{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:22:02Z","timestamp":1787656922659,"version":"build-2736575974"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":175,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"publisher","award":["UH3NS128150"],"award-info":[{"award-number":["UH3NS128150"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"publisher","award":["R21NS096398"],"award-info":[{"award-number":["R21NS096398"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"publisher","award":["UH3NS107709"],"award-info":[{"award-number":["UH3NS107709"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation","doi-asserted-by":"publisher","award":["9605"],"award-info":[{"award-number":["9605"]}],"id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Robert and Ruth Halperin Foundation"},{"name":"John A. Blume Foundation"},{"name":"John E. Cahill Family Foundation"},{"DOI":"10.13039\/100004374","name":"Medtronic Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Abnormal beta-band (13\u201330\u2005Hz) oscillations in the subthalamic nucleus are a well-established biomarker of motor dysfunction in Parkinson's disease. While most prior work has focused on beta activity during rest or sustained movement, far less is known about its transient dynamics during movement preparation\u2014a critical phase in which suppression of beta-band activity (beta desynchronization) is thought to facilitate motor circuit readiness. Here, we delineate subthalamic beta-band activity specifically in the pre-movement initiation window across diverse motor tasks and demonstrate its association with both clinical motor impairment severity and subsequent movement acceleration. We recorded subthalamic nucleus local field potentials and kinematics in sixteen individuals with Parkinson's disease (10 males, 6 females; mean age 57.9 \u00b1 10.5 years) implanted with sensing deep brain stimulation systems (Medtronic Activa\u00ae PC+S). While off medication and stimulation, participants performed cued motor tasks, including sit-to-stand, stand-to-walk and wrist flexion-extension. Pre-movement beta desynchronization, quantified as beta power normalized to resting baseline, was extracted and analysed using linear mixed-effects models to determine its relationship with clinical impairment severity and movement acceleration. Across all tasks, we observed robust pre-movement beta desynchronization in the subthalamic nucleus (P &amp;lt; 0.001). Critically, reduced desynchronization was associated with greater motor impairment, particularly bradykinesia (P &amp;lt; 0.001). This association appeared stronger during the more complex stand-to-walk task and was linked to reduced movement acceleration, as measured by acceleration indices (P &amp;lt; 0.05). A strong link between greater pre-movement beta desynchronization, less severe bradykinesia and more vigorous movement suggests that impaired beta modulation reflects disruptions in motor planning, delayed recruitment of motor networks and excessive basal ganglia inhibition. These circuit-level abnormalities likely contribute to the difficulties individuals with Parkinson's disease face in initiating and executing movements, offering valuable insight into the neurophysiological basis of motor dysfunction in Parkinson's disease.<\/jats:p>","DOI":"10.1093\/braincomms\/fcag245","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:52:54Z","timestamp":1782301974000},"source":"Crossref","is-referenced-by-count":0,"title":["Reduced pre-movement subthalamic beta desynchronization marks motor deficit in Parkinson\u2019s disease"],"prefix":"10.1093","volume":"8","author":[{"given":"Gang","family":"Seo","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurological Sciences, Stanford University School of Medicine , Stanford, CA 94305 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5907-4029","authenticated-orcid":false,"given":"Kevin B","family":"Wilkins","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological Sciences, Stanford University School of Medicine , Stanford, CA 94305 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen M","family":"Bronte-Stewart","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurological Sciences, Stanford University School of Medicine , Stanford, CA 94305 ,","place":["USA"]},{"name":"Department of Neurosurgery, Stanford University School of Medicine , Stanford, CA 94305 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"2026082506515882900_fcag245-B1","doi-asserted-by":"crossref","first-page":"17013","DOI":"10.1038\/nrdp.2017.13","article-title":"Parkinson disease","volume":"3","author":"Poewe","year":"2017","journal-title":"Nat Rev Dis 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Models of parkinsonian bradykinesia","volume":"25","author":"Williams","year":"2024","journal-title":"Nat Rev Neurosci"},{"issue":"1","key":"2026082506515882900_fcag245-B40","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/mds.26837","article-title":"Sixty-hertz stimulation improves bradykinesia and amplifies subthalamic low-frequency oscillations","volume":"32","author":"Blumenfeld","year":"2017","journal-title":"Mov Disord"},{"issue":"1","key":"2026082506515882900_fcag245-B41","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.neucli.2013.10.127","article-title":"Why we should study gait initiation in Parkinson\u2019s disease","volume":"44","author":"Delval","year":"2014","journal-title":"Neurophysiol Clin"},{"issue":"12","key":"2026082506515882900_fcag245-B42","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.tins.2011.09.003","article-title":"New insights into the relationship between dopamine, beta oscillations and motor function","volume":"34","author":"Jenkinson","year":"2011","journal-title":"Trends Neurosci"},{"issue":"13","key":"2026082506515882900_fcag245-B43","doi-asserted-by":"crossref","first-page":"1991\u2013","DOI":"10.1002\/mds.22741","article-title":"Quantitative lateralized measures of bradykinesia at different stages of Parkinson\u2019s disease: The role of the less affected side","volume":"24","author":"Louie","year":"2009","journal-title":"Mov Disord"},{"key":"2026082506515882900_fcag245-B44","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.nicl.2017.02.010","article-title":"The cortical signature of symptom laterality in Parkinson\u2019s disease","volume":"14","author":"Heinrichs-Graham","year":"2017","journal-title":"Neuroimage Clin"},{"key":"2026082506515882900_fcag245-B45","doi-asserted-by":"crossref","first-page":"1512130","DOI":"10.3389\/fnagi.2025.1512130","article-title":"Convergent reductions in interhemispheric functional, structural and callosal connectivity in Parkinson\u2019s disease","volume":"17","author":"Wang","year":"2025","journal-title":"Front Aging Neurosci"},{"key":"2026082506515882900_fcag245-B46","doi-asserted-by":"crossref","first-page":"107348","DOI":"10.1016\/j.parkreldis.2025.107348","article-title":"Closing the loop in DBS: A data-driven approach","volume":"134","author":"Acharyya","year":"2025","journal-title":"Parkinsonism Relat Disord"},{"issue":"4","key":"2026082506515882900_fcag245-B47","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.brs.2019.02.020","article-title":"Dual threshold neural closed loop deep brain stimulation in Parkinson disease patients","volume":"12","author":"Velisar","year":"2019","journal-title":"Brain Stimul"}],"container-title":["Brain Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/braincomms\/advance-article-pdf\/doi\/10.1093\/braincomms\/fcag245\/68610645\/fcag245.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/8\/4\/fcag245\/68610645\/fcag245.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/8\/4\/fcag245\/68610645\/fcag245.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:52:11Z","timestamp":1787655131000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/braincomms\/article\/doi\/10.1093\/braincomms\/fcag245\/8715980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/braincomms\/fcag245","relation":{},"ISSN":["2632-1297"],"issn-type":[{"value":"2632-1297","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026]]},"published":{"date-parts":[[2026]]},"article-number":"fcag245"}}