{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:56:23Z","timestamp":1787698583638,"version":"build-2784847793"},"reference-count":115,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T00:00:00Z","timestamp":1562544000000},"content-version":"vor","delay-in-days":188,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Wellcome Clinical Research Career Development Fellowship","award":["201567\/Z\/16\/Z"],"award-info":[{"award-number":["201567\/Z\/16\/Z"]}]},{"DOI":"10.13039\/100001479","name":"Sidney R. Baer, Jr. Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01MH113929"],"award-info":[{"award-number":["R01MH113929"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007429","name":"Nancy Lurie Marks Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007429","id-type":"DOI","asserted-by":"crossref"}]},{"name":"G. Harold"},{"name":"Leila Y. Mathers Charitable Foundation"},{"name":"Alzheimer\u2019s foundation"},{"DOI":"10.13039\/100006312","name":"Brightfocus foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Dementia is a common and devastating symptom of Parkinson\u2019s disease but the anatomical substrate remains unclear. Some evidence points towards hippocampal involvement but neuroimaging abnormalities have been reported throughout the brain and are largely inconsistent across studies. Here, we test whether these disparate neuroimaging findings for Parkinson\u2019s disease dementia localize to a common brain network. We used a literature search to identify studies reporting neuroimaging correlates of Parkinson\u2019s dementia (11 studies, 385 patients). We restricted our search to studies of brain atrophy and hypometabolism that compared Parkinson\u2019s patients with dementia to those without cognitive involvement. We used a standard coordinate-based activation likelihood estimation meta-analysis to assess for consistency in the neuroimaging findings. We then used a new approach, coordinate-based network mapping, to test whether neuroimaging findings localized to a common brain network. This approach uses resting-state functional connectivity from a large cohort of normative subjects (n\u2009=\u20091000) to identify the network of regions connected to a reported neuroimaging coordinate. Activation likelihood estimation meta-analysis failed to identify any brain regions consistently associated with Parkinson\u2019s dementia, showing major heterogeneity across studies. In contrast, coordinate-based network mapping found that these heterogeneous neuroimaging findings localized to a specific brain network centred on the hippocampus. Next, we tested whether this network showed symptom specificity and stage specificity by performing two further analyses. We tested symptom specificity by examining studies of Parkinson\u2019s hallucinations (9 studies, 402 patients) that are frequently co-morbid with Parkinson\u2019s dementia. We tested for stage specificity by using studies of mild cognitive impairment in Parkinson\u2019s disease (15 studies, 844 patients). Coordinate-based network mapping revealed that correlates of visual hallucinations fell within a network centred on bilateral lateral geniculate nucleus and correlates of mild cognitive impairment in Parkinson\u2019s disease fell within a network centred on posterior default mode network. In both cases, the identified networks were distinct from the hippocampal network of Parkinson\u2019s dementia. Our results link heterogeneous neuroimaging findings in Parkinson\u2019s dementia to a common network centred on the hippocampus. This finding was symptom and stage-specific, with implications for understanding Parkinson\u2019s dementia and heterogeneity of neuroimaging findings in general.<\/jats:p>","DOI":"10.1093\/braincomms\/fcz006","type":"journal-article","created":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T13:35:44Z","timestamp":1562592944000},"source":"Crossref","is-referenced-by-count":77,"title":["Neuroimaging in Parkinson\u2019s disease dementia: connecting the dots"],"prefix":"10.1093","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5092-6325","authenticated-orcid":false,"given":"Rimona S","family":"Weil","sequence":"first","affiliation":[{"name":"Dementia Research Centre, UCL, London"},{"name":"Wellcome Centre for Human Neuroimaging, UCL, London"},{"name":"Berenson-Allen Center, Beth Israel Deaconess Medical Center, Harvard Medical Center, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joey K","family":"Hsu","sequence":"additional","affiliation":[{"name":"Berenson-Allen Center, Beth Israel Deaconess Medical Center, Harvard Medical Center, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan R","family":"Darby","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2902-1983","authenticated-orcid":false,"given":"Louis","family":"Soussand","sequence":"additional","affiliation":[{"name":"Berenson-Allen Center, Beth Israel Deaconess Medical Center, Harvard Medical Center, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D","family":"Fox","sequence":"additional","affiliation":[{"name":"Berenson-Allen Center, Beth Israel Deaconess Medical Center, Harvard Medical Center, Boston, MA, USA"},{"name":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"},{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,7,8]]},"reference":[{"key":"2020081108564488700_fcz006-B1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nrneurol.2017.27","article-title":"Cognitive decline in Parkinson disease","volume":"13","author":"Aarsland","year":"2017","journal-title":"Nat Rev Neurol"},{"key":"2020081108564488700_fcz006-B2","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1002\/ana.20635","article-title":"Neuropathology of dementia in Parkinson's disease: a prospective, community-based study","volume":"58","author":"Aarsland","year":"2005","journal-title":"Ann Neurol"},{"key":"2020081108564488700_fcz006-B3","volume-title":"Diagnosis and statistical manual of mental disorders, DSM 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