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Our primary hypothesis was that a striatum-midbrain framework could provide a theoretical basis for understanding neural changes underlying response inhibition in autism. This conceptual approach considered two critical neurobehavioural factors: (a) inhibition as a dynamic process requiring trial-and-error learning, and (b) efficient error learning relying on the striatum receiving dopaminergic signals from the midbrain\u2014a framework analogous to an \u2018actor-critic\u2019 architecture. Eighteen adults with a diagnosis of autism spectrum disorder and 21 age-matched healthy controls performed a stop-signal task adjusted for functional MRI (fMRI). To dissect domain-dependent correlates of neural inhibition, we measured brain activation and connectivity as a function of task phases in the dorsal striatum and dopaminergic midbrain nuclei. Repetitive behaviour severity was assessed using the observer-reported Repetitive Behaviours Scale\u2014Revised. A striking hypoactivation in the midbrain during failed inhibition events was observed in relation with the severity of repetitive behaviours. We also identified, in the autism group, reduced functional connectivity between the midbrain-striatum hubs and regions involved in cognitive control (prefrontal cortex) and error monitoring (bilateral insula), during response preparation periods. Finally, although both groups achieved similar final performance levels, neurodivergent subjects learned slower and displayed delayed striatal engagement when behavioural adjustment was required. These results reveal a novel autism profile characterized by midbrain hypoactivation mediating repetitive behaviour manifestations and reduced long-range mesocortical hypoconnectivity during inhibitory response preparation phases. Accordingly, we suggest that individuals with autism exhibit midbrain-dependent reduced motivational arousal, limiting their ability to develop proactive strategies for trial-and-error learning and regulate out-of-context behaviours. By highlighting the key role of dopaminergic midbrain structures and related long-range pathways, we challenge the view autism as solely a cortical dysfunction condition and provide evidence for promising targets for neurobiologically-driven interventions based on dopaminergic mechanisms.<\/jats:p>","DOI":"10.1093\/braincomms\/fcag265","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T11:50:20Z","timestamp":1783684220000},"source":"Crossref","is-referenced-by-count":0,"title":["Midbrain hypoactivation and mesocortical hypoconnectivity in inhibitory control learning in autism"],"prefix":"10.1093","volume":"8","author":[{"given":"Ana","family":"Ara\u00fajo","sequence":"first","affiliation":[{"name":"Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra , Coimbra 3000-548 ,","place":["Portugal"]},{"name":"Institute for Nuclear Sciences Applied to Health (ICNAS), University of Coimbra , Coimbra 3000-548 ,","place":["Portugal"]},{"name":"Institute of Psychological Medicine, Faculty of Medicine, University of Coimbra , Coimbra 3004-504 ,","place":["Portugal"]},{"name":"Department of Psychiatry, Local Health Unit of Coimbra , Coimbra 3004-561 ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel C","family":"Duarte","sequence":"additional","affiliation":[{"name":"Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra , Coimbra 3000-548 ,","place":["Portugal"]},{"name":"Institute for Nuclear Sciences Applied to Health (ICNAS), University of Coimbra , Coimbra 3000-548 ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Sousa","sequence":"additional","affiliation":[{"name":"Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra , Coimbra 3000-548 ,","place":["Portugal"]},{"name":"Institute for Nuclear Sciences 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