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Existing clinical interventions, which mainly comprise debridement, decompression, and wound dressings, have limited efficacy. In addition, DW pathogenesis is complex, with diabetic peripheral neuropathy, diabetic peripheral arterial disease, and diabetic foot infections further complicating wound management. Owing to their unique versatility, tunability, and hydrophilicity, hydrogels show promise in several biomedical applications, including DW management. They can effectively promote DW healing by loading therapeutic substances for on-demand release. Given the distinct physiological milieu of DWs, hydrogels with tailored attributes can be engineered to enable on-demand drug release, optimize the wound microenvironment, and cater to the diverse stages of wound healing. Based on the clinical status and pathophysiological features of DWs, this review explores hydrogel wound dressings with the following effects: hypoglycemic, nerve regeneration, vascular regeneration, anti-infective, and bone repair. Additionally, the strategy for applying hydrogels to DWs has been comprehensively studied to provide a robust theoretical foundation for DW treatment and pave the way for clinical translation.<\/jats:p>","DOI":"10.1093\/burnst\/tkaf025","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T18:40:18Z","timestamp":1744051218000},"source":"Crossref","is-referenced-by-count":44,"title":["Innovations in hydrogel therapies for diabetic wound healing: bridging the gap between pathophysiology and clinical application"],"prefix":"10.1093","volume":"13","author":[{"given":"Yao","family":"Wang","sequence":"first","affiliation":[{"name":"Clinical Medical College and Affiliated Hospital of Chengdu University, Chengdu University , No. 82, North 2nd Section, 2nd Ring Road, Sichuan, Chengdu 610081 ,","place":["China"]},{"name":"College of Pharmacy of Chengdu University, Chengdu University , No. 2025 Chengluo Avenue, Sichuan, Chengdu 610106 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