{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,12,4]],"date-time":"2022-12-04T10:48:30Z","timestamp":1670150910104},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,5]]},"DOI":"10.1093\/carcin\/20.5.843","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T22:20:01Z","timestamp":1027722001000},"page":"843-850","source":"Crossref","is-referenced-by-count":8,"title":["Cutaneously applied 4-hydroxytamoxifen is not carcinogenic in female rats"],"prefix":"10.1093","volume":"20","author":[{"given":"Fabrice","family":"Sauvez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique Salin","family":"Drouin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Attia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Bertheux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy","family":"Forster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1999,5]]},"reference":[{"key":"key\n\t\t\t\t20170725012100_R1","unstructured":"Lerner,L.J. and Jordan,V.C. (1990) Development of antiestrogens and their use in breast cancer:Eighth Cain Memorial Award Lecture. Cancer Res.,50, 4177\u20134189."},{"key":"key\n\t\t\t\t20170725012100_R2","doi-asserted-by":"crossref","unstructured":"Josefson,D. (1998) Breast cancer trial stopped early. Br. Med. J.,316, 1187.","DOI":"10.1136\/bmj.316.7139.1185d"},{"key":"key\n\t\t\t\t20170725012100_R3","unstructured":"Love,R.R. (1992) Tamoxifen prophylaxis in breast cancer. Oncology,6, 33\u201343."},{"key":"key\n\t\t\t\t20170725012100_R4","doi-asserted-by":"crossref","unstructured":"Williams,G.M., Iatropoulos,M.J., Djordjevic,M.V. and Kaltenberg,O.P. (1993) The triphenylethylene drug tamoxifen is a strong liver carcinogen in the rat. Carcinogenesis,14, 315\u2013317.","DOI":"10.1093\/carcin\/14.2.315"},{"key":"key\n\t\t\t\t20170725012100_R5","unstructured":"Greaves,P., Goonetilleke,R., Nunn,G., Topham,J. and Orton,T. (1993) Two-year carcinogenicity study of tamoxifen in Alderley Park Wistar-derived rats. Cancer Res.,53, 3919\u20133924."},{"key":"key\n\t\t\t\t20170725012100_R6","doi-asserted-by":"crossref","unstructured":"Hirsim\u00e4ki,P., Hirsim\u00e4ki,Y., Nieminen,L. and Payne,B.J. (1993) Tamoxifen induces hepatocellular carcinoma in rat liver: a 1-year study with two antiestrogens. Arch. Toxicol., 67, 49\u201354.","DOI":"10.1007\/BF02072035"},{"key":"key\n\t\t\t\t20170725012100_R7","doi-asserted-by":"crossref","unstructured":"Girault,J., Istin,B. and Fourtillan,J.B. (1993) Quantitative measurement of 4-hydroxytamoxifen in human plasma and mammary tumours by combined gas-chromatography\/negative chemical ionisation mass spectrometry. Biol. Mass Spectrom., 22, 395\u2013402.","DOI":"10.1002\/bms.1200220706"},{"key":"key\n\t\t\t\t20170725012100_R8","unstructured":"Peto,R., Pike,M.C., Day,N.E., Gray,R.G., Lee,P.N., Parish,S., Peto,J., Richards,S. and Wahrendorf,J. (1980) Guidelines for Simple Sensitive Significance Tests for Carcinogenic Effects in Long-term Animal Experiments, IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Suppl. 2. IARC, Lyon, pp. 311\u2013346."},{"key":"key\n\t\t\t\t20170725012100_R9","unstructured":"Lang,P.L. (1992) Spontaneous Neoplastic Lesions and Selected Non-neoplastic Lesions in the Crl:CD\u00aeBR Rat. Charles River Laboratories, MA, USA."},{"key":"key\n\t\t\t\t20170725012100_R10","doi-asserted-by":"crossref","unstructured":"Attia,M. (1996) Neoplastic and non-neoplastic lesions in the mammary gland, endocrine and genital organs in ageing male and female Sprague\u2013Dawley rats. Arch. Toxicol., 70, 461\u2013473.","DOI":"10.1007\/s002040050300"},{"key":"key\n\t\t\t\t20170725012100_R11","doi-asserted-by":"crossref","unstructured":"White,A.N.H., de Matteis,F., Davies,A., Smith,L.L., Crofton-Sleigh,C., Venitt,S., Hewer,A. and Phillips,D.H. (1992) Genotoxic potential of tamoxifen and analogues in female Fischer F344\/n rats, DBA\/2 and C57BL\/6 mice and in human MCL-5 cells. Carcinogenesis, 13, 2197\u20132203.","DOI":"10.1093\/carcin\/13.12.2197"},{"key":"key\n\t\t\t\t20170725012100_R12","unstructured":"Sargent,L.M, Dragan,Y., Bahnub,N., Wiley,J.E., Sattler,C.A., Schroeder,P., Sattler,G., Jordan,V.C. and Pitot,H.C. (1994) Tamoxifen induces hepatic aneuploidy and mitotic spindle disruption after a single in vivo administration to female Sprague\u2013Dawley rats. Cancer Res., 54, 3357\u20133360."},{"key":"key\n\t\t\t\t20170725012100_R13","doi-asserted-by":"crossref","unstructured":"King,C.M. (1995) Tamoxifen and the induction of cancer. Carcinogenesis, 16, 1449\u20131454.","DOI":"10.1093\/carcin\/16.7.1449"},{"key":"key\n\t\t\t\t20170725012100_R14","unstructured":"Carmichael,P.L., Ugwumada,A.H.N., Neven,P., Hewer,A.J., Poon,G.K. and Phillips,D.H. (1996) Lack of genotoxicity of tamoxifen in human endometrium. Cancer Res., 56, 1475\u20131479."},{"key":"key\n\t\t\t\t20170725012100_R15","doi-asserted-by":"crossref","unstructured":"Rochefort,H. and Borgna,J.L. (1981) Differences between oestrogen receptor activation by oestrogen and antioestrogen. Nature, 292, 257\u2013259.","DOI":"10.1038\/292257a0"},{"key":"key\n\t\t\t\t20170725012100_R16","doi-asserted-by":"crossref","unstructured":"McConnell,R.F. (1989) Comparative aspects of contraceptive steroids: effects observed in rats. Toxicol. Pathol., 17, 385\u2013388.","DOI":"10.1177\/019262338901700215"},{"key":"key\n\t\t\t\t20170725012100_R17","unstructured":"Geary,C.P. and Cousins,F.B. (1969) An oestrogen linked nephrocalcinosis in rats. Br. J. Exp. Pathol., 50, 507\u2013515."},{"key":"key\n\t\t\t\t20170725012100_R18","doi-asserted-by":"crossref","unstructured":"Lullmann,H. and Lullmann-Rauch,R. (1981) Tamoxifen-induced generalised lipidosis in rats subchronically treated with high doses. Toxicol. Appl. Pharmacol., 61, 138\u2013146.","DOI":"10.1016\/0041-008X(81)90014-4"},{"key":"key\n\t\t\t\t20170725012100_R19","doi-asserted-by":"crossref","unstructured":"Pathak,D.N., Pongracz,K. and Bodell,W.J. (1995) Microsomal and peroxidase activation of 4-hydroxytamoxifen to form DNA adducts: comparison with DNA adducts formed in Sprague\u2013Dawley rats treated with tamoxifen. Carcinogenesis, 16, 11\u201315.","DOI":"10.1093\/carcin\/16.1.11"}],"container-title":["Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/carcin\/article\/20\/5\/843\/2529743\/Cutaneously-applied-4hydroxytamoxifen-is-not","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T05:37:29Z","timestamp":1500961049000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/carcin\/article-lookup\/doi\/10.1093\/carcin\/20.5.843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,5]]},"references-count":19,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1999,5]]},"published-print":{"date-parts":[[1999,5]]}},"URL":"https:\/\/doi.org\/10.1093\/carcin\/20.5.843","relation":{},"ISSN":["1460-2180","0143-3334"],"issn-type":[{"value":"1460-2180","type":"electronic"},{"value":"0143-3334","type":"print"}],"subject":[],"published":{"date-parts":[[1999,5]]}}}