{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:42:21Z","timestamp":1788327741519,"version":"build-2803163510"},"reference-count":72,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,6]]},"DOI":"10.1093\/carcin\/23.6.929","type":"journal-article","created":{"date-parts":[[2002,7,28]],"date-time":"2002-07-28T22:39:17Z","timestamp":1027895957000},"page":"929-941","source":"Crossref","is-referenced-by-count":85,"title":["Nitric oxide mediates apoptosis induction selectively in transformed fibroblasts compared to nontransformed fibroblasts"],"prefix":"10.1093","volume":"23","author":[{"given":"Stefanie","family":"Heigold","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Sers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wibke","family":"Bechtel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Ivanovas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhold","family":"Sch\u00e4fer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2002,6]]},"reference":[{"key":"key\n\t\t\t\t20170725014955_R1","doi-asserted-by":"crossref","unstructured":"Whittle,B.J., Jr. (1995) Nitric oxide in physiology and pathology. Histochem. J., 27, 727\u2013737.","DOI":"10.1007\/BF02388298"},{"key":"key\n\t\t\t\t20170725014955_R2","doi-asserted-by":"crossref","unstructured":"Lancaster,J.R., Jr. (1994) Simulation of the diffusion and reaction of endogenously produced nitric oxide. Proc. Natl Acad. Sci. USA, 91, 8137\u20138141.","DOI":"10.1073\/pnas.91.17.8137"},{"key":"key\n\t\t\t\t20170725014955_R3","doi-asserted-by":"crossref","unstructured":"Berendji,D., Kolb-Bachofen,V., Meier,K.L. and Kroencke,K.D. (1999). Influence of nitric oxide on the intracellular reduced glutathione pool: different cellular capacities and strategies to encounter nitric oxide-mediated stress. Free Rad. Biol. Med., 27, 773\u2013780.","DOI":"10.1016\/S0891-5849(99)00123-9"},{"key":"key\n\t\t\t\t20170725014955_R4","unstructured":"Kroencke,K.D., Berendji,D. and Kolb-Bachofen,V. (1998) Nitric oxide as a potent regulator of gene expression via interaction with the zinc finger transcription factor SP1. Nitric oxide, 2, 86."},{"key":"key\n\t\t\t\t20170725014955_R5","unstructured":"Sandau,K.B. and Bruene,B. (2000) Molecular actions of nitric oxide in mesangial cells. Histol. Histopathol.,15, 1151\u20131158."},{"key":"key\n\t\t\t\t20170725014955_R6","doi-asserted-by":"crossref","unstructured":"Huie,R.E. and Padmaja,S. (1993) The reaction of NO with superoxide. Free Rad. Res. Commun., 18, 195\u2013199.","DOI":"10.3109\/10715769309145868"},{"key":"key\n\t\t\t\t20170725014955_R7","doi-asserted-by":"crossref","unstructured":"Koppenol,W.H., Moreno,J.J., Pryor,W.A., Ischiropoulos,H. and Beckman,J.S. (1992) Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide. Chem. Res. Toxicol., 5, 834\u2013842.","DOI":"10.1021\/tx00030a017"},{"key":"key\n\t\t\t\t20170725014955_R8","doi-asserted-by":"crossref","unstructured":"Pryor,W.A. and Squadrito,G.L. (1995) The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide. Am. J. Physiol., 268, L699\u2013L722.","DOI":"10.1152\/ajplung.1995.268.5.L699"},{"key":"key\n\t\t\t\t20170725014955_R9","unstructured":"Radi,R., Beckman,J.S., Bush,K.M. and Freeman,B.A. (1991) Peroxynitrite oxidation of sulfhydryls: the cytotoxic potential of superoxide and nitric oxide. J. Biol. Chem., 266, 4244\u20134250."},{"key":"key\n\t\t\t\t20170725014955_R10","doi-asserted-by":"crossref","unstructured":"Beckman,J.S., Ischiropoulos,H., Zhu,L., Van der Woerd,M., Smith Chen,J., Harrison,J., Martin.,J.C. and Tsai,M. (1992) Kinetics of superoxide dismutase- and iron-catalyzed nitration of phenolics by peroxynitrite. Arch. Biochem. Biophys., 298, 438\u2013445.","DOI":"10.1016\/0003-9861(92)90432-V"},{"key":"key\n\t\t\t\t20170725014955_R11","doi-asserted-by":"crossref","unstructured":"Van der Vliet,A., O`Neill,C.A., Halliwell,B., Cross,C.E. and Kaur,H. (1994) Aromatic hydroxylation and nitration of phenylalanine and tyrosine by peroxynitrite: evidence for hydroxyl radical production from peroxynitrite. FEBS Lett., 339, 89\u201392.","DOI":"10.1016\/0014-5793(94)80391-9"},{"key":"key\n\t\t\t\t20170725014955_R12","unstructured":"Van der Vliet,A., T`Hoen,P.A.C., Wong,P.S.Y., Bast,A. and Cross,C.E. (1998) Formation of nitrosothiols via direct nucleophilic nitrosation of thiols by peroxynitrite with elimination of hydrogen peroxide. J. Biol. Chem., 273, 30255\u201330262."},{"key":"key\n\t\t\t\t20170725014955_R13","doi-asserted-by":"crossref","unstructured":"Wink,D.A., Cook,J.A., Kim,S.Y., et al. (1997) Superoxide modulates the oxidation and nitrosation of thiols by nitric oxide-derived intermediates. J. Biol. Chem., 272, 11147\u201311151.","DOI":"10.1074\/jbc.272.17.11147"},{"key":"key\n\t\t\t\t20170725014955_R14","doi-asserted-by":"crossref","unstructured":"Radi,R., Beckman,J.S., Bush,K.M. and Freeman,B.A. (1991) Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxide. Arch. Biochem. Biophys.,288, 481\u2013487.","DOI":"10.1016\/0003-9861(91)90224-7"},{"key":"key\n\t\t\t\t20170725014955_R15","doi-asserted-by":"crossref","unstructured":"Arteel,G.E., Briviba,K. and Sies,H. (1999) Protection against peroxynitrite. FEBS Lett., 445, 226\u2013230.","DOI":"10.1016\/S0014-5793(99)00073-3"},{"key":"key\n\t\t\t\t20170725014955_R16","doi-asserted-by":"crossref","unstructured":"Sies H., Sharov,V.S., Klotz,L.A. and Briviba,K. (1997) Glutathione peroxidase protects against peroxynitrite-mediated oxidations: a new function for selenoproteins as peroxynitrite reductase. J. Biol. Chem., 272, 27812\u201327817.","DOI":"10.1074\/jbc.272.44.27812"},{"key":"key\n\t\t\t\t20170725014955_R17","doi-asserted-by":"crossref","unstructured":"Misko,T.P., Highkin,M.K., Veenhuizen,A.W., Manning,P.T., Stern,M.K., Currie,M.G. and Salvemini,D. (1998) Characterization of the cytoprotective action of peroxynitrite decomposition catalysts. J. Biol. Chem., 273, 15646\u201315653.","DOI":"10.1074\/jbc.273.25.15646"},{"key":"key\n\t\t\t\t20170725014955_R18","doi-asserted-by":"crossref","unstructured":"Salvemini,D., Wang,Z.-Q., Stern,M.K., Currie,M.G. and Misko,T.P. (1998) Peroxynitrite decomposition catalysts: Therapeutics for peroxynitrite-mediated pathology. Proc. Natl Acad. Sci. USA, 95, 2659\u20132663.","DOI":"10.1073\/pnas.95.5.2659"},{"key":"key\n\t\t\t\t20170725014955_R19","doi-asserted-by":"crossref","unstructured":"Macmillan Crow,L.A., Crow,J.P. and Thompson,J.A. (1998) Peroxynitrite-mediated inactivation of manganese superoxide dismutase involves nitration and oxidation of critical tyrosine residues. Biochemistry, 37, 1613\u20131622.","DOI":"10.1021\/bi971894b"},{"key":"key\n\t\t\t\t20170725014955_R20","doi-asserted-by":"crossref","unstructured":"Padmaja,S., Squadrito,G.L. and Pryor,W.A. (1998) Inactivation of glutathione peroxidase by peroxynitrite. Arch. Biochem. Biophys., 349, 1\u20136.","DOI":"10.1006\/abbi.1997.0407"},{"key":"key\n\t\t\t\t20170725014955_R21","doi-asserted-by":"crossref","unstructured":"Beckman,J.S. and Koppenol,W.H. (1996). Nitric oxide, superoxide and peroxynitrite: the good, the bad and the ugly. Am. J. Physiol. Cell Physiol.,271, C1424\u2013C1437.","DOI":"10.1152\/ajpcell.1996.271.5.C1424"},{"key":"key\n\t\t\t\t20170725014955_R22","doi-asserted-by":"crossref","unstructured":"Murphy,M., Packer,M.A., Scarlett,J.L. and Martin,S.W. (1998) Peroxynitrite: a biologically significant oxidant. Gen. Pharmacol.,31, 179\u2013186.","DOI":"10.1016\/S0306-3623(97)00418-7"},{"key":"key\n\t\t\t\t20170725014955_R23","doi-asserted-by":"crossref","unstructured":"Fast,D.J., Lynch,R.C. and Leu,R.W. (1992) Nitric oxide production by tumor targets in response to TNF: paradoxical correlation with susceptibility to TNF-mediated cytotoxicity without direct involvement in the cytotoxic mechanism.J. Leukocyte Biol., 52, 255\u2013261.","DOI":"10.1002\/jlb.52.3.255"},{"key":"key\n\t\t\t\t20170725014955_R24","unstructured":"Bauer,G. (2000) Reactive oxygen and nitrogen species: efficient, selective and interactive signals during intercellular induction of apoptosis. Anticancer Res., 20, 4115\u20134140."},{"key":"key\n\t\t\t\t20170725014955_R25","unstructured":"Fehsel,K., Kroencke,K.D., Meyer,K.L., Huber,H., Wahn,V. and Kolb-Bachofen,V. (1995) Nitric oxide induces apoptosis in mouse thymocytes. J. Immunol., 155, 2858\u20132865."},{"key":"key\n\t\t\t\t20170725014955_R26","doi-asserted-by":"crossref","unstructured":"Kolb,J.P. (2000) Mechanisms involved in pro- and antiapoptotic role of NO in human leukemia. Leukemia (Basingstoke), 14, 1685\u20131694.","DOI":"10.1038\/sj.leu.2401896"},{"key":"key\n\t\t\t\t20170725014955_R27","doi-asserted-by":"crossref","unstructured":"Crow,J.P. and Beckman,J.S. (1996) The importance of superoxide in nitric oxide-dependent toxicity: evidence for peroxynitrite mediated injury. Adv. Exp. Med. Biol., 387, 147\u2013161.","DOI":"10.1007\/978-1-4757-9480-9_21"},{"key":"key\n\t\t\t\t20170725014955_R28","doi-asserted-by":"crossref","unstructured":"Jun,C.D., Lee,D.K., Chun,Y.H., et al. (1996) High-dose nitric oxide induces apoptosis in HL-60 human myeloid leukemia cells. Exp. Mol. Med., 28, 101\u2013108.","DOI":"10.1038\/emm.1996.16"},{"key":"key\n\t\t\t\t20170725014955_R29","doi-asserted-by":"crossref","unstructured":"Lin,K.T., Xue,J.Y., Nomen,M., Spur,B. and Wong,P.Y.K. (1995) Peroxynitrite-induced apoptosis in HL-60 cells. J. Biol. Chem., 270, 16487\u201316490.","DOI":"10.1074\/jbc.270.28.16487"},{"key":"key\n\t\t\t\t20170725014955_R30","doi-asserted-by":"crossref","unstructured":"Yabuki,M., Kariya,S., Ishisaka,R., Yasuda,T., Yoshioka,T., Horton,A.A. and Utsumi,K. (1999) Resistance to nitric oxide-mediated apoptosis in HL-60 variant cells is associated with increased activities of Cu,Zn-superoxide dismutase and catalase. Free Rad Biol. Med., 26, 325\u2013332.","DOI":"10.1016\/S0891-5849(98)00203-2"},{"key":"key\n\t\t\t\t20170725014955_R31","doi-asserted-by":"crossref","unstructured":"Keller,J.N., Kindy,M.S., Holtsberg,F.W., et al. (1998) Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury \u2013 suppression of peroxynitrite production, lipid peroxidation and mitochondrial dysfunction. J. Neurosci., 18, 687\u2013697.","DOI":"10.1523\/JNEUROSCI.18-02-00687.1998"},{"key":"key\n\t\t\t\t20170725014955_R32","unstructured":"Troy,C.M., Derossi,D., Prochiantz,A., Greene,L.A. and Shelanski,M.L. (1996) Downregulation of Cu\/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathway. J. Neurosci., 16, 253\u2013261."},{"key":"key\n\t\t\t\t20170725014955_R33","doi-asserted-by":"crossref","unstructured":"Hogg,N. and Kalyanaraman,B. (1999) Nitric oxide and lipid peroxidation. Biochem. Biophys. Acta, 1411, 378\u2013384.","DOI":"10.1016\/S0005-2728(99)00027-4"},{"key":"key\n\t\t\t\t20170725014955_R34","doi-asserted-by":"crossref","unstructured":"Padmaja,S. and Huie,R.E. (1993). The reaction of nitric oxide with organic peroxyl radicals. Biochem. Biophys. Res. Commun.,195, 539\u2013544.","DOI":"10.1006\/bbrc.1993.2079"},{"key":"key\n\t\t\t\t20170725014955_R35","doi-asserted-by":"crossref","unstructured":"Lin,K.T., Xue,J.Y., Lin,M.C., Spokas,E.G., Sun,F.F. and Wong,P.Y.K. (1998) Peroxynitrite induces apoptosis of HL-60 cells by activation of a caspase-3 family protease. Am. J. Physiol. Cell Physiol.,43, 855\u2013860.","DOI":"10.1152\/ajpcell.1998.274.4.C855"},{"key":"key\n\t\t\t\t20170725014955_R36","doi-asserted-by":"crossref","unstructured":"Li,J.R., Billiar,T.R., Talanian,R.V. and Kim,Y.M. (1997). Nitric oxide reversibly inhibits seven members of the caspase family via S-nitrosylation. Biochem. Biophys. Res. Commun., 240, 419\u2013424.","DOI":"10.1006\/bbrc.1997.7672"},{"key":"key\n\t\t\t\t20170725014955_R37","doi-asserted-by":"crossref","unstructured":"Packer,M.A. and Murphy,M.P. (1995) Peroxynitrite formed by simultaneous nitric acid and superoxide generation causes cyclosporin-A-sensitive mitochondrial calcium efflux and depolarisation. Eur. J. Biochem., 234, 231\u2013239.","DOI":"10.1111\/j.1432-1033.1995.231_c.x"},{"key":"key\n\t\t\t\t20170725014955_R38","doi-asserted-by":"crossref","unstructured":"Irani,K., Xia,Y., Zweier,J.L., Sollott,S. J., Der,C.J., Fearon,E.R., Sundaresan,M., Finkel,T. and Goldschmidt-Clermont,P.J. (1997) Mitogenic signalling by oxidants in Ras-transformed fibroblasts. Science, 275, 1649\u20131652.","DOI":"10.1126\/science.275.5306.1649"},{"key":"key\n\t\t\t\t20170725014955_R39","doi-asserted-by":"crossref","unstructured":"Suh,Y.-A., Arnold,R.S., Lassegue,B., Shi,J., Xu,X., Sorescu,D., Chung,A.B., Griendling,K. K. and Lambeth,J.D. (1999) Cell transformation by the superoxide-generating oxidase Mox1. Nature, 401, 79\u201382.","DOI":"10.1038\/43459"},{"key":"key\n\t\t\t\t20170725014955_R40","doi-asserted-by":"crossref","unstructured":"Sundaresan,M., Yu,Z.X., Ferrans,V.J., Sulciner,D.L., Gutkind,J.S., Irani,K., Goldschmidt-Clermont,P.J. and Finkel,T. (1996) Regulation of reactive oxygen species generation in fibroblasts by rac 1. Biochem. J., 318, 379\u2013382.","DOI":"10.1042\/bj3180379"},{"key":"key\n\t\t\t\t20170725014955_R41","doi-asserted-by":"crossref","unstructured":"Erpel,T. and Courtneidge,S.A. (1995) Src family protein tyrosine kinases and cellular signal transduction pathways. Curr. Opin. Cell Biol.7, 176\u2013182.","DOI":"10.1016\/0955-0674(95)80025-5"},{"key":"key\n\t\t\t\t20170725014955_R42","doi-asserted-by":"crossref","unstructured":"J\u00fcrgensmeier,J.M., Panse,J., Sch\u00e4fer,R. and Bauer,G. (1997) Reactive oxygen species as mediators of the transformed phenotype. Int. J. Cancer, 70, 587\u2013589.","DOI":"10.1002\/(SICI)1097-0215(19970304)70:5<587::AID-IJC16>3.0.CO;2-A"},{"key":"key\n\t\t\t\t20170725014955_R43","doi-asserted-by":"crossref","unstructured":"Morre,D.J., Chueh,P.J. and Morre,D.M. (1995) Capsaicin inhibits preferentially the NADH oxidase and growth of transformed cells in culture. Proc. Natl Acad. Sci. USA, 92, 1831\u20131835.","DOI":"10.1073\/pnas.92.6.1831"},{"key":"key\n\t\t\t\t20170725014955_R44","doi-asserted-by":"crossref","unstructured":"Morre,D.J. and Reust,T. (1997) A circulating form of NADH oxidase activity responsive to the antitumor sulfonylurea n-4-(methylphenylsulfonyl)-N\u2032-(4-chlorophenyl)urea (LY181984) specific to sera from cancer patients. J. Bioenerg. Biomemb., 29, 281\u2013289.","DOI":"10.1023\/A:1022466212083"},{"key":"key\n\t\t\t\t20170725014955_R45","doi-asserted-by":"crossref","unstructured":"Ohta,K., Rosner,G. and Graf,R. (1997) Nitric oxide generation from sodium nitroprusside and hydroxylamine in brain. Neuroreport, 8, 22229\u20132235.","DOI":"10.1097\/00001756-199707070-00028"},{"key":"key\n\t\t\t\t20170725014955_R46","doi-asserted-by":"crossref","unstructured":"Terwel,D., Nieland,L.J.M., Schutte,B., Reutelingsperger,C.P.M., Ramaekers,F.C.S. and Steinbusch,H.W.M. (2000) S-nitroso-N-acetylpenicillamine and nitroprusside induce apoptosis in a neuronal cell line by the production of different reactive molecules. Eur. J. Pharmacol., 400, 19\u201333.","DOI":"10.1016\/S0014-2999(00)00379-4"},{"key":"key\n\t\t\t\t20170725014955_R47","doi-asserted-by":"crossref","unstructured":"Keefer,L.K., Nims,R.W., Davies,K.M. and Wink,D.A. (1996) `NONOates' (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage forms. Methods Enzymol., 268, 281\u2013293.","DOI":"10.1016\/S0076-6879(96)68030-6"},{"key":"key\n\t\t\t\t20170725014955_R48","doi-asserted-by":"crossref","unstructured":"Konorev,E.A., Kennedy,M.C. and Kalyanaraman,B. (1999) Cell-permeable superoxide dismutase and glutathione peroxidase mimetics afford superior protection against doxorubicin-induced cardiotoxicity: the role of reactive oxygen and nitrogen intermediates. Arch. Biochem. Biophys., 368, 421\u2013428.","DOI":"10.1006\/abbi.1999.1337"},{"key":"key\n\t\t\t\t20170725014955_R49","doi-asserted-by":"crossref","unstructured":"Estevez,A.G., Sampson J.B., Zhuang,Y.X., Spear,N., Richardson,G.J., Crow,J.P., Tarpey,M.M., Barbeito,L. and Beckman,J.S. (2000) Liposome-delivered superoxide dismutase prevents nitric oxide-dependent motor neuron death induced by trophic factor withdrawal. Free Rad. Biol. Med.28, 437\u2013446.","DOI":"10.1016\/S0891-5849(99)00261-0"},{"key":"key\n\t\t\t\t20170725014955_R50","doi-asserted-by":"crossref","unstructured":"Liochev,S.I. and Fridovich,I. (2001) Copper, zinc superoxide dismutase as a univalent NO\u2212 oxidoreductase and as a dichlorofluorescin peroxidase. J. Biol. Chem., 276, 35253\u201335257.","DOI":"10.1074\/jbc.M104237200"},{"key":"key\n\t\t\t\t20170725014955_R51","unstructured":"T`Hart,B.A., Simons,J.M., Knaan Shanzer,S., Bakker,N.P.M. and Labadie,R.P. (1990) Antiarthritic activity of the newly developed neutrophil oxidative burst antagonist apocynin. Free Rad. Biol. Med., 9, 127\u2013132."},{"key":"key\n\t\t\t\t20170725014955_R52","doi-asserted-by":"crossref","unstructured":"Stolk,J., Hiltermann,T.J.N., Dijkman,J.H. and Verhoeven,A.J. (1994) Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol. Am. J. Respir. Cell Mol., 11, 95\u2013102.","DOI":"10.1165\/ajrcmb.11.1.8018341"},{"key":"key\n\t\t\t\t20170725014955_R53","doi-asserted-by":"crossref","unstructured":"Muijsers,R.B.R., van den Worm,E., Folkerts,G., Beukelman,C.J., Koster,A.S., Postma,D.S. and Nijkamp,F.P. (2000) Apocynin inhibits peroxynitrite formation by macrophages. Br. J. Pharmacol., 130, 932\u2013936.","DOI":"10.1038\/sj.bjp.0703401"},{"key":"key\n\t\t\t\t20170725014955_R54","doi-asserted-by":"crossref","unstructured":"Yang,C.F., Shen,H.M. and Ong,C.N. (1999) Protective effect of ebselen against hydrogen peroxide-induced cytotoxicity and DNA damage in HepG2 cells. Biochem. Pharmacol.,57, 273\u2013279.","DOI":"10.1016\/S0006-2952(98)00299-8"},{"key":"key\n\t\t\t\t20170725014955_R55","doi-asserted-by":"crossref","unstructured":"Schwieger,A., Bauer,L., Sers,C., Hanusch,J., Sch\u00e4fer,R. and Bauer,G. (2001) Ras oncogene expression determines sensitivity for intercellular induction of apoptosis. Carcinogenesis, 22, 1385\u20131392.","DOI":"10.1093\/carcin\/22.9.1385"},{"key":"key\n\t\t\t\t20170725014955_R56","doi-asserted-by":"crossref","unstructured":"Beck,E., Sch\u00e4fer,R. and Bauer,G. (1997) Sensitivity of transformed fibroblasts for intercellular induction of apoptosis is determined by their transformed phenotype. Exp. Cell Res., 234, 47\u201356.","DOI":"10.1006\/excr.1997.3587"},{"key":"key\n\t\t\t\t20170725014955_R57","doi-asserted-by":"crossref","unstructured":"Hipp,M.L. and Bauer,G. (1997) Intercellular induction of apoptosis in transformed cells does not depend on p53. Oncogene, 15, 791\u2013797.","DOI":"10.1038\/sj.onc.1201247"},{"key":"key\n\t\t\t\t20170725014955_R58","unstructured":"Gorcyca,W., Gong,J. and Darzynkiewicz,Z. (1993) Detection of DNA strand breaks in individual apoptotic cells by the in-situ terminal deoxynucleotidyl transferase and nick translation assays. Cancer Res., 53, 1945\u20131951."},{"key":"key\n\t\t\t\t20170725014955_R59","doi-asserted-by":"crossref","unstructured":"Kirsch,M. and de Groot,H. (1999) Reaction of peroxynitrite with reduced nicotinamide nucleotides, the formation of hydrogen peroxide. J. Biol. Chem., 274, 24664\u201324670.","DOI":"10.1074\/jbc.274.35.24664"},{"key":"key\n\t\t\t\t20170725014955_R60","unstructured":"Schimmel,M. and Bauer,G. Proapoptotic and redox state-related signalling of reactive oxygen species generated by transformed fibroblasts. Oncogene (in press)."},{"key":"key\n\t\t\t\t20170725014955_R61","doi-asserted-by":"crossref","unstructured":"Scaffidi,C., Fulda,S., Srinivasan,A., Friesen,C., Li,F., Tomaselli,K.J., Debatin,K.M., Krammer,P.H. and Peter,M.E. (1998) Two CD95 (Apo-1\/Fas) signalling pathways. EMBO J., 17, 1675\u20131687.","DOI":"10.1093\/emboj\/17.6.1675"},{"key":"key\n\t\t\t\t20170725014955_R62","doi-asserted-by":"crossref","unstructured":"Loeffler,M. and Kroemer,G. (2000) The mitochondrion in cell death control: certainties and incognita. Exp. Cell Res., 256, 19\u201326.","DOI":"10.1006\/excr.2000.4833"},{"key":"key\n\t\t\t\t20170725014955_R63","doi-asserted-by":"crossref","unstructured":"Kroemer,G. and Reed,J.G. (2000) Mitochondrial control of cell death. Nature Med.,6, 513\u2013519.","DOI":"10.1038\/74994"},{"key":"key\n\t\t\t\t20170725014955_R64","doi-asserted-by":"crossref","unstructured":"Engelmann,I., Dormann,S., Saran,M. and Bauer,G. (2000) Transformed target cell-derived superoxide anions drive apoptosis induction by myeloperoxidase. Redox Rep.,5, 207\u2013214.","DOI":"10.1179\/135100000101535762"},{"key":"key\n\t\t\t\t20170725014955_R65","doi-asserted-by":"crossref","unstructured":"Nappi,A.J. and Vass,E. (1998) Hydroxyl radical formation resulting from the interaction of nitric oxide and hydrogen peroxide. Biochem. Biophys. Acta, 1380, 55\u201363.","DOI":"10.1016\/S0304-4165(97)00125-6"},{"key":"key\n\t\t\t\t20170725014955_R66","doi-asserted-by":"crossref","unstructured":"Murrell,A.C., Francis,M.J.O. and Bromley,L. (1990) Modulation of fibroblast proliferation by oxygen free radicals. Biochem. J., 265, 659\u2013666.","DOI":"10.1042\/bj2650659"},{"key":"key\n\t\t\t\t20170725014955_R67","doi-asserted-by":"crossref","unstructured":"Saran,M. and Bors,W. (1994) Signalling by O2- and NO: how far can either radical, or any specific reaction product transmit a message under in vivo conditions? Chem. Biol. Interact., 90, 35\u201345.","DOI":"10.1016\/0009-2797(94)90109-0"},{"key":"key\n\t\t\t\t20170725014955_R68","doi-asserted-by":"crossref","unstructured":"Saran,M., Michel,C. and Bors,W. (1998) Radical functions in vivo: a critical review of current concepts and hypotheses. Zeitschr. Naturforsch., 53c, 210\u2013227.","DOI":"10.1515\/znc-1998-3-411"},{"key":"key\n\t\t\t\t20170725014955_R69","unstructured":"Heigold,S. and Bauer,G. Raw 264.7 macrophages induce apoptosis selectively in transformed cells: Intercellular signalling based on reactive oxygen species. J. Leukocyte Biology (in press)."},{"key":"key\n\t\t\t\t20170725014955_R70","unstructured":"Paul,K. and Bauer,G. (2001) Promyelocytic HL 60 cells induce apoptosis specifically in transformed cells: involvement of myeloperoxidase, nitric oxide and target cell-derived superoxide anions. Anticancer Res., 21, 3237\u20133246."},{"key":"key\n\t\t\t\t20170725014955_R71","doi-asserted-by":"crossref","unstructured":"Herdener,M., Heigold,S., Saran,M. and Bauer,G. (2000) Target cell-derived superoxide anions cause efficiency and selectivity of intercellular induction of apoptosis. Free Rad. Biol. Med., 29, 1260\u20131271.","DOI":"10.1016\/S0891-5849(00)00422-6"},{"key":"key\n\t\t\t\t20170725014955_R72","doi-asserted-by":"crossref","unstructured":"Haberstroh,K., Heigold,S. and Bauer,G. Transformed cell-derived reactive oxygen species support and inhibit nitric oxide-mediated apoptosis induction. Int. J. Oncol. (in press).","DOI":"10.3892\/ijo.21.1.145"}],"container-title":["Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/carcin\/article-pdf\/23\/6\/929\/19254854\/230929.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T21:10:30Z","timestamp":1583442630000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/carcin\/article-lookup\/doi\/10.1093\/carcin\/23.6.929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,6]]},"references-count":72,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2002,6]]},"published-print":{"date-parts":[[2002,6]]}},"URL":"https:\/\/doi.org\/10.1093\/carcin\/23.6.929","relation":{},"ISSN":["1460-2180","0143-3334"],"issn-type":[{"value":"1460-2180","type":"electronic"},{"value":"0143-3334","type":"print"}],"subject":[],"published":{"date-parts":[[2002,6]]}}}