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In cases of idiopathic normal pressure hydrocephalus (iNPH), the presence of ventriculomegaly is often neuroradiologically evaluated by visual rating and manual measurement of each image. Previously, we have developed a deep-learning-model that utilizes transfer learning from magnetic resonance imaging (MRI) for CT-based intracranial tissue segmentation. Accordingly, herein we aimed to enhance the segmentation of ventricular cerebrospinal fluid (VCSF) in brain CT scans and assess the performance of automated brain CT volumetrics in iNPH patient diagnostics.<\/jats:p>\n                  <jats:p>This retrospective study employed a two-stage approach in developing the model. Initially, a 2D U-Net model was trained to predict VCSF segmentations from CT scans, using paired MR-VCSF labels from healthy controls. This model was subsequently refined by incorporating manually segmented lateral CT-VCSF labels from iNPH patients, building on the features learned from the initial U-Net model. The training dataset included 734 CT datasets from healthy controls paired with T1-weighted MRI scans from the Gothenburg H70 Birth Cohort Studies and 62 CT scans from iNPH patients at Uppsala University Hospital. To validate the model's performance across diverse patient populations, external clinical images including scans of 11 iNPH patients from the Universit\u00e4tsmedizin Rostock, Germany, and 30 iNPH patients from the University of Alabama at Birmingham, United States were used. Further, we obtained three CT-based volumetric measures (CTVMs) related to iNPH.<\/jats:p>\n                  <jats:p>Our analyses demonstrated strong volumetric correlations (\u03c1 = 0.91, P &amp;lt; 0.001) between automatically and manually derived CT-VCSF measurements in iNPH patients. Based on the ventricular volume, the CTVMs exhibited high accuracy in differentiating iNPH patients from controls in external clinical datasets with an AUC of 0.97 (95% CI: 0.94\u20131.00) and in the Uppsala University Hospital datasets with an AUC of 0.99 (95% CI: 0.98\u20131.00).<\/jats:p>\n                  <jats:p>CTVMs derived through deep learning show potential for assessing and quantifying morphological features in hydrocephalus. Critically, these measures performed comparably to gold-standard neuroradiology assessments in iNPH patients and healthy controls, even in the presence of intraventricular shunt catheters. Accordingly, such an approach may serve to improve the radiological evaluations of the diagnostic work-up and treatment response monitoring in patients with hydrocephalus. Since CT is much more widely available than MRI, our results have considerable clinical impact.<\/jats:p>","DOI":"10.1093\/braincomms\/fcag300","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T11:19:43Z","timestamp":1785755983000},"source":"Crossref","is-referenced-by-count":0,"title":["Assessing CT-based volumetric analysis via deep learning for idiopathic normal pressure hydrocephalus"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5769-1653","authenticated-orcid":false,"given":"Meera","family":"Srikrishna","sequence":"first","affiliation":[{"name":"Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg , Gothenburg 40530 ,","place":["Sweden"]},{"name":"Department of Psychiatry and Neurochemistry, Institute of Physiology and Neuroscience, University of Gothenburg , Gothenburg 40530 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woosung","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Neuroradiology, Uppsala University , Uppsala 75185 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Zettergren","sequence":"additional","affiliation":[{"name":"Neuropsychiatric Epidemiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap), University of Gothenburg , Gothenburg 43141 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Kern","sequence":"additional","affiliation":[{"name":"Neuropsychiatric Epidemiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap), University of Gothenburg , Gothenburg 43141 ,","place":["Sweden"]},{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg , M\u00f6lndal 43141 ,","place":["Sweden"]},{"name":"Region V\u00e4stra G\u00f6taland, Department of Neuropsychiatry, Sahlgrenska University Hospital , Gothenburg 40530 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Cantr\u00e9","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology, Pediatric Radiology and Neuroradiology, University Medical Center Rostock , Rostock 18057 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Gessler","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Medicine of Rostock , Rostock 18057 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houman","family":"Sotoudeh","sequence":"additional","affiliation":[{"name":"Department of Radiology, UT Southwestern , Dallas, TX 5323 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Seidlitz","sequence":"additional","affiliation":[{"name":"Lifespan Brain Institute, The Children\u2019s Hospital of Philadelphia and Penn Medicine , Philadelphia, PA 19104 ,","place":["USA"]},{"name":"Institute for Translational Medicine and Therapeutics, University of Pennsylvania , Philadelphia, PA 19104-5158 ,","place":["USA"]},{"name":"Department of Psychiatry, University of Pennsylvania , Philadelphia 19104 ,","place":["USA"]},{"name":"Department of Child and Adolescent Psychiatry and Behavioral Science, The Children's Hospital of Philadelphia , Philadelphia 19104 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D","family":"Bernstock","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA 02115 ,","place":["USA"]},{"name":"David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology , Cambridge, MA 02139 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars-Olof","family":"Wahlund","sequence":"additional","affiliation":[{"name":"Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet , Stockholm 17177 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3115-2977","authenticated-orcid":false,"given":"Eric","family":"Westman","sequence":"additional","affiliation":[{"name":"Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet , Stockholm 17177 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingmar","family":"Skoog","sequence":"additional","affiliation":[{"name":"Neuropsychiatric Epidemiology, Institute of Neuroscience and Physiology, 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