{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:49:48Z","timestamp":1792273788532,"version":"4.4.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":169,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UH3-NS095495"],"award-info":[{"award-number":["UH3-NS095495"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015306","name":"Neurophysiologically Based Brain State Tracking & Modulation in Focal Epilepsy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015306","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018705","name":"European Union\u2019s HORIZON EUROPE","doi-asserted-by":"publisher","award":["101136607"],"award-info":[{"award-number":["101136607"]}],"id":[{"id":"10.13039\/100018705","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Drug-resistant epilepsy affects tens of millions of people worldwide and is associated with considerable morbidity and mortality. Thalamic deep brain stimulation and cortical responsive neurostimulation are proven treatments for focal epilepsy. Both have been used to target a range of thalamic nuclei; yet, the roles of these thalamic nuclei in focal seizure generation remain incompletely understood. Thirteen patients with drug-resistant focal epilepsy undergoing intracranial EEG were consented to undergo investigation of thalamocortical networks. Sampled regions included cortical, mesial temporal, and thalamic brain regions. Visual and spectral analyses were performed to identify seizure onset patterns and correlate thalamic and cortical seizure activity. Thalamic ictal discharges were observed in 89% of seizures. Of these, 56% demonstrated synchronous thalamocortical activity with distinct patterns. These onset patterns included hypersynchronous spiking, low-voltage fast activity, ictal baseline shifts, and broadband suppression. Multiple thalamic nuclei were involved in ictal organization and propagation, with the specific nuclei depending on the cortical seizure network. The thalamus plays a crucial role in focal onset seizure generation and propagation, with distinct seizure onset patterns and nuclei involved. These findings support exploring a broader range of thalamic nuclei in epilepsy neurostimulation and have implications for seizure detection settings in intracranial sensing devices.<\/jats:p>","DOI":"10.1093\/braincomms\/fcag227","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T11:42:01Z","timestamp":1781782921000},"source":"Crossref","is-referenced-by-count":1,"title":["Thalamocortical seizure onset patterns in drug-resistant focal epilepsy"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8695-1904","authenticated-orcid":false,"given":"Hugh D","family":"Simpson","sequence":"first","affiliation":[{"name":"Department of Neurology, Mayo Clinic , Rochester, MN 55905 ,","place":["USA"]},{"name":"Department of Neurology, The Alfred Hospital , Melbourne, VIC 3004 ,","place":["Australia"]},{"name":"Department of Neuroscience, Monash University , Melbourne, VIC 3004 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Czech Technical University in Prague , Prague 16000 ,","place":["Czech Republic"]},{"name":"Department of Natural Sciences, Faculty of Biomedical Engineering, Czech Technical University in Prague , Kladno 27201 ,","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2392-8608","authenticated-orcid":false,"given":"Benjamin H","family":"Brinkmann","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic , Rochester, MN 55905 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6151-043X","authenticated-orcid":false,"given":"Nicholas M","family":"Gregg","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic , Rochester, MN 55905 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5310-5549","authenticated-orcid":false,"given":"Brian 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