{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:00:32Z","timestamp":1790427632932,"version":"4.1.0"},"reference-count":82,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"vor","delay-in-days":233,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Jiangxi Province Key Laboratory of Precision Cell Therapy","award":["2024SSY06241"],"award-info":[{"award-number":["2024SSY06241"]}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20242BAB26140"],"award-info":[{"award-number":["20242BAB26140"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82460448"],"award-info":[{"award-number":["82460448"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Autologous fat grafting is widely used in reconstructive and esthetic surgery, but its clinical outcomes are limited by early ischemia\u2013hypoxia, oxidative stress, delayed vascularization, and subsequent lipid accumulation-induced inflammation. Current therapeutic strategies generally focus on single-stage regulation and lack temporal coordination with the dynamic pathological evolution of transplanted adipose tissue. Here, we developed a root system-inspired core\u2013shell microneedle (MN) platform capable of sequentially regulating the graft microenvironment through early vascular promotion and later lipid removal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Vascular endothelial growth factor-loaded modified silk fibroin methacryloyl\/grooved poly(lactic-co-glycolic acid) core\u2013shell MNs (VEGF@mSF\/gPLGA\u2013MNs) were fabricated by integrating a reactive oxygen species (ROS)-responsive mSF shell with a lipid-adsorbing gPLGA core. The physicochemical properties, ROS scavenging ability, VEGF release behavior, and lipid adsorption capacity of the MNs were systematically characterized. Their biological effects were evaluated using in vitro cellular assays and a mouse autologous fat grafting model. Graft survival, vascularization, inflammatory regulation, and adipose remodeling and the underlying molecular mechanisms were assessed by imaging, histological analyses, immunofluorescence staining, ribonucleic acid sequencing, and western blotting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mSF shell rapidly responded to oxidative stress and degraded during the early stage after implantation, enabling localized VEGF release while alleviating ROS-induced cellular damage. Following shell degradation, the exposed gPLGA core facilitated directional lipid adsorption owing to its lipophilic properties and groove-mediated capillary transport. In vitro studies demonstrated improved endothelial migration, angiogenesis, ROS clearance, and mitochondrial protection. In a mouse fat graft model, VEGF@mSF\/gPLGA\u2013MNs significantly improved graft retention, reduced cystic degeneration and fibrosis, increased vascularization, and promoted adipose tissue remodeling. Transcriptomic and protein analyses revealed that lipid metabolism-related pathways, including PPAR signaling, were activated, and that inflammatory pathways, such as the NF-\u03baB, TNF, IL-17, and toll-like receptor signaling pathways, were suppressed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The root system-inspired VEGF@mSF\/gPLGA\u2013MN platform enables spatiotemporally sequential regulation of the fat graft microenvironment by coordinating early vascular reconstruction with subsequent lipid clearance. This strategy provides a promising approach for improving fat graft survival and may offer a generalizable paradigm for regenerative therapies involving dynamic pathological transitions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/burnst\/tkag057","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T11:42:11Z","timestamp":1787398931000},"source":"Crossref","is-referenced-by-count":0,"title":["Root-system-inspired core\u2013shell microneedles enable spatiotemporal sequential therapy via ROS scavenging, angiogenesis, and capillary-driven lipid removal for enhanced fat graft survival"],"prefix":"10.1093","volume":"14","author":[{"given":"Hengyu","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University , No. 1 Minde Road, Donghu District, Nanchang, Jiangxi, 330006 ,","place":["China"]},{"name":"Jiangxi Province Key laboratory of Precision Cell Therapy, Jiangxi Medical College, Nanchang University , No. 1 Minde Road, Donghu District, Nanchang, Jiangxi, 330006 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganghua","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University , No. 1 Minde Road, Donghu District, Nanchang, Jiangxi, 330006 ,","place":["China"]},{"name":"Jiangxi Province Key laboratory of Precision Cell Therapy, Jiangxi Medical College, Nanchang University , No. 1 Minde Road, Donghu District, Nanchang, Jiangxi, 330006 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanzheng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University , No. 1 Minde Road, Donghu District, Nanchang, Jiangxi, 330006 ,","place":["China"]},{"name":"Jiangxi Province Key laboratory of Precision Cell Therapy, Jiangxi Medical College, Nanchang University , No. 1 Minde Road, Donghu District, Nanchang, Jiangxi, 330006 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanglong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University , No. 1 Minde Road, Donghu District, Nanchang, Jiangxi, 330006 ,","place":["China"]},{"name":"Jiangxi Province Key laboratory of Precision Cell Therapy, Jiangxi Medical College, Nanchang University , No. 1 Minde Road, Donghu District, Nanchang, Jiangxi, 330006 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HaoWen","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University , No. 1 Minde Road, Donghu District, Nanchang, Jiangxi, 330006 ,","place":["China"]},{"name":"Jiangxi Province Key laboratory of Precision Cell Therapy, Jiangxi Medical College, Nanchang University , No. 1 Minde Road, Donghu District, Nanchang, Jiangxi, 330006 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University , No. 1 Minde Road, Donghu District, Nanchang, Jiangxi, 330006 ,","place":["China"]},{"name":"Jiangxi Province Key laboratory of Precision Cell Therapy, Jiangxi Medical College, Nanchang University , No. 1 Minde Road, Donghu District, Nanchang, Jiangxi, 330006 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minchen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University , No. 1 Minde Road, Donghu District, Nanchang, Jiangxi, 330006 ,","place":["China"]},{"name":"Jiangxi Province Key laboratory of Precision Cell Therapy, Jiangxi Medical College, Nanchang University , No. 1 Minde Road, Donghu District, Nanchang, Jiangxi, 330006 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghong","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University , No. 1 Minde Road, Donghu District, Nanchang, Jiangxi, 330006 ,","place":["China"]},{"name":"Jiangxi Province Key laboratory of Precision Cell Therapy, Jiangxi Medical College, Nanchang University , No. 1 Minde Road, Donghu District, Nanchang, Jiangxi, 330006 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4070-6297","authenticated-orcid":false,"given":"Yangyan","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University , No. 1 Minde Road, Donghu District, Nanchang, Jiangxi, 330006 ,","place":["China"]},{"name":"Jiangxi Province Key laboratory of Precision Cell Therapy, Jiangxi Medical College, Nanchang University , No. 1 Minde Road, Donghu District, Nanchang, Jiangxi, 330006 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,22]]},"reference":[{"key":"2026092608265007800_ref1","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1007\/s00266-017-0793-3","article-title":"Literature review to optimize the autologous fat transplantation procedure and recent technologies to improve graft viability and overall outcome: a systematic and retrospective analytic approach","volume":"41","author":"Shim","year":"2017","journal-title":"Aesth Plast Surg"},{"key":"2026092608265007800_ref2","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/j.cps.2017.05.009","article-title":"Fat grafting for burn, traumatic, and surgical scars","volume":"44","author":"Fredman","year":"2017","journal-title":"Clin Plast Surg"},{"key":"2026092608265007800_ref3","doi-asserted-by":"publisher","first-page":"099","DOI":"10.1055\/s-0031-1287675","article-title":"The role of fat grafting in reconstructive and cosmetic breast surgery: a review of the literature","volume":"28","author":"Saint-Cyr","year":"2011","journal-title":"J Reconstr Microsurg"},{"key":"2026092608265007800_ref4","doi-asserted-by":"publisher","first-page":"e2705","DOI":"10.1097\/gox.0000000000002705","article-title":"How fat grafting works","volume":"8","author":"Evans","year":"2020","journal-title":"Plast Reconstr Surg Glob Open"},{"key":"2026092608265007800_ref5","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.tibtech.2021.04.006","article-title":"Overcoming functional challenges in autologous and engineered fat grafting trends","volume":"40","author":"Major","year":"2022","journal-title":"Trends Biotechnol"},{"key":"2026092608265007800_ref6","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1097\/prs.0000000000011903","article-title":"Lipophagy enhances fat graft retention by stimulating dedifferentiation of mature adipocytes and modulating inflammation","volume":"156","author":"Xu","year":"2024","journal-title":"Plast Reconstr Surg"},{"key":"2026092608265007800_ref7","doi-asserted-by":"publisher","first-page":"NP501","DOI":"10.1093\/asj\/sjae075","article-title":"Disulfiram improves fat graft retention by modulating macrophage polarization with inhibition of NLRP3 inflammasome-mediated pyroptosis","volume":"44","author":"Chen","year":"2024","journal-title":"Aesthet Surg J"},{"key":"2026092608265007800_ref8","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1007\/s00266-020-01784-1","article-title":"Fat necrosis after DIEP flap breast reconstruction: a review of perfusion-related causes","volume":"44","author":"Bhullar","year":"2020","journal-title":"Aesth Plast Surg"},{"key":"2026092608265007800_ref9","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1111\/coa.14000","article-title":"Effect of operative time on complications associated with free flap reconstruction of the head and neck","volume":"48","author":"Irawati","year":"2022","journal-title":"Clin Otolaryngol"},{"key":"2026092608265007800_ref10","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1097\/prs.0000000000004882","article-title":"The disturbed function of neutrophils at the early stage of fat grafting impairs long-term fat graft retention","volume":"142","author":"Liu","year":"2018","journal-title":"Plast Reconstr Surg"},{"key":"2026092608265007800_ref11","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202302090r","article-title":"Lipolysis inhibition improves the survival of fat grafts through ameliorating lipotoxicity and inflammation","volume":"38","author":"Niu","year":"2024","journal-title":"FASEB J"},{"key":"2026092608265007800_ref12","doi-asserted-by":"publisher","first-page":"NP585","DOI":"10.1093\/asj\/sjae108","article-title":"Inhibition of adipocyte necroptosis alleviates fat necrosis and fibrosis after grafting in a murine model","volume":"44","author":"Liu","year":"2024","journal-title":"Aesthet Surg J"},{"key":"2026092608265007800_ref13","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1097\/PRS.0b013e31824a2b19","article-title":"The fate of adipocytes after nonvascularized fat grafting: evidence of early death and replacement of adipocytes","volume":"129","author":"Eto","year":"2012","journal-title":"Plast Reconstr Surg"},{"key":"2026092608265007800_ref14","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.651360","article-title":"Necroptosis in macrophage foam cells promotes fat graft fibrosis in mice","author":"Chen","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"2026092608265007800_ref15","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1097\/PRS.0000000000000097","article-title":"Chronic inflammation and progressive calcification as a result of fat necrosis: the worst outcome in fat grafting","volume":"133","author":"Mineda","year":"2014","journal-title":"Plast Reconstr Surg"},{"key":"2026092608265007800_ref16","doi-asserted-by":"publisher","first-page":"676e","DOI":"10.1097\/prs.0000000000004312","article-title":"Improved long-term volume retention of stromal vascular fraction gel grafting with enhanced angiogenesis and adipogenesis","volume":"141","author":"Zhang","year":"2018","journal-title":"Plast Reconstr Surg"},{"key":"2026092608265007800_ref17","doi-asserted-by":"publisher","first-page":"3990","DOI":"10.1172\/jci129187","article-title":"Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome","volume":"129","author":"Kahn","year":"2019","journal-title":"J Clin Invest"},{"key":"2026092608265007800_ref18","doi-asserted-by":"publisher","first-page":"686","DOI":"10.14348\/molcells.2020.0046","article-title":"Lipophagy: molecular mechanisms and implications in metabolic disorders","volume":"43","author":"Shin","year":"2020","journal-title":"Mol Cells"},{"key":"2026092608265007800_ref19","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.jhep.2017.11.014","article-title":"Lipotoxicity and the gut-liver axis in NASH pathogenesis","volume":"68","author":"Marra","year":"2018","journal-title":"J Hepatol"},{"key":"2026092608265007800_ref20","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.cmet.2024.10.016","article-title":"Altered sphingolipid biosynthetic flux and lipoprotein trafficking contribute to trans-fat-induced atherosclerosis","volume":"37","author":"Gengatharan","year":"2025","journal-title":"Cell Metab"},{"key":"2026092608265007800_ref21","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-52621-x","article-title":"Lipid droplets sequester palmitic acid to disrupt endothelial ciliation and exacerbate atherosclerosis in male mice","volume":"15","author":"Tan","year":"2024","journal-title":"Nat Commun"},{"key":"2026092608265007800_ref22","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02251-6","article-title":"Porphyromonas gingivalis aggravates atherosclerotic plaque instability by promoting lipid-laden macrophage necroptosis","volume":"10","author":"Huang","year":"2025","journal-title":"Signal Transduct Target Ther"},{"key":"2026092608265007800_ref23","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-47553-5","article-title":"Lipopolysaccharide binding protein resists hepatic oxidative stress by regulating lipid droplet homeostasis","volume":"15","author":"Zhang","year":"2024","journal-title":"Nat Commun"},{"key":"2026092608265007800_ref24","doi-asserted-by":"publisher","first-page":"e70555","DOI":"10.1002\/mco2.70555","article-title":"Targeting ApoA5-associated hypertriglyceridemia to ameliorate acute pancreatitis: insights from a knockout hamster model","volume":"6","author":"Shi","year":"2025","journal-title":"MedComm 2020"},{"key":"2026092608265007800_ref25","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1038\/s42255-025-01379-7","article-title":"Cholesterol metabolic reprogramming mediates microglia-induced chronic neuroinflammation and hinders neurorestoration following stroke","volume":"7","author":"Zhao","year":"2025","journal-title":"Nat Metab"},{"key":"2026092608265007800_ref26","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1161\/circresaha.125.326839","article-title":"TRIB3 links endoplasmic reticulum stress to impaired efferocytosis in atherosclerosis","volume":"137","author":"Singhal","year":"2025","journal-title":"Circ Res"},{"key":"2026092608265007800_ref27","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1136\/gutjnl-2024-332535","article-title":"Integration of lipidomics with targeted, single cell, and spatial transcriptomics defines an unresolved pro-inflammatory state in colon cancer","volume":"74","author":"Soundararajan","year":"2024","journal-title":"Gut"},{"key":"2026092608265007800_ref28","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/j.jhep.2018.04.006","article-title":"CD36 palmitoylation disrupts free fatty acid metabolism and promotes tissue inflammation in non-alcoholic steatohepatitis","volume":"69","author":"Zhao","year":"2018","journal-title":"J Hepatol"},{"key":"2026092608265007800_ref29","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adp0849","article-title":"Lipolysis-microlipophagy cascade regulated by adipose triglyceride lipase drives pathogenic adaptive type 2 immunity","volume":"10","author":"Yagyu","year":"2025","journal-title":"Sci Immunol"},{"key":"2026092608265007800_ref30","doi-asserted-by":"publisher","first-page":"116497","DOI":"10.1016\/j.celrep.2025.116497","article-title":"Circulating FABP5 released by dying macrophages function as a DAMP to exacerbate septic inflammation","volume":"44","author":"Wu","year":"2025","journal-title":"Cell Rep"},{"key":"2026092608265007800_ref31","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.freeradbiomed.2024.12.061","article-title":"Enhancing fat graft survival: thymosin beta-4 facilitates mitochondrial transfer from ADSCs via tunneling nanotubes by upregulating the Rac\/F-actin pathway","volume":"228","author":"Zhang","year":"2025","journal-title":"Free Radic Biol Med"},{"key":"2026092608265007800_ref32","doi-asserted-by":"publisher","first-page":"e2500627","DOI":"10.1002\/adhm.202500627","article-title":"Bioprinting of adipose tissue graft with enhanced neo-vessel formation in vivo","volume":"14","author":"Mohamed","year":"2025","journal-title":"Adv Healthc Mater"},{"key":"2026092608265007800_ref33","doi-asserted-by":"publisher","first-page":"25628","DOI":"10.1021\/acsnano.5c00216","article-title":"Biomimetic nanoparticles simultaneously targeting modulation of lipid metabolism and phenotype of macrophages for programmed atherosclerosis management","volume":"19","author":"Dong","year":"2025","journal-title":"ACS Nano"},{"key":"2026092608265007800_ref34","doi-asserted-by":"publisher","first-page":"e11606","DOI":"10.1002\/adma.202511606","article-title":"Targeted lipid transfer nanoshuttle via lipid-specific transcytosis induces atherosclerotic plaque regression","volume":"38","author":"Tang","year":"2026","journal-title":"Adv Mater"},{"key":"2026092608265007800_ref35","doi-asserted-by":"publisher","DOI":"10.1002\/adma.72127","article-title":"LDI, a lipid droplet inhibitor, disrupts lipid accumulation and modulates hepatic lipid profiles in fatty liver","volume":"38","author":"Kim","year":"2026","journal-title":"Adv Mater"},{"key":"2026092608265007800_ref36","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202405255","article-title":"Multifunctional hydrogel based on silk fibroin promotes tissue repair and regeneration","volume":"34","author":"Lin","year":"2024","journal-title":"Adv Funct Mater"},{"key":"2026092608265007800_ref37","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.bioactmat.2025.11.005","article-title":"Barrier-disrupting microneedle technology: overcoming physical, physiological, and pathological skin defenses to enhance therapeutic efficacy","volume":"57","author":"Jiang","year":"2026","journal-title":"Bioact Mater"},{"key":"2026092608265007800_ref38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bioactmat.2025.04.025","article-title":"From mechanism to applications: advanced microneedles for clinical medicine","volume":"51","author":"Yang","year":"2025","journal-title":"Bioact Mater"},{"key":"2026092608265007800_ref39","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202401667","article-title":"Grooved microneedle patch augments adoptive T cell therapy against solid tumors via diverting regulatory T cells","volume":"36","author":"Zhou","year":"2024","journal-title":"Adv Mater"},{"key":"2026092608265007800_ref40","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202513324","article-title":"Surface fluidic microneedle patches for lymphatic delivery of diagnostic and therapeutic agents","volume":"35","author":"Cheon","year":"2025","journal-title":"Adv Funct Mater"},{"key":"2026092608265007800_ref41","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.jconrel.2015.09.001","article-title":"Polymeric nanoparticles and microparticles for the delivery of peptides, biologics, and soluble therapeutics","volume":"219","author":"Pagels","year":"2015","journal-title":"J Control Release"},{"key":"2026092608265007800_ref42","doi-asserted-by":"publisher","first-page":"e46584","DOI":"10.1371\/journal.pone.0046584","article-title":"Gene expression profiling unravels cancer-related hepatic molecular signatures in steatohepatitis but not in steatosis","volume":"7","author":"Starmann","year":"2012","journal-title":"PLoS One"},{"key":"2026092608265007800_ref43","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22292-y","article-title":"Identification of genomic differences among peripheral arterial beds in atherosclerotic and healthy arteries","volume":"8","author":"Steenman","year":"2018","journal-title":"Sci Rep"},{"key":"2026092608265007800_ref44","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1097\/xcs.0000000000000115","article-title":"Gene expression profiling: identification of novel pathways and potential biomarkers in severe acute pancreatitis","volume":"234","author":"Nesvaderani","year":"2022","journal-title":"J Am Coll Surg"},{"key":"2026092608265007800_ref45","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.bjps.2023.04.010","article-title":"Fat graft survival requires metabolic reprogramming toward the glycolytic pathway","volume":"83","author":"Lee","year":"2023","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"2026092608265007800_ref46","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"2026092608265007800_ref47","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"2026092608265007800_ref48","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA-Seq data","volume":"14","author":"H\u00e4nzelmann","year":"2013","journal-title":"BMC Bioinformatics"},{"key":"2026092608265007800_ref49","doi-asserted-by":"publisher","first-page":"4200","DOI":"10.1093\/bioinformatics\/btz210","article-title":"TISIDB: an integrated repository portal for tumor-immune system interactions","volume":"35","author":"Ru","year":"2019","journal-title":"Bioinformatics"},{"key":"2026092608265007800_ref50","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1097\/prs.0000000000010643","article-title":"Technical precision with autologous fat grafting for facial rejuvenation: a review of the evolving science","volume":"153","author":"Strong","year":"2023","journal-title":"Plast Reconstr Surg"},{"key":"2026092608265007800_ref51","doi-asserted-by":"publisher","first-page":"243e","DOI":"10.1097\/prs.0000000000011653","article-title":"Optimal strategies for autologous fat grafting in breast augmentation and reconstruction: a systematic review and network meta-analysis","volume":"155","author":"Sun","year":"2024","journal-title":"Plast Reconstr Surg"},{"key":"2026092608265007800_ref52","doi-asserted-by":"publisher","first-page":"025014","DOI":"10.1088\/1758-5090\/adb2e7","article-title":"Purified adipose tissue-derived extracellular vesicles facilitate adipose organoid vascularization through coordinating adipogenesis and angiogenesis","volume":"17","author":"Zhu","year":"2025","journal-title":"Biofabrication"},{"key":"2026092608265007800_ref53","doi-asserted-by":"publisher","first-page":"108685","DOI":"10.1016\/j.pharmthera.2024.108685","article-title":"Pharmacological interventions for intraplaque neovascularization in atherosclerosis","volume":"261","author":"Ugusman","year":"2024","journal-title":"Pharmacol Ther"},{"key":"2026092608265007800_ref54","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-019-1228-6","article-title":"Extracellular lipid loading augments hypoxic paracrine signaling and promotes glioma angiogenesis and macrophage infiltration","volume":"38","author":"Offer","year":"2019","journal-title":"J Exp Clin Cancer Res"},{"key":"2026092608265007800_ref55","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-026-72756-3","article-title":"Flow-mediated endothelial remodeling and inflammation drive developmental vascular susceptibility in ldlr loss of function","volume":"17","author":"Kaveh","year":"2026","journal-title":"Nat Commun"},{"key":"2026092608265007800_ref56","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202417801","article-title":"Andrias davidianus derived glycosaminoglycans direct diabetic wound repair by reprogramming reparative macrophage glucolipid metabolism","volume":"37","author":"Yang","year":"2025","journal-title":"Adv Mater"},{"key":"2026092608265007800_ref57","doi-asserted-by":"publisher","first-page":"114233","DOI":"10.1016\/j.addr.2022.114233","article-title":"Immunoengineering strategies to enhance vascularization and tissue regeneration","volume":"184","author":"Zarubova","year":"2022","journal-title":"Adv Drug Deliv Rev"},{"key":"2026092608265007800_ref58","doi-asserted-by":"publisher","first-page":"37065","DOI":"10.1021\/acsnano.5c10610","article-title":"Highly efficient intrastromal dual-drug delivery by a dissolving bilayer microneedle for synergistic therapy against corneal neovascularization","volume":"19","author":"Zhang","year":"2025","journal-title":"ACS Nano"},{"key":"2026092608265007800_ref59","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.bioactmat.2024.04.020","article-title":"Hydrogel forming microneedles loaded with VEGF and Ritlecitinib\/polyhydroxyalkanoates nanoparticles for mini-invasive androgenetic alopecia treatment","volume":"38","author":"Ding","year":"2024","journal-title":"Bioact Mater"},{"key":"2026092608265007800_ref60","doi-asserted-by":"publisher","first-page":"165993","DOI":"10.1016\/j.cej.2025.165993","article-title":"Multifunctional NGF-loaded PLGA microsphere-PCL\/GelMA scaffold enables coordinated osteo-neuro-vascular regeneration via PI3K\/AKT pathway activation","volume":"520","author":"Tang","year":"2025","journal-title":"Chem Eng J"},{"key":"2026092608265007800_ref61","doi-asserted-by":"publisher","first-page":"2210707","DOI":"10.1002\/adma.202210707","article-title":"Hydrogel-based growth factor delivery platforms: strategies and recent advances","volume":"36","author":"Shan","year":"2024","journal-title":"Adv Mater"},{"key":"2026092608265007800_ref62","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-61965-x","article-title":"Dual-targeted siRubicon delivery strategy triggers hepatocellular lipophagy for mitigating liver steatosis","volume":"16","author":"Lan","year":"2025","journal-title":"Nat Commun"},{"key":"2026092608265007800_ref63","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adv8999","article-title":"A self-assembled nano micelle-exosome with high selectivity and penetrability achieves precise intracartilage lipid delivery","volume":"11","author":"Li","year":"2025","journal-title":"Sci Adv"},{"key":"2026092608265007800_ref64","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1016\/j.cmet.2024.03.014","article-title":"Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK","volume":"36","author":"Li","year":"2024","journal-title":"Cell Metab"},{"key":"2026092608265007800_ref65","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/s41593-019-0566-1","article-title":"Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain","volume":"23","author":"Marschallinger","year":"2020","journal-title":"Nat Neurosci"},{"key":"2026092608265007800_ref66","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1111\/jocd.14295","article-title":"Effects of macrophage regulation on fat grafting survival: improvement, mechanisms, and potential application\u2014a review","volume":"21","author":"Chen","year":"2022","journal-title":"J Cosmet Dermatol"},{"key":"2026092608265007800_ref67","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.cyto.2018.10.022","article-title":"Interleukins as modulators of angiogenesis and anti-angiogenesis in tumors","volume":"118","author":"Ribatti","year":"2019","journal-title":"Cytokine"},{"key":"2026092608265007800_ref68","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1097\/prs.0000000000004028","article-title":"Early macrophage infiltration improves fat graft survival by inducing angiogenesis and hematopoietic stem cell recruitment","volume":"141","author":"Cai","year":"2018","journal-title":"Plast Reconstr Surg"},{"key":"2026092608265007800_ref69","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-025-04473-5","article-title":"Enhancing fat graft retention through adipose tissue browning: a systematic review","volume":"16","author":"Qiu","year":"2025","journal-title":"Stem Cell Res Ther"},{"key":"2026092608265007800_ref70","doi-asserted-by":"publisher","first-page":"e23613","DOI":"10.1096\/fj.202400126R","article-title":"PPAR -\u03b3 regulates the polarization of M2 macrophages to improve the microenvironment for autologous fat grafting","volume":"38","author":"Zhang","year":"2024","journal-title":"FASEB J"},{"key":"2026092608265007800_ref71","doi-asserted-by":"publisher","first-page":"155718","DOI":"10.1016\/j.metabol.2023.155718","article-title":"Interplay of lipid metabolism and inflammation in podocyte injury","volume":"150","author":"Luo","year":"2024","journal-title":"Metabolism"},{"key":"2026092608265007800_ref72","doi-asserted-by":"publisher","first-page":"NP653","DOI":"10.1093\/asj\/sjaa401","article-title":"Compact fat grafting: a novel method to improve graft retention through modulation of adipocyte size","volume":"41","author":"Kim","year":"2020","journal-title":"Aesthet Surg J"},{"key":"2026092608265007800_ref73","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-022-02709-2","article-title":"Bone marrow mesenchymal stem cells enhance angiogenesis and promote fat retention in fat grafting via polarized macrophages","volume":"13","author":"Dang","year":"2022","journal-title":"Stem Cell Res Ther"},{"key":"2026092608265007800_ref74","doi-asserted-by":"publisher","first-page":"433e","DOI":"10.1097\/prs.0000000000008872","article-title":"Enrichment of nanofiber hydrogel composite with fractionated fat promotes regenerative macrophage polarization and vascularization for soft-tissue engineering","volume":"149","author":"Henn","year":"2022","journal-title":"Plast Reconstr Surg"},{"key":"2026092608265007800_ref75","doi-asserted-by":"publisher","first-page":"2417377","DOI":"10.1002\/adma.202417377","article-title":"Photosensitive biomimetic nanomedicine-mediated recombination of adipose microenvironments for antiobesity therapy","volume":"37","author":"Song","year":"2025","journal-title":"Adv Mater"},{"key":"2026092608265007800_ref76","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1038\/s41563-024-02115-4","article-title":"On-patient medical record and mRNA therapeutics using intradermal microneedles","volume":"24","author":"Han","year":"2025","journal-title":"Nat Mater"},{"key":"2026092608265007800_ref77","doi-asserted-by":"publisher","DOI":"10.1007\/s40820-025-01662-y","article-title":"Microneedle-based approaches for skin disease treatment","volume":"17","author":"Han","year":"2025","journal-title":"Nano Micro Lett"},{"key":"2026092608265007800_ref78","doi-asserted-by":"publisher","first-page":"941e","DOI":"10.1097\/prs.0000000000009655","article-title":"Large-volume fat grafting: identifying risk factors for fat necrosis","volume":"150","author":"Chang","year":"2022","journal-title":"Plast Reconstr Surg"},{"key":"2026092608265007800_ref79","doi-asserted-by":"publisher","DOI":"10.1177\/09636897241264976","article-title":"The evolving function of vasculature and pro-angiogenic therapy in fat grafting","author":"Xining","year":"2024","journal-title":"Cell Transplant"},{"key":"2026092608265007800_ref80","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1001\/jamadermatol.2023.5908","article-title":"Clinical, histologic, and transcriptomic evaluation of sequential fat grafting for morphea: a nonrandomized controlled trial","volume":"160","author":"Liu","year":"2024","journal-title":"JAMA Dermatol"},{"key":"2026092608265007800_ref81","doi-asserted-by":"publisher","first-page":"e12719","DOI":"10.1002\/adma.202512719","article-title":"Hydrogel-based ROS-regulating strategy: reprogramming the oxidative stress imbalance in advanced diabetic wound repair","volume":"38","author":"Zhou","year":"2026","journal-title":"Adv Mater"},{"key":"2026092608265007800_ref82","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/s41578-023-00617-2","article-title":"Responsive biomaterials: optimizing control of cancer immunotherapy","volume":"9","author":"Xue","year":"2023","journal-title":"Nat Rev Mater"}],"container-title":["Burns &amp; Trauma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/burnstrauma\/advance-article-pdf\/doi\/10.1093\/burnst\/tkag057\/70763803\/tkag057.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/burnstrauma\/article-pdf\/doi\/10.1093\/burnst\/tkag057\/70763803\/tkag057.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/burnstrauma\/article-pdf\/doi\/10.1093\/burnst\/tkag057\/70763803\/tkag057.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:32:00Z","timestamp":1790425920000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/burnstrauma\/article\/doi\/10.1093\/burnst\/tkag057\/8768677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":82,"URL":"https:\/\/doi.org\/10.1093\/burnst\/tkag057","relation":{},"ISSN":["2321-3876"],"issn-type":[{"value":"2321-3876","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026]]},"published":{"date-parts":[[2026]]},"article-number":"tkag057"}}