{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T12:08:14Z","timestamp":1791720494466,"version":"4.3.4"},"reference-count":77,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T00:00:00Z","timestamp":1592870400000},"content-version":"vor","delay-in-days":174,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program","doi-asserted-by":"publisher","award":["2016YFC1000805"],"award-info":[{"award-number":["2016YFC1000805"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University Innovation Team Building Program of Chongqing","award":["CXTDG201602020"],"award-info":[{"award-number":["CXTDG201602020"]}]},{"name":"Intramural research project grants","award":["AWS17J007"],"award-info":[{"award-number":["AWS17J007"]}]},{"name":"Intramural research project grants","award":["2018-JCJQ-ZQ-001"],"award-info":[{"award-number":["2018-JCJQ-ZQ-001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic wounds include, but are not limited to, radiation ulcers, pressure ulcers, vascular ulcers and diabetic foot ulcers. These chronic wounds can persist for years without healing and severe ulcers may lead to amputation. Unfortunately, the underlying pathologies of refractory chronic wounds are not fully characterized, and new treatments are urgently needed. Recently, increasing evidence has indicated that cell senescence plays an important role in the development of chronic wounds, and preventing cell senescence or removing senescent cells holds promise as a new therapeutic strategy. In this review, we aim to probe these latest findings to promote the understanding of cellular senescence in the pathological process and potential management of chronic wounds.<\/jats:p>","DOI":"10.1093\/burnst\/tkaa021","type":"journal-article","created":{"date-parts":[[2020,6,13]],"date-time":"2020-06-13T07:09:32Z","timestamp":1592032172000},"source":"Crossref","is-referenced-by-count":65,"title":["Cellular senescence is a promising target for chronic wounds: a comprehensive review"],"prefix":"10.1093","volume":"8","author":[{"given":"Ziwen","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Rocket Force Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University (Army Medical University), No. 30 Gaotanyan Street, Chongqing, 400038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8264-738X","authenticated-orcid":false,"given":"Chunmeng","family":"Shi","sequence":"first","affiliation":[{"name":"Institute of Rocket Force Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University (Army Medical University), No. 30 Gaotanyan Street, Chongqing, 400038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,6,23]]},"reference":[{"key":"2020062308233543100_ref1","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.ejvs.2013.02.014","article-title":"Evidence-based management of PAD & the diabetic foot","volume":"45","author":"Brownrigg","year":"2013","journal-title":"Eur J Vasc Endovasc Surg."},{"key":"2020062308233543100_ref2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/dth.12051","article-title":"Evidence-based management of common chronic lower extremity ulcers","volume":"26","author":"Richmond","year":"2013","journal-title":"Dermatol Ther."},{"key":"2020062308233543100_ref3","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1089\/wound.2015.0635","article-title":"Challenges in the treatment of chronic wounds","volume":"4","author":"Frykberg","year":"2015","journal-title":"Adv Wound Care (New Rochelle)."},{"key":"2020062308233543100_ref4","doi-asserted-by":"crossref","first-page":"651","DOI":"10.2337\/dc13-2176","article-title":"Burden of diabetic foot ulcers for medicare and private insurers","volume":"37","author":"Rice","year":"2014","journal-title":"Diabetes Care."},{"key":"2020062308233543100_ref5","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1089\/wound.2015.0663","article-title":"Regenerative medicine: charting a new course in wound healing","volume":"5","author":"Gurtner","year":"2016","journal-title":"Adv Wound Care (New Rochelle)."},{"key":"2020062308233543100_ref6","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s12325-017-0478-y","article-title":"Chronic wound healing: a review of current management and treatments","author":"Han","year":"2017","journal-title":"Adv Ther."},{"key":"2020062308233543100_ref7","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1001\/jama.2018.12426","article-title":"Management of Chronic Wounds-2018","volume":"320","author":"Jones","year":"2018","journal-title":"JAMA."},{"key":"2020062308233543100_ref8","doi-asserted-by":"crossref","first-page":"34","DOI":"10.7547\/87507315-92-1-34","article-title":"Cellular senescence and matrix metalloproteinase activity in chronic wounds. 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