{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T12:43:56Z","timestamp":1722689036298},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,9]]},"DOI":"10.1093\/carcin\/21.9.1631","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T18:35:07Z","timestamp":1027708507000},"page":"1631-1638","source":"Crossref","is-referenced-by-count":7,"title":["Defective nuclear localization of p53 protein in a Chinese hamster cell line is associated with the formation of stable cytoplasmic protein multimers in cells with gene amplification"],"prefix":"10.1093","volume":"21","author":[{"given":"Laura","family":"Ottaggio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simonetta","family":"Bozzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Moro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Sparks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Campomenosi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariangela","family":"Miele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Bonatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilberto","family":"Fronza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David P.","family":"Lane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Abbondandolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2000,9]]},"reference":[{"key":"key\n\t\t\t\t20170725013401_R1","doi-asserted-by":"crossref","unstructured":"Lane,D.P. (1992) p53, guardian of the genome. Nature, 358, 15\u201316.","DOI":"10.1038\/358015a0"},{"key":"key\n\t\t\t\t20170725013401_R2","doi-asserted-by":"crossref","unstructured":"Ko,L.J. and Prives,C. (1996) p53: puzzle and paradigm. Genes Dev., 10, 1054\u20131072.","DOI":"10.1101\/gad.10.9.1054"},{"key":"key\n\t\t\t\t20170725013401_R3","doi-asserted-by":"crossref","unstructured":"Levine,A.J. (1997) p53, the cellular gatekeeper for growth and division. Cell, 88, 323\u2013331.","DOI":"10.1016\/S0092-8674(00)81871-1"},{"key":"key\n\t\t\t\t20170725013401_R4","doi-asserted-by":"crossref","unstructured":"Funk,J.O. and Galloway,D.A. (1998) Inhibiting CDK inhibitors: new lessons from DNA tumor viruses. Trends Biochem. Sci., 23, 337\u2013341.","DOI":"10.1016\/S0968-0004(98)01242-0"},{"key":"key\n\t\t\t\t20170725013401_R5","unstructured":"Knippshild,U., Oren,M. and Deppert,W. (1996) Abrogation of wild type p53 mediated growth-inhibition by nuclear exclusion. Oncogene, 12, 1755\u20131765."},{"key":"key\n\t\t\t\t20170725013401_R6","doi-asserted-by":"crossref","unstructured":"Moll,U.M., Ostermeyer,A.G., Haladay,R., Winkfield,B., Frazier,M. and Zambetti,G. (1996) Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage. Mol. Cell. Biol., 16, 1126\u20131137.","DOI":"10.1128\/MCB.16.3.1126"},{"key":"key\n\t\t\t\t20170725013401_R7","doi-asserted-by":"crossref","unstructured":"Moll,U.M., Riou,G. and Levine,A.J. (1992) Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion. Proc. Natl Acad. Sci. USA, 89, 7262\u20137266.","DOI":"10.1073\/pnas.89.15.7262"},{"key":"key\n\t\t\t\t20170725013401_R8","doi-asserted-by":"crossref","unstructured":"Bosari,S., Viale,G., Bossi,P., Maggioni,M., Coggi,G., Murray,J.J. and Lee,A.K.C. (1994) Cytoplasmic accumulation of p53 protein: an independent prognostic indicator in colorectal adenocarcinomas. J. Natl Cancer Inst., 86, 681\u2013687.","DOI":"10.1093\/jnci\/86.9.681"},{"key":"key\n\t\t\t\t20170725013401_R9","doi-asserted-by":"crossref","unstructured":"Moll,U.M., LaQuaglia,M., Bernard,J. and Riou,G. (1995) Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage. Proc. Natl Acad. Sci. USA, 92, 4407\u20134411.","DOI":"10.1073\/pnas.92.10.4407"},{"key":"key\n\t\t\t\t20170725013401_R10","unstructured":"Ali,I.U., Schweitzer,J.B., Ikejiri,B., Saxena,A., Robertson,J.T. and Oldfield,E.H. (1994) Heterogeneity of subcellular localization of p53 protein in human glioblastoma. Cancer Res., 54, 1\u20135."},{"key":"key\n\t\t\t\t20170725013401_R11","doi-asserted-by":"crossref","unstructured":"Gannon,J.V. and Lane,D.P. (1991) Protein synthesis required to anchor mutant p53 protein which is temperature-sensitive for nuclear transport. Nature, 349, 802\u2013806.","DOI":"10.1038\/349802a0"},{"key":"key\n\t\t\t\t20170725013401_R12","doi-asserted-by":"crossref","unstructured":"Ostermeyer A.G., Runko E., Winkfield B., Ahn B. and Moll U.M. (1996) Cytoplasmically sequestered wild type p53 protein in neuroblastoma is relocated to the nucleus by a c-terminal peptide. Proc. Natl Acad. Sci. USA, 93, 15190\u201315194.","DOI":"10.1073\/pnas.93.26.15190"},{"key":"key\n\t\t\t\t20170725013401_R13","doi-asserted-by":"crossref","unstructured":"Stommel,J.M., Marchenko,N.D., Jimenez, G.S.,Moll,U.M., Hope,T.J. and Wahl,J.M. (1999) A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking. EMBO J., 18, 1660\u20131672.","DOI":"10.1093\/emboj\/18.6.1660"},{"key":"key\n\t\t\t\t20170725013401_R14","doi-asserted-by":"crossref","unstructured":"Moro,F., Ottaggio,L., Bonatti,S., Simili,S., Miele,M., Bozzo,S. and Abbondandolo,A. (1995) p53 expression in normal versus transformed mammalian cells. Carcinogenesis, 16, 2435\u20132440.","DOI":"10.1093\/carcin\/16.10.2435"},{"key":"key\n\t\t\t\t20170725013401_R15","doi-asserted-by":"crossref","unstructured":"Miele,M., Bonatti,S., Menichini,P., Ottaggio,L. and Abbondandolo,A. (1989) The presence of amplified region affects the stability of chromosomes in drug-resistance Chinese hamster cells. Mutat. Res., 219, 171\u2013178.","DOI":"10.1016\/0921-8734(89)90012-X"},{"key":"key\n\t\t\t\t20170725013401_R16","unstructured":"Harlow,E. and Lane,D. (1988) Antibodies: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, p. 646."},{"key":"key\n\t\t\t\t20170725013401_R17","doi-asserted-by":"crossref","unstructured":"Baker,S.J., Markowitz,S., Fearon,E.R., Willson,J.K.V. and Vogelstein,B. (1990) Suppression of human colorectal carcinoma cell growth by wild-type p53. Science, 249, 912\u2013915.","DOI":"10.1126\/science.2144057"},{"key":"key\n\t\t\t\t20170725013401_R18","doi-asserted-by":"crossref","unstructured":"Meek,D.W. (1998) Multisite phosphorylation and the integration of stress signals at p53. Cell. Signal., 10, 159\u2013166.","DOI":"10.1016\/S0898-6568(97)00119-8"},{"key":"key\n\t\t\t\t20170725013401_R19","doi-asserted-by":"crossref","unstructured":"Kudo,N., Wolff,B., Sekimoto,T., Schreiner,E.P., Yoneda,Y., Yanagida,M., Horinouchi,S. and Yoshida,M. (1998) Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. Exp. Cell Res., 242, 540\u2013547.","DOI":"10.1006\/excr.1998.4136"},{"key":"key\n\t\t\t\t20170725013401_R20","unstructured":"Dunn,M.J. (1993) Electrophoresis in the presence of additives. In Graham,J.M. and Billington,D. (eds) Gel Electrophoresis; Proteins. Bios Scientific Publishers, Oxford, UK, pp. 41\u201349."},{"key":"key\n\t\t\t\t20170725013401_R21","unstructured":"Hainaut,P. and Milner,J. (1993) A structural role for metal ions in the `wild type' conformation of the tumor suppressor protein p53. Cancer Res., 53, 1739\u20131742."},{"key":"key\n\t\t\t\t20170725013401_R22","doi-asserted-by":"crossref","unstructured":"Stenger,J.E., Mayr,G.A., Mann,K. and Tegtmeyer,P. (1992) Formation of stable p53 homotetramers and multiples of tetramers. Mol. Carcinog., 5, 102\u2013106.","DOI":"10.1002\/mc.2940050204"},{"key":"key\n\t\t\t\t20170725013401_R23","doi-asserted-by":"crossref","unstructured":"Rihs,H.P. and Peters,R. (1989) Nuclear transport kinetics depend on phosphorylation-site-containing sequences flanking the karyophilic signal of the Simian virus 40 T-antigen. EMBO J., 8, 1479\u20131484.","DOI":"10.1002\/j.1460-2075.1989.tb03531.x"},{"key":"key\n\t\t\t\t20170725013401_R24","doi-asserted-by":"crossref","unstructured":"Hunter,T. and Karin,M. (1992) The regulation of transcription by phosphorylation. Cell, 70, 375\u2013387.","DOI":"10.1016\/0092-8674(92)90162-6"},{"key":"key\n\t\t\t\t20170725013401_R25","doi-asserted-by":"crossref","unstructured":"Hupp,T.R., Sparks,A.and Lane,D.P. (1995) Small peptides activate the latent sequence-specific DNA binding function of p53. Cell, 83, 237\u2013245.","DOI":"10.1016\/0092-8674(95)90165-5"},{"key":"key\n\t\t\t\t20170725013401_R26","doi-asserted-by":"crossref","unstructured":"Vesely,J., Havlicek,L., Stroud,M., Blow,J.J., Donella-Deanna,A, Pinna,L., Letham,D.S., Kato,J., Detivaud,L., Leclerc,S. and Meuer,L. (1994) Inhibition of cyclin-dependent kinases by purine analogues. Eur. J. Biochem., 224, 771\u2013786.","DOI":"10.1111\/j.1432-1033.1994.00771.x"},{"key":"key\n\t\t\t\t20170725013401_R27","doi-asserted-by":"crossref","unstructured":"Klarlund,J.K. (1985) Transformation of cells by an inhibitor of phosphatases acting on phosphotyrosine in proteins. Cell, 41, 707\u2013717.","DOI":"10.1016\/S0092-8674(85)80051-9"},{"key":"key\n\t\t\t\t20170725013401_R28","doi-asserted-by":"crossref","unstructured":"Rabinovitch,P.S. and Norwood,T.H. (1981) Rapid kinetics of polyethylene glycol-mediated fusion. Somat. Cell Genet., 7, 281\u2013287.","DOI":"10.1007\/BF01538853"},{"key":"key\n\t\t\t\t20170725013401_R29","doi-asserted-by":"crossref","unstructured":"Middeler,G.,Zerf,K., Jenovai,S., Thulig,A., Tschodrich-Rotter,M., Kubitschek,U. and Peters,R. (1997) The tumor suppressor p53 is subject to both nuclear import and export, and both are fast, energy-dependent and lectin-inhibited. Oncogene, 14, 1407\u20131417.","DOI":"10.1038\/sj.onc.1200949"},{"key":"key\n\t\t\t\t20170725013401_R30","doi-asserted-by":"crossref","unstructured":"Mateu,M.G. and Fersht,A.R. (1999) Mutually compensatory mutations during evolution of the tetramerization domain of tumor suppressor p53 lead to impaired hetero-oligomerization. Proc. Natl Acad. Sci. USA, 96, 3585\u20133599.","DOI":"10.1073\/pnas.96.7.3595"}],"container-title":["Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/carcin\/article\/21\/9\/1631\/2529868\/Defective-nuclear-localization-of-p53-protein-in-a","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T03:44:05Z","timestamp":1583293445000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/carcin\/article-lookup\/doi\/10.1093\/carcin\/21.9.1631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9]]},"references-count":30,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2000,9]]},"published-print":{"date-parts":[[2000,9]]}},"URL":"https:\/\/doi.org\/10.1093\/carcin\/21.9.1631","relation":{},"ISSN":["1460-2180","0143-3334"],"issn-type":[{"value":"1460-2180","type":"electronic"},{"value":"0143-3334","type":"print"}],"subject":[],"published":{"date-parts":[[2000,9]]}}}