{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:47:14Z","timestamp":1791582434483,"version":"4.3.4"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":201,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017506","name":"Alzheimer\u2019s Society","doi-asserted-by":"publisher","award":["549\/SERA-52"],"award-info":[{"award-number":["549\/SERA-52"]}],"id":[{"id":"10.13039\/501100017506","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010055","name":"University of Salford","doi-asserted-by":"publisher","award":["SEFA-39"],"award-info":[{"award-number":["SEFA-39"]}],"id":[{"id":"10.13039\/100010055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Dementia is a syndrome caused by various diseases including Alzheimer's disease (AD) and frontotemporal dementia (FTD) with an estimated global prevalence of 60 million individuals. Recently, therapeutic development in the dementia field has accelerated, with the introduction of monoclonal antibody therapeutics such as Lecanemab and Donanemab. However, AD and FTD patients are still either diagnosed too late to benefit from available therapies or are misdiagnosed due to the clinical overlap between dementia subgroups making therapeutic intervention challenging. This highlights a real need to improve early diagnostic tools of neurodegenerative disease (ND) biomarkers. A potential source of such biomarkers come from small extracellular vesicles (sEVs), groups of cell-derived, lipid-bound assemblies with the capability to cross the blood\u2013brain barrier (BBB) and known to carry pathogenic proteins associated with AD and FTD. A known cargo of sEVs is microRNA (miRNA), regulatory molecules that post-transcriptionally silence gene expression including transcripts of autophagic systems, processes which dysfunction in dementia-causing diseases leading to toxic aggregate build-up, causing neurodegeneration. The targeting of functional machineries in macroautophagy (MA) and chaperone-mediated autophagy (CMA) by different miRNA may vary between AD and FTD mutations, leading to potential biomarkers of disease being highlighted. Through isolating sEVs from the frontal cortex of post-mortem brain tissue of AD, FTD-MAPT, FTD-C9orf72, FTD-GRN and no-disease control patients (Manchester Brain Bank), miRNA cargoes were analysed and compared using real-time quantitative PCR (RT-qPCR). Seven autophagy-associated miRNA candidates (MA: miR-124-3p, miR-30a-5p, miR-128-3p; and CMA: miR-224-5p, miR-373-5p, miR-106a-3p and miR-26b-5p) were tested to identify dementia sub-group variations, used alongside small RNA-sequencing to explore broader miRNA variation within sEV populations. Of the miRNA tested miR-224-5p (P = 1.76 \u00d7 10\u22125) and miR-106a-3p (P = 0.033) showed significant group differences, and further significant pairwise comparison differences [miR-224-5p: AD fold change (FC) = 4.29, MAPT FC = 7.62; miR-106a-5p: AD FC = 5.59] when compared with no disease controls and other dementia subgroups, potentially showing initial diagnostic and differentiating potential. Small RNA-sequencing results revealed 8 AD, 2 FTD-GRN, 52 FTD-MAPT and 12 FTD-C9orf72 differentially expressed sEV-miRNAs when compared with no disease controls. Further direct comparisons between AD versus FTD mutation-derived sEV cargoes, and even FTD mutation versus FTD mutation-derived sEV cargoes, identified additional miRNA with differentiating capabilities. These findings demonstrate sEV-derived miRNA signatures vary across dementia sub-types and suggest potential roles of sEV cargoes in both disease diagnostics and identifying drivers of ND, such as autophagic impairments and signalling pathways.<\/jats:p>","DOI":"10.1093\/braincomms\/fcag277","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:20:39Z","timestamp":1784546439000},"source":"Crossref","is-referenced-by-count":1,"title":["Distinct brain extracellular vesicle microRNA profiles differ in frontotemporal dementia and Alzheimer\u2019s disease"],"prefix":"10.1093","volume":"8","author":[{"given":"Joseph","family":"Morgan","sequence":"first","affiliation":[{"name":"Translational Medicine Laboratory, Biomedical Research and Innovations Centre, University of Salford , Manchester M5 4NT ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toby","family":"Aarons","sequence":"additional","affiliation":[{"name":"Translational Medicine Laboratory, Biomedical Research and Innovations Centre, University of Salford , Manchester M5 4NT ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1089-7179","authenticated-orcid":false,"given":"Arijit","family":"Mukhopadhyay","sequence":"additional","affiliation":[{"name":"Translational Medicine Laboratory, Biomedical Research and Innovations Centre, University of Salford , Manchester M5 4NT ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4819-3625","authenticated-orcid":false,"given":"Gemma","family":"Lace","sequence":"additional","affiliation":[{"name":"Translational Medicine Laboratory, Biomedical Research and Innovations Centre, University of Salford , Manchester M5 4NT ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"2026080410191216900_fcag277-B1","first-page":"1","volume-title":"World Alzheimer Report 2024\u2014Global changes in attitudes to dementia","author":"Evans-Lacko","year":"2024"},{"key":"2026080410191216900_fcag277-B2","volume-title":"Frontotemporal lobe dementia","author":"Khan","year":"2023"},{"issue":"6","key":"2026080410191216900_fcag277-B3","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1001\/jamaneurol.2022.0976","article-title":"Risk factors associated with Alzheimer disease and related dementias by sex and race and ethnicity in the US","volume":"79","author":"Nianogo","year":"2022","journal-title":"JAMA Neurol."},{"issue":"3","key":"2026080410191216900_fcag277-B4","doi-asserted-by":"crossref","first-page":"833","DOI":"10.3233\/JAD-190924","article-title":"Alzheimer\u2019s disease or behavioral variant frontotemporal dementia? Review of key points toward an accurate clinical and neuropsychological diagnosis","volume":"73","author":"Musa","year":"2020","journal-title":"J Alzheimer\u2019s Dis"},{"key":"2026080410191216900_fcag277-B5","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.663407","article-title":"Systematic review: Genetic, neuroimaging, and fluids biomarkers for frontotemporal dementia across Latin America countries","volume":"12","author":"Duran-Aniotz","year":"2021","journal-title":"Front Neurol."},{"issue":"14","key":"2026080410191216900_fcag277-B6","first-page":"1","article-title":"Frontotemporal dementia, where do we stand? A narrative review","volume":"24","author":"Antonio","year":"2023","journal-title":"Int J Mol Sci."},{"issue":"2","key":"2026080410191216900_fcag277-B7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms25021125","article-title":"Autophagy markers are altered in Alzheimer\u2019s disease, dementia with Lewy bodies and frontotemporal dementia","volume":"25","author":"Longobardi","year":"2024","journal-title":"Int J Mol Sci."},{"issue":"10","key":"2026080410191216900_fcag277-B8","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.1038\/s41380-021-01249-0","article-title":"The amyloid-\u03b2 pathway in Alzheimer\u2019s disease","volume":"26","author":"Hampel","year":"2021","journal-title":"Mol Psychiatry."},{"issue":"1","key":"2026080410191216900_fcag277-B9","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-08724-w","article-title":"C9orf72 dipeptides disrupt the nucleocytoplasmic transport machinery and cause TDP-43 mislocalisation to the cytoplasm","volume":"12","author":"Ryan","year":"2022","journal-title":"Sci Rep."},{"issue":"4","key":"2026080410191216900_fcag277-B10","doi-asserted-by":"crossref","DOI":"10.1002\/jnr.24541","article-title":"Oxidative stress differentially induces tau dissociation from neuronal microtubules in neurites of neurons cultured from different regions of the embryonic Gallus domesticus brain","volume":"98","author":"Beyrent","year":"2020","journal-title":"J Neurosci Res."},{"issue":"9","key":"2026080410191216900_fcag277-B11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/antiox10091479","article-title":"Oxidative stress and beta amyloid in Alzheimer\u2019s disease. Which comes first: The chicken or the egg?","volume":"10","author":"Tamagno","year":"2021","journal-title":"Antioxidants"},{"issue":"385","key":"2026080410191216900_fcag277-B12","article-title":"High glucose induces tau hyperphosphorylation in hippocampal neurons vis inhibition of ALKBH5-mediated dgkh m6A demethylation: A potential mechanism for diabetic cognitive dysfunction","volume":"14","author":"Qu","year":"2023","journal-title":"Cell Death Dis."},{"key":"2026080410191216900_fcag277-B13","doi-asserted-by":"crossref","first-page":"141.e15","DOI":"10.1016\/j.neurobiolaging.2019.11.009","article-title":"Two pathologically confirmed cases of novel mutations in the MAPT gene causing frontotemporal dementia","volume":"87","author":"Shafei","year":"2020","journal-title":"Neurobiol Aging."},{"key":"2026080410191216900_fcag277-B14","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2023.1086895","article-title":"Autophagy and neurodegeneration: Unravelling the role of C9ORF72 in the regulation of autophagy and its relationship to ALS-FTD pathology","volume":"17","author":"Diab","year":"2023","journal-title":"Front Cell Neurosci."},{"key":"2026080410191216900_fcag277-B15","doi-asserted-by":"crossref","DOI":"10.1155\/2024\/9550301","article-title":"Autophagy improves inflammatory response in sepsis accompanied by changes in gut microbiota","volume":"2024","author":"Wang","year":"2024","journal-title":"Mediat Inflamm."},{"issue":"9","key":"2026080410191216900_fcag277-B16","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1084\/jem.20160999","article-title":"Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation","volume":"214","author":"Chang","year":"2017","journal-title":"J Exp Med."},{"issue":"1","key":"2026080410191216900_fcag277-B17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/acel.12692","article-title":"Interplay of pathogenic form of human tau with different autophagic pathways","volume":"17","author":"Caballero","year":"2018","journal-title":"Aging Cell"},{"issue":"151","key":"2026080410191216900_fcag277-B18","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s40478-023-01648-0","article-title":"A toxic gain-of-function mechanism in C9orf72 ALS impairs the autophagy-lysosome pathway in neurons","volume":"11","author":"Beckers","year":"2023","journal-title":"Acta Neuropathol Commun."},{"key":"2026080410191216900_fcag277-B19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneumeth.2020.108980","article-title":"A novel approach to correlate the salivary exosomes and their protein cargo in the progression of cognitive impairment into Alzheimer\u2019s disease","volume":"347","author":"Rani","year":"2021","journal-title":"J Neurosci Methods."},{"issue":"5","key":"2026080410191216900_fcag277-B20","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1007\/s12035-022-02762-1","article-title":"Novel exosome biomarker candidates for Alzheimer\u2019s disease unravelled through mass spectrometry analysis","volume":"59","author":"Martins","year":"2022","journal-title":"Mol Neurobiol."},{"issue":"402","key":"2026080410191216900_fcag277-B21","first-page":"1","article-title":"Overview of microRNA biogenesis, mechanisms of actions, and circulation","volume":"9","author":"O\u2019Brien","year":"2018","journal-title":"Front Endocrinol (Lausanne)."},{"key":"2026080410191216900_fcag277-B22","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1038\/mp.2014.127","article-title":"Prognostic serum miRNA biomarkers associated with Alzheimer\u2019s disease shows concordance with neuropsychological and neuroimaging assessment","volume":"20","author":"Cheng","year":"2015","journal-title":"Mol Psychiatry."},{"issue":"4","key":"2026080410191216900_fcag277-B23","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/jnen\/nlae014","article-title":"Brain banking in the United States and Europe: Importance, challenges, and future trends","volume":"83","author":"Danner","year":"2024","journal-title":"J Neuropathol Exp Neurol."},{"issue":"4","key":"2026080410191216900_fcag277-B24","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1093\/brain\/awf069","article-title":"Inherited frontotemporal dementia in nine British families associated with intronic mutations in the tau gene","volume":"125","author":"Pickering-Brown","year":"2002","journal-title":"Brain"},{"issue":"3","key":"2026080410191216900_fcag277-B25","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/brain\/awm331","article-title":"Frequency and clinical characteristics of progranulin mutation carriers in the Manchester frontotemporal degeneration cohort: Comparison with patients with MAPT and no known mutations","volume":"131","author":"Pickering-Brown","year":"2008","journal-title":"Brain"},{"issue":"7\u20138","key":"2026080410191216900_fcag277-B26","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3109\/21678421.2015.1074700","article-title":"Distinct clinical and pathological phenotypes in frontotemporal dementia associated with MAPT, PGRN and C9orf72 mutations","volume":"16","author":"Snowden","year":"2015","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener."},{"key":"2026080410191216900_fcag277-B27","first-page":"e67379","article-title":"Harnessing the power of MicroRNA cargoes in small extracellular vesicles released from fresh-frozen human brain sections","volume":"213","author":"Morgan","year":"2024","journal-title":"J Vis Exp."},{"issue":"1","key":"2026080410191216900_fcag277-B28","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): A position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines","volume":"7","author":"Th\u00e9ry","year":"2018","journal-title":"J Extracell Vesicles."},{"issue":"2","key":"2026080410191216900_fcag277-B29","first-page":"1","article-title":"Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches","volume":"13","author":"Welsh","year":"2023","journal-title":"J Extracell Vesicles."},{"key":"2026080410191216900_fcag277-B30","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.73","article-title":"Influence of microRNA deregulation on chaperone-mediated autophagy and \u03b1-synuclein pathology in Parkinson\u2019s disease","volume":"4","author":"Alvarez-Erviti","year":"2013","journal-title":"Cell Death Dis."},{"issue":"5","key":"2026080410191216900_fcag277-B31","first-page":"2127","article-title":"miR-124 regulates cell apoptosis and autophagy in dopaminergic neurons and protects them by regulating AMPK\/mTOR pathway in Parkinson\u2019s disease","volume":"8","author":"Gong","year":"2016","journal-title":"Am J Transl Res."},{"key":"2026080410191216900_fcag277-B32","first-page":"1","article-title":"The microRNA in ventricular remodeling: The miR-30 family","volume":"39","author":"Zhang","year":"2019","journal-title":"Biosci Rep."},{"issue":"10","key":"2026080410191216900_fcag277-B33","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1002\/kjm2.12582","article-title":"LncRNA NEAT1 induces autophagy through the miR-128-3p\/ADAM28 axis to suppress apoptosis of nonsmall-cell lung cancer","volume":"38","author":"Xie","year":"2022","journal-title":"Kaohsiung J Med Sci."},{"issue":"19","key":"2026080410191216900_fcag277-B34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1073\/pnas.1305623110","article-title":"TFEB-mediated autophagy rescues midbrain dopamine neurons from \u03b1-synuclein toxicity","volume":"110","author":"Decressac","year":"2013","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"12","key":"2026080410191216900_fcag277-B35","doi-asserted-by":"crossref","first-page":"5227","DOI":"10.1038\/s44319-024-00294-4","article-title":"The controversy around anti-amyloid antibodies for treating Alzheimer\u2019s disease","volume":"25","author":"Hunter","year":"2024","journal-title":"EMBO Rep."},{"issue":"9","key":"2026080410191216900_fcag277-B36","doi-asserted-by":"crossref","first-page":"6639","DOI":"10.1002\/alz.14108","article-title":"Considering challenges for the new Alzheimer\u2019s drugs: Clinical, population, and health system perspectives","volume":"20","author":"Walsh","year":"2024","journal-title":"Alzheimers Dement"},{"issue":"189","key":"2026080410191216900_fcag277-B37","article-title":"Cellular and extracellular microRNA dysregulation in LRRK2-linked Parkinson\u2019s disease","volume":"63","author":"Knab","year":"2025","journal-title":"Mol Neurobiol."},{"issue":"4","key":"2026080410191216900_fcag277-B38","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.bbrc.2018.10.150","article-title":"MiRNA-224-5p inhibits autophagy in breast cancer cells via targeting Smad4","volume":"506","author":"Cheng","year":"2018","journal-title":"Biochem Biophys Res Commun."},{"issue":"2","key":"2026080410191216900_fcag277-B39","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-022-04588-0","article-title":"Myocardin\/microRNA-30a\/beclin1 signaling controls the phenotypic modulation of vascular smooth muscle cells by regulating autophagy","volume":"13","author":"Shi","year":"2022","journal-title":"Cell Death Dis."},{"issue":"7","key":"2026080410191216900_fcag277-B40","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2013-14-7-r78","article-title":"A blood based 12 miRNA signature of Alzheimer disease patients","volume":"14","author":"Leidinger","year":"2013","journal-title":"Genome Biol."},{"issue":"3","key":"2026080410191216900_fcag277-B41","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jbiotec.2011.01.023","article-title":"Identification of blood microRNAs associated to Parkinson\u2019s disease","volume":"152","author":"Margis","year":"2011","journal-title":"J Biotechnol."},{"key":"2026080410191216900_fcag277-B42","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.mod.2012.11.002","article-title":"The role of cell adhesion molecules for navigating axons: Density matters","volume":"130","author":"Pollerberg","year":"2013","journal-title":"Mech Dev."},{"issue":"378","key":"2026080410191216900_fcag277-B43","article-title":"Glycosylphosphatidylinositol-anchored immunoglobulin superfamily cell adhesion molecules and their role in neuronal development and synapse regulation","volume":"10","author":"Tan","year":"2017","journal-title":"Front Mol Neurosci."},{"key":"2026080410191216900_fcag277-B44","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.expneurol.2006.10.014","article-title":"Reduced expression of PSA-NCAM in the hippocampus and piriform cortex of the R6\/1 and R6\/2 mouse models of huntington\u2019s disease","volume":"204","author":"Van der Borght","year":"2007","journal-title":"Exp Neurol."},{"issue":"18","key":"2026080410191216900_fcag277-B45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cells13181554","article-title":"Intercellular adhesion molecule 1 (ICSAM-1): An inflammatory regulator with potential implications in ferroptosis and Parkinson\u2019s disease","volume":"13","author":"Miller","year":"2024","journal-title":"Cells"},{"key":"2026080410191216900_fcag277-B46","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/2792884","article-title":"Decreased serum NCAM levels associated with cognitive impairment in vascular dementia","volume":"2021","author":"Zhao","year":"2021","journal-title":"Dis Markers."},{"key":"2026080410191216900_fcag277-B47","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/6427537","article-title":"Synaptic cell adhesion molecules in Alzheimer\u2019s disease","volume":"2016","author":"Leshchyns\u2019ka","year":"2016","journal-title":"Neural Plast."},{"key":"2026080410191216900_fcag277-B48","first-page":"1","article-title":"Amyloid precursor protein (APP) and amyloid \u00df (A\u00df) interact with cell adhesion molecules: Implications in Alzheimer\u2019s disease and normal physiology","author":"Pfundstein","year":"2022","journal-title":"Front Cell Dev Biol"},{"issue":"488","key":"2026080410191216900_fcag277-B49","first-page":"1","article-title":"Plasma small extracellular vesicles with complement alterations in GRN\/C9orf72 and sporadic frontotemporal lobar degeneration","volume":"11","author":"Bellini","year":"2022","journal-title":"Cells"},{"issue":"254","key":"2026080410191216900_fcag277-B50","article-title":"Circulating small extracellular vesicles in Alzheimer\u2019s disease: A cause-control study of neuro-inflammation and synaptic dysfunction","volume":"22","author":"Singh","year":"2024","journal-title":"BMC Med."},{"issue":"5485","key":"2026080410191216900_fcag277-B51","first-page":"1","article-title":"P38( MAPK signaling\u2014A robust therapeutic target for Rab5-mediated neurodegenerative disease","volume":"21","author":"Germann","year":"2020","journal-title":"Int J Mol Sci."},{"issue":"45","key":"2026080410191216900_fcag277-B52","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2405152121","article-title":"Pan-ErbB inhibition impairs cognition via disrupting myelination and aerobic glycolysis in oligodendrocytes","volume":"121","author":"Hu","year":"2024","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"4581","key":"2026080410191216900_fcag277-B53","first-page":"1","article-title":"The role of oxygen homeostasis and the HIF-1 factor in the development of neurodegeneration","volume":"25","author":"Mitroshina","year":"2024","journal-title":"Int J Mol Sci."},{"issue":"9","key":"2026080410191216900_fcag277-B54","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1016\/j.ymthe.2024.06.025","article-title":"Prospects and challenges of tissue-derived extracellular vesicles","volume":"32","author":"Lee","year":"2024","journal-title":"Mol Ther."},{"issue":"42","key":"2026080410191216900_fcag277-B55","article-title":"The overlapping genetics of amyotrophic lateral sclerosis and frontotemporal dementia","volume":"14","author":"Abramzon","year":"2020","journal-title":"Front Neurosci."},{"key":"2026080410191216900_fcag277-B56","article-title":"Single extracellular vesicle detection assay identifies membrane-associated (-synuclein as an early-stage biomarker in Parkinson\u2019s disease","volume":"6","author":"Yan","year":"2025","journal-title":"Cell Rep Med."},{"issue":"1","key":"2026080410191216900_fcag277-B57","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-023-02708-x","article-title":"Plasma derived extracellular vesicle biomarkers of microglia activation in an experimental stroke model","volume":"20","author":"Roseborough","year":"2023","journal-title":"J Neuroinflammation."},{"issue":"3575","key":"2026080410191216900_fcag277-B58","first-page":"1","article-title":"Comparison of extracellular vesicles from induced pluripotent stem cell-derived brain cells","volume":"25","author":"Xavier","year":"2024","journal-title":"Int J Mol Sci."},{"issue":"19","key":"2026080410191216900_fcag277-B59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/JCI162731","article-title":"Pathogenic myelin-specific antibodies in multiple sclerosis target conformational proteolipid protein 1-anchored membrane domains","volume":"133","author":"Owens","year":"2023","journal-title":"J Clin Invest."},{"issue":"3","key":"2026080410191216900_fcag277-B60","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.bbamcr.2011.08.006","article-title":"Quality control and fate determination of Hsp90 client proteins","volume":"1823","author":"Theodoraki","year":"2012","journal-title":"Biochim Biophys Acta."},{"key":"2026080410191216900_fcag277-B61","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12089","article-title":"Characterisation of brain-derived extracellular vesicle lipids in Alzheimer\u2019s disease","volume":"10","author":"Su","year":"2021","journal-title":"J Extracell Vesicles."}],"container-title":["Brain Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/braincomms\/advance-article-pdf\/doi\/10.1093\/braincomms\/fcag277\/69695589\/fcag277.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/8\/4\/fcag277\/69695589\/fcag277.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/8\/4\/fcag277\/69695589\/fcag277.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:32:32Z","timestamp":1785853952000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/braincomms\/article\/doi\/10.1093\/braincomms\/fcag277\/8739165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":61,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/braincomms\/fcag277","relation":{},"ISSN":["2632-1297"],"issn-type":[{"value":"2632-1297","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026]]},"published":{"date-parts":[[2026]]},"article-number":"fcag277"}}