{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:05:08Z","timestamp":1792015508663,"version":"4.4.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"vor","delay-in-days":135,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172706"],"award-info":[{"award-number":["82172706"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["22S21902700"],"award-info":[{"award-number":["22S21902700"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["23S21900800"],"award-info":[{"award-number":["23S21900800"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["202240370"],"award-info":[{"award-number":["202240370"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic skin wounds are a leading cause of hospital admissions and reduced life expectancy among older people and individuals with diabetes. Delayed wound healing is often attributed to a series of cellular abnormalities. Matrine, a well-studied component found in Sophora flavescens, is recognized for its anti-inflammatory effects. However, its impact on wound healing still remains uncertain. This study aims to explore the potential of matrine in promoting wound healing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, we utilized gradient extrusion to produce fibroblast-derived exosome-mimetic vesicles as carriers for matrine (MHEM). MHEM were characterized using transmission electron microscopy and dynamic light scattering analysis. The therapeutic effect of MHEM in wound healing was explored in vitro and in vivo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both matrine and MHEM enhanced the cellular activity as well as the migration of fibroblasts and keratinocytes. The potent anti-inflammatory effect of matrine diluted the inflammatory response in the vicinity of wounds. Furthermore, MHEM worked together to promote angiogenesis and the expression of transforming growth factor \u03b2 and collagen I. MHEM contained growth factors of fibroblasts that regulated the functions of fibroblasts, keratinocytes and monocytes, which synergistically promoted wound healing with the anti-inflammatory effect of matrine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MHEM showed enhanced therapeutic efficacy in the inflammatory microenvironment, for new tissue formation and angiogenesis of wound healing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/burnst\/tkae015","type":"journal-article","created":{"date-parts":[[2024,3,17]],"date-time":"2024-03-17T11:23:53Z","timestamp":1710674633000},"source":"Crossref","is-referenced-by-count":19,"title":["Exosome-mimetic vesicles derived from fibroblasts carrying matrine for wound healing"],"prefix":"10.1093","volume":"12","author":[{"given":"Xinyue","family":"Zhang","sequence":"first","affiliation":[{"name":"Shanghai Skin Disease Hospital, School of Medicine, Tongji University , 1278 Baode Road, Shanghai 200443 , China"},{"name":"Shanghai Engineering Research Center for Topical Chinese Medicine , 1278 Baode Road, Shanghai 200443 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahua","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology , Shanghai Public Health Clinical Center, , 2901 Caolang Road, Shanghai 201500 , China"},{"name":"Fudan University , Shanghai Public Health Clinical Center, , 2901 Caolang Road, Shanghai 201500 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Central Hospital of Wuhan , Tongji Medical College, , 26 Shengli Street, Wuhan 430014, Hubei , China"},{"name":"Huazhong University of Science and Technology , Tongji Medical College, , 26 Shengli Street, Wuhan 430014, Hubei , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisha","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Skin Disease Hospital, School of Medicine, Tongji University , 1278 Baode Road, Shanghai 200443 , China"},{"name":"Shanghai Engineering Research Center for Topical Chinese Medicine , 1278 Baode Road, Shanghai 200443 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengze","family":"Miao","sequence":"additional","affiliation":[{"name":"Shanghai Skin Disease Hospital, School of Medicine, Tongji University , 1278 Baode Road, Shanghai 200443 , China"},{"name":"Shanghai Engineering Research Center for Topical Chinese Medicine , 1278 Baode Road, Shanghai 200443 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingrui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Skin Disease Hospital, School of Medicine, Tongji University , 1278 Baode Road, Shanghai 200443 , 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5603-745X","authenticated-orcid":false,"given":"Zongguang","family":"Tai","sequence":"additional","affiliation":[{"name":"Shanghai Skin Disease Hospital, School of Medicine, Tongji University , 1278 Baode Road, Shanghai 200443 , China"},{"name":"Shanghai Engineering Research Center for Topical Chinese Medicine , 1278 Baode Road, Shanghai 200443 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quangang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Shanghai Skin Disease Hospital, School of Medicine, Tongji University , 1278 Baode Road, Shanghai 200443 , China"},{"name":"Shanghai Engineering Research Center for Topical Chinese Medicine , 1278 Baode Road, Shanghai 200443 , 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