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Severe burns trigger rapid changes in patients\u2019 conditions, leading to ischemia\u2013reperfusion injury from early fluid resuscitation, neuroendocrine stress, and fluid imbalances, which exacerbate oxidative damage and organ dysfunction. This review highlights the critical role of oxidative stress in post-burn wound healing, its potential to cause cellular and tissue damage, and oxidative stress mechanisms. Antioxidant therapy is recommended as a cost-effective method of modulating inflammation and burn outcome. Preparative measures of successful antioxidant therapy should be developed in improving burn patients\u2019 wound healing.<\/jats:p>","DOI":"10.1093\/burnst\/tkaf040","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T07:35:20Z","timestamp":1749540920000},"source":"Crossref","is-referenced-by-count":33,"title":["Role of oxidative stress in post-burn wound healing"],"prefix":"10.1093","volume":"13","author":[{"given":"Ruiqi","family":"Chen","sequence":"first","affiliation":[{"name":"The Affiliated Guangdong Second Provincial General Hospital of Jinan University , No. 466, Middle Xingang Road, Haizhu District, Guangzhou, Guangdong 510317 ,","place":["China"]},{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment, The Biomedical Translational Research Institute, Health Science Center (School of Medicine), Jinan University , No. 601 Huangpu Avenue West, Tianhe District, Guangzhou, Guangdong 510632 ,","place":["China"]},{"name":"School of Traditional Chinese Medicine, Guangdong Pharmaceutical University , No. 280, Outer Ring East Road, Guangzhou University City, Guangzhou, Guangdong 510006 ,","place":["China"]},{"name":"Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction , The Fifth Affiliated Hospital of Jinan University Heyuan 517000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbiao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Thyroid and Breast Surgery, The First Affiliated Hospital, Sun Yat-sen University , No. 58 Zhongshan 2nd Road, Guangzhou, Guangdong 510275 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueshi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, The First Affiliated Hospital, Jinan University , 613 Huangpu Avenue West, Tianhe District, Guangzhou, Guangdong 510632 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