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In addition to their role in energy metabolism, mitochondria are integral to cellular homeostasis and regulate cell cycle progression, differentiation, and apoptosis pathways. In recent years, the importance of mitochondrial function in skin health and disease has garnered increasing attention. Mitochondrial dysfunction has been implicated in a spectrum of skin disorders, including skin aging, psoriasis, vitiligo, keloids, scleroderma, and skin cancer. The pathogenesis of these conditions is closely linked to mitochondrial deoxyribonucleic acid (mtDNA) damage, excessive reactive oxygen species (ROS) production, and alterations in mitochondrial metabolic pathways. In terms of therapeutic strategies, this review summarizes a range of mitochondrion-targeted interventions. These treatments include the activation of the PGC-1\u03b1 pathway to increase mitochondrial adenosine triphosphate synthesis, the use of antioxidants to mitigate mitochondrial ROS production, and the application of bioactive compounds and drugs to protect mitochondria or promote mtDNA repair. These approaches not only contribute to improved skin health but also provide novel insights for the treatment of skin diseases. Additionally, mitochondrial transplantation technology has shown considerable promise in skin regeneration and wound healing and is emerging as a new frontier for skin tissue repair.<\/jats:p>","DOI":"10.1093\/burnst\/tkag008","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T12:23:13Z","timestamp":1768220593000},"source":"Crossref","is-referenced-by-count":6,"title":["Mitochondrial dynamics in skin health and disease: energy, aging, and therapeutic perspectives"],"prefix":"10.1093","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6997-7060","authenticated-orcid":false,"given":"Rong","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Plastic and Aesthetic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , No. 41, Dashucang Hutong, Xicheng District, Beijing 100032 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Beijing 100032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiuzuo","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Plastic and Aesthetic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , No. 41, Dashucang Hutong, Xicheng District, Beijing 100032 ,","place":["China"]},{"name":"Center for Regenerative Medicine and Plastic Surgery Research, Peking Union Medical College Hospital , No. 41, Dashucang Hutong, Xicheng District, Beijing 100032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanze","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Plastic and Aesthetic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , No. 41, Dashucang Hutong, Xicheng District, Beijing 100032 ,","place":["China"]},{"name":"Center for Regenerative Medicine and Plastic Surgery Research, Peking Union Medical College Hospital , No. 41, Dashucang Hutong, Xicheng District, Beijing 100032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0136-2508","authenticated-orcid":false,"given":"Xiao","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Plastic and Aesthetic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , No. 41, Dashucang Hutong, Xicheng District, Beijing 100032 ,","place":["China"]},{"name":"Center for Regenerative Medicine and Plastic Surgery Research, Peking Union Medical College Hospital , No. 41, Dashucang Hutong, Xicheng District, Beijing 100032 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