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The MAPT p.A152T variant has been identified as a risk factor for Alzheimer\u2019s disease and progressive supranuclear palsy, but its role in Pick\u2019s disease is unknown. In this study, we examined the prevalence of MAPT p.A152T in the largest series of neuropathologically confirmed Pick\u2019s disease cases to date (n = 401). Through genotyping, we identified a single mutation carrier in the Pick\u2019s disease cohort (minor allele frequency = 0.12%). We previously reported MAPT p.A152T at a 0.20% frequency in healthy controls (n = 2456), suggesting that it does not associate with 3-Repeat tauopathy risk. To further investigate the effect of the variant on MAPT transcript expression, we used bulk RNA sequencing in Alzheimer\u2019s disease and progressive supranuclear palsy A152T mutation carriers. We did not detect significant differences in 4-Repeat tau levels, though preliminary trends may indicate more nuanced effects that need to be examined with long-read sequencing in a larger series. 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