{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T08:22:57Z","timestamp":1788596577591,"version":"build-2803163510"},"reference-count":237,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"vor","delay-in-days":23,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sichuan Science and Technology Program","award":["2024NSFSC0002"],"award-info":[{"award-number":["2024NSFSC0002"]}]},{"name":"Sichuan Science and Technology Program","award":["2023YFS0063"],"award-info":[{"award-number":["2023YFS0063"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202705"],"award-info":[{"award-number":["82202705"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Frontiers Medical Center, Tianfu Jincheng Laboratory Foundation","award":["TFJC2023010002"],"award-info":[{"award-number":["TFJC2023010002"]}]},{"name":"Project for Disciplines of Excellence, West China Hospital, Sichuan University","award":["ZYGD23037"],"award-info":[{"award-number":["ZYGD23037"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Bacterial infections pose a serious threat to human health. While antibiotics have been effective in treating bacterial infectious diseases, antibiotic resistance significantly reduces their effectiveness. Therefore, it is crucial to develop new and effective antimicrobial strategies. Metal\u2013organic frameworks (MOFs) have become ideal nanomaterials for various antimicrobial applications due to their crystalline porous structure, tunable size, good mechanical stability, large surface area, and chemical stability. Importantly, the performance of MOFs can be adjusted by changing the synthesis steps and conditions. Pure MOFs can release metal ions to modulate cellular behaviors and kill various microorganisms. Additionally, MOFs can act as carriers for delivering antimicrobial agents in a desired manner. Importantly, the performance of MOFs can be adjusted by changing the synthesis steps and conditions. Furthermore, certain types of MOFs can be combined with traditional photothermal or other physical stimuli to achieve broad-spectrum antimicrobial activity. Recently an increasing number of researchers have conducted many studies on applying various MOFs for diseases caused by bacterial infections. Based on this, we perform this study to report the current status of MOF-based antimicrobial strategy. In addition, we also discussed some challenges that MOFs currently face in biomedical applications, such as biocompatibility and controlled release capabilities. Although these challenges currently limit their widespread use, we believe that with further research and development, new MOFs with higher biocompatibility and targeting capabilities can provide diversified treatment strategies for various diseases caused by bacterial infections.<\/jats:p>","DOI":"10.1093\/burnst\/tkaf008","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T15:18:01Z","timestamp":1737559081000},"source":"Crossref","is-referenced-by-count":34,"title":["Multifunctional metal\u2013organic frameworks as promising nanomaterials for antimicrobial strategies"],"prefix":"10.1093","volume":"13","author":[{"given":"Qian-Jin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University , Chengdu 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