glymphatic activity. However, it remains unclear whether this coupling can be modulated through rehabilitation. This study investigated whether language therapy in patients with post-stroke aphasia enhances global blood-oxygen-level-dependent\u2013 cerebrospinal fluid coupling, thereby reflecting potential restoration of fluid\u2013brain interaction. This longitudinal observational study was conducted at a single centre and included 20 patients with post-stroke aphasia and 35 age- and sex-balanced healthy controls. All participants underwent MRI scanning, including resting-state blood-oxygen-level-dependent and structural imaging. Among the post-stroke aphasia group, 14 patients completed both pre- and post-treatment assessments after undergoing a standardized 4-week speech-language therapy programme. The Western Aphasia Battery was used to quantify language deficits and monitor treatment-related changes. Global blood-oxygen-level-dependent\u2013cerebrospinal fluid coupling was quantified using cross-correlation analysis across the whole brain and four predefined language-related resting-state networks. At baseline, patients exhibited significantly reduced global blood-oxygen-level-dependent\u2013cerebrospinal fluid coupling compared to healthy controls (P &amp;lt; 0.05). Following therapy, coupling significantly increased within the language, salience and dorsal attention networks, whereas coupling within the default mode network significantly decreased (all P &amp;lt; 0.05). Notably, increased global blood-oxygen-level-dependent\u2013cerebrospinal fluid coupling in specific networks was significantly correlated with improvements in targeted language functions, such as object naming, responsive naming and auditory word recognition (P &amp;lt; 0.05). These findings suggest that language rehabilitation enhances neurophysiological coupling between brain activity and cerebrospinal fluid flow, potentially reflecting restoration of fluid\u2013brain interaction in post-stroke aphasia.<\/jats:p>","DOI":"10.1093\/braincomms\/fcag106","type":"journal-article","created":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T12:38:19Z","timestamp":1774096699000},"source":"Crossref","is-referenced-by-count":0,"title":["Network-specific enhancement of global blood-oxygen-level-dependent signals and CSF coupling after language therapy in post-stroke aphasia"],"prefix":"10.1093","volume":"8","author":[{"given":"Chao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Radiology, Affiliated Hospital of Xuzhou Medical University , Xuzhou, Jiangsu Province 221006 ,","place":["P.R. 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