{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:17:33Z","timestamp":1785161853219,"version":"3.55.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":196,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018749","name":"Korea Brain Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018749","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and Information and Communications Technology","doi-asserted-by":"publisher","award":["26-BR-02-03"],"award-info":[{"award-number":["26-BR-02-03"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and Information and Communications Technology","doi-asserted-by":"publisher","award":["26-BR-02-05"],"award-info":[{"award-number":["26-BR-02-05"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and Information and Communications Technology","doi-asserted-by":"publisher","award":["26-BR-04-01"],"award-info":[{"award-number":["26-BR-04-01"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and Information and Communications Technology","doi-asserted-by":"publisher","award":["26-BR-06-02"],"award-info":[{"award-number":["26-BR-06-02"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and Information and Communications Technology","doi-asserted-by":"publisher","award":["RS-2024-00343239"],"award-info":[{"award-number":["RS-2024-00343239"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and Information and Communications Technology","doi-asserted-by":"publisher","award":["RS-2024-00454715"],"award-info":[{"award-number":["RS-2024-00454715"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and Information and Communications Technology","doi-asserted-by":"publisher","award":["RS-2024-00508681"],"award-info":[{"award-number":["RS-2024-00508681"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013128","name":"Korea Technology and Information Promotion Agency for Small and Medium-sized Enterprises","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013129","name":"Ministry of Small and Medium Enterprises and Startups","doi-asserted-by":"publisher","award":["RS-2024-00512888"],"award-info":[{"award-number":["RS-2024-00512888"]}],"id":[{"id":"10.13039\/501100013129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study aimed to identify and validate a robust, generalizable panel of plasma protein biomarkers to improve diagnostic precision in Parkinson\u2019s disease. We analysed plasma samples from 12 patients with [18F]-FP-CIT PET-confirmed Parkinson\u2019s disease and 15 healthy controls using the Olink Target 96 Inflammation Panel to identify differentially expressed proteins. Candidate biomarkers were subsequently validated through absolute quantification using Luminex and Olink Flex platforms in an independent cohort of 46 patients with Parkinson\u2019s disease and 33 amyloid-negative and cognitively normal control participants. To assess generalizability, the findings were replicated across multiple heterogeneous populations using large-scale datasets from the UK Biobank and Global Neurodegeneration Proteomics Consortium (GNPC) cohorts. Markers of neurodegeneration [neurofilament light chain (NfL)] and Alzheimer\u2019s disease [phosphorylated tau (pTau181), amyloid \u03b2 [A\u03b2]42, A\u03b240] co-pathology were measured using the single molecule array platform. Our analyses revealed elevated levels of interleukin (IL)-10 and IL-17C and reduced levels of urokinase plasminogen activator (uPA) and neurotrophin-3 (NTF3) in patients with Parkinson\u2019s disease. These findings were confirmed in the validation cohort. Multitarget models demonstrated superior diagnostic performance over individual markers, with the combination of IL-17C and uPA achieving the highest discrimination (area under the curve = 0.780). External validation in the UK Biobank and GNPC datasets confirmed consistent directional changes of three candidates (IL-17C, NTF3 and uPA), reinforcing the biological relevance of these markers. Notably, while NfL levels were significantly elevated in Parkinson\u2019s disease, no significant differences were observed for pTau181 levels or A\u03b242\/A\u03b240 ratios. These findings identify a specific plasma protein panel, particularly the combination of IL-17C and uPA, as a robust and generalizable diagnostic signature that captures fundamental pathophysiological aspects of Parkinson\u2019s disease and enhances diagnostic precision alongside established biomarkers.<\/jats:p>","DOI":"10.1093\/braincomms\/fcag282","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T11:47:51Z","timestamp":1784116071000},"source":"Crossref","is-referenced-by-count":0,"title":["Identification of a robust multitarget protein panel for Parkinson\u2019s disease via absolute quantification and large-scale external replication"],"prefix":"10.1093","volume":"8","author":[{"given":"Ho-Won","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Neurology, Kyungpook National University Chilgok Hospital , Daegu 41404 ,","place":["Republic of Korea"]},{"name":"Department of Neurology, School of Medicine, Kyungpook National University , Daegu 41944 ,","place":["Republic of Korea"]},{"name":"Brain Science & Engineering Institute, Kyungpook National University , Daegu 41944 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngtae","family":"Choi","sequence":"additional","affiliation":[{"name":"Dementia Research Group, Korea Brain Research Institute (KBRI) , Daegu 41062 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinrye","family":"Lee","sequence":"additional","affiliation":[{"name":"Dementia Research Group, Korea Brain Research Institute (KBRI) , Daegu 41062 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kyungpook National University Chilgok Hospital , Daegu 41404 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Tae","family":"Jeon","sequence":"additional","affiliation":[{"name":"Dementia Research Group, Korea Brain Research Institute (KBRI) , Daegu 41062 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myungjin","family":"Jo","sequence":"additional","affiliation":[{"name":"Dementia Research Group, Korea Brain Research Institute (KBRI) , Daegu 41062 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyuri","family":"Park","sequence":"additional","affiliation":[{"name":"Dementia Research Group, Korea Brain Research Institute (KBRI) , Daegu 41062 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5506-9206","authenticated-orcid":false,"given":"Jin-Sung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kyungpook National University Chilgok Hospital , Daegu 41404 ,","place":["Republic of Korea"]},{"name":"Department of Neurology, School of Medicine, Kyungpook National University , Daegu 41944 ,","place":["Republic of Korea"]},{"name":"Brain Science & Engineering Institute, Kyungpook National University , Daegu 41944 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do-Geun","family":"Kim","sequence":"additional","affiliation":[{"name":"Dementia Research Group, Korea Brain Research Institute (KBRI) , Daegu 41062 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6777-6725","authenticated-orcid":false,"given":"Mookyung","family":"Cheon","sequence":"additional","affiliation":[{"name":"Dementia Research Group, Korea Brain Research Institute (KBRI) , Daegu 41062 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung-Jun","family":"Kim","sequence":"additional","affiliation":[{"name":"Dementia Research Group, Korea Brain Research Institute (KBRI) , Daegu 41062 ,","place":["Republic of Korea"]},{"name":"Graduate School, DGIST , Daegu 42988 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"issue":"9996","key":"2026072709462123100_fcag282-B1","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson\u2019s disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"issue":"5","key":"2026072709462123100_fcag282-B2","doi-asserted-by":"crossref","first-page":"318","DOI":"10.4274\/balkanmedj.galenos.2022.2022-7-100","article-title":"Neuroinflammation in Parkinson\u2019s disease and its treatment opportunities","volume":"39","author":"\u00c7\u0131nar","year":"2022","journal-title":"Balkan Med J."},{"issue":"1","key":"2026072709462123100_fcag282-B3","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41531-023-00449-5","article-title":"A systematic review and meta-analysis of inflammatory biomarkers in Parkinson\u2019s disease","volume":"9","author":"Qu","year":"2023","journal-title":"NPJ Parkinsons Dis."},{"issue":"s1","key":"2026072709462123100_fcag282-B4","doi-asserted-by":"crossref","first-page":"S183","DOI":"10.3233\/JPD-223277","article-title":"Blood and cerebrospinal fluid biomarkers of inflammation in Parkinson\u2019s disease","volume":"12","author":"Zimmermann","year":"2022","journal-title":"J Parkinsons Dis."},{"issue":"9","key":"2026072709462123100_fcag282-B5","doi-asserted-by":"crossref","first-page":"11890","DOI":"10.1007\/s12035-025-05022-0","article-title":"Identifying immune response protein biomarkers in Parkinson\u2019s-related cognitive impairment and depression","volume":"62","author":"Su","year":"2025","journal-title":"Mol Neurobiol."},{"key":"2026072709462123100_fcag282-B6","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1104393","article-title":"Serum inflammatory cytokines levels and the correlation analyses in Parkinson\u2019s disease","volume":"11","author":"Fu","year":"2023","journal-title":"Front Cell Dev Biol."},{"issue":"1","key":"2026072709462123100_fcag282-B7","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41398-025-03264-z","article-title":"Predicting antipsychotic responsiveness using a machine learning classifier trained on plasma levels of inflammatory markers in schizophrenia","volume":"15","author":"Yee","year":"2025","journal-title":"Transl Psychiatry."},{"issue":"2","key":"2026072709462123100_fcag282-B8","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202402183RR","article-title":"Novel inflammatory markers in intracerebral hemorrhage: Results from Olink proteomics analysis","volume":"39","author":"Hu","year":"2025","journal-title":"FASEB J."},{"key":"2026072709462123100_fcag282-B9","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2024.107188","article-title":"Inflammation proteomic profiling of psychosis in young adults: Findings from the ALSPAC birth cohort","volume":"171","author":"Tsang","year":"2025","journal-title":"Psychoneuroendocrinology"},{"issue":"4","key":"2026072709462123100_fcag282-B10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095192","article-title":"Homogenous 96-plex PEA immunoassay exhibiting high sensitivity, specificity, and excellent scalability","volume":"9","author":"Assarsson","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"2026072709462123100_fcag282-B11","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/mds.29257","article-title":"Blood markers of inflammation, neurodegeneration, and cardiovascular risk in early Parkinson\u2019s disease","volume":"38","author":"Bartl","year":"2023","journal-title":"Mov Disord."},{"issue":"19","key":"2026072709462123100_fcag282-B12","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241914915","article-title":"Inflammatory blood biomarkers are associated with long-term clinical disease severity in Parkinson\u2019s disease","volume":"24","author":"Hepp","year":"2023","journal-title":"Int J Mol Sci."},{"issue":"4","key":"2026072709462123100_fcag282-B13","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000200132","article-title":"Inflammatory biomarkers in newly diagnosed patients with Parkinson disease and related neurodegenerative disorders","volume":"10","author":"Pedersen","year":"2023","journal-title":"Neurol Neuroimmunol Neuroinflamm."},{"issue":"1","key":"2026072709462123100_fcag282-B14","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12883-020-1608-8","article-title":"Inflammation biomarker discovery in Parkinson\u2019s disease and atypical parkinsonisms","volume":"20","author":"Santaella","year":"2020","journal-title":"BMC Neurol."},{"issue":"1","key":"2026072709462123100_fcag282-B15","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s00401-024-02706-0","article-title":"Comprehensive proteomics of CSF, plasma, and urine identify DDC and other biomarkers of early Parkinson\u2019s disease","volume":"147","author":"Rutledge","year":"2024","journal-title":"Acta Neuropathol."},{"issue":"1","key":"2026072709462123100_fcag282-B16","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s40035-023-00374-w","article-title":"Large-scale proximity extension assay reveals CSF midkine and DOPA decarboxylase as supportive diagnostic biomarkers for Parkinson\u2019s disease","volume":"12","author":"Paslawski","year":"2023","journal-title":"Transl Neurodegener."},{"issue":"21","key":"2026072709462123100_fcag282-B17","doi-asserted-by":"crossref","first-page":"11663","DOI":"10.3390\/ijms252111663","article-title":"Proximity elongation assay and ELISA for the identification of serum diagnostic biomarkers in Parkinson\u2019s disease and progressive supranuclear palsy","volume":"25","author":"Cristiani","year":"2024","journal-title":"Int J Mol Sci."},{"issue":"8","key":"2026072709462123100_fcag282-B18","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.1038\/s41591-025-03834-0","article-title":"The Global Neurodegeneration Proteomics Consortium: Biomarker and drug target discovery for common neurodegenerative diseases and aging","volume":"31","author":"Imam","year":"2025","journal-title":"Nat Med."},{"issue":"7982","key":"2026072709462123100_fcag282-B19","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/s41586-023-06592-6","article-title":"Plasma proteomic associations with genetics and health in the UK Biobank","volume":"622","author":"Sun","year":"2023","journal-title":"Nature"},{"issue":"3","key":"2026072709462123100_fcag282-B20","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/jnnp.55.3.181","article-title":"Accuracy of clinical diagnosis of idiopathic Parkinson\u2019s disease: A clinico-pathological study of 100 cases","volume":"55","author":"Hughes","year":"1992","journal-title":"J Neurol Neurosurg Psychiatry."},{"issue":"6","key":"2026072709462123100_fcag282-B21","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.3390\/healthcare10061062","article-title":"Effect of aging on educational differences in the risk of cognitive impairment: A gender-specific analysis using Korean Longitudinal Study of Aging (2006-2016)","volume":"10","author":"Kim","year":"2022","journal-title":"Healthcare"},{"issue":"8","key":"2026072709462123100_fcag282-B22","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1038\/s41591-025-03833-1","article-title":"Shared and disease-specific pathways in frontotemporal dementia and Alzheimer\u2019s and Parkinson\u2019s diseases","volume":"31","author":"Ali","year":"2025","journal-title":"Nat Med."},{"issue":"8","key":"2026072709462123100_fcag282-B23","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1038\/s41591-025-03831-3","article-title":"Disruption of the cerebrospinal fluid-plasma protein balance in cognitive impairment and aging","volume":"31","author":"Farinas","year":"2025","journal-title":"Nat Med."},{"issue":"7982","key":"2026072709462123100_fcag282-B24","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/s41586-023-06563-x","article-title":"Large-scale plasma proteomics comparisons through genetics and disease associations","volume":"622","author":"Eldjarn","year":"2023","journal-title":"Nature"},{"issue":"1","key":"2026072709462123100_fcag282-B25","doi-asserted-by":"crossref","first-page":"4759","DOI":"10.1038\/s41467-024-48961-3","article-title":"Plasma proteomics identify biomarkers predicting Parkinson\u2019s disease up to 7 years before symptom onset","volume":"15","author":"Hallqvist","year":"2024","journal-title":"Nat Commun."},{"issue":"6","key":"2026072709462123100_fcag282-B26","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s00702-025-02902-6","article-title":"Comparison of inflammatory biomarker levels in neurodegenerative proteinopathies: A case-control study","volume":"132","author":"Cook","year":"2025","journal-title":"J Neural Transm"},{"issue":"1","key":"2026072709462123100_fcag282-B27","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/s41531-025-01146-1","article-title":"Recommendations for clinical study protocols for immune and inflammatory profiling in Parkinson\u2019s disease","volume":"11","author":"Mu\u00f1oz-Delgado","year":"2025","journal-title":"NPJ Parkinsons Dis."},{"key":"2026072709462123100_fcag282-B28","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.821730","article-title":"Asymptomatic SARS-CoV-2 infection is associated with higher levels of serum IL-17C, matrix metalloproteinase 10 and fibroblast growth factors than mild symptomatic COVID-19","volume":"13","author":"Soares-Schanoski","year":"2022","journal-title":"Front Immunol."},{"issue":"1","key":"2026072709462123100_fcag282-B29","doi-asserted-by":"crossref","first-page":"3756","DOI":"10.1038\/s41467-024-48141-3","article-title":"IL-17C is a driver of damaging inflammation during Neisseria gonorrhoeae infection of human Fallopian tube","volume":"15","author":"Garcia","year":"2024","journal-title":"Nat Commun."},{"key":"2026072709462123100_fcag282-B30","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1307447","article-title":"Neuroprotective effects of neurotrophin-3 in MPTP-induced zebrafish Parkinson\u2019s disease model","volume":"14","author":"Omar","year":"2023","journal-title":"Front Pharmacol."},{"issue":"2","key":"2026072709462123100_fcag282-B31","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s12035-020-02128-5","article-title":"Molecular regulatory mechanism and toxicology of neurodegenerative processes in MPTP\/probenecid-induced progressive Parkinson\u2019s disease mice model revealed by transcriptome","volume":"58","author":"Yang","year":"2021","journal-title":"Mol Neurobiol."},{"issue":"16","key":"2026072709462123100_fcag282-B32","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1002\/glia.20892","article-title":"Microglia and the urokinase plasminogen activator receptor\/uPA system in innate brain inflammation","volume":"57","author":"Cunningham","year":"2009","journal-title":"Glia"},{"issue":"1","key":"2026072709462123100_fcag282-B33","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.stem.2018.06.016","article-title":"Th17 cells in Parkinson\u2019s disease: The bane of the midbrain","volume":"23","author":"Bolte","year":"2018","journal-title":"Cell Stem Cell"},{"issue":"1","key":"2026072709462123100_fcag282-B34","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.stem.2018.06.015","article-title":"Th17 lymphocytes induce neuronal cell death in a human iPSC-based model of Parkinson\u2019s disease","volume":"23","author":"Sommer","year":"2018","journal-title":"Cell Stem Cell"},{"key":"2026072709462123100_fcag282-B35","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2023.1284304","article-title":"Advances in the study of IL-17 in neurological diseases and mental disorders","volume":"14","author":"Lu","year":"2023","journal-title":"Front Neurol."},{"key":"2026072709462123100_fcag282-B36","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.682597","article-title":"Neurotrophic factors in Parkinson\u2019s disease: Clinical trials, open challenges and nanoparticle-mediated delivery to the brain","volume":"15","author":"Bondarenko","year":"2021","journal-title":"Front Cell Neurosci."},{"key":"2026072709462123100_fcag282-B37","doi-asserted-by":"crossref","DOI":"10.1016\/j.mehy.2020.109602","article-title":"Synergy between plasminogen activator inhibitor-1, \u03b1-synuclein, and neuroinflammation in Parkinson\u2019s disease","volume":"138","author":"Reuland","year":"2020","journal-title":"Med Hypotheses."},{"issue":"1","key":"2026072709462123100_fcag282-B38","doi-asserted-by":"crossref","first-page":"8581","DOI":"10.1038\/s41598-024-59090-8","article-title":"Plasminogen degrades \u03b1-synuclein, Tau and TDP-43 and decreases dopaminergic neurodegeneration in mouse models of Parkinson\u2019s disease","volume":"14","author":"Guo","year":"2024","journal-title":"Sci Rep."},{"issue":"11","key":"2026072709462123100_fcag282-B39","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1002\/mds.28206","article-title":"Validation of serum neurofilament light chain as a biomarker of Parkinson\u2019s disease progression","volume":"35","author":"Mollenhauer","year":"2020","journal-title":"Mov Disord."},{"key":"2026072709462123100_fcag282-B40","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2021.577662","article-title":"Association between plasma neurofilament light chain levels and cognitive function in patients with Parkinson\u2019s disease","volume":"358","author":"Zhu","year":"2021","journal-title":"J Neuroimmunol."},{"issue":"1","key":"2026072709462123100_fcag282-B41","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/s41531-022-00384-x","article-title":"Plasma p-tau181, neurofilament light chain and association with cognition in Parkinson\u2019s disease","volume":"8","author":"Batzu","year":"2022","journal-title":"NPJ Parkinsons Dis."},{"issue":"12","key":"2026072709462123100_fcag282-B42","doi-asserted-by":"crossref","first-page":"7537","DOI":"10.1007\/s00415-024-12669-7","article-title":"Plasma NfL, GFAP, amyloid, and p-tau species as prognostic biomarkers in Parkinson\u2019s disease","volume":"271","author":"Pilotto","year":"2024","journal-title":"J Neurol."},{"issue":"6","key":"2026072709462123100_fcag282-B43","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/jnc.15601","article-title":"Plasma \u03b1-synuclein and phosphorylated tau 181 as a diagnostic biomarker panel for de novo Parkinson\u2019s disease","volume":"161","author":"Ren","year":"2022","journal-title":"J Neurochem."},{"issue":"4","key":"2026072709462123100_fcag282-B44","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s13139-024-00840-x","article-title":"Imaging procedure and clinical studies of [18F]FP-CIT PET","volume":"58","author":"Sung","year":"2024","journal-title":"Nucl Med Mol Imaging."},{"issue":"1","key":"2026072709462123100_fcag282-B45","doi-asserted-by":"crossref","first-page":"14992","DOI":"10.1038\/s41598-021-94040-8","article-title":"Diagnostic accuracy of dual-phase 18F-FP-CIT PET imaging for detection and differential diagnosis of Parkinsonism","volume":"11","author":"Oh","year":"2021","journal-title":"Sci Rep."}],"container-title":["Brain Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/braincomms\/advance-article-pdf\/doi\/10.1093\/braincomms\/fcag282\/69070887\/fcag282.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/8\/4\/fcag282\/69070887\/fcag282.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/braincomms\/article-pdf\/8\/4\/fcag282\/69070887\/fcag282.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T13:46:32Z","timestamp":1785159992000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/braincomms\/article\/doi\/10.1093\/braincomms\/fcag282\/8736018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/braincomms\/fcag282","relation":{},"ISSN":["2632-1297"],"issn-type":[{"value":"2632-1297","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026]]},"published":{"date-parts":[[2026]]},"article-number":"fcag282"}}