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Hypertrophic scar formation is considered a result of the imbalance between extracellular matrix synthesis and degradation during wound healing. However, the underlying mechanisms of hypertrophic scar development are poorly understood. The purpose of this review was to outline the management in the early stage after wound healing to prevent hypertrophic scar formation, focusing on strategies excluding therapeutic agents of internal use. Treatment aimed at molecular targets, including cytokines, will be future options to prevent and treat hypertrophic scars. More basic studies and clinical trials, including combination therapy, are required to investigate the mechanisms and prevent hypertrophic scar formation.<\/jats:p>","DOI":"10.1093\/burnst\/tkz003","type":"journal-article","created":{"date-parts":[[2020,1,26]],"date-time":"2020-01-26T21:26:56Z","timestamp":1580074016000},"source":"Crossref","is-referenced-by-count":121,"title":["Strategies to prevent hypertrophic scar formation: a review of therapeutic interventions based on molecular evidence"],"prefix":"10.1093","volume":"8","author":[{"given":"Eri","family":"Shirakami","sequence":"first","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Yamakawa","sequence":"first","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Hayashida","sequence":"first","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,1,27]]},"reference":[{"key":"2020050707074730400_ref1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2119\/molmed.2009.00153","article-title":"Hypertrophic scarring and keloids: Pathomechanisms and current and emerging treatment strategies","volume":"17","author":"Gauglitz","year":"2011","journal-title":"Mol Med."},{"key":"2020050707074730400_ref2","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.burns.2013.12.017","article-title":"Prevention or treatment of hypertrophic burn scarring: A review of when and how to treat with the pulsed dye 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