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Considering the interactions among the brain, liver, and gut, the brain\u2013liver\u2013gut axis has been proposed and gradually recognized. In this article, we summarized the complex network of interactions within the brain\u2013liver\u2013gut axis, encompassing the vagus nerve, barrier permeability, immunity and inflammation, the blood\u2013brain barrier, gut microbial metabolites, the gut barrier, neurotoxic metabolites, and beta-amyloid (A\u03b2) metabolism. We also elaborated on the impact of the brain\u2013liver\u2013gut axis on various neurological disorders. Furthermore, we outline several therapies aimed at modulating the brain\u2013liver\u2013gut axis, including antibiotics, probiotics and prebiotics, fecal microbiota transplantation (FMT), vagus nerve stimulation (VNS), and dietary interventions. The focus is on elucidating possible mechanisms underlying neurological disorders pathogenesis and identifying effective treatments that are based on our understanding of the brain\u2013liver\u2013gut axis.<\/jats:p>","DOI":"10.1093\/burnst\/tkaf011","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T23:30:06Z","timestamp":1738971006000},"source":"Crossref","is-referenced-by-count":15,"title":["The role of brain\u2013liver\u2013gut Axis in neurological disorders"],"prefix":"10.1093","volume":"13","author":[{"given":"Li","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, the First Affiliated Hospital of Anhui Medical University , No. 218 Jixi Road, Hefei, Anhui 230022 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizheng","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, the First Affiliated Hospital of Anhui Medical University , No. 218 Jixi Road, Hefei, Anhui 230022 ,","place":["China"]},{"name":"Innovation and Entrepreneurship Laboratory for College Students, Anhui Medical University , No. 81 Meishan Road, Hefei, Anhui 230022 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenpei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, the First Affiliated Hospital of Anhui Medical University , No. 218 Jixi Road, Hefei, Anhui 230022 ,","place":["China"]},{"name":"Innovation and Entrepreneurship Laboratory for College Students, Anhui Medical University , No. 81 Meishan Road, Hefei, Anhui 230022 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, the First Affiliated Hospital of Anhui Medical University , No. 218 Jixi Road, Hefei, Anhui 230022 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbao","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, the First Affiliated Hospital of Anhui Medical University , No. 218 Jixi Road, Hefei, Anhui 230022 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, the First Affiliated Hospital of Anhui Medical University , No. 218 Jixi Road, Hefei, Anhui 230022 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, the First Affiliated Hospital of Anhui Medical University , No. 218 Jixi Road, Hefei, Anhui 230022 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Emergency, the First Affiliated Hospital of Anhui Medical University , No. 218 Jixi Road, Hefei, Anhui 230022 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1897-2751","authenticated-orcid":false,"given":"Xiang","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, the First Affiliated Hospital of Anhui Medical University , No. 218 Jixi Road, Hefei, Anhui 230022 ,","place":["China"]},{"name":"Innovation and Entrepreneurship Laboratory for College Students, Anhui Medical University , No. 81 Meishan Road, Hefei, Anhui 230022 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