{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:00:49Z","timestamp":1791406849842,"version":"4.3.3"},"reference-count":168,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":89,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["#2023-00356"],"award-info":[{"award-number":["#2023-00356"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["#2022-01018"],"award-info":[{"award-number":["#2022-01018"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["#2019-02397"],"award-info":[{"award-number":["#2019-02397"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["101053962"],"award-info":[{"award-number":["101053962"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["#22HLT07"],"award-info":[{"award-number":["#22HLT07"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swedish State Support for Clinical Research","award":["#ALFGBG-71320"],"award-info":[{"award-number":["#ALFGBG-71320"]}]},{"DOI":"10.13039\/100002565","name":"Alzheimer Drug Discovery Foundation","doi-asserted-by":"publisher","award":["#201809-2016862"],"award-info":[{"award-number":["#201809-2016862"]}],"id":[{"id":"10.13039\/100002565","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["#ADSF-21-831376-C"],"award-info":[{"award-number":["#ADSF-21-831376-C"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["#ADSF-21-831381-C"],"award-info":[{"award-number":["#ADSF-21-831381-C"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["#ADSF-21-831377-C"],"award-info":[{"award-number":["#ADSF-21-831377-C"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["#ADSF-24-1284328-C"],"award-info":[{"award-number":["#ADSF-24-1284328-C"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019599","name":"European Partnership on Metrology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019599","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bluefield Project"},{"DOI":"10.13039\/100007625","name":"Cure Alzheimer\u2019s Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021720","name":"Olav Thon Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021720","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007436","name":"Erling-Persson Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007436","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Familjen R\u00f6nstr\u00f6ms Stiftelse"},{"DOI":"10.13039\/100010815","name":"Stiftelsen f\u00f6r Gamla Tj\u00e4narinnor","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010815","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hj\u00e4rnfonden, Sweden","award":["#FO2022-0270"],"award-info":[{"award-number":["#FO2022-0270"]}]},{"name":"Marie Sk\u0142odowska-Curie","award":["860197"],"award-info":[{"award-number":["860197"]}]},{"DOI":"10.13039\/100013278","name":"European Union Joint Programme\u2014Neurodegenerative Disease Research","doi-asserted-by":"publisher","award":["JPND2021-00694"],"award-info":[{"award-number":["JPND2021-00694"]}],"id":[{"id":"10.13039\/100013278","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre"},{"DOI":"10.13039\/501100017510","name":"UK Dementia Research Institute at UCL","doi-asserted-by":"publisher","award":["UKDRI-1003"],"award-info":[{"award-number":["UKDRI-1003"]}],"id":[{"id":"10.13039\/501100017510","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ferroptosis is a redox-driven and iron-dependent type of programmed cell death, with lipid peroxidation as a central and required feature of the process. During ferroptosis, cells exert strong proinflammatory effects, suggesting that ferroptosis may play a role in the regulation of inflammation and immune response. However, very few studies have investigated the process of ferroptosis and lipid peroxidation in microglia, the innate immune cells of the brain. In this review, we summarize the concept of ferroptosis and present a list of 120 ferroptosis-relevant proteins, which includes over twice as many entries as the current Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway for ferroptosis. We compare our manually compiled list with microglial activation signatures reported by us and others, revealing ferroptosis-relevant changes in models for microglial activation. Finally, we highlight a selection of ferroptosis-relevant proteins as potential biomarker candidates for ferroptosis.<\/jats:p>","DOI":"10.1093\/braincomms\/fcag109","type":"journal-article","created":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T12:47:13Z","timestamp":1774702033000},"source":"Crossref","is-referenced-by-count":6,"title":["Ferroptosis in microglial activation: a systematic review and multidata comparison"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3902-3137","authenticated-orcid":false,"given":"Ida","family":"Pes\u00e4maa","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg , Gothenberg 413 45 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivas","family":"Koutarapu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine , St Louis, MO 63110 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3930-4354","authenticated-orcid":false,"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg , Gothenberg 413 45 ,","place":["Sweden"]},{"name":"Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Sahlgrenska University Hospital , M\u00f6lndal 431 80 ,","place":["Sweden"]},{"name":"Department of Neurodegenerative Disease, University College London (UCL) Institute of Neurology , London WC1N 3BG ,","place":["UK"]},{"name":"UK Dementia Research Institute at University College London , London NW1 3BT ,","place":["UK"]},{"name":"Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health , Madison, WI 53705 ,","place":["USA"]},{"name":"Wisconsin Alzheimer\u2019s Disease Research Center, School of Medicine and Public Health, University of Wisconsin, University of Wisconsin-Madison , Madison, WI 53792 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Fruhw\u00fcrth","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg , Gothenberg 413 45 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"issue":"1","key":"2026041704023984800_fcag109-B1","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/s41420-023-01581-0","article-title":"Different types of cell death and their shift in shaping disease","volume":"9","author":"Shen","year":"2023","journal-title":"Cell Death Discov"},{"issue":"2","key":"2026041704023984800_fcag109-B2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41419-023-05691-6","article-title":"The double-edged functions of necroptosis","volume":"14","author":"Ye","year":"2023","journal-title":"Cell Death Dis"},{"issue":"2","key":"2026041704023984800_fcag109-B3","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.cell.2023.11.044","article-title":"Cell death","volume":"187","author":"Newton","year":"2024","journal-title":"Cell"},{"issue":"5","key":"2026041704023984800_fcag109-B4","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: An iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"2026041704023984800_fcag109-B5","doi-asserted-by":"crossref","first-page":"110108","DOI":"10.1016\/j.biopha.2020.110108","article-title":"The emerging role of ferroptosis in inflammation","volume":"127","author":"Sun","year":"2020","journal-title":"Biomed Pharmacother"},{"issue":"3","key":"2026041704023984800_fcag109-B6","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/s41419-023-05716-0","article-title":"The interaction between ferroptosis and inflammatory signaling pathways","volume":"14","author":"Chen","year":"2023","journal-title":"Cell Death Dis"},{"issue":"8","key":"2026041704023984800_fcag109-B7","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1038\/s12276-023-01069-y","article-title":"Regulated cell death pathways and their roles in homeostasis, infection, inflammation, and tumorigenesis","volume":"55","author":"Lee","year":"2023","journal-title":"Exp Mol Med"},{"issue":"1","key":"2026041704023984800_fcag109-B8","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1038\/s41467-025-58175-w","article-title":"Ferroptosis spreads to neighboring cells via plasma membrane contacts","volume":"16","author":"Roeck","year":"2025","journal-title":"Nat Commun"},{"issue":"7","key":"2026041704023984800_fcag109-B9","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.cell.2017.05.018","article-title":"A unique microglia type associated with restricting development of Alzheimer's disease","volume":"169","author":"Keren-Shaul","year":"2017","journal-title":"Cell"},{"issue":"1","key":"2026041704023984800_fcag109-B10","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s13024-023-00657-w","article-title":"A microglial activity state biomarker panel differentiates FTD-granulin and Alzheimer's disease patients from controls","volume":"18","author":"Pesamaa","year":"2023","journal-title":"Mol Neurodegener"},{"key":"2026041704023984800_fcag109-B11","doi-asserted-by":"crossref","first-page":"e54083","DOI":"10.7554\/eLife.54083","article-title":"Fibrillar Abeta triggers microglial proteome alterations and dysfunction in Alzheimer mouse models","volume":"9","author":"Sebastian Monasor","year":"2020","journal-title":"Elife"},{"issue":"24","key":"2026041704023984800_fcag109-B12","doi-asserted-by":"crossref","first-page":"e2119804119","DOI":"10.1073\/pnas.2119804119","article-title":"Signatures of glial activity can be detected in the CSF proteome","volume":"119","author":"Eninger","year":"2022","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026041704023984800_fcag109-B13","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1146\/annurev.neuro.30.051606.094232","article-title":"Copper and iron disorders of the brain","volume":"30","author":"Madsen","year":"2007","journal-title":"Annu Rev Neurosci"},{"issue":"4","key":"2026041704023984800_fcag109-B14","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1038\/s41380-023-02399-z","article-title":"Iron imbalance in neurodegeneration","volume":"29","author":"Levi","year":"2024","journal-title":"Mol Psychiatry"},{"issue":"2","key":"2026041704023984800_fcag109-B15","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/biof.80","article-title":"Iron in neuronal function and dysfunction","volume":"36","author":"Salvador","year":"2010","journal-title":"Biofactors"},{"key":"2026041704023984800_fcag109-B16","doi-asserted-by":"crossref","first-page":"830569","DOI":"10.3389\/fnagi.2022.830569","article-title":"Iron dyshomeostasis and ferroptosis: A new Alzheimer's Disease hypothesis?","volume":"14","author":"Wang","year":"2022","journal-title":"Front Aging Neurosci"},{"issue":"20","key":"2026041704023984800_fcag109-B17","doi-asserted-by":"crossref","first-page":"7853","DOI":"10.1074\/jbc.RA118.001949","article-title":"Inflammation-induced iron transport and metabolism by brain microglia","volume":"293","author":"McCarthy","year":"2018","journal-title":"J Biol Chem"},{"key":"2026041704023984800_fcag109-B18","doi-asserted-by":"crossref","first-page":"579286","DOI":"10.3389\/fonc.2021.579286","article-title":"Ferroptosis: Biochemistry and biology in cancers","volume":"11","author":"Shi","year":"2021","journal-title":"Front Oncol"},{"issue":"3","key":"2026041704023984800_fcag109-B19","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/s41418-021-00883-z","article-title":"MS4A15 drives ferroptosis resistance through calcium-restricted lipid remodeling","volume":"29","author":"Xin","year":"2022","journal-title":"Cell Death Differ."},{"issue":"6","key":"2026041704023984800_fcag109-B20","doi-asserted-by":"crossref","first-page":"e20210518","DOI":"10.1084\/jem.20210518","article-title":"Ferroptosis in infection, inflammation, and immunity","volume":"218","author":"Chen","year":"2021","journal-title":"J Exp Med"},{"issue":"2","key":"2026041704023984800_fcag109-B21","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: Molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res"},{"issue":"3","key":"2026041704023984800_fcag109-B22","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s12640-010-9195-x","article-title":"Accumulation of non-transferrin-bound iron by neurons, astrocytes, and microglia","volume":"19","author":"Bishop","year":"2011","journal-title":"Neurotox Res"},{"issue":"3","key":"2026041704023984800_fcag109-B23","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.bbadis.2018.01.008","article-title":"Astroglial and microglial contributions to iron metabolism disturbance in Parkinson's disease","volume":"1864","author":"Song","year":"2018","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"1","key":"2026041704023984800_fcag109-B24","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40478-021-01126-5","article-title":"Iron loading is a prominent feature of activated microglia in Alzheimer\u2019s disease patients","volume":"9","author":"Kenkhuis","year":"2021","journal-title":"Acta Neuropathol Commun."},{"issue":"6","key":"2026041704023984800_fcag109-B25","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.stemcr.2022.04.006","article-title":"Iron accumulation induces oxidative stress, while depressing inflammatory polarization in human iPSC-derived microglia","volume":"17","author":"Kenkhuis","year":"2022","journal-title":"Stem Cell Reports"},{"issue":"1","key":"2026041704023984800_fcag109-B26","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41593-022-01221-3","article-title":"Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration","volume":"26","author":"Ryan","year":"2023","journal-title":"Nat Neurosci"},{"issue":"10","key":"2026041704023984800_fcag109-B27","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1007\/s00011-024-01927-z","article-title":"Minocycline alleviates microglia ferroptosis by inhibiting HO-1 during cerebral ischemia-reperfusion injury","volume":"73","author":"Wang","year":"2024","journal-title":"Inflamm Res"},{"issue":"11","key":"2026041704023984800_fcag109-B28","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1038\/s41401-025-01560-4","article-title":"The role of microglia in neurodegenerative diseases: From the perspective of ferroptosis","volume":"46","author":"Liu","year":"2025","journal-title":"Acta Pharmacol Sin"},{"issue":"10","key":"2026041704023984800_fcag109-B29","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1016\/j.celrep.2020.02.049","article-title":"Transferrin receptor is a specific ferroptosis marker","volume":"30","author":"Feng","year":"2020","journal-title":"Cell Rep"},{"issue":"6","key":"2026041704023984800_fcag109-B30","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.cmet.2020.10.011","article-title":"The metabolic underpinnings of ferroptosis","volume":"32","author":"Zheng","year":"2020","journal-title":"Cell Metab"},{"issue":"1","key":"2026041704023984800_fcag109-B31","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/nrm2295","article-title":"Regulation of iron acquisition and storage: Consequences for iron-linked disorders","volume":"9","author":"De Domenico","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"6927","key":"2026041704023984800_fcag109-B32","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nature01451","article-title":"Regulated portals of entry into the cell","volume":"422","author":"Conner","year":"2003","journal-title":"Nature"},{"key":"2026041704023984800_fcag109-B33","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.3389\/fneur.2018.01062","article-title":"Rusty microglia: Trainers of innate immunity in Alzheimer's Disease","volume":"9","author":"Sfera","year":"2018","journal-title":"Front Neurol"},{"issue":"1","key":"2026041704023984800_fcag109-B34","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12987-020-00230-3","article-title":"A blood-brain barrier overview on structure, function, impairment, and biomarkers of integrity","volume":"17","author":"Kadry","year":"2020","journal-title":"Fluids Barriers CNS"},{"key":"2026041704023984800_fcag109-B35","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.coche.2020.08.009","article-title":"Caveolae-mediated transport at the injured blood-brain barrier as an underexplored pathway for central nervous system drug delivery","volume":"30","author":"Sorets","year":"2020","journal-title":"Curr Opin Chem Eng"},{"issue":"1","key":"2026041704023984800_fcag109-B36","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41392-024-01969-z","article-title":"Iron homeostasis and ferroptosis in human diseases: Mechanisms and therapeutic prospects","volume":"9","author":"Ru","year":"2024","journal-title":"Signal Transduct Target Ther"},{"issue":"8","key":"2026041704023984800_fcag109-B37","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/s41419-022-05043-w","article-title":"Astrocyte-derived hepcidin controls iron traffic at the blood-brain-barrier via regulating ferroportin 1 of microvascular endothelial cells","volume":"13","author":"You","year":"2022","journal-title":"Cell Death Dis"},{"issue":"1","key":"2026041704023984800_fcag109-B38","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/s41420-020-00346-3","article-title":"Hepcidin overexpression in astrocytes alters brain iron metabolism and protects against amyloid-beta induced brain damage in mice","volume":"6","author":"Zhang","year":"2020","journal-title":"Cell Death Discov"},{"issue":"10","key":"2026041704023984800_fcag109-B39","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/S1357-2725(99)00065-5","article-title":"The iron transporter DMT1","volume":"31","author":"Andrews","year":"1999","journal-title":"Int J Biochem Cell Biol"},{"issue":"11","key":"2026041704023984800_fcag109-B40","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1038\/ng1658","article-title":"Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells","volume":"37","author":"Ohgami","year":"2005","journal-title":"Nat Genet"},{"key":"2026041704023984800_fcag109-B41","doi-asserted-by":"crossref","first-page":"1269451","DOI":"10.3389\/fimmu.2023.1269451","article-title":"Mechanisms and regulations of ferroptosis","volume":"14","author":"Zhang","year":"2023","journal-title":"Front Immunol"},{"key":"2026041704023984800_fcag109-B42","doi-asserted-by":"crossref","first-page":"590226","DOI":"10.3389\/fcell.2020.590226","article-title":"Iron metabolism in ferroptosis","volume":"8","author":"Chen","year":"2020","journal-title":"Front Cell Dev Biol"},{"issue":"9","key":"2026041704023984800_fcag109-B43","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1080\/15548627.2020.1810918","article-title":"Ferroptosis: Machinery and regulation","volume":"17","author":"Chen","year":"2021","journal-title":"Autophagy"},{"issue":"6","key":"2026041704023984800_fcag109-B44","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nrd.2016.248","article-title":"Targeting iron metabolism in drug discovery and delivery","volume":"16","author":"Crielaard","year":"2017","journal-title":"Nat Rev Drug Discov"},{"issue":"41","key":"2026041704023984800_fcag109-B45","doi-asserted-by":"crossref","first-page":"34032","DOI":"10.1074\/jbc.M112.367284","article-title":"ZIP8 is an iron and zinc transporter whose cell-surface expression is up-regulated by cellular iron loading","volume":"287","author":"Wang","year":"2012","journal-title":"J Biol Chem"},{"issue":"42","key":"2026041704023984800_fcag109-B46","doi-asserted-by":"crossref","first-page":"32141","DOI":"10.1074\/jbc.M110.143248","article-title":"ZRT\/IRT-like protein 14 (ZIP14) promotes the cellular assimilation of iron from transferrin","volume":"285","author":"Zhao","year":"2010","journal-title":"J Biol Chem"},{"issue":"2","key":"2026041704023984800_fcag109-B47","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/s41419-021-03482-5","article-title":"Zinc transporter ZIP7 is a novel determinant of ferroptosis","volume":"12","author":"Chen","year":"2021","journal-title":"Cell Death Dis"},{"key":"2026041704023984800_fcag109-B48","doi-asserted-by":"crossref","first-page":"916082","DOI":"10.3389\/fonc.2022.916082","article-title":"The crosstalk effect between ferrous and other ions metabolism in ferroptosis for therapy of cancer","volume":"12","author":"Ke","year":"2022","journal-title":"Front Oncol"},{"issue":"1","key":"2026041704023984800_fcag109-B49","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s43556-023-00142-2","article-title":"The mechanism of ferroptosis and its related diseases","volume":"4","author":"Feng","year":"2023","journal-title":"Mol Biomed"},{"key":"2026041704023984800_fcag109-B50","doi-asserted-by":"crossref","first-page":"110387","DOI":"10.1016\/j.cbi.2023.110387","article-title":"Revisiting the intersection of microglial activation and neuroinflammation in Alzheimer's disease from the perspective of ferroptosis","volume":"375","author":"Wang","year":"2023","journal-title":"Chem Biol Interact"},{"key":"2026041704023984800_fcag109-B51","doi-asserted-by":"crossref","first-page":"1226044","DOI":"10.3389\/fcell.2023.1226044","article-title":"ROS induced lipid peroxidation and their role in ferroptosis","volume":"11","author":"Endale","year":"2023","journal-title":"Front Cell Dev Biol"},{"issue":"13","key":"2026041704023984800_fcag109-B52","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1111\/febs.16993","article-title":"A guide to ferroptosis, the biological rust of cellular membranes","volume":"291","author":"Veeckmans","year":"2024","journal-title":"FEBS J"},{"issue":"3","key":"2026041704023984800_fcag109-B53","first-page":"184","article-title":"Lipid metabolism and ferroptosis","volume":"10","author":"Lee","year":"2021","journal-title":"Biology (Basel)"},{"issue":"34","key":"2026041704023984800_fcag109-B54","doi-asserted-by":"crossref","first-page":"E4966","DOI":"10.1073\/pnas.1603244113","article-title":"Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis","volume":"113","author":"Yang","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7\u20138","key":"2026041704023984800_fcag109-B55","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1101\/gad.334219.119","article-title":"MDM2 and MDMX promote ferroptosis by PPARalpha-mediated lipid remodeling","volume":"34","author":"Venkatesh","year":"2020","journal-title":"Genes Dev"},{"issue":"1","key":"2026041704023984800_fcag109-B56","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nchembio.2238","article-title":"Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis","volume":"13","author":"Kagan","year":"2017","journal-title":"Nat Chem Biol"},{"issue":"40","key":"2026041704023984800_fcag109-B57","doi-asserted-by":"crossref","first-page":"5435","DOI":"10.1038\/s41388-018-0315-z","article-title":"The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma","volume":"37","author":"Miess","year":"2018","journal-title":"Oncogene"},{"issue":"6","key":"2026041704023984800_fcag109-B58","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.tcb.2020.02.009","article-title":"Emerging mechanisms and disease relevance of ferroptosis","volume":"30","author":"Stockwell","year":"2020","journal-title":"Trends Cell Biol"},{"issue":"3","key":"2026041704023984800_fcag109-B59","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.chembiol.2018.11.016","article-title":"Exogenous monounsaturated fatty acids promote a ferroptosis-resistant cell state","volume":"26","author":"Magtanong","year":"2019","journal-title":"Cell Chem Biol"},{"issue":"5","key":"2026041704023984800_fcag109-B60","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/j.cell.2020.04.039","article-title":"SnapShot: Ferroptosis","volume":"181","author":"Hadian","year":"2020","journal-title":"Cell"},{"key":"2026041704023984800_fcag109-B61","doi-asserted-by":"crossref","first-page":"737971","DOI":"10.3389\/fcell.2021.737971","article-title":"Targeting ferroptosis to treat cardiovascular diseases: A new continent to be explored","volume":"9","author":"Huang","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"2026041704023984800_fcag109-B62","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3389\/fnagi.2016.00308","article-title":"The protective role of mitochondrial ferritin on erastin-induced ferroptosis","volume":"8","author":"Wang","year":"2016","journal-title":"Front Aging Neurosci"},{"key":"2026041704023984800_fcag109-B63","doi-asserted-by":"crossref","first-page":"1043344","DOI":"10.3389\/fphar.2022.1043344","article-title":"Ferritinophagy, a form of autophagic ferroptosis: New insights into cancer treatment","volume":"13","author":"Sun","year":"2022","journal-title":"Front Pharmacol"},{"issue":"9","key":"2026041704023984800_fcag109-B64","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.tcb.2025.01.005","article-title":"Autophagy-dependent versus autophagy-independent ferroptosis","volume":"35","author":"Zhu","year":"2025","journal-title":"Trends Cell Biol"},{"key":"2026041704023984800_fcag109-B65","doi-asserted-by":"crossref","first-page":"106094","DOI":"10.1016\/j.biocel.2021.106094","article-title":"Cancer: The role of iron and ferroptosis","volume":"141","author":"Rishi","year":"2021","journal-title":"Int J Biochem Cell Biol"},{"issue":"1","key":"2026041704023984800_fcag109-B66","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1042\/BJ20140225","article-title":"Chaperone protein involved in transmembrane transport of iron","volume":"462","author":"Yanatori","year":"2014","journal-title":"Biochem J"},{"issue":"13","key":"2026041704023984800_fcag109-B67","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1096\/fj.04-3486fje","article-title":"Functional relevance of ceruloplasmin mutations in Parkinson's disease","volume":"19","author":"Hochstrasser","year":"2005","journal-title":"FASEB J"},{"key":"2026041704023984800_fcag109-B68","doi-asserted-by":"crossref","first-page":"109633","DOI":"10.1016\/j.cellsig.2020.109633","article-title":"Ceruloplasmin suppresses ferroptosis by regulating iron homeostasis in hepatocellular carcinoma cells","volume":"72","author":"Shang","year":"2020","journal-title":"Cell Signal"},{"issue":"45","key":"2026041704023984800_fcag109-B69","doi-asserted-by":"crossref","first-page":"5617","DOI":"10.1038\/onc.2015.32","article-title":"HSPB1 as a novel regulator of ferroptotic cancer cell death","volume":"34","author":"Sun","year":"2015","journal-title":"Oncogene"},{"issue":"8","key":"2026041704023984800_fcag109-B70","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1038\/s12276-023-01077-y","article-title":"An integrated view of lipid metabolism in ferroptosis revisited via lipidomic analysis","volume":"55","author":"Kim","year":"2023","journal-title":"Exp Mol Med"},{"issue":"1","key":"2026041704023984800_fcag109-B71","doi-asserted-by":"crossref","first-page":"7147","DOI":"10.1038\/s41467-021-27414-1","article-title":"Molecular basis for redox control by the human cystine\/glutamate antiporter system xc","volume":"12","author":"Parker","year":"2021","journal-title":"Nat Commun"},{"key":"2026041704023984800_fcag109-B72","doi-asserted-by":"crossref","first-page":"910292","DOI":"10.3389\/fphar.2022.910292","article-title":"System X(c) (-)\/GSH\/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy","volume":"13","author":"Li","year":"2022","journal-title":"Front Pharmacol"},{"issue":"1","key":"2026041704023984800_fcag109-B73","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.cmet.2020.12.007","article-title":"Non-canonical glutamate-cysteine ligase activity protects against ferroptosis","volume":"33","author":"Kang","year":"2021","journal-title":"Cell Metab"},{"issue":"1","key":"2026041704023984800_fcag109-B74","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/s41392-023-01606-1","article-title":"Targeting ferroptosis opens new avenues for the development of novel therapeutics","volume":"8","author":"Sun","year":"2023","journal-title":"Signal Transduct Target Ther"},{"issue":"7769","key":"2026041704023984800_fcag109-B75","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41586-019-1426-6","article-title":"Intercellular interaction dictates cancer cell ferroptosis via NF2-YAP signalling","volume":"572","author":"Wu","year":"2019","journal-title":"Nature"},{"issue":"13","key":"2026041704023984800_fcag109-B76","doi-asserted-by":"crossref","first-page":"e00099-20","DOI":"10.1128\/MCB.00099-20","article-title":"The molecular mechanisms regulating the KEAP1-NRF2 pathway","volume":"40","author":"Baird","year":"2020","journal-title":"Mol Cell Biol"},{"issue":"1","key":"2026041704023984800_fcag109-B77","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.redox.2012.10.001","article-title":"The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer","volume":"1","author":"Kansanen","year":"2013","journal-title":"Redox Biol"},{"key":"2026041704023984800_fcag109-B78","volume-title":"Hemochromatosis","author":"Porter","year":"2024"},{"issue":"24","key":"2026041704023984800_fcag109-B79","doi-asserted-by":"crossref","first-page":"25866","DOI":"10.1074\/jbc.M401467200","article-title":"HFE and transferrin directly compete for transferrin receptor in solution and at the cell surface","volume":"279","author":"Giannetti","year":"2004","journal-title":"J Biol Chem"},{"issue":"9","key":"2026041704023984800_fcag109-B80","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1001\/jamaneurol.2022.2030","article-title":"Association of genetic variant linked to hemochromatosis with brain magnetic resonance imaging measures of iron and movement disorders","volume":"79","author":"Loughnan","year":"2022","journal-title":"JAMA Neurol"},{"issue":"4","key":"2026041704023984800_fcag109-B81","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1136\/jnnp.2003.027441","article-title":"Concurrent hereditary haemochromatosis and idiopathic Parkinson's disease: A case report series","volume":"75","author":"Costello","year":"2004","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2026041704023984800_fcag109-B82","first-page":"83","volume-title":"Genereviews((R))","author":"Miyajima","year":"1993"},{"key":"2026041704023984800_fcag109-B83","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3389\/fnins.2019.00325","article-title":"Aceruloplasminemia: A severe neurodegenerative disorder deserving an early diagnosis","volume":"13","author":"Marchi","year":"2019","journal-title":"Front Neurosci"},{"issue":"2","key":"2026041704023984800_fcag109-B84","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.bbadis.2007.12.002","article-title":"Microglia and astroglia prevent oxidative stress-induced neuronal cell death: Implications for aceruloplasminemia","volume":"1782","author":"Oshiro","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"2026041704023984800_fcag109-B85","doi-asserted-by":"crossref","first-page":"903","DOI":"10.3389\/fnins.2018.00903","article-title":"Aceruloplasminemia: Waiting for an efficient therapy","volume":"12","author":"Piperno","year":"2018","journal-title":"Front Neurosci"},{"issue":"2","key":"2026041704023984800_fcag109-B86","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: A regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"issue":"22","key":"2026041704023984800_fcag109-B87","doi-asserted-by":"crossref","first-page":"8765","DOI":"10.3390\/ijms21228765","article-title":"Ferroptosis mechanisms involved in neurodegenerative diseases","volume":"21","author":"Reichert","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"2","key":"2026041704023984800_fcag109-B88","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/s12017-018-8518-6","article-title":"The emerging roles of ferroptosis in Huntington's disease","volume":"21","author":"Mi","year":"2019","journal-title":"Neuromolecular Med"},{"key":"2026041704023984800_fcag109-B89","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.2147\/JIR.S351799","article-title":"Ferroptosis and its potential role in the nervous system diseases","volume":"15","author":"Zhou","year":"2022","journal-title":"J Inflamm Res"},{"key":"2026041704023984800_fcag109-B90","doi-asserted-by":"crossref","first-page":"101494","DOI":"10.1016\/j.redox.2020.101494","article-title":"Iron dyshomeostasis, lipid peroxidation and perturbed expression of cystine\/glutamate antiporter in Alzheimer's disease: Evidence of ferroptosis","volume":"32","author":"Ashraf","year":"2020","journal-title":"Redox Biol"},{"key":"2026041704023984800_fcag109-B91","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3389\/fnagi.2020.00196","article-title":"Spotlight on ferroptosis: Iron-dependent cell death in Alzheimer's disease","volume":"12","author":"Ashraf","year":"2020","journal-title":"Front Aging Neurosci"},{"issue":"1","key":"2026041704023984800_fcag109-B92","doi-asserted-by":"crossref","first-page":"e14541","DOI":"10.1002\/alz.14541","article-title":"Iron-associated lipid peroxidation in Alzheimer's disease is increased in lipid rafts with decreased ferroptosis suppressors, tested by chelation in mice","volume":"21","author":"Thorwald","year":"2025","journal-title":"Alzheimers Dement"},{"issue":"11","key":"2026041704023984800_fcag109-B93","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1038\/s41380-019-0375-7","article-title":"Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology","volume":"25","author":"Ayton","year":"2020","journal-title":"Mol Psychiatry"},{"issue":"8","key":"2026041704023984800_fcag109-B94","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1093\/brain\/awx137","article-title":"Cerebral quantitative susceptibility mapping predicts amyloid-beta-related cognitive decline","volume":"140","author":"Ayton","year":"2017","journal-title":"Brain"},{"key":"2026041704023984800_fcag109-B95","doi-asserted-by":"crossref","first-page":"6760","DOI":"10.1038\/ncomms7760","article-title":"Alzheimer's disease neuroimaging I. Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE","volume":"6","author":"Ayton","year":"2015","journal-title":"Nat Commun"},{"issue":"5","key":"2026041704023984800_fcag109-B96","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1038\/s41418-020-00685-9","article-title":"Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer's disease","volume":"28","author":"Bao","year":"2021","journal-title":"Cell Death Differ"},{"issue":"1","key":"2026041704023984800_fcag109-B97","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1001\/jamaneurol.2024.3733","article-title":"Deferiprone in Alzheimer disease: A randomized clinical trial","volume":"82","author":"Ayton","year":"2025","journal-title":"JAMA Neurol"},{"issue":"8","key":"2026041704023984800_fcag109-B98","doi-asserted-by":"crossref","first-page":"e0201369","DOI":"10.1371\/journal.pone.0201369","article-title":"Vitamin E hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase","volume":"13","author":"Hinman","year":"2018","journal-title":"PLoS One"},{"issue":"1","key":"2026041704023984800_fcag109-B99","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3892\/mmr.2025.13557","article-title":"The role of ferroptosis in Alzheimer's disease: Mechanisms and therapeutic potential (review)","volume":"32","author":"Zeng","year":"2025","journal-title":"Mol Med Rep"},{"issue":"4","key":"2026041704023984800_fcag109-B100","doi-asserted-by":"crossref","first-page":"879","DOI":"10.3390\/ijms20040879","article-title":"The effectiveness of vitamin E treatment in Alzheimer's disease","volume":"20","author":"Lloret","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"2","key":"2026041704023984800_fcag109-B101","doi-asserted-by":"crossref","first-page":"95","DOI":"10.4103\/aam.aam_35_19","article-title":"Role of serum ferritin as a prognostic marker in acute ischemic stroke: A preliminary observation","volume":"19","author":"Garg","year":"2020","journal-title":"Ann Afr Med"},{"issue":"4","key":"2026041704023984800_fcag109-B102","first-page":"11","article-title":"Evaluation of Serum ferritin as a prognostic marker in acute ischemic stroke patients-A prospective cohort study","volume":"70","author":"Sultana","year":"2022","journal-title":"J Assoc Physicians India"},{"issue":"1","key":"2026041704023984800_fcag109-B103","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s10571-024-01457-6","article-title":"Progress of ferroptosis in ischemic stroke and therapeutic targets","volume":"44","author":"Tian","year":"2024","journal-title":"Cell Mol Neurobiol"},{"issue":"5","key":"2026041704023984800_fcag109-B104","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.cell.2019.03.032","article-title":"Selenium drives a transcriptional adaptive program to block ferroptosis and treat stroke","volume":"177","author":"Alim","year":"2019","journal-title":"Cell"},{"issue":"4","key":"2026041704023984800_fcag109-B105","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1161\/STROKEAHA.107.501213","article-title":"Association between serum ferritin level and perihematoma edema volume in patients with spontaneous intracerebral hemorrhage","volume":"39","author":"Mehdiratta","year":"2008","journal-title":"Stroke"},{"issue":"Pt 4","key":"2026041704023984800_fcag109-B106","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1093\/brain\/114.4.1953","article-title":"Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia","volume":"114","author":"Dexter","year":"1991","journal-title":"Brain"},{"issue":"2","key":"2026041704023984800_fcag109-B107","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/jon.12957","article-title":"Quantitative evaluation of brain iron accumulation in different stages of Parkinson's disease","volume":"32","author":"Li","year":"2022","journal-title":"J Neuroimaging"},{"key":"2026041704023984800_fcag109-B108","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.parkreldis.2017.08.013","article-title":"Different iron deposition patterns in early- and middle-late-onset Parkinson's disease","volume":"44","author":"Xuan","year":"2017","journal-title":"Parkinsonism Relat Disord"},{"issue":"1","key":"2026041704023984800_fcag109-B109","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s10571-024-01459-4","article-title":"Iron deposition in Parkinson's disease: A Mini-review","volume":"44","author":"Zeng","year":"2024","journal-title":"Cell Mol Neurobiol"},{"issue":"4","key":"2026041704023984800_fcag109-B110","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1134\/S1819712419040020","article-title":"Lipid peroxidation products in the blood plasma of patients with Parkinson\u2019s disease as possible biomarkers of different stages of the disease","volume":"13","author":"Fedorova","year":"2019","journal-title":"Neurochemical Journal"},{"issue":"1\u20132","key":"2026041704023984800_fcag109-B111","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0300-483X(03)00158-6","article-title":"Vitamin E therapy in Parkinson's disease","volume":"189","author":"Fariss","year":"2003","journal-title":"Toxicology"},{"key":"2026041704023984800_fcag109-B112","doi-asserted-by":"crossref","first-page":"1289238","DOI":"10.3389\/fnut.2023.1289238","article-title":"Dietary vitamin E intake and risk of Parkinson's disease: A cross-sectional study","volume":"10","author":"Hao","year":"2024","journal-title":"Front Nutr"},{"key":"2026041704023984800_fcag109-B113","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3389\/fneur.2019.00148","article-title":"Dietary vitamin E as a protective factor for Parkinson's disease: Clinical and experimental evidence","volume":"10","author":"Schirinzi","year":"2019","journal-title":"Front Neurol"},{"issue":"5","key":"2026041704023984800_fcag109-B114","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1093\/ajcn\/70.5.793","article-title":"High doses of vitamin E in the treatment of disorders of the central nervous system in the aged","volume":"70","author":"Vatassery","year":"1999","journal-title":"Am J Clin Nutr"},{"issue":"4","key":"2026041704023984800_fcag109-B115","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1007\/s13311-020-00929-z","article-title":"FTH1 inhibits ferroptosis through ferritinophagy in the 6-OHDA model of Parkinson's disease","volume":"17","author":"Tian","year":"2020","journal-title":"Neurotherapeutics"},{"issue":"3","key":"2026041704023984800_fcag109-B116","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3233\/JHD-160205","article-title":"Oxidative stress and Huntington's disease: The good, the bad, and the ugly","volume":"5","author":"Kumar","year":"2016","journal-title":"J Huntingtons Dis"},{"issue":"12","key":"2026041704023984800_fcag109-B117","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1007\/s00415-007-0611-y","article-title":"Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington's disease gene carriers and healthy subjects: A cross-sectional study","volume":"254","author":"Klepac","year":"2007","journal-title":"J Neurol"},{"issue":"10","key":"2026041704023984800_fcag109-B118","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1002\/glia.20526","article-title":"Ferritin accumulation in dystrophic microglia is an early event in the development of Huntington's disease","volume":"55","author":"Simmons","year":"2007","journal-title":"Glia"},{"issue":"10","key":"2026041704023984800_fcag109-B119","doi-asserted-by":"crossref","first-page":"e77023","DOI":"10.1371\/journal.pone.0077023","article-title":"Iron accumulates in Huntington's disease neurons: Protection by deferoxamine","volume":"8","author":"Chen","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"2026041704023984800_fcag109-B120","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/s41573-022-00612-2","article-title":"Amyotrophic lateral sclerosis: A neurodegenerative disorder poised for successful therapeutic translation","volume":"22","author":"Mead","year":"2023","journal-title":"Nat Rev Drug Discov"},{"issue":"1","key":"2026041704023984800_fcag109-B121","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/s41598-021-03891-8","article-title":"SOD1 mutations associated with amyotrophic lateral sclerosis analysis of variant severity","volume":"12","author":"Berdynski","year":"2022","journal-title":"Sci Rep"},{"key":"2026041704023984800_fcag109-B122","doi-asserted-by":"crossref","first-page":"380","DOI":"10.3389\/fneur.2020.00380","article-title":"Abnormal Serum iron-Status indicator changes in Amyotrophic Lateral Sclerosis (ALS) patients: A meta-analysis","volume":"11","author":"Wang","year":"2020","journal-title":"Front Neurol"},{"issue":"11","key":"2026041704023984800_fcag109-B123","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1007\/s00415-008-0945-0","article-title":"Increased serum ferritin levels in amyotrophic lateral sclerosis (ALS) patients","volume":"255","author":"Goodall","year":"2008","journal-title":"J Neurol"},{"issue":"1","key":"2026041704023984800_fcag109-B124","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1038\/s41598-019-39739-5","article-title":"A ferroptosis\u2013based panel of prognostic biomarkers for Amyotrophic Lateral Sclerosis","volume":"9","author":"Devos","year":"2019","journal-title":"Sci Rep."},{"issue":"1","key":"2026041704023984800_fcag109-B125","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13024-023-00691-8","article-title":"Microglial ferroptotic stress causes non-cell autonomous neuronal death","volume":"19","author":"Liddell","year":"2024","journal-title":"Mol Neurodegener"},{"issue":"Pt 1","key":"2026041704023984800_fcag109-B126","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1093\/brain\/awu312","article-title":"System xC- is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice","volume":"138","author":"Mesci","year":"2015","journal-title":"Brain"},{"issue":"1","key":"2026041704023984800_fcag109-B127","doi-asserted-by":"crossref","first-page":"e00136","DOI":"10.1042\/AN20130037","article-title":"Iron chelation and multiple sclerosis","volume":"6","author":"Weigel","year":"2014","journal-title":"ASN Neuro"},{"issue":"3","key":"2026041704023984800_fcag109-B128","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.mri.2012.11.011","article-title":"Visualizing iron in multiple sclerosis","volume":"31","author":"Bagnato","year":"2013","journal-title":"Magn Reson Imaging"},{"issue":"1\u20132","key":"2026041704023984800_fcag109-B129","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S0006-8993(97)00470-8","article-title":"Iron deposits in multiple sclerosis and Alzheimer's disease brains","volume":"760","author":"LeVine","year":"1997","journal-title":"Brain Res"},{"issue":"2","key":"2026041704023984800_fcag109-B130","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0006-8993(98)01360-2","article-title":"Ferritin, transferrin and iron concentrations in the cerebrospinal fluid of multiple sclerosis patients","volume":"821","author":"LeVine","year":"1999","journal-title":"Brain Res"},{"issue":"1","key":"2026041704023984800_fcag109-B131","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s40478-023-01617-7","article-title":"Ferroptosis induces detrimental effects in chronic EAE and its implications for progressive MS","volume":"11","author":"Jhelum","year":"2023","journal-title":"Acta Neuropathol Commun"},{"issue":"9","key":"2026041704023984800_fcag109-B132","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1038\/s41418-023-01195-0","article-title":"Ferroptosis contributes to multiple sclerosis and its pharmacological targeting suppresses experimental disease progression","volume":"30","author":"Van San","year":"2023","journal-title":"Cell Death Differ"},{"issue":"8","key":"2026041704023984800_fcag109-B133","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1212\/01.wnl.0000208510.76323.5b","article-title":"Superficial siderosis","volume":"66","author":"Kumar","year":"2006","journal-title":"Neurology"},{"issue":"6","key":"2026041704023984800_fcag109-B134","doi-asserted-by":"crossref","first-page":"507","DOI":"10.2174\/138920010791636149","article-title":"Specific hemosiderin deposition in spleen induced by a low dose of cisplatin: Altered iron metabolism and its implication as an acute hemosiderin formation model","volume":"11","author":"Wang","year":"2010","journal-title":"Curr Drug Metab"},{"issue":"5 Suppl","key":"2026041704023984800_fcag109-B135","first-page":"S116","article-title":"Focal hemosiderin deposits and beta-amyloid load in the ADNI cohort","volume":"9","author":"Kantarci","year":"2013","journal-title":"Alzheimers Dement"},{"issue":"1","key":"2026041704023984800_fcag109-B136","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jsb.2005.11.001","article-title":"Study of the localization of iron, ferritin, and hemosiderin in Alzheimer's disease hippocampus by analytical microscopy at the subcellular level","volume":"153","author":"Quintana","year":"2006","journal-title":"J Struct Biol"},{"key":"2026041704023984800_fcag109-B137","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/978-3-7091-1434-6_14","article-title":"Cerebral hemorrhage, brain edema, and heme oxygenase-1 expression after experimental traumatic brain injury","volume":"118","author":"Okubo","year":"2013","journal-title":"Acta Neurochir Suppl"},{"issue":"4","key":"2026041704023984800_fcag109-B138","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s004010000202","article-title":"Long-term expression of heme oxygenase-1 (HO-1, HSP-32) following focal cerebral infarctions and traumatic brain injury in humans","volume":"100","author":"Beschorner","year":"2000","journal-title":"Acta Neuropathol"},{"issue":"8","key":"2026041704023984800_fcag109-B139","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/S1474-4422(08)70164-9","article-title":"Moderate and severe traumatic brain injury in adults","volume":"7","author":"Maas","year":"2008","journal-title":"Lancet Neurol"},{"key":"2026041704023984800_fcag109-B140","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.bbrc.2022.06.040","article-title":"Ferroptosis in brain microvascular endothelial cells mediates blood-brain barrier disruption after traumatic brain injury","volume":"619","author":"Fang","year":"2022","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"2026041704023984800_fcag109-B141","doi-asserted-by":"crossref","first-page":"e12704","DOI":"10.1111\/jpi.12704","article-title":"Deletion of ferritin H in neurons counteracts the protective effect of melatonin against traumatic brain injury-induced ferroptosis","volume":"70","author":"Rui","year":"2021","journal-title":"J Pineal Res"},{"key":"2026041704023984800_fcag109-B142","doi-asserted-by":"crossref","first-page":"949573","DOI":"10.3389\/fnmol.2022.949573","article-title":"Spatial-temporal changes of iron deposition and iron metabolism after traumatic brain injury in mice","volume":"15","author":"Cheng","year":"2022","journal-title":"Front Mol Neurosci"},{"issue":"4","key":"2026041704023984800_fcag109-B143","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s00401-021-02348-6","article-title":"Seizure-mediated iron accumulation and dysregulated iron metabolism after status epilepticus and in temporal lobe epilepsy","volume":"142","author":"Zimmer","year":"2021","journal-title":"Acta Neuropathol"},{"key":"2026041704023984800_fcag109-B144","doi-asserted-by":"crossref","first-page":"981","DOI":"10.3389\/fnins.2018.00981","article-title":"The involvement of iron in traumatic brain injury and neurodegenerative disease","volume":"12","author":"Daglas","year":"2018","journal-title":"Front Neurosci"},{"issue":"5","key":"2026041704023984800_fcag109-B145","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.neuron.2012.11.021","article-title":"The neuropathology and neurobiology of traumatic brain injury","volume":"76","author":"Blennow","year":"2012","journal-title":"Neuron"},{"issue":"1","key":"2026041704023984800_fcag109-B146","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41392-023-01588-0","article-title":"Microglia in neurodegenerative diseases: Mechanism and potential therapeutic targets","volume":"8","author":"Gao","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"2026041704023984800_fcag109-B147","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev-immunol-051116-052358","article-title":"Microglia function in the central nervous system during health and neurodegeneration","volume":"35","author":"Colonna","year":"2017","journal-title":"Annu Rev Immunol"},{"issue":"2","key":"2026041704023984800_fcag109-B148","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.cell.2019.08.053","article-title":"Microglia biology: One century of evolving concepts","volume":"179","author":"Prinz","year":"2019","journal-title":"Cell"},{"issue":"3","key":"2026041704023984800_fcag109-B149","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/s41589-019-0462-8","article-title":"Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death","volume":"16","author":"Kapralov","year":"2020","journal-title":"Nat Chem Biol"},{"issue":"1","key":"2026041704023984800_fcag109-B150","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12868-019-0507-7","article-title":"Iron concentrations in neurons and glial cells with estimates on ferritin concentrations","volume":"20","author":"Reinert","year":"2019","journal-title":"BMC Neurosci"},{"issue":"4","key":"2026041704023984800_fcag109-B151","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.3233\/JAD-161143","article-title":"Cortical iron reflects severity of Alzheimer's disease","volume":"60","author":"van Duijn","year":"2017","journal-title":"J Alzheimers Dis"},{"issue":"9","key":"2026041704023984800_fcag109-B152","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1016\/j.neurobiolaging.2015.05.022","article-title":"Activated iron-containing microglia in the human hippocampus identified by magnetic resonance imaging in Alzheimer disease","volume":"36","author":"Zeineh","year":"2015","journal-title":"Neurobiol Aging"},{"issue":"1","key":"2026041704023984800_fcag109-B153","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1186\/s12974-021-02231-x","article-title":"Microglia and macrophage exhibit attenuated inflammatory response and ferroptosis resistance after RSL3 stimulation via increasing Nrf2 expression","volume":"18","author":"Cui","year":"2021","journal-title":"J Neuroinflammation"},{"key":"2026041704023984800_fcag109-B154","doi-asserted-by":"crossref","first-page":"17590914221133236","DOI":"10.1177\/17590914221133236","article-title":"New target for prevention and treatment of neuroinflammation: Microglia iron accumulation and ferroptosis","volume":"14","author":"Liu","year":"2022","journal-title":"ASN Neuro"},{"issue":"40","key":"2026041704023984800_fcag109-B155","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","article-title":"Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: Potential factors in amyloid plaque formation","volume":"26","author":"Oakley","year":"2006","journal-title":"J Neurosci"},{"issue":"9","key":"2026041704023984800_fcag109-B156","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/sj.embor.7400784","article-title":"Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology","volume":"7","author":"Radde","year":"2006","journal-title":"EMBO Rep"},{"issue":"5","key":"2026041704023984800_fcag109-B157","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nn.3697","article-title":"Single app knock-in mouse models of Alzheimer's disease","volume":"17","author":"Saito","year":"2014","journal-title":"Nat Neurosci"},{"issue":"6","key":"2026041704023984800_fcag109-B158","doi-asserted-by":"crossref","first-page":"e9711","DOI":"10.15252\/emmm.201809711","article-title":"Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism","volume":"11","author":"Gotzl","year":"2019","journal-title":"EMBO Mol Med"},{"issue":"4","key":"2026041704023984800_fcag109-B159","doi-asserted-by":"crossref","first-page":"e109108","DOI":"10.15252\/embj.2021109108","article-title":"Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency","volume":"41","author":"Reifschneider","year":"2022","journal-title":"EMBO J"},{"key":"2026041704023984800_fcag109-B160","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.freeradbiomed.2024.04.208","article-title":"Peroxiredoxin 6 suppresses ferroptosis in lung endothelial cells","volume":"218","author":"Torres-Velarde","year":"2024","journal-title":"Free Radic Biol Med"},{"issue":"8","key":"2026041704023984800_fcag109-B161","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1038\/s41594-024-01329-z","article-title":"PRDX6 augments selenium utilization to limit iron toxicity and ferroptosis","volume":"31","author":"Fujita","year":"2024","journal-title":"Nat Struct Mol Biol"},{"issue":"21","key":"2026041704023984800_fcag109-B162","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.1016\/j.neuron.2022.10.020","article-title":"Microglia states and nomenclature: A field at its crossroads","volume":"110","author":"Paolicelli","year":"2022","journal-title":"Neuron"},{"issue":"3","key":"2026041704023984800_fcag109-B163","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1136\/jnnp-2022-330052","article-title":"CSF ferritin in the clinicopathological progression of Alzheimer's disease and associations with APOE and inflammation biomarkers","volume":"94","author":"Ayton","year":"2023","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"9","key":"2026041704023984800_fcag109-B164","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/s41419-019-1854-0","article-title":"Ferroportin downregulation promotes cell proliferation by modulating the Nrf2-miR-17-5p axis in multiple myeloma","volume":"10","author":"Kong","year":"2019","journal-title":"Cell Death Dis"},{"issue":"5","key":"2026041704023984800_fcag109-B165","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.cmet.2015.09.006","article-title":"Ironing out Ferroportin","volume":"22","author":"Drakesmith","year":"2015","journal-title":"Cell Metab"},{"issue":"12","key":"2026041704023984800_fcag109-B166","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1038\/s41401-021-00703-7","article-title":"Lp-PLA2 inhibition prevents Ang II-induced cardiac inflammation and fibrosis by blocking macrophage NLRP3 inflammasome activation","volume":"42","author":"Lv","year":"2021","journal-title":"Acta Pharmacol Sin"},{"issue":"32","key":"2026041704023984800_fcag109-B167","doi-asserted-by":"crossref","first-page":"20185","DOI":"10.1074\/jbc.272.32.20185","article-title":"A novel glycosylphosphatidylinositol-anchored form of ceruloplasmin is expressed by mammalian astrocytes","volume":"272","author":"Patel","year":"1997","journal-title":"J Biol Chem"},{"issue":"6586","key":"2026041704023984800_fcag109-B168","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1126\/science.abf0529","article-title":"Copper induces cell death by targeting lipoylated TCA cycle proteins","volume":"375","author":"Tsvetkov","year":"2022","journal-title":"Science"}],"container-title":["Brain Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/braincomms\/advance-article-pdf\/doi\/10.1093\/braincomms\/fcag109\/67680741\/fcag109.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/8\/2\/fcag109\/68101339\/fcag109.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/8\/2\/fcag109\/68101339\/fcag109.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T08:03:46Z","timestamp":1776413026000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/braincomms\/article\/doi\/10.1093\/braincomms\/fcag109\/8565930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":168,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3,3]]}},"URL":"https:\/\/doi.org\/10.1093\/braincomms\/fcag109","relation":{},"ISSN":["2632-1297"],"issn-type":[{"value":"2632-1297","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026]]},"published":{"date-parts":[[2026]]},"article-number":"fcag109"}}