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The skin, the largest organ, depends on a complex system of nerves to manage responses to injury. Recent research has emphasized the crucial role of neuroregulation in maximizing wound healing outcomes. Recently, researchers have also explained the interactive contact between the peripheral nervous system and skin cells during the different phases of wound healing. Neurotransmitters and neuropeptides, once observed as simple signalling molecules, have since been recognized as effective regulators of inflammation, angiogenesis, and cell proliferation. The significance of skin innervation and neuromodulators is underscored by the delayed wound healing observed in patients with diabetes and the regenerative capabilities of foetal skin. Foetal skin regeneration is influenced by the neuroregulatory environment, immature immune system, abundant growth factors, and increased pluripotency of cells. Foetal skin cells exhibit greater flexibility and specialized cell types, and the extracellular matrix composition promotes regeneration. The extracellular matrix composition of foetal skin promotes regeneration, making it more capable than adult skin because neuroregulatory signals affect skin regeneration. The understanding of these systems can facilitate the development of therapeutic strategies to alter the nerve supply to the skin to enhance the process of wound healing. Neuroregulation is being explored as a potential therapeutic strategy for enhancing skin wound repair. Bioelectronic strategies and neuromodulation techniques can manipulate neural signalling, optimize the neuroimmune axis, and modulate inflammation. This review describes the function of skin innervation in wound healing, emphasizing the importance of neuropeptides released by sensory and autonomic nerve fibres. This article discusses significant discoveries related to neuroregulation and its impact on skin wound healing.<\/jats:p>","DOI":"10.1093\/burnst\/tkae072","type":"journal-article","created":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T16:20:59Z","timestamp":1730478059000},"source":"Crossref","is-referenced-by-count":26,"title":["Recent advances in the role of neuroregulation in skin wound healing"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9936-3925","authenticated-orcid":false,"given":"Abdullah","family":"Al Mamun","sequence":"first","affiliation":[{"name":"Central Laboratory of The Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital , Lishui, Zhejiang 323000 ,","place":["China"]},{"name":"Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine , Vision and Brain Health), School of Pharmaceutical Sciences, , Wenzhou, Zhejiang 325035 ,","place":["China"]},{"name":"Wenzhou Medical University , Vision and Brain Health), School of Pharmaceutical Sciences, , Wenzhou, Zhejiang 325035 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuxiao","family":"Shao","sequence":"additional","affiliation":[{"name":"Central Laboratory of The Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital , Lishui, Zhejiang 323000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9714-7660","authenticated-orcid":false,"given":"Peiwu","family":"Geng","sequence":"additional","affiliation":[{"name":"Central Laboratory of The Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital , Lishui, Zhejiang 323000 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325035 ,","place":["China"]},{"name":"Wenzhou Medical University , Vision and Brain Health), School of Pharmaceutical Sciences, , Wenzhou, Zhejiang 325035 ,","place":["China"]},{"name":"Department of Wound Healing, The First Affiliated Hospital of Wenzhou Medical University , Wenzhou, Zhejiang 325000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"key":"2025073002473784800_ref1","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1111\/j.1524-475X.2009.00543.x","article-title":"Human skin wounds: a major and snowballing threat to public health and the economy","volume":"17","author":"Sen","year":"2009","journal-title":"Wound Repair Regen"},{"key":"2025073002473784800_ref2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/B978-0-323-65381-7.00001-0","volume-title":"Plastic Surgery-Principles and 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