{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:10:59Z","timestamp":1791141059645,"version":"4.1.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,6]]},"DOI":"10.1093\/carcin\/23.6.959","type":"journal-article","created":{"date-parts":[[2002,7,28]],"date-time":"2002-07-28T18:39:17Z","timestamp":1027881557000},"page":"959-966","source":"Crossref","is-referenced-by-count":25,"title":["DNA damage responses protect xeroderma pigmentosum variant from UVC-induced clastogenesis"],"prefix":"10.1093","volume":"23","author":[{"given":"Marila","family":"Cordeiro-Stone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Frank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Bryant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikechukwu","family":"Oguejiofor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie B.","family":"Hatch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa D.","family":"McDaniel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William K.","family":"Kaufmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2002,6]]},"reference":[{"key":"key\n\t\t\t\t20170725015014_R1","doi-asserted-by":"crossref","unstructured":"Zhou,B.B. and Elledge,S.J. (2000) The DNA damage response: putting checkpoints in perspective. Nature, 408, 433\u2013439.","DOI":"10.1038\/35044005"},{"key":"key\n\t\t\t\t20170725015014_R2","doi-asserted-by":"crossref","unstructured":"Kaufmann,W.K. (1995) Cell cycle checkpoints and DNA repair preserve the stability of the human genome. Cancer Metastasis Rev., 14, 31\u201341.","DOI":"10.1007\/BF00690209"},{"key":"key\n\t\t\t\t20170725015014_R3","doi-asserted-by":"crossref","unstructured":"Maher,V.M., Ouellette,L.M., Curren,R.D. and McCormick,J.J. (1976) Frequency of ultraviolet light-induced mutations is higher in xeroderma pigmentosum variant cells than in normal human cells. Nature, 261, 593\u2013595.","DOI":"10.1038\/261593a0"},{"key":"key\n\t\t\t\t20170725015014_R4","doi-asserted-by":"crossref","unstructured":"Myhr,B.C., Turnbull,D. and DiPaolo,J.A. (1979) Ultraviolet mutagenesis of normal and xeroderma pigmentosum variant human fibroblasts. Mutat. Res., 62, 341\u2013353.","DOI":"10.1016\/0027-5107(79)90089-7"},{"key":"key\n\t\t\t\t20170725015014_R5","doi-asserted-by":"crossref","unstructured":"Wang,Y.-C., Maher,V.M., Mitchell,D.L. and McCormick,J.J. (1993) Evidence from mutation spectra that the UV hypermutability of xeroderma pigmentosum variant cells reflect abnormal, error-prone replication on a template containing photoproducts. Mol. Cell. Biol., 13, 4276\u20134283.","DOI":"10.1128\/MCB.13.7.4276"},{"key":"key\n\t\t\t\t20170725015014_R6","unstructured":"Cleaver,J.E. and Kraemer,K.H. (1995) Xeroderma pigmentosum. In Scriver,C.R., Beaudet,A.L., Sly,W.S. and Valle,D. (eds) The Metabolic and Molecular Basis of Inherited Disease. McGraw Hill, New York, vol. 3, pp. 4393\u20134419."},{"key":"key\n\t\t\t\t20170725015014_R7","doi-asserted-by":"crossref","unstructured":"Lehmann,A.R., Kirk-Bell,S., Arlet,C.F., Patterson,M.C., Lohman,P.H.M., de Weerd-Kastelein,E.A. and Bootsma,D. (1975) Xeroderma pigmentosum cells with normal levels of excision repair have defect in DNA synthesis after UV-irradiation. Proc. Natl Acad. Sci. USA, 72, 219\u2013223.","DOI":"10.1073\/pnas.72.1.219"},{"key":"key\n\t\t\t\t20170725015014_R8","unstructured":"van Zeland,A.A. and Filon,A.R. (1982) Post-replication repair: elongation of daughter strand DNA in UV-irradiated mammalian cells in culture. Prog. Mutat. Res., 4, 375\u2013384."},{"key":"key\n\t\t\t\t20170725015014_R9","unstructured":"Boyer,J.C., Kaufmann,W.K., Brylawski,B.P. and Cordeiro-Stone,M. (1990) Defective postreplication repair in xeroderma pigmentosum variant fibroblasts. Cancer Res., 50, 2593\u20132598."},{"key":"key\n\t\t\t\t20170725015014_R10","doi-asserted-by":"crossref","unstructured":"Cordeiro-Stone,M., Zaritskaya,L.S., Price,L.K. and Kaufmann,W.K. (1997) Replication fork bypass of a pyrimidine dimer blocking leading strand DNA synthesis. J. Biol. Chem., 272, 13945\u201313954.","DOI":"10.1074\/jbc.272.21.13945"},{"key":"key\n\t\t\t\t20170725015014_R11","unstructured":"Svoboda,D.L., Briley,L.P. and Vos,J.-M.H. (1998) Defective bypass replication of a leading strand cyclobutane thymine dimer in xeroderma pigmentosum variant cell extracts. Cancer Res., 58, 2445\u20132448."},{"key":"key\n\t\t\t\t20170725015014_R12","doi-asserted-by":"crossref","unstructured":"Ensch-Simon,I., Burgers,P.M.J. and Taylor,J.-S. (1998) Bypass of a site-specific cis-syn thymine dimer in an SV40 vector during in vitro replication by HeLa and XPV cell-free extracts. Biochemistry, 37, 8218\u20138226.","DOI":"10.1021\/bi972460j"},{"key":"key\n\t\t\t\t20170725015014_R13","doi-asserted-by":"crossref","unstructured":"McGregor,W.G., Wei,D., Maher,V.M. and McCormick,J.J. (1999) Abnormal, error-prone bypass of photoproducts by xeroderma pigmentosum variant cell extracts results in extreme strand bias for the kind of mutations induced by UV light. Mol. Cell. Biol., 19, 147\u2013154.","DOI":"10.1128\/MCB.19.1.147"},{"key":"key\n\t\t\t\t20170725015014_R14","doi-asserted-by":"crossref","unstructured":"Masutani,C., Kusumoto,R., Yamada,A., et al. (1999) The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase \u03b7. Nature, 399, 700\u2013704.","DOI":"10.1038\/21447"},{"key":"key\n\t\t\t\t20170725015014_R15","doi-asserted-by":"crossref","unstructured":"Johnson,R.E., Kondratick,C.M., Prakash,S. and Prakash,L. (1999) hRAD30 mutations in the variant form of xeroderma pigmentosum. Science, 285, 263\u2013265.","DOI":"10.1126\/science.285.5425.263"},{"key":"key\n\t\t\t\t20170725015014_R16","doi-asserted-by":"crossref","unstructured":"Yuasa,M., Masutani,C., Eki,T. and Hanaoka,F. (2000) Genomic structure, chromosomal localization and identification of mutations in the xeroderma pigmentosum variant (XPV) gene. Oncogene, 19, 4721\u20134728.","DOI":"10.1038\/sj.onc.1203842"},{"key":"key\n\t\t\t\t20170725015014_R17","doi-asserted-by":"crossref","unstructured":"Masutani,C., Araki,M., Yamada,A., Kusumoto,R., Nogimori,T., Maekawa,T., Iwai,S. and Hanaoka,F. (1999) Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity. EMBO J., 18, 3491\u20133501.","DOI":"10.1093\/emboj\/18.12.3491"},{"key":"key\n\t\t\t\t20170725015014_R18","doi-asserted-by":"crossref","unstructured":"Johnson,R.E., Prakash,S. and Prakash,L. (1999) Efficient bypass of a thymine\u2013thymine dimer by yeast DNA polymerase, pol \u03b7. Science, 283, 1001\u20131004.","DOI":"10.1126\/science.283.5404.1001"},{"key":"key\n\t\t\t\t20170725015014_R19","unstructured":"Washington,M.T., Johnson,R.E., Prakash,S. and Prakash,L. (2000) Accuracy of thymine\u2013thymine dimer bypass by Saccharomyces cerevisiae DNA polymerase \u03b7. Proc. Natl Acad. Sci. USA, 97, 3094\u20133099."},{"key":"key\n\t\t\t\t20170725015014_R20","doi-asserted-by":"crossref","unstructured":"Masutani,C., Kusumoto,R., Iwai,S. and Hanaoka,F. (2000) Mechanisms of accurate translesion synthesis by human DNA polymerase \u03b7. EMBO J., 19, 3100\u20133109.","DOI":"10.1093\/emboj\/19.12.3100"},{"key":"key\n\t\t\t\t20170725015014_R21","doi-asserted-by":"crossref","unstructured":"Bodnar,A.G., Ouellette,M., Frolkis,M., et al. (1998) Extension of life-span by introduction of telomerase into normal human cells. Science, 279, 349\u2013352.","DOI":"10.1126\/science.279.5349.349"},{"key":"key\n\t\t\t\t20170725015014_R22","doi-asserted-by":"crossref","unstructured":"Vaziri,H. and Benchimol,S. (1998) Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr. Biol., 8, 279\u2013282.","DOI":"10.1016\/S0960-9822(98)70109-5"},{"key":"key\n\t\t\t\t20170725015014_R23","doi-asserted-by":"crossref","unstructured":"Morales,C.P., Holt,S.E., Ouellette,M., Kaur,K.J., Yan,Y., Wilson,K.S., White,M.A., Wright,W.E. and Shay,J.W. (1999) Absence of cancer-associated changes in human fibroblasts immortalized with telomerase. Nature Genet., 21, 115\u2013118.","DOI":"10.1038\/5063"},{"key":"key\n\t\t\t\t20170725015014_R24","doi-asserted-by":"crossref","unstructured":"Jiang,X.R., Jimenez,G., Chang,E., et al. (1999) Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype. Nature Genet., 21, 111\u2013114.","DOI":"10.1038\/5056"},{"key":"key\n\t\t\t\t20170725015014_R25","doi-asserted-by":"crossref","unstructured":"Ouellette,M.M., McDaniel,L.D., Wright,W.E., Shay,J.W. and Schultz,R.A. (2000) The establishment of telomerase-immortalized cell lines representing human chromosome instability syndromes. Hum. Mol. Genet., 9, 403\u2013411.","DOI":"10.1093\/hmg\/9.3.403"},{"key":"key\n\t\t\t\t20170725015014_R26","doi-asserted-by":"crossref","unstructured":"Wood,L.D., Halvorsen,T.L., Dhar,S., et al. (2001) Characterization of ataxia telangectasia fibroblasts with extended life-span through telomerase expression. Oncogene, 20, 278\u2013288.","DOI":"10.1038\/sj.onc.1204072"},{"key":"key\n\t\t\t\t20170725015014_R27","unstructured":"Sasaki,M.S. (1979) Chromosome aberration formation and sister chromatid exchange in relation to DNA repair in human cells. In: Generoso,W.M., Shelby,M.D. and de Serres,F.J. (eds) DNA Repair and Mutagenesis in Eukaryotes. Plenum, New York, pp. 285\u2013311."},{"key":"key\n\t\t\t\t20170725015014_R28","doi-asserted-by":"crossref","unstructured":"de Weerd-Kastelein,E.A., Keijzer,W., Rainaldi,G. and Bootsma,D. (1977) Induction of sister chromatid exchanges in xeroderma pigmentosum cells after exposure to ultraviolet light. Mutat. Res., 45, 252\u2013261.","DOI":"10.1016\/0027-5107(77)90025-2"},{"key":"key\n\t\t\t\t20170725015014_R29","unstructured":"Cleaver,J.E., Afzal,V., Feeney,L., et al. (1999) Increased ultraviolet sensitivity and chromosomal instability related to p53 function in the xeroderma pigmentosum variant. Cancer Res., 59, 1102\u20131108."},{"key":"key\n\t\t\t\t20170725015014_R30","doi-asserted-by":"crossref","unstructured":"Limoli,C.L., Giedzinski,E., Morgan,W.F. and Cleaver,J.E. (2000) Polymerase \u03b7 deficiency in the xeroderma pigmentosum variant uncovers an overlap between the S phase checkpoint and double-strand break repair. Proc. Natl Acad. Sci. USA, 97, 7939\u20137946.","DOI":"10.1073\/pnas.130182897"},{"key":"key\n\t\t\t\t20170725015014_R31","unstructured":"Gustashaw,K.M. (1991) Chromosome stains. In Barch,M.J. (ed.) The ACT Cytogenetics Laboratory Manual, 2nd edn. Raven Press, New York, pp. 205\u2013296."},{"key":"key\n\t\t\t\t20170725015014_R32","doi-asserted-by":"crossref","unstructured":"Cordeiro-Stone,M. and Kaufman,D.G. (1985) Kinetics of DNA replication in C3H 10T1\/2 cells synchronized with aphidicolin. Biochemistry, 24, 4815\u20134822.","DOI":"10.1021\/bi00339a015"},{"key":"key\n\t\t\t\t20170725015014_R33","doi-asserted-by":"crossref","unstructured":"Studier,F.W. (1965) Sedimentation studies of the size and shape of DNA. J. Mol. Biol., 11, 373\u2013390.","DOI":"10.1016\/S0022-2836(65)80064-X"},{"key":"key\n\t\t\t\t20170725015014_R34","doi-asserted-by":"crossref","unstructured":"Meneghini,R., Cordeiro-Stone,M. and Schumacher,R.I. (1981) Size and frequency of gaps in newly synthesized DNA of xeroderma pigmentosum human cells irradiated with ultraviolet light. Biophys. J., 33, 81\u201392.","DOI":"10.1016\/S0006-3495(81)84873-4"},{"key":"key\n\t\t\t\t20170725015014_R35","unstructured":"Kaufmann,W.K., Levedakou,E.N., Grady,H.L., Paules,R.S. and Stein,G.H. (1995) Attenuation of G2 checkpoint function precedes human cell immortalization. Cancer Res., 55, 7\u201311."},{"key":"key\n\t\t\t\t20170725015014_R36","doi-asserted-by":"crossref","unstructured":"Kaufmann,W.K. and Cleaver,J.E. (1981) Mechanisms of inhibition of DNA replication by ultraviolet light in normal human and xeroderma pigmentosum fibroblasts. J. Mol. Biol., 149, 171\u2013187.","DOI":"10.1016\/0022-2836(81)90297-7"},{"key":"key\n\t\t\t\t20170725015014_R37","doi-asserted-by":"crossref","unstructured":"Cleaver,J.E., Kaufmann,W.K., Kapp,L.N. and Park,S.D. (1983) Replicon size and excision repair as factors in the inhibition and recovery of DNA synthesis from ultraviolet damage. Biochim. Biophys. Acta, 739, 207\u2013215.","DOI":"10.1016\/0167-4781(83)90031-3"},{"key":"key\n\t\t\t\t20170725015014_R38","doi-asserted-by":"crossref","unstructured":"Kaufmann,W.K. and Wilson,S.J. (1994) G1 arrest and cell cycle-dependent clastogenesis in UV-irradiated fibroblasts. Mutat. Res., 314, 67\u201376.","DOI":"10.1016\/0921-8777(94)90062-0"},{"key":"key\n\t\t\t\t20170725015014_R39","doi-asserted-by":"crossref","unstructured":"Cordeiro-Stone,M., Boyer,J.C., Smith,B.A. and Kaufmann,W.K. (1986) Effect of benzo[a]pyrene-diol-epoxide-I on growth of nascent DNA in synchronized human fibroblasts. Carcinogenesis, 7, 1775\u20131781.","DOI":"10.1093\/carcin\/7.10.1775"},{"key":"key\n\t\t\t\t20170725015014_R40","doi-asserted-by":"crossref","unstructured":"Bullock,S.K., Kaufmann,W.K. and Cordeiro-Stone,M. (2001) Enhanced S phase delay and inhibition of replication of an undamaged shuttle vector in UVC-irradiated xeroderma pigmentosum variant. Carcinogenesis, 22, 233\u2013241.","DOI":"10.1093\/carcin\/22.2.233"},{"key":"key\n\t\t\t\t20170725015014_R41","unstructured":"Cistulli,C.A. and Kaufmann,W.K. (1998) p53-dependent signaling sustains DNA replication and enhances clonogenic survival in 254 nm ultraviolet-irradiated human fibroblasts. Cancer Res., 58, 1993\u20132002."}],"container-title":["Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/carcin\/article-pdf\/23\/6\/959\/19254897\/230959.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T09:26:13Z","timestamp":1503566773000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/carcin\/article-lookup\/doi\/10.1093\/carcin\/23.6.959"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,6]]},"references-count":41,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2002,6]]},"published-print":{"date-parts":[[2002,6]]}},"URL":"https:\/\/doi.org\/10.1093\/carcin\/23.6.959","relation":{},"ISSN":["1460-2180","0143-3334"],"issn-type":[{"value":"1460-2180","type":"electronic"},{"value":"0143-3334","type":"print"}],"subject":[],"published":{"date-parts":[[2002,6]]}}}