{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:51:34Z","timestamp":1793137894390,"version":"4.5.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:00:00Z","timestamp":1774656000000},"content-version":"vor","delay-in-days":86,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["111-2314-B-A49-080-MY3"],"award-info":[{"award-number":["111-2314-B-A49-080-MY3"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["112-2314-B-A49-056-MY3"],"award-info":[{"award-number":["112-2314-B-A49-056-MY3"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["113-2314-B-A49-070-MY3"],"award-info":[{"award-number":["113-2314-B-A49-070-MY3"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["114-2314-B-A49-041-MY3"],"award-info":[{"award-number":["114-2314-B-A49-041-MY3"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["107-2314-B-075-058-MY3"],"award-info":[{"award-number":["107-2314-B-075-058-MY3"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["113-2321-B-A49-015-MY3"],"award-info":[{"award-number":["113-2321-B-A49-015-MY3"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Migraine is increasingly recognized as more than just an episodic headache disorder\u2014it often carries a profound burden marked by emotional and cognitive disturbances. Recent insights point towards a possible link between migraine and accelerated brain ageing, yet the specific brain regions affected and the clinical implications remain poorly understood. We investigated grey matter-based brain age using voxel-based morphometry in 110 preventive treatment\u2013na\u00efve patients with migraine and 70 healthy controls, based on T1-weighted MRI and a validated brain-age prediction framework trained on data from 1318 healthy individuals. Compared with controls, patients with migraine exhibited a significantly higher global brain-age gap [mean difference = 4.24 years; confidence interval (CI, 0.12, 8.36); P = 0.039; \u03b7p\u00b2 = 0.024]. Regionally, 66 out of 442 brain parcels\u2014primarily within the prefrontal, frontal, cingulate, parietal and temporal cortices and the amygdala\u2014showed elevated ageing patterns. Permutation-based canonical correlation analysis revealed a stable multivariate association between regional brain-age deviations and a combination of migraine-related clinical factors (headache frequency, painkiller usage and depressive symptoms), although individual factor contributions were variable. Functional annotation of the affected regions highlighted their roles in cognitive, emotional and perceptual processing. Together, these findings reveal that migraine is linked to widespread, regionally patterned brain ageing, mirroring the clinical and neurobiological complexity of the disease. This work not only deepens our understanding of migraine\u2019s impact on the brain but also opens new avenues for exploring how timely intervention might protect brain health in this population.<\/jats:p>","DOI":"10.1093\/braincomms\/fcag110","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T12:45:31Z","timestamp":1774529131000},"source":"Crossref","is-referenced-by-count":3,"title":["Accelerated brain ageing in migraine: a multilevel MRI-based brain-age modelling study"],"prefix":"10.1093","volume":"8","author":[{"given":"Hung-Yu","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital , Taipei 112201 ,","place":["Taiwan"]},{"name":"School of Medicine, National Yang Ming Chiao Tung University , Taipei 112304 ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Yuan","family":"Kuo","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, National Yang Ming Chiao Tung University , Taipei 112304 ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Lin","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University , Taipei 112304 ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Hsuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, National Yang Ming Chiao Tung University , Taipei 112304 ,","place":["Taiwan"]},{"name":"Department of Neurology, Columbia University , New York 10032 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Ta","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Medicine, National Yang Ming Chiao Tung University , Taipei 112304 ,","place":["Taiwan"]},{"name":"Department of Neurology, Keelung Hospital, Ministry of Health and Welfare , Keelung 20148 ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3492-9902","authenticated-orcid":false,"given":"Shih-Pin","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Medicine, National Yang Ming Chiao Tung University , Taipei 112304 ,","place":["Taiwan"]},{"name":"Brain Research Center, National Yang Ming Chiao Tung University , Taipei 112304 ,","place":["Taiwan"]},{"name":"Division of Translational Research, Department of Medical Research, Taipei Veterans General Hospital , Taipei 112201 ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital , Taipei 112201 ,","place":["Taiwan"]},{"name":"School of Medicine, National Yang Ming Chiao Tung University , Taipei 112304 ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6848-8776","authenticated-orcid":false,"given":"Ching-Po","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, National Yang Ming Chiao Tung University , Taipei 112304 ,","place":["Taiwan"]},{"name":"Brain Research Center, National Yang Ming Chiao Tung University , Taipei 112304 ,","place":["Taiwan"]},{"name":"Department of Education and Research, Taipei City Hospital , Taipei 24213 ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun-Hsien","family":"Chou","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, National Yang Ming Chiao Tung University , Taipei 112304 ,","place":["Taiwan"]},{"name":"Brain Research Center, National Yang Ming Chiao Tung University , Taipei 112304 ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuu-Jiun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital , Taipei 112201 ,","place":["Taiwan"]},{"name":"School of Medicine, National Yang Ming Chiao Tung University , Taipei 112304 ,","place":["Taiwan"]},{"name":"Brain Research Center, National Yang Ming Chiao Tung University , Taipei 112304 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