{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T03:44:40Z","timestamp":1793418280920,"version":"4.5.0"},"reference-count":218,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:00:00Z","timestamp":1700179200000},"content-version":"vor","delay-in-days":320,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic wounds are wounds that cannot heal properly due to various factors, such as underlying diseases, infection or reinjury, and improper healing of skin wounds and ulcers can cause a serious economic burden. Numerous studies have shown that extracellular vesicles (EVs) derived from stem\/progenitor cells promote wound healing, reduce scar formation and have significant advantages over traditional treatment methods. EVs are membranous particles that carry various bioactive molecules from their cellular origins, such as cytokines, nucleic acids, enzymes, lipids and proteins. EVs can mediate cell-to-cell communication and modulate various physiological processes, such as cell differentiation, angiogenesis, immune response and tissue remodelling. In this review, we summarize the recent advances in EV-based wound healing, focusing on the signalling pathways that are regulated by EVs and their cargos. We discuss how EVs derived from different types of stem\/progenitor cells can promote wound healing and reduce scar formation by modulating the Wnt\/\u03b2-catenin, phosphoinositide 3-kinase\/protein kinase B\/mammalian target of rapamycin, vascular endothelial growth factor, transforming growth factor \u03b2 and JAK\u2013STAT pathways. Moreover, we also highlight the challenges and opportunities for engineering or modifying EVs to enhance their efficacy and specificity for wound healing.<\/jats:p>","DOI":"10.1093\/burnst\/tkad039","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T13:24:00Z","timestamp":1700227440000},"source":"Crossref","is-referenced-by-count":55,"title":["Extracellular vesicles modulate key signalling pathways in refractory wound healing"],"prefix":"10.1093","volume":"11","author":[{"given":"Bowen","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases , National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, , No. 14, Section 3, Renmin South Road, Wuhou District, Chengdu 610041 , China"},{"name":"Sichuan University , National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, , No. 14, Section 3, Renmin South Road, Wuhou District, Chengdu 610041 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumeng","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases , National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, , No. 14, Section 3, Renmin South Road, Wuhou District, Chengdu 610041 , China"},{"name":"Sichuan University , National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, , No. 14, Section 3, Renmin South Road, Wuhou District, Chengdu 610041 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibo","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases , National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, , No. 14, Section 3, Renmin South Road, Wuhou District, Chengdu 610041 , China"},{"name":"Sichuan University , National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, , No. 14, Section 3, Renmin South Road, Wuhou District, Chengdu 610041 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanxi","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases , National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, , No. 14, Section 3, Renmin South Road, Wuhou District, Chengdu 610041 , China"},{"name":"Sichuan University , National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, , No. 14, Section 3, Renmin South Road, Wuhou District, Chengdu 610041 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9727-7959","authenticated-orcid":false,"given":"Ying-Qiang","family":"Shen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases , National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, , No. 14, Section 3, Renmin South Road, Wuhou District, Chengdu 610041 , China"},{"name":"Sichuan University , National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, , No. 14, Section 3, Renmin South Road, Wuhou District, Chengdu 610041 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,11,16]]},"reference":[{"key":"2023111706535512700_ref1","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1152\/physrev.00067.2017","article-title":"Wound healing: a cellular perspective","volume":"99","author":"Rodrigues","year":"2019","journal-title":"Physiol Rev"},{"key":"2023111706535512700_ref2","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1182\/blood-2016-08-734053","article-title":"Abnormal joint and bone wound healing in hemophilia mice is improved by extending factor IX activity after 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