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Poor blood circulation and neuropathy impair the body\u2019s ability to heal wounds effectively, creating a conducive environment for ulcers. Excessive reactive oxygen species contribute to ulcer development by damaging cellular structures and hindering wound healing. The administration of antioxidants can protect cells from oxidative damage and promote wound recovery. Antioxidants such as epidermal growth factors, flavonoid hesperidin, alpha-lipoic acid, and N-acetylcysteine effectively reduce oxidative stress. Encapsulating various drugs into nanoparticles and targeting carriers such as hydrogels, metal\u2013organic frameworks, and nanohydrogels can improve their therapeutic effects. Nanotechnologies have been shown to boost tissue regeneration by modifying biomaterial properties, modulating signal release, and targeting key factors. Here, we describe the occurrence and development of diabetic foot ulcers (DFUs), emphasizing the role of oxidative damage in these processes. This review summarizes the strategy for targeting oxidative damage in DFUs using nanotechnology-loaded antioxidant drugs. This review advocates for the use of personalized biomaterials in treating DFUs and provides a theoretical basis for their potential clinical and translational applications.<\/jats:p>","DOI":"10.1093\/burnst\/tkaf020","type":"journal-article","created":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T23:18:10Z","timestamp":1741475890000},"source":"Crossref","is-referenced-by-count":32,"title":["Targeting oxidative damage in diabetic foot ulcers: integrative strategies involving antioxidant drugs and nanotechnologies"],"prefix":"10.1093","volume":"13","author":[{"given":"Runze","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pathology and Pathophysiology, School of Basic Medicine, Kunming Medical University , No. 1168, Chunrong West Road, Yuhua Street, Chenggong District, Kunming 650500 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and West China School of Basic Medical Sciences and Forensic Medicine, Sichuan Universi,ty, and Collaborative Innovation Center for Biotherapy , No. 17 People\u2019s South Road, Chengdu 610041 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengchao","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University , No. 1, Jianshe East Road, Erqi District, Zhengzhou 450052 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huili","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital of Sichuan University , No. 20 People\u2019s South Road, Chengdu 610041 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Jin","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Life Sciences, Yunnan University , East Outer Ring South Road, Chenggong District, Kunming, Yunnan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1015-150X","authenticated-orcid":false,"given":"Yingying","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Pathology and Pathophysiology, School of Basic Medicine, Kunming Medical University , No. 1168, Chunrong West Road, Yuhua Street, Chenggong District, Kunming 650500 ,","place":["China"]},{"name":"Frontiers Medical Center, Tianfu Jincheng Laboratory , Intersection of Hexiang 1st Street and Xinchuan Road, Shuangliu District, Chengdu 610095 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