{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T10:50:36Z","timestamp":1791715836849,"version":"4.3.4"},"reference-count":63,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":244,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Postgraduate Innovation Program of Jiangsu Province","award":["KYCX25_3302"],"award-info":[{"award-number":["KYCX25_3302"]}]},{"name":"Foundation of 71st Group Army Hospital of PLA","award":["YNZD-2022002"],"award-info":[{"award-number":["YNZD-2022002"]}]},{"name":"Foundation of 71st Group Army Hospital of PLA","award":["YNMS-2021006"],"award-info":[{"award-number":["YNMS-2021006"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302798"],"award-info":[{"award-number":["82302798"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017962","name":"Jiangsu Provincial Health Commission","doi-asserted-by":"publisher","award":["M2024032"],"award-info":[{"award-number":["M2024032"]}],"id":[{"id":"10.13039\/100017962","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intestinal barrier failure following ischemia\u2013reperfusion (IR) injury is a critical event that drives lethal systemic complications; however, the specific intercellular signals governing epithelial cell fate under these pathological conditions remain incompletely understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed single-cell ribonucleic acid sequencing (scRNA-seq) on intestinal tissues from a murine IR model to map intercellular communication networks. The identified ligand\u2013receptor pair was functionally validated using neutrophil-specific thrombospondin-1 (Thbs1) knockout mice, combined with pharmacological inhibition and activation of CD36, as well as biochemical and histological analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>scRNA-seq analysis of the IR-injured gut revealed a key neutrophil\u2013epithelial signaling pathway mediated by the Thbs1\u2013Cd36 ligand\u2013receptor pair. Neutrophil-specific genetic ablation of Thbs1 markedly attenuated IR-induced epithelial apoptosis and barrier disruption. Mechanistically, THBS1 binding to epithelial CD36 activated JNK signaling, mediating a proapoptotic cascade. CD36 inhibition was protective, whereas its activation bypassed the requirement for THBS1 and provoked mucosal injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study elucidates a key mechanism of gut barrier failure and identifies the THBS1\u2013CD36\u2013JNK axis as a promising therapeutic target for mitigating intestinal IR injury in critical conditions such as burns and shock.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/burnst\/tkag059","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T18:50:08Z","timestamp":1788375008000},"source":"Crossref","is-referenced-by-count":0,"title":["A neutrophil\u2013epithelial thrombospondin\u20111\u2013CD36\u2013c\u2011Jun N\u2011terminal kinase axis orchestrates mucosal barrier failure in intestinal ischemia\u2013reperfusion"],"prefix":"10.1093","volume":"14","author":[{"given":"Yiwen","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Burn Surgery, The Affiliated Huaihai Hospital of Xuzhou Medical University , 226 Tongshan Street, Yunlong District, Xuzhou, Jiangsu Province 221004 ,","place":["China"]},{"name":"Department of Burn Surgery, The 71st Group Army Hospital of People\u2019s Liberation Army , 226 Tongshan Street, Yunlong District, Xuzhou, Jiangsu Province 221004 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Burn Surgery, The 71st Group Army Hospital of People\u2019s Liberation Army , 226 Tongshan Street, Yunlong District, Xuzhou, Jiangsu Province 221004 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Burn Surgery, The Affiliated Huaihai Hospital of Xuzhou Medical University , 226 Tongshan Street, Yunlong District, Xuzhou, Jiangsu Province 221004 ,","place":["China"]},{"name":"Department of Burn Surgery, The 71st Group Army Hospital of People\u2019s Liberation Army , 226 Tongshan Street, Yunlong District, Xuzhou, Jiangsu Province 221004 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuechen","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Burn Surgery, The Affiliated Huaihai Hospital of Xuzhou Medical University , 226 Tongshan Street, Yunlong District, Xuzhou, Jiangsu Province 221004 ,","place":["China"]},{"name":"Department of Burn Surgery, The 71st Group Army Hospital of People\u2019s Liberation Army , 226 Tongshan Street, Yunlong District, Xuzhou, Jiangsu Province 221004 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Jiangsu Province 221004 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Burn Surgery, The Affiliated Huaihai Hospital of Xuzhou Medical University , 226 Tongshan Street, Yunlong District, Xuzhou, Jiangsu Province 221004 ,","place":["China"]},{"name":"Department of Burn Surgery, The 71st Group Army Hospital of People\u2019s Liberation Army , 226 Tongshan Street, Yunlong District, Xuzhou, Jiangsu Province 221004 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Burn Surgery, The Affiliated Huaihai Hospital of Xuzhou Medical University , 226 Tongshan Street, Yunlong District, Xuzhou, Jiangsu Province 221004 ,","place":["China"]},{"name":"Department of Burn Surgery, The 71st Group Army Hospital of People\u2019s Liberation Army , 226 Tongshan Street, Yunlong District, Xuzhou, Jiangsu Province 221004 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kehui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Burn Surgery, The Affiliated Huaihai Hospital of Xuzhou Medical University , 226 Tongshan Street, Yunlong District, Xuzhou, Jiangsu Province 221004 ,","place":["China"]},{"name":"Department of Burn Surgery, The 71st Group Army Hospital of People\u2019s Liberation Army , 226 Tongshan Street, Yunlong District, Xuzhou, Jiangsu Province 221004 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Burn Surgery, The Affiliated Huaihai Hospital of Xuzhou Medical University , 226 Tongshan Street, Yunlong District, Xuzhou, Jiangsu Province 221004 ,","place":["China"]},{"name":"Department of Burn Surgery, The 71st Group Army Hospital of People\u2019s Liberation Army , 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