{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T08:44:32Z","timestamp":1783586672607,"version":"3.55.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T00:00:00Z","timestamp":1656028800000},"content-version":"vor","delay-in-days":174,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172222"],"award-info":[{"award-number":["82172222"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102328"],"award-info":[{"award-number":["82102328"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","award":["20152227"],"award-info":[{"award-number":["20152227"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Jiao Tong University School of Medicine","award":["2017\u20131-007"],"award-info":[{"award-number":["2017\u20131-007"]}]},{"name":"Cross Research Project of Ninth People\u2019s Hospital"},{"name":"Shanghai Jiao Tong University School of Medicine","award":["JYJC202009"],"award-info":[{"award-number":["JYJC202009"]}]},{"name":"Shanghai Health Industry Clinical Research Special Project","award":["20204Y0443"],"award-info":[{"award-number":["20204Y0443"]}]},{"name":"Shanghai Municipal Key Clinical Specialty","award":["shslczdzk00901"],"award-info":[{"award-number":["shslczdzk00901"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Hypertrophic scars (HS) represent one of the most common clinical challenges due to unsatisfactory therapeutic results. HS formation is associated with the abnormal activation of fibroblasts and their excessive fibrotic behavior. Glycolysis dysregulation has been shown to participate in the incidence and progression of various fibrotic diseases and shows potential as a means of controlling HS formation. This work aimed to discuss the impact of augmented glycolysis on HS and to propose a method for controlling HS formation through glycolysis regulation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Here, augmented glycolysis was confirmed together with enhanced fibrotic activity in both HS fibroblasts (HFs) and HS tissues, and the suppression of glycolysis also attenuated fibroblast activation. We also introduced IR780, a heptamethine cyanine dye, to regulate glycolysis for the control of HS formation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In vitro, cell studies indicated that IR780 significantly down-regulated glycolysis and suppressed the fibrotic activity of HFs. In vivo, the intralesional injection of IR780 into rabbit HS models led to the downregulation of glycolysis and the control of HS formation. Furthermore, IR780 accumulated preferentially in activated fibroblasts in both in vitro and in vivo studies, and thus specifically downregulated glycolysis and efficiently controlled fibrosis by targeting activated fibroblasts.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This work identified a strategy for controlling fibrosis and HS formation from the perspective of glycolysis regulation with IR780 targeting of activated fibroblasts.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/burnst\/tkac015","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T12:21:49Z","timestamp":1646828509000},"source":"Crossref","is-referenced-by-count":16,"title":["Control of fibrosis and hypertrophic scar formation via glycolysis regulation with IR780"],"prefix":"10.1093","volume":"10","author":[{"given":"Xinxian","family":"Meng","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery , Shanghai Ninth People's Hospital, , Shanghai Jiao Tong University, 639 Zhizaoju Rd, Shanghai 200011 , China"},{"name":"School of Medicine , Shanghai Ninth People's Hospital, , Shanghai Jiao Tong University, 639 Zhizaoju Rd, Shanghai 200011 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixi","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery , Shanghai Ninth People's Hospital, , Shanghai Jiao Tong University, 639 Zhizaoju Rd, Shanghai 200011 , China"},{"name":"School of Medicine , Shanghai Ninth People's Hospital, , Shanghai Jiao Tong University, 639 Zhizaoju Rd, Shanghai 200011 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanyu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery , Shanghai Ninth People's Hospital, , Shanghai Jiao Tong University, 639 Zhizaoju Rd, Shanghai 200011 , China"},{"name":"School of Medicine , Shanghai Ninth People's Hospital, , Shanghai Jiao Tong University, 639 Zhizaoju Rd, Shanghai 200011 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2260-4000","authenticated-orcid":false,"given":"Jun","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery , Shanghai Ninth People's Hospital, , Shanghai Jiao Tong University, 639 Zhizaoju Rd, Shanghai 200011 , China"},{"name":"School of Medicine , Shanghai Ninth People's Hospital, , Shanghai Jiao Tong University, 639 Zhizaoju Rd, Shanghai 200011 , China"},{"name":"Department of Plastic and Reconstructive Surgery, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal hospital, Gusu school, Nanjing Medical University , Suzhou 215008, Jiangsu , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstruction, First Affiliated Hospital of Naval Medical University , Shanghai 200433 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiru","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery , Shanghai Ninth People's Hospital, , Shanghai Jiao Tong University, 639 Zhizaoju Rd, Shanghai 200011 , China"},{"name":"School of Medicine , Shanghai Ninth People's Hospital, , Shanghai Jiao Tong University, 639 Zhizaoju Rd, Shanghai 200011 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunsheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery , Shanghai Ninth People's Hospital, , Shanghai Jiao Tong University, 639 Zhizaoju Rd, Shanghai 200011 , China"},{"name":"School of Medicine , Shanghai Ninth People's Hospital, , Shanghai Jiao Tong University, 639 Zhizaoju Rd, Shanghai 200011 , China"},{"name":"Department of Burns and Plastic Surgery , Shanghai Institute of Burns Research, , Shanghai 200025 , China"},{"name":"Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai Institute of Burns Research, , Shanghai 200025 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery , Shanghai Ninth People's Hospital, , Shanghai Jiao Tong University, 639 Zhizaoju Rd, Shanghai 200011 , China"},{"name":"School of Medicine , Shanghai Ninth People's Hospital, , Shanghai Jiao Tong University, 639 Zhizaoju Rd, Shanghai 200011 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1961-7070","authenticated-orcid":false,"given":"Zheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery , Shanghai Ninth People's Hospital, , Shanghai Jiao Tong University, 639 Zhizaoju Rd, Shanghai 200011 , China"},{"name":"School of Medicine , Shanghai Ninth People's Hospital, , Shanghai Jiao Tong University, 639 Zhizaoju Rd, Shanghai 200011 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,6,24]]},"reference":[{"key":"2022062409361593500_ref1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1046\/j.1524-4725.1999.98257.x","article-title":"Keloids and hypertrophic 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