{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T08:46:15Z","timestamp":1772527575175,"version":"3.50.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100007313","name":"University of Texas MD Anderson Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30-CA016672"],"award-info":[{"award-number":["P30-CA016672"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In multifocal intrahepatic cholangiocarcinoma (IHC), intrahepatic metastases (IM) represent a contraindication to surgical resection, whereas satellite nodules (SN) do not. However, no consensus criteria exist to distinguish IM from SN. The purpose of this study was to determine genetic alterations and clonal relationships in surgically resected multifocal IHC. Next-generation sequencing of 34 spatially separated IHC tumors was performed using a targeted panel of 201 cancer-associated genes. Proposed definitions in the literature were applied of SN located in the same liver segment and \u22642 cm from the primary tumor; and IM located in a different liver segment and\/or &amp;gt;2 cm from the primary tumor. Somatic point mutations concordant across tumors from individual patients included BAP1, SMARCA4 and IDH1. Small insertions and deletions (indels) present at the same genome positions among all tumors from individuals included indels in DNA repair genes, CHEK1, ERCC5, ATR and MSH6. Copy number alterations were also similar between all tumors in each patient. In this cohort of multifocal IHC, genomic profiles were concordant across all tumors in each patient, suggesting a common progenitor cell origin, regardless of the location of tumors in the liver. The decision to perform surgery should not be based upon a perceived distinction between IM and SN.<\/jats:p>","DOI":"10.1093\/carcin\/bgaa124","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T12:10:58Z","timestamp":1605096658000},"page":"436-441","source":"Crossref","is-referenced-by-count":13,"title":["Genomic profiling of multifocal intrahepatic cholangiocarcinoma reveals intraindividual concordance of genetic alterations"],"prefix":"10.1093","volume":"42","author":[{"given":"Sung Hwan","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eve B","family":"Simoneau","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana","family":"Karpinets","sequence":"additional","affiliation":[{"name":"Department of Genomic Medicine, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P Andrew","family":"Futreal","sequence":"additional","affiliation":[{"name":"Department of Genomic Medicine, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Thoracic\/Head and Neck Medical Oncology, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milind","family":"Javle","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Medical Oncology, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Genomic Medicine, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Nicolas","family":"Vauthey","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju-Seog","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Systems Biology, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeannelyn S","family":"Estrella","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1384-8927","authenticated-orcid":false,"given":"Yun Shin","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,11,17]]},"reference":[{"key":"2021041713560511300_CIT0001","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.jhep.2014.01.021","article-title":"Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma","volume":"60","author":"Bridgewater","year":"2014","journal-title":"J. Hepatol"},{"key":"2021041713560511300_CIT0002","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1158\/1078-0432.CCR-14-3296","article-title":"Molecular pathogenesis and targeted therapies for intrahepatic cholangiocarcinoma","volume":"22","author":"Moeini","year":"2016","journal-title":"Clin. Cancer Res"},{"key":"2021041713560511300_CIT0003","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1007\/s00268-011-1242-0","article-title":"Staging of peripheral-type intrahepatic cholangiocarcinoma: appraisal of the new TNM classification and its modifications","volume":"35","author":"Igami","year":"2011","journal-title":"World J. Surg"},{"key":"2021041713560511300_CIT0004","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/hpb.12441","article-title":"Intrahepatic cholangiocarcinoma: expert consensus statement","volume":"17","author":"Weber","year":"2015","journal-title":"HPB (Oxford)"},{"key":"2021041713560511300_CIT0005","volume-title":"Surgery of the Liver, Biliary Tract, and Pancreas","author":"Blumgart","year":"2007"},{"key":"2021041713560511300_CIT0006","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1007\/s00261-014-0167-0","article-title":"Correlation of CT patterns of primary intrahepatic cholangiocarcinoma at the time of presentation with the metastatic spread and clinical outcomes: retrospective study of 92 patients","volume":"39","author":"Baheti","year":"2014","journal-title":"Abdom. Imaging"},{"key":"2021041713560511300_CIT0007","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.1245\/s10434-018-6669-1","article-title":"Patterns of distribution of hepatic nodules (single, satellites or multifocal) in intrahepatic cholangiocarcinoma: prognostic impact after surgery","volume":"25","author":"Conci","year":"2018","journal-title":"Ann. Surg. Oncol"},{"key":"2021041713560511300_CIT0008","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1007\/s00261-018-1505-4","article-title":"Intrahepatic cholangiocarcinoma: can imaging phenotypes predict survival and tumor genetics?","volume":"43","author":"Aherne","year":"2018","journal-title":"Abdom. Radiol. (NY)"},{"key":"2021041713560511300_CIT0009","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1007\/s11605-018-4052-y","article-title":"Prognostic impact of tumor multinodularity in intrahepatic cholangiocarcinoma","volume":"23","author":"Addeo","year":"2019","journal-title":"J. Gastrointest. Surg"},{"key":"2021041713560511300_CIT0010","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1373\/clinchem.2014.231100","article-title":"Clinical actionability enhanced through deep targeted sequencing of solid tumors","volume":"61","author":"Chen","year":"2015","journal-title":"Clin. Chem"},{"key":"2021041713560511300_CIT0011","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/hpb.12359","article-title":"Outcomes following resection of intrahepatic cholangiocarcinoma","volume":"17","author":"Tabrizian","year":"2015","journal-title":"HPB (Oxford)"},{"key":"2021041713560511300_CIT0012","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1093\/bioinformatics\/btp394","article-title":"Pindel: a pattern growth approach to detect break points of large deletions and medium sized insertions from paired-end short reads","volume":"25","author":"Ye","year":"2009","journal-title":"Bioinformatics"},{"key":"2021041713560511300_CIT0013","doi-asserted-by":"crossref","first-page":"R41","DOI":"10.1186\/gb-2011-12-4-r41","article-title":"GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers","volume":"12","author":"Mermel","year":"2011","journal-title":"Genome Biol"},{"key":"2021041713560511300_CIT0014","first-page":"2579","article-title":"Visualizing data using t-SNE","volume":"9","author":"Van Der Maaten","year":"2008","journal-title":"J. Mach. Learn. Res"},{"key":"2021041713560511300_CIT0015","doi-asserted-by":"crossref","first-page":"1073274817729241","DOI":"10.1177\/1073274817729241","article-title":"Systemic and adjuvant therapies for intrahepatic cholangiocarcinoma","volume":"24","author":"Chun","year":"2017","journal-title":"Cancer Control"},{"key":"2021041713560511300_CIT0016","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1158\/2159-8290.CD-17-0245","article-title":"New horizons for precision medicine in biliary tract cancers","volume":"7","author":"Valle","year":"2017","journal-title":"Cancer Discov"},{"key":"2021041713560511300_CIT0017","doi-asserted-by":"crossref","first-page":"3838","DOI":"10.1002\/cncr.30254","article-title":"Biliary cancer: utility of next-generation sequencing for clinical management","volume":"122","author":"Javle","year":"2016","journal-title":"Cancer"},{"key":"2021041713560511300_CIT0018","doi-asserted-by":"crossref","first-page":"4861","DOI":"10.1038\/onc.2012.617","article-title":"Intrahepatic cholangiocarcinoma: pathogenesis and rationale for molecular therapies","volume":"32","author":"Sia","year":"2013","journal-title":"Oncogene"},{"key":"2021041713560511300_CIT0019","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1016\/j.celrep.2017.06.008","article-title":"Integrative genomic analysis of cholangiocarcinoma identifies distinct IDH-mutant molecular profiles","volume":"19","author":"Farshidfar","year":"2017","journal-title":"Cell Rep"},{"key":"2021041713560511300_CIT0020","doi-asserted-by":"crossref","first-page":"4154","DOI":"10.1158\/1078-0432.CCR-18-0078","article-title":"Comprehensive molecular profiling of intrahepatic and extrahepatic cholangiocarcinomas: potential targets for intervention","volume":"24","author":"Lowery","year":"2018","journal-title":"Clin. Cancer Res"},{"key":"2021041713560511300_CIT0021","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41698-018-0064-z","article-title":"Emerging role of precision medicine in biliary tract cancers","volume":"2","author":"Bogenberger","year":"2018","journal-title":"NPJ Precis. Oncol"},{"key":"2021041713560511300_CIT0022","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S1470-2045(17)30516-8","article-title":"Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis","volume":"18","author":"Turajlic","year":"2017","journal-title":"Lancet Oncol"},{"key":"2021041713560511300_CIT0023","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1158\/2159-8290.CD-16-1000","article-title":"Polyclonal secondary FGFR2 mutations drive acquired resistance to FGFR inhibition in patients with FGFR2 fusion-positive cholangiocarcinoma","volume":"7","author":"Goyal","year":"2017","journal-title":"Cancer Discov"},{"key":"2021041713560511300_CIT0024","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1200\/JCO.2017.75.5009","article-title":"Phase II study of BGJ398 in patients with FGFR-altered advanced cholangiocarcinoma","volume":"36","author":"Javle","year":"2018","journal-title":"J. Clin. Oncol"},{"key":"2021041713560511300_CIT0025","doi-asserted-by":"crossref","DOI":"10.1016\/S1470-2045(20)30109-1","article-title":"Pemigatinib for previously treated, locally advanced or metastatic cholangiocarcinoma: a multicentre, open-label, phase 2 study","author":"Abou-Alfa","year":"2020","journal-title":"Lancet Oncol., 21, 671\u2013684"}],"container-title":["Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/carcin\/advance-article-pdf\/doi\/10.1093\/carcin\/bgaa124\/34338468\/bgaa124.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/carcin\/article-pdf\/42\/3\/436\/37119147\/bgaa124.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/carcin\/article-pdf\/42\/3\/436\/37119147\/bgaa124.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T13:56:31Z","timestamp":1618667791000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/carcin\/article\/42\/3\/436\/5983886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,17]]},"references-count":25,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,11,17]]},"published-print":{"date-parts":[[2021,4,17]]}},"URL":"https:\/\/doi.org\/10.1093\/carcin\/bgaa124","relation":{},"ISSN":["0143-3334","1460-2180"],"issn-type":[{"value":"0143-3334","type":"print"},{"value":"1460-2180","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,3,1]]},"published":{"date-parts":[[2020,11,17]]}}}