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This review systematically summarizes the functional properties of piezoelectric electrospun biomaterials and their biological mechanisms in promoting wound healing via electrical stimulation (ES). Piezoelectric nanofiber wound dressings fabricated by electrospinning technology offer dual advantages: on one hand, their unique fibrous architecture enables adaptation to irregular wound contours, facilitates rapid hemostasis, and provides an effective barrier against microbial invasion; on the other hand, their inherent piezoelectric effect converts micromechanical deformations into localized electrical signals in real time, thereby modulating cellular behaviors and accelerating tissue repair. This review highlights recent studies elucidating the mechanisms by which ES promotes wound healing, and the functional characteristics of piezoelectric fibrous dressings. It aims to establish a theoretical foundation for the rational design and performance optimization of next-generation intelligent piezoelectric wound dressings, thereby advancing their clinical translation and industrial development.<\/jats:p>","DOI":"10.1093\/burnst\/tkag032","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T11:26:00Z","timestamp":1776770760000},"source":"Crossref","is-referenced-by-count":0,"title":["Application of electrospun piezoelectric nanofibers in wound healing"],"prefix":"10.1093","volume":"14","author":[{"given":"Jing","family":"Wang","sequence":"first","affiliation":[{"name":"Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou 310003, Zhejiang ,","place":["People\u2019s Republic China"]},{"name":"The First Affiliated Hospital, Heilongjiang University of Chinese Medicine , No. 26 Heping Road, Xiangfang District, Harbin 150040, 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310003, Zhejiang ,","place":["People\u2019s Republic China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjun","family":"Jia","sequence":"additional","affiliation":[{"name":"General Education Department, Qilu Medical University , Zibo 255300, Shandong ,","place":["People\u2019s Republic China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianming","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Robotics and Intelligent Systems, Shenyang Institute of Automation, Chinese Academy of Sciences , Shenyang, 110016, Liaoning ,","place":["People\u2019s Republic China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seeram","family":"Ramakrishna","sequence":"additional","affiliation":[{"name":"College of Design and Engineering, National University of Singapore , Singapore 117575 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