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Using resting-state functional MRI from 201 isolated craniocervical dystonia patients (102 blepharospasm, 43 blepharospasm\u2013oromandibular dystonia and 56 cervical dystonia) and 160 healthy controls, we applied a sliding-window approach to evaluate dynamic functional metrics and dynamic functional connectivity patterns. Isolated craniocervical dystonia patients showed widespread abnormalities in dynamic regional activity involving the cerebellum, primary motor cortex and visual cortex, which were consistent with instability in neural activity or coordination. Subnetwork analyses indicated significant alterations\u2014particularly increased dynamic functional connectivity variability in cerebello-cortical and cortico-cortical circuits\u2014in isolated craniocervical dystonia and blepharospasm as compared to healthy controls. Clustering of time-resolved connectivity revealed two recurring brain states: a strongly connected State 1 and a weakly connected State 2. Compared to healthy controls, isolated craniocervical dystonia, blepharospasm, blepharospasm\u2013oromandibular dystonia and cervical dystonia groups spent proportionally more time in State 2 and exhibited fewer state transitions, suggesting reduced network flexibility and a bias toward hypo-connected configurations. Together, these findings demonstrated shared and subtype-specific disruptions in the dynamics of spontaneous activity and interregional coupling in isolated craniocervical dystonia, implicating alterations of cerebello-cortical and sensorimotor-visual systems in its pathophysiology and highlighting temporal instability and diminished switching as potential disease signatures.<\/jats:p>","DOI":"10.1093\/braincomms\/fcag122","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T11:46:47Z","timestamp":1775130407000},"source":"Crossref","is-referenced-by-count":0,"title":["Shared and distinct dynamic brain activity and functional connectivity variability in patients with isolated craniocervical dystonia"],"prefix":"10.1093","volume":"8","author":[{"given":"Jiatai","family":"Lin","sequence":"first","affiliation":[{"name":"Southern University of Science and Technology Department of Biomedical Engineering, , Shenzhen 518055 ,","place":["China"]},{"name":"Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences , Shenzhen 518055 ,","place":["China"]},{"name":"Shenzhen University of Advanced Technology Department of Biomedical Engineering, , Shenzhen 518107 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiana","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology , Guangzhou 510080 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1741-3373","authenticated-orcid":false,"given":"Zhengkun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology , Guangzhou 510080 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HaiLiang","family":"Shen","sequence":"additional","affiliation":[{"name":"Southern University of Science and Technology Department of Biomedical Engineering, , Shenzhen 518055 ,","place":["China"]},{"name":"Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences , Shenzhen 518055 ,","place":["China"]},{"name":"Shenzhen University of Advanced Technology Department of Biomedical Engineering, , Shenzhen 518107 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linchang","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine , Guangzhou 510060 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiming","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine , Guangzhou 510060 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zilin","family":"Ou","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology , Guangzhou 510080 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhicong","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology , Guangzhou 510080 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weixi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology , Guangzhou 510080 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