{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:09:09Z","timestamp":1790168949153,"version":"4.1.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":258,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004807","name":"DFG","doi-asserted-by":"publisher","award":["CO 799\/9-1"],"award-info":[{"award-number":["CO 799\/9-1"]}],"id":[{"id":"10.13039\/100004807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004807","name":"DFG","doi-asserted-by":"publisher","award":["VE 1274\/1-2"],"award-info":[{"award-number":["VE 1274\/1-2"]}],"id":[{"id":"10.13039\/100004807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Impaired cerebral blood flow contributes to delayed neurological deficits after subarachnoid haemorrhage, but cerebral autoregulation, which regulates cerebral blood flow to the brain in the hyperacute phase is poorly defined. We characterized early pressure- and flow-based reactivity in a rat subarachnoid haemorrhage perforation model. This is a retrospective analysis of older data acquired to investigate a different hypothesis. Male Sprague\u2013Dawley rats underwent endovascular perforation subarachnoid haemorrhage. Arterial blood pressure, intracranial pressure and bilateral laser Doppler flow were continuously recorded. Pressure reactivity (PRx*) and flow reactivity (LDx*) were calculated as 5-min moving Pearson correlations between arterial and intracranial pressure and arterial pressure and laser Doppler flowmetry, respectively. Exposure above impairment thresholds (PRx* &amp;gt; 0.3; LDx* &amp;gt; 0.5) was compared pre-subarachnoid haemorrahge (\u221230\u20130\u2005min) versus post-subarachnoid haemorrhage (15\u201360\u2005min) and related to haemorrhage severity. Group-mean PRx* and LDx* remained below impairment thresholds. Nevertheless, time with PRx* &amp;gt; 0.3 increased after subarachnoid haemorrhage (median 0.0% versus 1.9%, P &amp;lt; 0.001) and correlated with intracranial pressure elevation (r = 0.527, P &amp;lt; 0.001). LDx* showed no significant pre\u2013post change in either hemisphere. PRx* and LDx* correlated weakly (r = 0.089, P &amp;lt; 0.001) with frequent discordance. Cerebral autoregulation is largely preserved within 60\u2005min after subarachnoid haemorrhage, with transient pressure\u2013reactivity impairment in a subset linked to intracranial pressure peaks. Pressure- and flow-based indices provide non-interchangeable information.<\/jats:p>","DOI":"10.1093\/braincomms\/fcag356","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:06:26Z","timestamp":1789473986000},"source":"Crossref","is-referenced-by-count":0,"title":["Cerebral autoregulation in the hyperacute phase after experimental subarachnoid haemorrhage using an endovascular perforation model"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3648-6842","authenticated-orcid":false,"given":"Michael","family":"Veldeman","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Rheinisch-Westf\u00e4lische Technische Hochschule, Aachen University Hospital , 52074 Aachen ,","place":["Germany"]},{"name":"Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge , Hills Rd, Cambridge CB2 0QQ. \u00a0","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erta","family":"Beqiri","sequence":"additional","affiliation":[{"name":"Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge , Hills Rd, Cambridge CB2 0QQ. \u00a0","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Czosnyka","sequence":"additional","affiliation":[{"name":"Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge , Hills Rd, Cambridge CB2 0QQ. \u00a0","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Coburn","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn , 53127 Bonn ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"H\u00f6llig","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Rheinisch-Westf\u00e4lische Technische Hochschule, Aachen University Hospital , 52074 Aachen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Smielewski","sequence":"additional","affiliation":[{"name":"Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge , Hills Rd, Cambridge CB2 0QQ. \u00a0","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"2026092308521734800_fcag356-B1","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1001\/jamaneurol.2019.0006","article-title":"Worldwide incidence of aneurysmal subarachnoid hemorrhage according to region, time period, blood pressure, 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