{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T19:50:15Z","timestamp":1791661815083,"version":"4.3.4"},"reference-count":79,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T00:00:00Z","timestamp":1576540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-AG058853"],"award-info":[{"award-number":["R01-AG058853"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Alzheimer\u2019s disease is a personally devastating neurodegenerative disorder and a major public health concern. There is an urgent need for medical imaging techniques that better characterize the early stages and monitor the progression of the disease. Magnetic resonance elastography (MRE) is a relatively new and highly sensitive MRI technique that can non-invasively assess tissue microstructural integrity via measurement of brain viscoelastic mechanical properties. For the first time, we use high-resolution MRE methods to conduct a voxel-wise MRE investigation and state-of-the-art post hoc region of interest analysis of the viscoelastic properties of the cerebral cortex in patients with Alzheimer\u2019s disease (N\u2009=\u200911) compared with cognitively healthy older adults (N\u2009=\u200912). We replicated previous findings that have reported significant volume and stiffness reductions at the whole-brain level. Significant reductions in volume were also observed in Alzheimer\u2019s disease when white matter, cortical grey matter and subcortical grey matter compartments were considered separately; lower stiffness was also observed in white matter and cortical grey matter, but not in subcortical grey matter. Voxel-based morphometry of both cortical and subcortical grey matter revealed localized reductions in volume due to Alzheimer\u2019s disease in the hippocampus, fusiform, middle, superior temporal gyri and precuneus. Similarly, voxel-based MRE identified lower stiffness in the middle and superior temporal gyri and precuneus, although the spatial distribution of these effects was not identical to the pattern of volume reduction. Notably, MRE additionally identified stiffness deficits in the operculum and precentral gyrus located within the frontal lobe; regions that did not undergo volume loss identified through voxel-based morphometry. Voxel-based-morphometry and voxel-based MRE results were confirmed by a\u00a0complementary post hoc region-of-interest approach in native space where the viscoelastic changes remained significant even after statistically controlling for regional volumes. The pattern of reduction in cortical stiffness observed in Alzheimer\u2019s disease patients raises the possibility that MRE may provide unique insights regarding the neural mechanisms which underlie the development and progression of the disease. The measured mechanical property changes that we have observed warrant further exploration to investigate the diagnostic usefulness of MRE in cases of Alzheimer\u2019s disease and other dementias.<\/jats:p>","DOI":"10.1093\/braincomms\/fcz049","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T13:47:25Z","timestamp":1576590445000},"source":"Crossref","is-referenced-by-count":98,"title":["Mechanical property alterations across the cerebral cortex due to Alzheimer\u2019s disease"],"prefix":"10.1093","volume":"2","author":[{"given":"Lucy V","family":"Hiscox","sequence":"first","affiliation":[{"name":"Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh EH8 9JZ, UK"},{"name":"Department of Biomedical Engineering, University of Delaware, Newark, DE 19713, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curtis L","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Delaware, Newark, DE 19713, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D J","family":"McGarry","sequence":"additional","affiliation":[{"name":"Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Marshall","sequence":"additional","affiliation":[{"name":"Edinburgh Imaging Facility, School of Clinical Sciences, The Queen\u2019s Medical Research Institute (QMRI), University of Edinburgh, Edinburgh EH16 4TJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig W","family":"Ritchie","sequence":"additional","affiliation":[{"name":"Centre for Dementia Prevention at Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4UX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2777-5071","authenticated-orcid":false,"given":"Edwin J R","family":"van Beek","sequence":"additional","affiliation":[{"name":"Edinburgh Imaging Facility, School of Clinical Sciences, The Queen\u2019s Medical Research Institute (QMRI), University of Edinburgh, Edinburgh EH16 4TJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Roberts","sequence":"additional","affiliation":[{"name":"Edinburgh Imaging Facility, School of Clinical Sciences, The Queen\u2019s Medical Research Institute (QMRI), University of Edinburgh, Edinburgh EH16 4TJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M","family":"Starr","sequence":"additional","affiliation":[{"name":"Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh EH8 9JZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,12,17]]},"reference":[{"key":"2020081109064468700_fcz049-B21621026","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1017\/S0140525X99002034","article-title":"Episodic memory, amnesia, and the hippocampal\u2013anterior thalamic axis","volume":"22","author":"Aggleton","year":"1999","journal-title":"Behav Brain Sci"},{"key":"2020081109064468700_fcz049-B1","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/j.neurobiolaging.2011.06.007","article-title":"Resting state fMRI in Alzheimer\u2019s disease: beyond the default mode network","volume":"33","author":"Agosta","year":"2012","journal-title":"Neurobiol Aging"},{"key":"2020081109064468700_fcz049-B2","first-page":"367","year":"2018"},{"key":"2020081109064468700_fcz049-B3","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.jmbbm.2016.03.005","article-title":"Observation of direction-dependent mechanical properties in the human brain with multi-excitation MR elastography","volume":"59","author":"Anderson","year":"2016","journal-title":"J Mech Behav Biomed Mater"},{"key":"2020081109064468700_fcz049-B4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.neuroimage.2015.02.016","article-title":"Measuring the effects of aging and sex on regional brain stiffness with MR elastography in healthy older adults","volume":"111","author":"Arani","year":"2015","journal-title":"Neuroimage"},{"key":"2020081109064468700_fcz049-B5","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neuroimage.2007.07.007","article-title":"A fast diffeomorphic image registration algorithm","volume":"38","author":"Ashburner","year":"2007","journal-title":"Neuroimage"},{"key":"2020081109064468700_fcz049-B6","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.3389\/fneur.2018.01010","article-title":"Magnetic resonance elastography of rodent brain","volume":"9","author":"Bigot","year":"2018","journal-title":"Front Neurol"},{"key":"2020081109064468700_fcz049-B9467273","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1111\/ejn.13567","article-title":"Bilateral rolandic operculum processing underlying heartbeat awareness reflects changes in bodily self-consciousness","volume":"45","author":"Blefari","year":"2017","journal-title":"Eur J Neurosci"},{"key":"2020081109064468700_fcz049-B7","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol"},{"key":"2020081109064468700_fcz049-B8","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nature20412","article-title":"The road to restoring neural circuits for the treatment of Alzheimer\u2019s disease","volume":"539","author":"Canter","year":"2016","journal-title":"Nature"},{"key":"2020081109064468700_fcz049-B10","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","article-title":"An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest","volume":"31","author":"Desikan","year":"2006","journal-title":"Neuroimage"},{"key":"2020081109064468700_fcz049-B4649420","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev.neuro.30.051606.094328","article-title":"The medial temporal lobe and recognition memory","volume":"30","author":"Eichenbaum","year":"2007","journal-title":"Annu Rev Neurosci"},{"key":"2020081109064468700_fcz049-B11","doi-asserted-by":"crossref","first-page":"403","DOI":"10.2214\/AJR.16.17455","article-title":"MR elastography demonstrates unique regional brain stiffness patterns in dementias","volume":"209","author":"ElSheikh","year":"2017","journal-title":"AJR Am J Roentgenol"},{"key":"2020081109064468700_fcz049-B12"},{"key":"2020081109064468700_fcz049-B13","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0896-6273(02)00569-X","article-title":"Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain","volume":"33","author":"Fischl","year":"2002","journal-title":"Neuron"},{"key":"2020081109064468700_fcz049-B14","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1002\/nbm.2987","article-title":"MR elastography in a murine stroke model reveals correlation of macroscopic viscoelastic properties of the brain with neuronal density","volume":"26","author":"Freimann","year":"2013","journal-title":"NMR Biomed"},{"key":"2020081109064468700_fcz049-B15","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nrneurol.2009.215","article-title":"The clinical use of structural MRI in Alzheimer disease","volume":"6","author":"Frisoni","year":"2010","journal-title":"Nat Rev Neurol"},{"key":"2020081109064468700_fcz049-B17","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.nicl.2017.12.023","article-title":"Combining viscoelasticity, diffusivity and volume of the hippocampus for the diagnosis of Alzheimer\u2019s disease based on magnetic resonance imaging","volume":"18","author":"Gerischer","year":"2018","journal-title":"NeuroImage Clin"},{"key":"2020081109064468700_fcz049-B18","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1212\/WNL.0000000000004733","article-title":"Increased florbetapir binding in the temporal neocortex from age 20 to 60 years","volume":"89","author":"Gonneaud","year":"2017","journal-title":"Neurology"},{"key":"2020081109064468700_fcz049-B19","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/S1474-4422(17)30343-5","article-title":"Pathology and hippocampal atrophy in Alzheimer\u2019s disease","volume":"16","author":"Halliday","year":"2017","journal-title":"Lancet Neurol"},{"key":"2020081109064468700_fcz049-B20","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.1566067","article-title":"Alzheimer\u2019s disease: the amyloid cascade hypothesis","volume":"256","author":"Hardy","year":"1992","journal-title":"Science"},{"key":"2020081109064468700_fcz049-B22","doi-asserted-by":"crossref","first-page":"R401","DOI":"10.1088\/0031-9155\/61\/24\/R401","article-title":"Magnetic resonance elastography (MRE) of the human brain: technique, findings and clinical applications","volume":"61","author":"Hiscox","year":"2016","journal-title":"Phys Med Biol"},{"key":"2020081109064468700_fcz049-B23","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.neurobiolaging.2018.01.010","article-title":"High-resolution magnetic resonance elastography reveals differences in subcortical gray matter viscoelasticity between young and healthy older adults","volume":"65","author":"Hiscox","year":"2018","journal-title":"Neurobiol Aging"},{"key":"2020081109064468700_fcz049-B24","article-title":"Hippocampal viscoelasticity and episodic memory performance in healthy older adults examined with magnetic resonance elastography","author":"Hiscox","year":"2018","journal-title":"Brain Imaging Behav"},{"key":"2020081109064468700_fcz049-B1431826","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA research framework: toward a biological definition of Alzheimer's disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimer's and Dementia"},{"key":"2020081109064468700_fcz049-B8748533","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/brain\/awm336","article-title":"11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment","volume":"131","author":"Jack","year":"2008","journal-title":"Brain"},{"key":"2020081109064468700_fcz049-B25","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.jalz.2011.04.007","article-title":"Steps to standardization and validation of hippocampal volumetry as a biomarker in clinical trials and diagnostic criterion for Alzheimer\u2019s disease","volume":"7","author":"Jack","year":"2011","journal-title":"Alzheimers Dement"},{"key":"2020081109064468700_fcz049-B26","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1093\/brain\/awv283","article-title":"Different definitions of neurodegeneration produce similar amyloid\/neurodegeneration biomarker group findings","volume":"138","author":"Jack","year":"2015","journal-title":"Brain"},{"key":"2020081109064468700_fcz049-B29","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S1474-4422(09)70299-6","article-title":"Hypothetical model of dynamic biomarkers of the Alzheimer\u2019s pathological cascade","volume":"9","author":"Jack","year":"2010","journal-title":"Lancet Neurol"},{"key":"2020081109064468700_fcz049-B30","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.neuroimage.2011.09.015","article-title":"FSL","volume":"62","author":"Jenkinson","year":"2012","journal-title":"NeuroImage"},{"key":"2020081109064468700_fcz049-B9467873","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.mri.2011.12.014","article-title":"A preliminary study of functional abnormalities in aMCI subjects during different episodic memory tasks","volume":"30","author":"Jin","year":"2012","journal-title":"Magn Reson Imaging"},{"key":"2020081109064468700_fcz049-B31","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/mrm.25065","article-title":"3D multislab, multishot acquisition for fast, whole-brain MR elastography with high signal-to- noise efficiency","volume":"71","author":"Johnson","year":"2014","journal-title":"Magn Reson Med"},{"key":"2020081109064468700_fcz049-B32","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.neuroimage.2018.01.007","article-title":"Double dissociation of structure-function relationships in memory and fluid intelligence observed with magnetic resonance elastography","volume":"171","author":"Johnson","year":"2018","journal-title":"Neuroimage"},{"key":"2020081109064468700_fcz049-B33","doi-asserted-by":"crossref","first-page":"4221","DOI":"10.1002\/hbm.23314","article-title":"Viscoelasticity of subcortical gray matter structures","volume":"12","author":"Johnson","year":"2016","journal-title":"Hum Brain Mapp"},{"key":"2020081109064468700_fcz049-B34","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s00234-007-0269-2","article-title":"Precuneus atrophy in early-onset Alzheimer\u2019s disease: a morphometric structural MRI study","volume":"49","author":"Karas","year":"2007","journal-title":"Neuroradiology"},{"key":"2020081109064468700_fcz049-B98611731","article-title":"Estimated intracranial volume from FreeSurfer is biased by total brain volume. Eur Radiol Exp","author":"Klasson"},{"key":"2020081109064468700_fcz049-B36","doi-asserted-by":"crossref","first-page":"e92582","DOI":"10.1371\/journal.pone.0092582","article-title":"Enhanced adult neurogenesis increases brain stiffness: in vivo magnetic resonance elastography in a mouse model of dopamine depletion","volume":"9","author":"Klein","year":"2014","journal-title":"PLoS One"},{"key":"2020081109064468700_fcz049-B37","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/brain\/awt162","article-title":"The role of the posterior cingulate cortex in cognition and disease","volume":"137","author":"Leech","year":"2014","journal-title":"Brain"},{"key":"2020081109064468700_fcz049-B38","doi-asserted-by":"crossref","first-page":"17759","DOI":"10.1073\/pnas.0606150103","article-title":"Viscoelastic properties of individual glial cells and neurons in the CNS","volume":"103","author":"Lu","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020081109064468700_fcz049-B39","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/S1053-8119(03)00169-1","article-title":"An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets","volume":"19","author":"Maldjian","year":"2003","journal-title":"Neuroimage"},{"key":"2020081109064468700_fcz049-B40","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/ca.21006","article-title":"Magnetic resonance elastography: a review","volume":"23","author":"Mariappan","year":"2010","journal-title":"Clin Anat"},{"key":"2020081109064468700_fcz049-B41","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1109\/TMI.2013.2268978","article-title":"Including spatial information in nonlinear inversion MR elastography using soft prior regularization","volume":"32","author":"McGarry","year":"2013","journal-title":"IEEE Trans Med Imaging"},{"key":"2020081109064468700_fcz049-B42","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/s11517-008-0356-5","article-title":"Use of a Rayleigh damping model in elastography","volume":"46","author":"McGarry","year":"2008","journal-title":"Med Biol Eng Comput"},{"key":"2020081109064468700_fcz049-B43","doi-asserted-by":"crossref","first-page":"6388","DOI":"10.1118\/1.4754649","article-title":"Multiresolution MR elastography using nonlinear inversion","volume":"39","author":"McGarry","year":"2012","journal-title":"Med Phys"},{"key":"2020081109064468700_fcz049-B44","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1088\/0031-9155\/56\/13\/N02","article-title":"An octahedral shear strain-based measure of SNR for 3D MR elastography","volume":"56","author":"McGarry","year":"2011","journal-title":"Phys Med Biol"},{"key":"2020081109064468700_fcz049-B45","doi-asserted-by":"crossref","first-page":"7499","DOI":"10.1038\/s41598-019-42632-w","article-title":"Combining hippocampal volume metrics to better understand Alzheimer\u2019s disease progression in at-risk individuals","volume":"9","author":"McRae-McKee","year":"2019","journal-title":"Sci Rep"},{"key":"2020081109064468700_fcz049-B46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fneur.2018.00001","article-title":"Alzheimer\u2019s disease mutant mice exhibit reduced brain tissue stiffness compared to wild-type mice in both normoxia and following intermittent hypoxia mimicking sleep apnea","volume":"9","author":"Menal","year":"2018","journal-title":"Front Neurol"},{"key":"2020081109064468700_fcz049-B47","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3233\/JAD-142292","article-title":"Mapping the progression of atrophy in early- and late-onset Alzheimer\u2019s disease","volume":"46","author":"Migliaccio","year":"2015","journal-title":"JAD"},{"key":"2020081109064468700_fcz049-B48","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/jmri.25741","article-title":"MR elastography detection of early viscoelastic response of the murine hippocampus to amyloid beta accumulation and neuronal cell loss due to Alzheimer\u2019s disease","volume":"47","author":"Munder","year":"2018","journal-title":"J Magn Reson Imaging"},{"key":"2020081109064468700_fcz049-B49","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.mri.2011.12.019","article-title":"Magnetic resonance elastography of the brain in a mouse model of Alzheimer\u2019s disease: initial results","volume":"30","author":"Murphy","year":"2012","journal-title":"J Mag Reson Imaging"},{"key":"2020081109064468700_fcz049-B50","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.neuroimage.2017.10.008","article-title":"MR elastography of the brain and its application in neurological diseases","volume":"187","author":"Murphy","year":"2019","journal-title":"NeuroImage"},{"key":"2020081109064468700_fcz049-B51","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1002\/jmri.22707","article-title":"Decreased brain stiffness in Alzheimer\u2019s disease determined by magnetic resonance elastography","volume":"34","author":"Murphy","year":"2011","journal-title":"J Magn Reson Imaging"},{"key":"2020081109064468700_fcz049-B52","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.nicl.2015.12.007","article-title":"Regional brain stiffness changes across the Alzheimer\u2019s disease spectrum","volume":"10","author":"Murphy","year":"2016","journal-title":"Neuroimage Clin"},{"key":"2020081109064468700_fcz049-B53","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1126\/science.7569924","article-title":"Magnetic resonance elastography by direct visualization of propagating acoustic strain waves","volume":"169","author":"Muthupillai","year":"1995","journal-title":"Science"},{"key":"2020081109064468700_fcz049-B7171122","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40478-018-0515-3","article-title":"White matter changes in Alzheimer's disease: a focus on myelin and oligodendrocytes","volume":"6","author":"Nasrabady","year":"2018","journal-title":"Acta Neuropathol Commun"},{"key":"2020081109064468700_fcz049-B54","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"2020081109064468700_fcz049-B55","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/j.neuroimage.2011.12.086","article-title":"Adjusting for global effects in voxel-based morphometry: gray matter decline in normal aging","volume":"60","author":"Peelle","year":"2012","journal-title":"NeuroImage"},{"key":"2020081109064468700_fcz049-B57","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1093\/cercor\/bhi044","article-title":"Regional brain changes in aging healthy adults: general trends, individual differences and modifiers","volume":"15","author":"Raz","year":"2005","journal-title":"Cereb Cortex"},{"key":"2020081109064468700_fcz049-B59","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.nicl.2012.09.003","article-title":"Magnetic resonance elastography reveals altered brain viscoelasticity in experimental autoimmune encephalomyelitis","volume":"1","author":"Riek","year":"2012","journal-title":"Neuroimage Clin"},{"key":"2020081109064468700_fcz049-B1692571","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1055\/s-0033-1359312","article-title":"Neuroimaging biomarkers of neurodegenerative diseases and dementia","volume":"33","author":"Risacher","year":"2013","journal-title":"Semin Neurol"},{"key":"2020081109064468700_fcz049-B60","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.trci.2015.06.004","article-title":"Is late-onset Alzheimer\u2019s disease really a disease of midlife?","volume":"1","author":"Ritchie","year":"2015","journal-title":"Alzheimers Dement"},{"key":"2020081109064468700_fcz049-B61","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.neuroscience.2015.01.007","article-title":"Astrocytes in physiological aging and Alzheimer\u2019s disease","volume":"323","author":"Rodriguez-Arellano","year":"2016","journal-title":"Neuroscience"},{"key":"2020081109064468700_fcz049-B63","doi-asserted-by":"crossref","first-page":"5672","DOI":"10.1039\/c3sm50552a","article-title":"Structure-sensitive elastography: on the viscoelastic powerlaw behavior of in vivo human tissue in health and disease","volume":"9","author":"Sack","year":"2013","journal-title":"Soft Matter"},{"key":"2020081109064468700_fcz049-B228242787","doi-asserted-by":"crossref","first-page":"3774","DOI":"10.1016\/j.neuroimage.2011.11.032","article-title":"An automated tool for detection of FLAIR-hyperintense white-matter lesions in Multiple Sclerosis","volume":"59","author":"Schmidt","year":"2012","journal-title":"NeuroImage"},{"key":"2020081109064468700_fcz049-B64","doi-asserted-by":"crossref","first-page":"6650","DOI":"10.1073\/pnas.1200151109","article-title":"Demyelination reduces brain parenchymal stiffness quantified in vivo by magnetic resonance elastography","volume":"109","author":"Schregel","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020081109064468700_fcz049-B65","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1093\/brain\/awp007","article-title":"MRI of hippocampal volume loss in early Alzheimer\u2019s disease in relation to ApoE genotype and biomarkers","volume":"132","author":"Schuff","year":"2009","journal-title":"Brain"},{"key":"2020081109064468700_fcz049-B66","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.neuroimage.2017.03.061","article-title":"Aerobic fitness, hippocampal viscoelasticity, and relational memory performance","volume":"153","author":"Schwarb","year":"2017","journal-title":"NeuroImage"},{"key":"2020081109064468700_fcz049-B67","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1162\/jocn_a_01454","article-title":"Structural and functional MRI evidence for distinct medial temporal and prefrontal roles in context-dependent relational memory","volume":"31","author":"Schwarb","year":"2019","journal-title":"J Cogn Neurosci"},{"key":"2020081109064468700_fcz049-B68","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.neuroimage.2016.02.059","article-title":"Medial temporal lobe viscoelasticity and relational memory performance","volume":"132","author":"Schwarb","year":"2016","journal-title":"NeuroImage"},{"key":"2020081109064468700_fcz049-B69","doi-asserted-by":"crossref","first-page":"145021","DOI":"10.1088\/1361-6560\/aacb08","article-title":"Phantom evaluations of nonlinear inversion MR elastography","volume":"63","author":"Solamen","year":"2018","journal-title":"Phys Med Biol"},{"key":"2020081109064468700_fcz049-B72368281","doi-asserted-by":"crossref","first-page":"3240","DOI":"10.1523\/JNEUROSCI.2092-14.2015","article-title":"Brain amyloid-\u00a0 burden is associated with disruption of intrinsic functional connectivity within the medial temporal lobe in cognitively normal elderly","volume":"35","author":"Song","year":"2015","journal-title":"J Neurosci"},{"key":"2020081109064468700_fcz049-B70","doi-asserted-by":"crossref","first-page":"S225","DOI":"10.1016\/j.jalz.2011.05.632","article-title":"Cortical atrophy rates in Alzheimer\u2019s disease and mild cognitive impairment from the ADNI study","volume":"7","author":"Spenger","year":"2011","journal-title":"Alzheimers Dement"},{"key":"2020081109064468700_fcz049-B73","doi-asserted-by":"crossref","first-page":"20160002","DOI":"10.1098\/rstb.2016.0002","article-title":"Interoception beyond homeostasis: affect, cognition and mental health","volume":"371","author":"Tsakiris","year":"2016","journal-title":"Phil Trans R Soc B"},{"key":"2020081109064468700_fcz049-B74","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1006\/nimg.2001.0978","article-title":"Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain","volume":"15","author":"Tzourio-Mazoyer","year":"2002","journal-title":"Neuroimage"},{"key":"2020081109064468700_fcz049-B75","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1523\/JNEUROSCI.4227-13.2014","article-title":"Precuneus is a functional core of the default-mode network","volume":"34","author":"Utevsky","year":"2014","journal-title":"J Neurosci"},{"key":"2020081109064468700_fcz049-B76","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/(SICI)1522-2594(199910)42:4<779::AID-MRM21>3.0.CO;2-Z","article-title":"An overlapping subzone technique for MR-based elastic property reconstruction","volume":"42","author":"Van Houten","year":"1999","journal-title":"Magn Reson Med"},{"key":"2020081109064468700_fcz049-B77","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jmbbm.2017.04.017","article-title":"The mechanical importance of myelination in the central nervous system","volume":"76","author":"Weickenmeier","year":"2017","journal-title":"J Mech Behav Biomed Mater"},{"key":"2020081109064468700_fcz049-B78","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.actbio.2016.07.040","article-title":"Brain stiffness increases with myelin content","volume":"42","author":"Weickenmeier","year":"2016","journal-title":"Acta Biomater"},{"key":"2020081109064468700_fcz049-B0949579","article-title":"Detection of subjects and brain regions related to Alzheimer's disease using 3DMRI scans based on eigenbrain and machine learning","author":"Zhang","journal-title":"Front Comput Neurosci 2015"}],"container-title":["Brain Communications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/braincomms\/advance-article-pdf\/doi\/10.1093\/braincomms\/fcz049\/31554493\/fcz049.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/braincomms\/article-pdf\/2\/1\/fcz049\/33639894\/fcz049.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/braincomms\/article-pdf\/2\/1\/fcz049\/33639894\/fcz049.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T18:44:17Z","timestamp":1613155457000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/braincomms\/article\/doi\/10.1093\/braincomms\/fcz049\/5679770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,17]]},"references-count":79,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/braincomms\/fcz049","relation":{},"ISSN":["2632-1297"],"issn-type":[{"value":"2632-1297","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020]]},"published":{"date-parts":[[2019,12,17]]},"article-number":"fcz049"}}