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Kirby Research Center"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Numerous large-scale epidemiological studies investigating the trajectory of brain function after ischaemic stroke have presented data suggesting, on average, a persistent, accelerated decline in cognitive domains, including language, after accounting for the immediate impact of the stroke. We sought to further examine this trend, speculating that the average persistent decline may be a reflection of two subgroups with vastly different prognoses: (i) a minority experiencing decline secondary to neurodegenerative processes such as vascular dementia and Alzheimer\u2019s disease and (ii) a majority without marked progressive brain atrophy who typically see improvement. Our team thus investigated atrophy\u2019s association with language recovery, hypothesizing that declining naming performance in the year after left hemisphere ischaemic stroke would be correlated to atrophy of the contralesional hemisphere. We postulated that volume loss within the lesioned hemisphere would be less informative due to separate confounding processes related to the stroke itself, such as Wallerian degeneration and encephalomalacia.<\/jats:p>\n                  <jats:p>Participants [n = 72; M (SD) age = 60 (11)] in a longitudinal cohort study of language following left hemisphere ischaemic stroke were included if they completed an MRI both acutely and chronically (either 6 or 12 months post-stroke). Naming performance was assessed using the Boston Naming Test; stroke volumes were extracted from acute imaging; and atrophy was measured as the monthly per cent change in hemispheric volume from baseline to chronic scan for each individual. Pearson\u2019s correlations were calculated to determine the relationship between lesion volume and atrophy along with atrophy and change in Boston Naming Test score.<\/jats:p>\n                  <jats:p>Lesion volume negatively correlated with the monthly per cent change in volume of the left (ipsilesional) hemisphere (r = \u22120.48; P &amp;lt; 0.0001) but did not correlate with rate of right (contralesional) hemisphere volume loss. While there was no clear relationship between atrophy of the left hemisphere and language recovery, we found that volume changes of greater negative magnitude within the right hemisphere (increased atrophy) were associated with worse functional recovery of language (r = 0.38; P = 0.0025).<\/jats:p>\n                  <jats:p>By showing that atrophy of the right hemisphere was not significantly impacted by left hemisphere lesion size, we suggest that accelerated volume loss in the non-lesioned hemisphere after stroke may be indicative of a separate pathology. We then support this claim with behavioural data showing that greater rates of volume loss within the non-lesioned hemisphere were associated with poorer naming recovery. Together, these findings imply that contralesional atrophy after stroke may have negative implications for recovery and could serve as a useful imaging signature for separate neurodegenerative processes.<\/jats:p>","DOI":"10.1093\/braincomms\/fcag291","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:42:32Z","timestamp":1784893352000},"source":"Crossref","is-referenced-by-count":0,"title":["Right hemisphere atrophy rate associates with naming recovery after left hemisphere ischaemic stroke"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5661-5639","authenticated-orcid":false,"given":"Voss","family":"Neal","sequence":"first","affiliation":[{"name":"Department of Neurology, Johns Hopkins University School of Medicine , Baltimore, MD 21287 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1673-002X","authenticated-orcid":false,"given":"Andreia V","family":"Faria","sequence":"additional","affiliation":[{"name":"Department of Radiology, Johns Hopkins University School of Medicine , Baltimore, MD 21205 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Johns Hopkins University School of Medicine , Baltimore, MD 21205 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5192-1171","authenticated-orcid":false,"given":"Argye E","family":"Hillis","sequence":"additional","affiliation":[{"name":"Department of Neurology, Johns Hopkins University School of Medicine , Baltimore, MD 21287 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9069-1236","authenticated-orcid":false,"given":"Melissa D","family":"Stockbridge","sequence":"additional","affiliation":[{"name":"Department of Neurology, 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