{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T18:10:40Z","timestamp":1770919840252,"version":"3.50.1"},"reference-count":35,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T00:00:00Z","timestamp":1592784000000},"content-version":"vor","delay-in-days":173,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Patients with burns present with different clinical features depending on the types of burn injury and burn patients with lower levels of vitamin D have worse prognoses and more complications. The study aims to investigate the association between vitamin D levels and burn factors according to each burn type in relation to early intensive rehabilitation therapy initiated for inpatients with burns.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this retrospective study, we enrolled 757 of 1716 inpatients who underwent rehabilitative therapy between May 2013 and April 2017. Burn types were divided into flame burn, electrical burn and other burns, including scalding, contact and chemical burns. Age, burned body surface area (BSA), wound healing time (WHT), length of hospital stay (LOS) and body mass index were analysed between vitamin D deficient and non-deficient patient groups using Student\u2019s t-tests, or Mann-Whitney U test and among three burn types using one-way analysis of variance (ANOVA) or Kruskal-Wallis one-way ANOVA. The relationship between vitamin D levels and burn factors was evaluated using Pearson's or Spearman's correlation coefficient tests, and multiple linear regression analysis in different burn groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In total, 88.9% patients were vitamin D deficient, and these patients had a larger burned BSA (p\u2009=\u20090.015) and longer WHT and LOS (all p\u2009&amp;lt;\u20090.001) than non-deficient patients. Burned BSA, WHT and vitamin D levels showed significant differences in their mean values according to three burn types (all p\u2009&amp;lt;\u20090.001). WHT was a communal factor significantly associated with vitamin D levels in all three burn types (p\u2009&amp;lt;\u20090.05). The WHT cut-off points to predict vitamin D deficiency were 55\u00a0days for flame burn (p\u2009&amp;lt;\u20090.001) and 62.5\u00a0days for electrical burn (p\u2009=\u20090.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>WHT across all three burn types was a common factor associated with vitamin D levels for inpatients with burns who had undergone rehabilitative therapy. Electrical burn patients with vitamin D deficiency, even those with a low burned BSA percentage, showed prolonged wound healing over a two-month post-burn period. Independent of burned BSA, nutritional intervention concerning vitamin D in relation to burn wound healing should be considered to guide early initiation of intensive rehabilitation therapy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/burnst\/tkaa018","type":"journal-article","created":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T11:11:28Z","timestamp":1586344288000},"source":"Crossref","is-referenced-by-count":13,"title":["The association between vitamin D levels and burn factors in different burn types"],"prefix":"10.1093","volume":"8","author":[{"given":"Yoon Soo","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, Burn Center, Hangang Sacred Heart Hospital, 94-200 Yeongdeungpo-dong, Yeongdeungpo-gu, Seoul 07247, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4091-6382","authenticated-orcid":false,"given":"Cheong Hoon","family":"Seo","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, Burn Center, Hangang Sacred Heart Hospital, 94-200 Yeongdeungpo-dong, Yeongdeungpo-gu, Seoul 07247, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So Young","family":"Joo","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, Burn Center, Hangang Sacred Heart Hospital, 94-200 Yeongdeungpo-dong, Yeongdeungpo-gu, Seoul 07247, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9959-3285","authenticated-orcid":false,"given":"Suk Hoon","family":"Ohn","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Hallym University Sacred Heart Hospital, 22 Gwanpyeong-ro 170 Beon-gil Dongan-gu Anyang Gyeonggi-do 14068, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,6,19]]},"reference":[{"key":"2020062120233072500_ref1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0140-6736(03)15388-3","article-title":"Synthesis of vitamin D in skin after burns","volume":"363","author":"Klein","year":"2004","journal-title":"Lancet."},{"key":"2020062120233072500_ref2","first-page":"346","article-title":"Vitamin D depletion following burn injury in children: a possible factor in post-burn osteopenia","volume":"52","author":"Klein","year":"2002","journal-title":"J Trauma."},{"key":"2020062120233072500_ref3","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1111\/j.0022-202X.2004.22424.x","article-title":"25 Hydroxyvitamin D 1 alpha-hydroxylase is required for optimal epidermal differentiation and permeability barrier homeostasis","volume":"122","author":"Bikle","year":"2004","journal-title":"J Invest Dermatol."},{"key":"2020062120233072500_ref4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.18388\/abp.2015_1104","article-title":"Vitamin D in the skin physiology and pathology","volume":"63","author":"Piotrowska","year":"2016","journal-title":"Acta Biochim Pol."},{"key":"2020062120233072500_ref5","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/j.burns.2016.03.009","article-title":"Synergistic effect of vitamin D and low concentration of transforming growth factor beta 1, a potential role in dermal wound healing","volume":"42","author":"Ding","year":"2016","journal-title":"Burns."},{"key":"2020062120233072500_ref6","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.coph.2010.04.001","article-title":"Vitamin D: modulator of the immune system","volume":"10","author":"Baeke","year":"2010","journal-title":"Curr Opin Pharmacol."},{"key":"2020062120233072500_ref7","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1093\/jbcr\/irz028","article-title":"The association between postburn vitamin D deficiency and the biomechanical properties of hypertrophic scars","volume":"40","author":"Cho","year":"2019","journal-title":"J Burn Care Res."},{"key":"2020062120233072500_ref8","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/j.burns.2019.04.019","article-title":"Crosstalk among adipose tissue, vitamin D level, and biomechanical properties of hypertrophic burn scars","volume":"45","author":"Cho","year":"2019","journal-title":"Burns."},{"key":"2020062120233072500_ref9","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.burns.2018.04.015","article-title":"Vitamin D in burn-injured patients","volume":"45","author":"Rech","year":"2019","journal-title":"Burns."},{"key":"2020062120233072500_ref10","doi-asserted-by":"publisher","DOI":"10.1186\/s41038-018-0113-4","article-title":"Vitamin D status and its influence on outcomes following major burn injury and critical illness","volume":"6","author":"Al-Tarrah","year":"2018","journal-title":"Burns Trauma."},{"key":"2020062120233072500_ref11","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1097\/00003246-200211001-00007","article-title":"Electrical injuries","volume":"30","author":"Koumbourlis","year":"2002","journal-title":"Crit Care Med."},{"key":"2020062120233072500_ref12","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.burns.2015.09.009","article-title":"Autonomic dysfunction and osteoporosis after electrical 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Dermatol."},{"key":"2020062120233072500_ref35","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.jdiacomp.2016.06.017","article-title":"The effects of vitamin D supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: a randomized, double-blind, placebo-controlled trial","volume":"31","author":"Razzaghi","year":"2017","journal-title":"J Diabetes Complicat."}],"container-title":["Burns &amp; Trauma"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/burnstrauma\/article-pdf\/doi\/10.1093\/burnst\/tkaa018\/33407493\/tkaa018.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/burnstrauma\/article-pdf\/doi\/10.1093\/burnst\/tkaa018\/33407493\/tkaa018.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T00:23:49Z","timestamp":1592785429000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/burnstrauma\/article\/doi\/10.1093\/burnst\/tkaa018\/5859894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,1]]},"references-count":35,"URL":"https:\/\/doi.org\/10.1093\/burnst\/tkaa018","relation":{},"ISSN":["2321-3876"],"issn-type":[{"value":"2321-3876","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020]]},"published":{"date-parts":[[2020,1,1]]},"article-number":"tkaa018"}}