{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:16:12Z","timestamp":1787008572065,"version":"build-2736575974"},"reference-count":117,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T00:00:00Z","timestamp":1637884800000},"content-version":"vor","delay-in-days":329,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University","award":["ZYJC18002"],"award-info":[{"award-number":["ZYJC18002"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31771065"],"award-info":[{"award-number":["31771065"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>As an emerging type of adult stem cell featuring non-invasive acquisition, urine-derived stem cells (USCs) have shown great potential for applications in tissue engineering and regenerative medicine. With a growing amount of research on the topic, the effectiveness of USCs in various disease models has been shown and the underlying mechanisms have also been explored, though many aspects still remain unclear. In this review, we aim to provide an up-to-date overview of the biological characteristics of USCs and their applications in skin, bone and articular cartilage repair. In addition to the identification procedure of USCs, we also summarize current knowledge of the underlying repair mechanisms and application modes of USCs. Potential concerns and perspectives have also been summarized.<\/jats:p>","DOI":"10.1093\/burnst\/tkab039","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T11:33:22Z","timestamp":1633001602000},"source":"Crossref","is-referenced-by-count":32,"title":["Urine-derived stem cells: applications in skin, bone and articular cartilage repair"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6919-8508","authenticated-orcid":false,"given":"Wenqian","family":"Zhang","sequence":"first","affiliation":[{"name":"Laboratory of Stem Cell and Tissue Engineering, Orthopedic Research Institute, Med-X Center for Materials, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jungen","family":"Hu","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cell and Tissue Engineering, Orthopedic Research Institute, Med-X Center for Materials, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhou","family":"Huang","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cell and Tissue Engineering, Orthopedic Research Institute, Med-X Center for Materials, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyu","family":"Wu","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cell and Tissue Engineering, Orthopedic Research Institute, Med-X Center for Materials, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqi","family":"Xie","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cell and Tissue Engineering, Orthopedic Research Institute, Med-X Center for Materials, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,11,26]]},"reference":[{"key":"2022010308342963900_ref1","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1136\/injuryprev-2014-041336","article-title":"RESTORE: REcovery after serious trauma - outcomes, resource use and patient experiences study protocol","volume":"21","author":"Gabbe","year":"2015","journal-title":"Inj Prev"},{"key":"2022010308342963900_ref2","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.burns.2011.06.005","article-title":"Epidemiology of burns throughout the world. 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Focus on \u201cthe proliferation capacity of the renal proximal tubule involves the bulk of differentiated epithelial cells\u201d","volume":"294","author":"Witzgall","year":"2008","journal-title":"Am J Physiol Cell Physiol"},{"key":"2022010308342963900_ref10","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1056\/NEJMe020084","article-title":"Nephrogenic adenomas as renal tubular outposts","volume":"347","author":"Ingelfinger","year":"2002","journal-title":"N Engl J Med"},{"key":"2022010308342963900_ref11","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1007\/s002040000173","article-title":"Cultures of exfoliated epithelial cells from different locations of the human urinary tract and the renal tubular system","volume":"74","author":"D\u00f6rrenhaus","year":"2000","journal-title":"Arch Toxicol"},{"key":"2022010308342963900_ref12","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1016\/j.juro.2008.07.023","article-title":"Urine derived cells are a potential 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