{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T16:10:32Z","timestamp":1785514232797,"version":"3.56.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":200,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2008085QH366"],"award-info":[{"award-number":["2008085QH366"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hippocampal sclerosis in temporal lobe epilepsy is linked to cognitive impairment. This study investigates its exacerbating role in visual working memory deficits in right temporal lobe epilepsy and the involvement of contralateral hippocampal subregions. We enrolled 103 patients with right temporal lobe epilepsy (57 with right hippocampal sclerosis and 46 without hippocampal sclerosis) and 36 healthy controls who underwent high-resolution MRI and neuropsychological assessment. Patients with hippocampal sclerosis showed more severe visual working memory impairment, widespread grey matter atrophy and significant volume loss in bilateral cornu ammonis 3 and right dentate gyrus. Contralateral cornu ammonis 3 atrophy correlated with poorer visual working memory performance. Hippocampal sclerosis in right temporal lobe epilepsy is linked to severe visual working memory deficits and extensive bilateral hippocampal atrophy. These findings establish hippocampal sclerosis as a key biomarker and underscore the role of bilateral hippocampal network disruption, with contralateral cornu ammonis 3 integrity influencing cognitive outcomes.<\/jats:p>","DOI":"10.1093\/braincomms\/fcag284","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T11:39:29Z","timestamp":1784374769000},"source":"Crossref","is-referenced-by-count":0,"title":["Bilateral cornu ammonis 3\u2013dominant mechanism of visual working memory impairment in right temporal lobe epilepsy and hippocampal sclerosis"],"prefix":"10.1093","volume":"8","author":[{"given":"Qiao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pathology, Wuhu Hospital, East China Normal University (The Second People\u2019s Hospital of Wuhu) , Wuhu 241000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotian","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Wuhu Hospital, East China Normal University (The Second People\u2019s Hospital of Wuhu) , Wuhu 241000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Deyu Medical Maanshan General Hospital , Ma\u2019anshan 243000 Anhui ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linan","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Neurology, Lixin County People\u2019s Hospital , Bozhou 236702 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Wuhu Hospital, East China Normal University , Wuhu 241001 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqi","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Wuhu Hospital, East China Normal University , Wuhu 241001 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengye","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Wuhu Hospital, East China Normal University , Wuhu 241001 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei 230001 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ximu","family":"He","sequence":"additional","affiliation":[{"name":"East China Normal University The School of 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