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The aim of this study was to assess the impact of antenatal maternal anaemia on infant brain structure across the first 2 years of life, using high-field (3\u2005T) and ultra-low-field (64\u2005mT) MRI. This neuroimaging substudy was embedded within Khula, an observational population-based birth cohort in South Africa. Pregnant women were enrolled antenatally and postnatally. Mother-child dyads (n = 394) were followed prospectively with a subsample attending neuroimaging at \u223c3, 6, 12, 18 and 24 months of age. Anaemia was classified using World Health Organization thresholds, and neuroimaging data were processed using MiniMORPH. Linear mixed-effects models were used to investigate associations between antenatal maternal anaemia status and absolute regional infant brain volumes using high-field and ultra-low-field MRI. In repeated measures high-field (n = 195) and ultra-low-field (n = 341) infant neuroimaging subsamples, the prevalence of antenatal maternal anaemia was 28.24% (37\/131) and 29.76% (61\/205), respectively. Maternal anaemia in pregnancy was associated with altered child brain structure across both MRI systems, with group differences becoming detectable at \u223c12 months. In the ultra-low-field subsample, infants born to anaemic mothers had 3.77% smaller intracranial volume (\u03b2 = \u22120.24, P = 0.004) and 3.32% smaller putamen volumes (\u03b2 = \u22120.18, P = 0.040) across the first 2 years of life. The interaction between antenatal maternal anaemia and age was significant for the caudate nucleus (\u03b2 = \u22120.13, P = 0.038) and corpus callosum (\u03b2 = \u22120.15, P = 0.007). Antenatal maternal anaemia was associated with 3.70% and 4.29% smaller caudate nucleus volumes at 18 and 24 months of age, respectively. Similarly, infants born to anaemic mothers had 4.39% smaller corpus callosum volumes by 12 months and 6.27% smaller corpus callosum volumes by 24 months. Postnatal child anaemia and antenatal maternal iron deficiency status were not associated with total or regional child brain volumes in the ultra-low-field subsample from this cohort. Maternal anaemia remained a robust predictor of volume differences in sensitivity analyses. This study is the first to demonstrate that the impact of maternal anaemia in pregnancy on child brain structure is detectable as early as infancy. The implications of this research are 2-fold: (i) informing the feasibility of ultra-low-field MRI in low- and middle-income countries and (ii) the timing and optimization of targeted recommendations for anaemia management in practice and policy.<\/jats:p>","DOI":"10.1093\/braincomms\/fcag318","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T11:43:37Z","timestamp":1787139817000},"source":"Crossref","is-referenced-by-count":1,"title":["Antenatal maternal anaemia and infant brain structure: high-field (3\u2005T) and ultra-low-field (64\u2005mT) MRI findings from South Africa"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6885-8351","authenticated-orcid":false,"given":"Jessica E","family":"Ringshaw","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Child Health, Red Cross War Memorial Children\u2019s Hospital, University of Cape Town , Cape Town, 7700 ,","place":["South Africa"]},{"name":"Neuroscience Institute, University of Cape Town , Cape Town, 7925 ,","place":["South Africa"]},{"name":"Centre for Neuroimaging Sciences, Department of Neuroimaging, King's College London , London, England ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal R","family":"Zieff","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, Red Cross War Memorial Children\u2019s Hospital, University of Cape Town , Cape Town, 7700 ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6478-1430","authenticated-orcid":false,"given":"Niall J","family":"Bourke","sequence":"additional","affiliation":[{"name":"Centre for Neuroimaging Sciences, Department of Neuroimaging, King's College London , London, England ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0292-3330","authenticated-orcid":false,"given":"Chiara","family":"Casella","sequence":"additional","affiliation":[{"name":"Research Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King\u2019s College London , London, England ,","place":["UK"]},{"name":"Department for Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King\u2019s College London , London, England ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5195-9081","authenticated-orcid":false,"given":"Layla E","family":"Bradford","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, Red Cross War Memorial Children\u2019s Hospital, University of Cape Town , Cape Town, 7700 ,","place":["South Africa"]},{"name":"Neuroscience Institute, University of Cape Town , Cape Town, 7925 ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone R","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, Red Cross War Memorial Children\u2019s Hospital, University of Cape Town , Cape Town, 7700 ,","place":["South Africa"]},{"name":"Neuroscience Institute, University of Cape Town , Cape Town, 7925 ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Herr","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, Red Cross War Memorial Children\u2019s Hospital, University of Cape Town , Cape Town, 7700 ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlie","family":"Miles","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, Red Cross War Memorial Children\u2019s 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