{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:20:57Z","timestamp":1788330057451,"version":"build-2803163510"},"reference-count":107,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":196,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Ageing","doi-asserted-by":"publisher","award":["R01 AG038465"],"award-info":[{"award-number":["R01 AG038465"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Ageing","doi-asserted-by":"publisher","award":["R01 AG026158"],"award-info":[{"award-number":["R01 AG026158"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>As one of the earliest pathological events in Alzheimer\u2019s disease, amyloid-beta accumulation has been linked to alterations in large-scale brain networks, especially the default mode network. While most prior work has focused on resting-state functional connectivity or task-evoked activation, how amyloid-beta relates to task-modulated connectivity that directly supports behaviour is less explored. Here, we examined the relationship between amyloid-beta burden and task-modulated connectivity during a Letter\u2013Sternberg verbal working memory task in 84 cognitively normal older adults from an ongoing longitudinal cohort (aged 56\u201371\u2005years; 41 females). To further understand these connectivity alterations, we tested whether these connections were associated with task performance or with cognitive reserve proxies. We found that higher amyloid-beta burden was associated with reduced connectivity\u2014specifically during the probe-phase of working memory retrieval. At the regional scale, lower node strength in posterior\u2013medial regions of the default mode network was related to worse task performance and mediated the amyloid\u2013behaviour relationship. At the network scale, altered coupling between the default mode and dorsal attention networks was related to task performance but did not mediate the amyloid\u2013behaviour relationship. Moreover, physical activity was associated with network-level coupling but not with regional node strength. These findings suggest that amyloid-beta burden disrupts retrieval-related working memory systems, particularly regions of the default mode network, while coupling between the default mode and dorsal attention networks is related to physical activity, a cognitive reserve proxy. Collectively, task-modulated connectivity provides insight into pathways through which early Alzheimer\u2019s disease pathology influences working memory performance and may inform targeted lifestyle or neuromodulation interventions for older adults.<\/jats:p>","DOI":"10.1093\/braincomms\/fcag278","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T11:47:22Z","timestamp":1784116042000},"source":"Crossref","is-referenced-by-count":1,"title":["Amyloid-beta relates to default and attention network connectivity during working memory retrieval"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6925-8179","authenticated-orcid":false,"given":"Hengda","family":"He","sequence":"first","affiliation":[{"name":"Cognitive Neuroscience Division, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY 10032 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9961-7446","authenticated-orcid":false,"given":"Christian G","family":"Habeck","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience Division, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY 10032 ,","place":["USA"]},{"name":"Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain, Columbia University , New York, NY 10032 ,","place":["USA"]},{"name":"Gertrude H. Sergievsky Center, Columbia University , New York, NY 10032 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7542-3241","authenticated-orcid":false,"given":"Yaakov","family":"Stern","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience Division, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY 10032 ,","place":["USA"]},{"name":"Taub Institute for Research on Alzheimer\u2019s Disease and the Aging Brain, Columbia University , New York, NY 10032 ,","place":["USA"]},{"name":"Gertrude H. Sergievsky Center, Columbia University , New York, NY 10032 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"issue":"2","key":"2026081809165997900_fcag278-B1","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1093\/brain\/awv338","article-title":"Cascading network failure across the Alzheimer\u2019s disease spectrum","volume":"139","author":"Jones","year":"2016","journal-title":"Brain"},{"issue":"3","key":"2026081809165997900_fcag278-B2","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jalz.2011.03.003","article-title":"Toward defining the preclinical stages of Alzheimer\u2019s disease: Recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"Sperling","year":"2011","journal-title":"Alzheimers 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