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FTSECs are repeatedly exposed to inflammation induced by follicular fluid (FF) that is released with every ovulation cycle throughout a woman\u2019s reproductive years. Uninterrupted ovulation cycles are an established risk factor for HGSOC. Stimuli present in the FF induce an inflammatory environment which may cause DNA damage eventually leading to serous tumorigenesis. With the aim of elucidating possible mechanistic pathways, we established an \u2018ex vivo persistent ovulation model\u2019 mimicking the repeated exposure of human benign fallopian tube epithelium (FTE) to FF. We performed mass spectrometry analysis of the secretome of the ex vivo cultures as well as confirmatory targeted expressional and functional analyses. We demonstrated activation of the NF-\u03baB pathway and upregulation of miR-155 following short-term exposure of FTE to human FF. Increased expression of miR-155 was also detected in primary HGSOC tumors compared with benign primary human FTE and corresponded with changes in the expression of miR-155 target genes. The phenotype of miR-155 overexpression in FTSEC cell line is of increased migratory and altered adhesion capacities. Overall, activation of the NF-\u03baB-miR-155 axis in FTE may represent a possible link between ovulation-induced inflammation, DNA damage, and transcriptional changes that may eventually lead to serious carcinogenesis.<\/jats:p>","DOI":"10.1093\/carcin\/bgaa068","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T03:19:11Z","timestamp":1593573551000},"page":"1703-1712","source":"Crossref","is-referenced-by-count":7,"title":["NF-\u03baB-miR-155 axis activation mediates ovulation-induced oncogenic effects in fallopian tube epithelium"],"prefix":"10.1093","volume":"41","author":[{"given":"Hadar","family":"Brand","sequence":"first","affiliation":[{"name":"Sheba Cancer Research Center, Chaim Sheba Medical Center, Ramat Gan, Israel"},{"name":"Sackler Faculty of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgina D","family":"Barnabas","sequence":"additional","affiliation":[{"name":"Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stav","family":"Sapoznik","sequence":"additional","affiliation":[{"name":"Sheba Cancer Research Center, Chaim Sheba Medical Center, Ramat Gan, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keren","family":"Bahar-Shany","sequence":"additional","affiliation":[{"name":"Sheba Cancer Research Center, Chaim Sheba Medical Center, Ramat Gan, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yair","family":"Pozniak","sequence":"additional","affiliation":[{"name":"Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuval","family":"Yung","sequence":"additional","affiliation":[{"name":"IVF Unit and Reproduction Lab, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Ramat Gan, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariel","family":"Hourvitz","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel"},{"name":"IVF Unit and Reproduction Lab, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Ramat Gan, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamar","family":"Geiger","sequence":"additional","affiliation":[{"name":"Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmine","family":"Jacob-Hirsch","sequence":"additional","affiliation":[{"name":"Sheba Cancer Research Center, Chaim Sheba Medical Center, Ramat Gan, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5122-064X","authenticated-orcid":false,"given":"Keren","family":"Levanon","sequence":"additional","affiliation":[{"name":"Sheba Cancer Research Center, Chaim Sheba Medical Center, Ramat Gan, Israel"},{"name":"Sackler Faculty of Medicine, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,7,2]]},"reference":[{"key":"2021010806304816000_CIT0001","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature01322","article-title":"Inflammation and cancer","volume":"420","author":"Coussens","year":"2002","journal-title":"Nature"},{"key":"2021010806304816000_CIT0002","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.3390\/ijms18081808","article-title":"Crosstalk between DNA damage and inflammation in the multiple steps of carcinogenesis","volume":"18","author":"Kawanishi","year":"2017","journal-title":"Int. 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