{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:40:08Z","timestamp":1792190408600,"version":"4.4.0"},"reference-count":73,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"vor","delay-in-days":99,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Talent Programme of Chongqing","award":["cstc2024ycjh-bgzxm0055"],"award-info":[{"award-number":["cstc2024ycjh-bgzxm0055"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Programmed cell death, which occurs via modes such as apoptosis, necroptosis, and pyroptosis, is an important mechanism for host defence against pathogens and inflammation-mediated immune responses. Recently, interactions between various types of cell death have gradually been discovered. PANoptosis is a newly discovered mode of programmed cell death that involves apoptosis, necroptosis, and pyroptosis and is closely related to many diseases. Ischaemia\u2013reperfusion injury (IRI) is common in patients with blood circulation disorders such as those related to burns, traumatic shock, surgery, organ transplantation, and thrombus. However, the literature on the role of PANoptosis in IRI is limited. Herein, we systematically described the emergence of PANoptosis as a cell death mode, clinical evidence of its occurrence, the molecular mechanisms of PANoptosis, and its role in IRI. This study is expected to provide novel approaches for the prevention and treatment of tissue and organ IRI after severe burns.<\/jats:p>","DOI":"10.1093\/burnst\/tkaf026","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T11:15:54Z","timestamp":1744110954000},"source":"Crossref","is-referenced-by-count":8,"title":["PANoptosis: a new insight into the mechanism of ischaemia\u2013reperfusion injury"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5157-239X","authenticated-orcid":false,"given":"Huapei","family":"Song","sequence":"first","affiliation":[{"name":"Institute of Burn Research, The First Affiliated Hospital of Army Medical University (The Third Military Medical University), State Key Laboratory of Trauma and Chemical Poisoning , Gaotanyan Street, Shapingba Disdrict, Chongqing 400038 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangping","family":"Liang","sequence":"additional","affiliation":[{"name":"Institute of Burn Research, The First Affiliated Hospital of Army Medical University (The Third Military Medical University), State Key Laboratory of Trauma and Chemical Poisoning , Gaotanyan Street, Shapingba Disdrict, Chongqing 400038 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengjun","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Burn Research, The First Affiliated Hospital of Army Medical University (The Third Military Medical University), State Key Laboratory of Trauma and Chemical Poisoning , Gaotanyan Street, Shapingba Disdrict, Chongqing 400038 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,4,10]]},"reference":[{"key":"2025073002473048400_ref1","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1038\/s41580-020-0270-8","article-title":"Emerging connectivity of programmed cell death pathways and its physiological implications","volume":"21","author":"Bedoui","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2025073002473048400_ref2","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1038\/s41423-020-00630-3","article-title":"Necroptosis, pyroptosis and apoptosis: an intricate game of cell death","volume":"18","author":"Bertheloot","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"2025073002473048400_ref3","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aag2045","article-title":"ZBP1\/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death 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