{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T13:16:04Z","timestamp":1774617364718,"version":"3.50.1"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,2]]},"DOI":"10.1093\/carcin\/23.2.317","type":"journal-article","created":{"date-parts":[[2002,9,30]],"date-time":"2002-09-30T18:33:00Z","timestamp":1033410780000},"page":"317-321","source":"Crossref","is-referenced-by-count":49,"title":["Effects of the isoflavone 4\u2032,5,7-trihydroxyisoflavone (genistein) on psoralen plus ultraviolet A radiation (PUVA)-induced photodamage"],"prefix":"10.1093","volume":"23","author":[{"given":"Eileen Q.","family":"Shyong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Lazinsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rao N.","family":"Saladi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert G.","family":"Phelps","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa M.","family":"Austin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Lebwohl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huachen","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2002,2]]},"reference":[{"key":"key\n\t\t\t\t20170725014704_R1","doi-asserted-by":"crossref","unstructured":"Momtaz,K. and Fitzpatrick,T.B. (1998) The benefits and risks of long-term PUVA photochemotherapy. Dermatol. Clin., 16, 227\u2013234.","DOI":"10.1016\/S0733-8635(05)70005-X"},{"key":"key\n\t\t\t\t20170725014704_R2","unstructured":"Gunther,E.J., Yeasky,T.M., Gasparro,F.P. and Glazer,P.M. (1995) Mutagenesis by 8-methoxypsoralen and 5-methylangelicin photoadducts in mouse fibroblasts: mutations at cross-linkable sites induced by offoadducts as well as cross-links. Cancer Res., 55, 1283\u20131288."},{"key":"key\n\t\t\t\t20170725014704_R3","doi-asserted-by":"crossref","unstructured":"Yang,S.-C., Lin,J.-G., Chiou,C.-C., Chen,L.-Y. and Yang,J.-L. (1994) Mutation specificity of 8-methoxypsoralen plus two doses of UVA irradiation in the hprt gene in diploid human fibroblasts. Carcinogenesis, 15, 201\u2013207.","DOI":"10.1093\/carcin\/15.2.201"},{"key":"key\n\t\t\t\t20170725014704_R4","unstructured":"Kripke,M.L., Morison,W.L. and Parrish,J.A. (1982) Induction and transplantation of murine skin cancers induced by methox salen plus ultraviolet (320\u2013400 nm) radiation. J. Natl Cancer Inst., 68, 685\u2013690."},{"key":"key\n\t\t\t\t20170725014704_R5","doi-asserted-by":"crossref","unstructured":"Morison,W.L., Wimberly,J., Parrish,J.A. and Bloch,K.J. (1983) Abnormal lymphocyte function following long-term PUVA therapy for psoriasis. Br. J. Dermatol., 18, 445\u2013450.","DOI":"10.1111\/j.1365-2133.1983.tb04597.x"},{"key":"key\n\t\t\t\t20170725014704_R6","doi-asserted-by":"crossref","unstructured":"Moscicki,R.A., Morison,W.L., Parrish,J.A., Bloch,K.J. and Colvin,R.B. (1982) Reduction of the function of circulating helper-inducer T-cell identified by monoclonal antibodies in psoriatic patients treated with long-term 8-MOP\/ultraviolet-A radiation (PUVA). J. Invest. Dermatol., 79, 205\u2013208.","DOI":"10.1111\/1523-1747.ep12500058"},{"key":"key\n\t\t\t\t20170725014704_R7","doi-asserted-by":"crossref","unstructured":"Wang,S.Q., Setlow,R., Berwick,M., Polsky,D., Marghoob,A.A., Kopf,A.W. and Bart,R.S. (2001) Ultraviolet A and melanoma: a review. J. Am. Acad. Dermatol., 44, 837\u2013846.","DOI":"10.1067\/mjd.2001.114594"},{"key":"key\n\t\t\t\t20170725014704_R8","doi-asserted-by":"crossref","unstructured":"Wolff,K. (1988) Side-effects of psoralen photochemotherapy (PUVA). Br. J. Dermatol., 122 (Suppl. 36), 117\u2013125.","DOI":"10.1111\/j.1365-2133.1990.tb02889.x"},{"key":"key\n\t\t\t\t20170725014704_R9","doi-asserted-by":"crossref","unstructured":"Nataraj,A.J., Black,H.S. and Ananthaswamy,H.N. (1996) Signature p53 mutation at DNA cross-linking sites in 8-methoxypsoralen and ultraviolet A (PUVA)-induced murine skin cancers. Proc. Natl Acad. Sci. USA, 93, 7961\u20137965.","DOI":"10.1073\/pnas.93.15.7961"},{"key":"key\n\t\t\t\t20170725014704_R10","doi-asserted-by":"crossref","unstructured":"Liu,Z., Lu,Y., Lebwohl,M. and Wei,H. (1999) PUVA (8-methoxy-psoralen plus ultraviolet A) induces the formation of 8-hydroxy-2\u2032-deoxyguanosine and DNA fragmentation in calf thymus DNA and human epidermoid carcinoma cells. Free Radic. Biol. Med., 27, 127\u2013133.","DOI":"10.1016\/S0891-5849(99)00058-1"},{"key":"key\n\t\t\t\t20170725014704_R11","unstructured":"Setchell,K.D.R., Borriello,S.P., Kirk,D.N. and Axelson,M. (1984) Nonsteroidal estrogens of dietary origin: Possible role in hormone-dependent disease. Am. J. Clin. Nutr., 40, 569\u2013578."},{"key":"key\n\t\t\t\t20170725014704_R12","doi-asserted-by":"crossref","unstructured":"Shimizu,H., Ross,R.K., Bernstein,L., Yatani,R., Henerson,B.E. and Mack,T.M. (1991) Cancers of the prostate and breast among Japanese and white immigrants in Los Angeles County. Br. J. Cancer, 63, 963\u2013966.","DOI":"10.1038\/bjc.1991.210"},{"key":"key\n\t\t\t\t20170725014704_R13","unstructured":"Tominga,S. (1985) Cancer incidence in Japanese in Japan, Hawaii, and western United States. Natl Cancer Inst. Monogr., 69, 83\u201392."},{"key":"key\n\t\t\t\t20170725014704_R14","doi-asserted-by":"crossref","unstructured":"Messina,M. and Barnes,S. (1991) The role of soy products in reducing risk of cancer. J. Natl Cancer Inst., 83, 541\u2013546.","DOI":"10.1093\/jnci\/83.8.541"},{"key":"key\n\t\t\t\t20170725014704_R15","doi-asserted-by":"crossref","unstructured":"Troll,W., Klassen,A. and Janoff,A. (1970) Tumorigenesis in mouse skin: Inhibition by synthetic inhibitors of proteases. Science, 169, 1211\u20131213.","DOI":"10.1126\/science.169.3951.1211"},{"key":"key\n\t\t\t\t20170725014704_R16","doi-asserted-by":"crossref","unstructured":"Troll,W., Weisner,R., Shellabarger,C.J., Holtzman,S. and Stone,J.P. (1980) Soybean diet lowers breast tumor incidence in irradiated rats. Carcinogenesis, 1, 469\u2013472.","DOI":"10.1093\/carcin\/1.6.469"},{"key":"key\n\t\t\t\t20170725014704_R17","doi-asserted-by":"crossref","unstructured":"Becher,F.F. (1981) Inhibition of spontaneous hepatocarcinogenesis in C3H\/HEN mice by Edipro A and isolated soy protein. Carcinogenesis, 2, 1213\u20131214.","DOI":"10.1093\/carcin\/2.11.1213"},{"key":"key\n\t\t\t\t20170725014704_R18","unstructured":"Akiyama,T., Ishida,J., Nakagawa,S., Ogawara,H., Watanabe,S., Itoh,N., Shibuya,M. and Fukami,Y. (1987) Genistein, a specific inhibitor of tyrosine-specific protein kinases. J. Biol. Chem., 262, 5592\u20135595."},{"key":"key\n\t\t\t\t20170725014704_R19","doi-asserted-by":"crossref","unstructured":"Wei,H., Wei,L., Frenkel,K., Bowen,R. and Barnes,S. (1993) Inhibition of tumor promoter-induced hydrogen peroxide production in vitro and in vivo by genistein. Nutr. Cancer, 2, 1\u201312.","DOI":"10.1080\/01635589309514265"},{"key":"key\n\t\t\t\t20170725014704_R20","doi-asserted-by":"crossref","unstructured":"Wei,H., Barnes,S. and Wang,Y. (1996) The inhibitory effect of genistein on a tumor promoter c-fos and c-jun expression in mouse skin. Oncol. Rep., 3, 125\u2013128.","DOI":"10.3892\/or.3.1.125"},{"key":"key\n\t\t\t\t20170725014704_R21","doi-asserted-by":"crossref","unstructured":"Wei,H., Bowen,R., Barnes,S., Cai,Q. and Wang,Y. (1995) Antioxidant and anticarcinogenic properties of the soybean isoflavone genistein. Proc. Soc. Exp. Biol. Med., 208, 124\u2013130.","DOI":"10.3181\/00379727-208-43844"},{"key":"key\n\t\t\t\t20170725014704_R22","doi-asserted-by":"crossref","unstructured":"Wang,Y., Yaping,E., Zhang,X., Lebwohl,M., DeLeo,V. and Wei,H. (1998) Inhibition of ultraviolet B (UVB)-induced c-fos and c-jun expression in vivo by a protein tyrosine kinase inhibitor genistein. Carcinogenesis, 19, 649\u2013654.","DOI":"10.1093\/carcin\/19.4.649"},{"key":"key\n\t\t\t\t20170725014704_R23","doi-asserted-by":"crossref","unstructured":"Wei,H., Bowen,R., Zhang,X. and Lebwohl,M. (1998) Isoflavone genistein inhibits the initiation and promotion of two-stage skin carcinogenesis in mice. Carcinogenesis, 19, 1509\u20131514.","DOI":"10.1093\/carcin\/19.8.1509"},{"key":"key\n\t\t\t\t20170725014704_R24","doi-asserted-by":"crossref","unstructured":"Wei,H. (1998) Photoprotective action of isoflavone genistein: Models, mechanisms, and relevance to clinical dermatology. J. Am. Acad. Dermatol., 39, 271\u2013272.","DOI":"10.1016\/S0190-9622(98)70099-4"},{"key":"key\n\t\t\t\t20170725014704_R25","unstructured":"Wei,H., Spencer,J., Gelfand,J., Phelps,R. and Lebwohl,M. (2001) The isoflavone genistein, a new agent in dermatology? Cosmet. Dermatol., 14, 13\u201319."},{"key":"key\n\t\t\t\t20170725014704_R26","doi-asserted-by":"crossref","unstructured":"Kim,J.W., Won,J., Sohn,S. and Joe,C.O. (2000) DNA-binding activity of the N-terminal cleavage product of poly(ADP-ribose) polymerase is required for UV mediated apoptosis. J. Cell. Sci., 113, 955\u2013961.","DOI":"10.1242\/jcs.113.6.955"},{"key":"key\n\t\t\t\t20170725014704_R27","doi-asserted-by":"crossref","unstructured":"Fernet,M., Ponette,V., Deniaud-Alexandre,E., Menissier de Murcia,J., De Murcia,G., Giocanti,N., Megnin-Chanet,F. and Favaudon,V. (2000) Poly(ADP-ribose) polymerase, a major determinant of early cell response to ionizing radiation. Int. J. Radiat. Biol.,76, 1621\u20131629.","DOI":"10.1080\/09553000050201118"},{"key":"key\n\t\t\t\t20170725014704_R28","doi-asserted-by":"crossref","unstructured":"Chan,W.-H. and Yu,J.-S. (2000) Inhibition of UV irradiation-induced oxidative stress and apoptotic biochemical changes in human epidermal carcinoma A431 cells by genistein. J. Cell. Biochem., 78, 73\u201384.","DOI":"10.1002\/(SICI)1097-4644(20000701)78:1<73::AID-JCB7>3.0.CO;2-P"},{"key":"key\n\t\t\t\t20170725014704_R29","doi-asserted-by":"crossref","unstructured":"Thornberry,N.A. and Lazebnik,Y. (1998) Caspases: enemies within. Science, 281, 1312\u20131316.","DOI":"10.1126\/science.281.5381.1312"},{"key":"key\n\t\t\t\t20170725014704_R30","doi-asserted-by":"crossref","unstructured":"Stadelmann,C. and Lassmann,H. (2000) Detection of apoptosis in tissue sections. Cell Tissue Res., 301, 19\u201331.","DOI":"10.1007\/s004410000203"},{"key":"key\n\t\t\t\t20170725014704_R31","doi-asserted-by":"crossref","unstructured":"Cryns,V. and Yuan,J. (1998) Proteases to die for. Genes Dev.,125, 1551\u20131570.","DOI":"10.1101\/gad.12.11.1551"},{"key":"key\n\t\t\t\t20170725014704_R32","doi-asserted-by":"crossref","unstructured":"Tewari,M., Quan,L.T., O'Rourke,K., Desnoyers,S., Zeng,Z., Beidler,D.R., Poirier,G.G., Salvesen,G.S. and Dixit,V.M. (1995) Yama\/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell, 81, 801\u2013809.","DOI":"10.1016\/0092-8674(95)90541-3"},{"key":"key\n\t\t\t\t20170725014704_R33","doi-asserted-by":"crossref","unstructured":"B\u00fcrkle,A. (2001) Poly(APD-ribosyl)ation, a DNA damage-driven protein modification and regulator of genomic instability. Cancer Lett., 163, 1\u20135.","DOI":"10.1016\/S0304-3835(00)00694-7"},{"key":"key\n\t\t\t\t20170725014704_R34","doi-asserted-by":"crossref","unstructured":"Herceg,Z. and Wang,Z.Q. (2001) Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death. Mutat. Res., 477, 97\u2013110.","DOI":"10.1016\/S0027-5107(01)00111-7"},{"key":"key\n\t\t\t\t20170725014704_R35","doi-asserted-by":"crossref","unstructured":"Liu,Z., Lu,Y., Lebwohl,M. and Wei,H. (1999) PUVA (8-methoxy-psoralen plus ultraviolet A) induces the formation of 8-hydroxy-2\u2032-deoxyguanosine and DNA fragmentation in calf thymus DNA and human epidermoid carcinoma cells. Free Radic. Biol. Med., 27,127\u2013133.","DOI":"10.1016\/S0891-5849(99)00058-1"},{"key":"key\n\t\t\t\t20170725014704_R36","doi-asserted-by":"crossref","unstructured":"Shivji,K.K., Kenny,M.K. and Wood,R.D. (1992) Proliferating cell nuclear antigen is required for DNA excision repair. Cell, 69, 367\u2013374.","DOI":"10.1016\/0092-8674(92)90416-A"},{"key":"key\n\t\t\t\t20170725014704_R37","unstructured":"Yang,G., Wang,Z.Y., Kim,S., Liao,J., Seril,D.N., Chen,X., Smith,T.J. and Yang,C.S. (1997) Characterization of early pulmonary hyperproliferation and tumor progression and their inhibition by black tea in a 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis model with A\/J mice. Cancer Res., 57, 1889\u20131894."},{"key":"key\n\t\t\t\t20170725014704_R38","doi-asserted-by":"crossref","unstructured":"Celis,J.E. and Madson,P. (1986) Increased nuclear cyclin\/PCNA antigen staining of non S-phase transformed human amnion cells engaged in nucleotide excision DNA repair. FEBS Lett., 209, 277\u2013283.","DOI":"10.1016\/0014-5793(86)81127-9"},{"key":"key\n\t\t\t\t20170725014704_R39","unstructured":"Boone,C.W., Keloff,G.J. and Steele,V.E. (1992) Natural history of intraepithelial neoplasia in humans with implications for cancer chemoprevention strategy. Cancer Res., 52, 1651\u20131659."}],"container-title":["Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/carcin\/article-pdf\/23\/2\/317\/19254521\/230317.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T19:04:37Z","timestamp":1682363077000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/carcin\/article-lookup\/doi\/10.1093\/carcin\/23.2.317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,2]]},"references-count":39,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2002,2]]},"published-print":{"date-parts":[[2002,2]]}},"URL":"https:\/\/doi.org\/10.1093\/carcin\/23.2.317","relation":{},"ISSN":["1460-2180","0143-3334"],"issn-type":[{"value":"1460-2180","type":"electronic"},{"value":"0143-3334","type":"print"}],"subject":[],"published":{"date-parts":[[2002,2]]}}}