{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:51:21Z","timestamp":1770965481833,"version":"3.50.1"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T00:00:00Z","timestamp":1632182400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Patients with superficial head and neck squamous cell carcinoma (HNSCC) can be completely treated by techniques of transoral surgery (TOS). The aim of this study was to evaluate the risk of metachronous multiple HNSCC arising after TOS based on alcohol dehydrogenase 1B (ADH1B) and aldehyde dehydrogenase 2 (ALDH2). We registered patients who underwent TOS for superficial HNSCC. Buccal cell samples were obtained by using a cotton swab to examine two single nucleotide polymorphisms in ADH1B and ALDH2 genotyping. We used Cox proportional hazards models to examine the risk of metachronous HNSCC. A total of 198 patients who underwent TOS for HNSCC were evaluated. In multivariate analysis, risks for second HNSCC were ADH1B*1\/*1 [hazard ratio (HR), 1.88; 95% confidence interval (CI), 1.11\u20133.19; P = 0.02], ALDH2*1\/*2 (HR, 2.11; 95% CI, 1.00\u20135.16; P = 0.048) and alcohol consumption before TOS (HR, 1.17; 95% CI, 1.06\u20131.27; P = 0.01). The 5-year incidence rates of second primary HNSCC in the temperance group and the non-temperance group were 20.8 and 46.5%, respectively (HR, 0.54; 95% CI, 0.31\u20130.92; P = 0.02). Cumulative development rates of third HNSCC in the temperance group and non-temperance group at 10 years were 11.3 and 36.1%, respectively (HR, 0.19; 95% CI, 0.03\u20130.65; P = 0.006). ADH1B*1\/*1, ALDH2*1\/*2 and moderate or heavy alcohol consumption before treatment are independent risk factors of metachronous HNSCC. Since it was shown that temperance decreased the incidences of second and third metachronous HNSCC, advice to discontinue alcohol drinking is necessary.<\/jats:p>","DOI":"10.1093\/carcin\/bgab085","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T11:09:05Z","timestamp":1632136145000},"page":"1232-1238","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of the risk of metachronous multiple squamous cell carcinoma of the head and neck after transoral surgery based on the genetic polymorphisms of alcohol dehydrogenase 1B and aldehyde dehydrogenase 2"],"prefix":"10.1093","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2912-9305","authenticated-orcid":false,"given":"Masaki","family":"Inoue","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Graduate School of Medicine and Faculty of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Division of Endoscopy, Hokkaido University Hospital, Sapporo, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanobu","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Keiyukai Sapporo Hospital, Sapporo, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Keiyukai Sapporo Hospital, Sapporo, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroto","family":"Furuhashi","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Dobashi","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Ikeya","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, St. Luke\u2019s International Hospital, Chuo-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Goda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Dokkyo Medical University, Shimotsuga, Tochigi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, The Jikei University Katsushika Medical Center, Katsushika-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mototsugu","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, National Hospital Organization Hakodate National Hospital, Hakodate, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Graduate School of Medicine and Faculty of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5403-4121","authenticated-orcid":false,"given":"Akihito","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Keiyukai Sapporo Hospital, Sapporo, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,9,21]]},"reference":[{"key":"2021102611231516100_CIT0001","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1002\/ijc.31937","article-title":"Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods","volume":"144","author":"Ferlay","year":"2019","journal-title":"Int. J. Cancer"},{"key":"2021102611231516100_CIT0002","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1055\/s-0029-1243963","article-title":"Narrow band imaging for detecting superficial squamous cell carcinoma of the head and neck in patients with esophageal squamous cell carcinoma","volume":"42","author":"Katada","year":"2010","journal-title":"Endoscopy"},{"key":"2021102611231516100_CIT0003","doi-asserted-by":"crossref","first-page":"AB110","DOI":"10.1016\/j.gie.2007.03.027","article-title":"Multicenter prospective randomized controlled study on the detection and diagnosis of superficial squamous cell carcinoma by back-to-back endoscopic examination of narrow band imaging and white light observation","volume":"65","author":"Muto","year":"2007","journal-title":"Gastrointest. Endosc."},{"key":"2021102611231516100_CIT0004","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1055\/s-0035-1569644","article-title":"Dual-focus versus conventional magnification endoscopy for the diagnosis of superficial squamous neoplasms in the pharynx and esophagus: a randomized trial","volume":"48","author":"Goda","year":"2016","journal-title":"Endoscopy"},{"key":"2021102611231516100_CIT0005","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.gie.2006.01.049","article-title":"Endoscopic submucosal dissection for treatment of early stage hypopharyngeal carcinoma","volume":"64","author":"Shimizu","year":"2006","journal-title":"Gastrointest. Endosc."},{"key":"2021102611231516100_CIT0006","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.gie.2011.04.027","article-title":"Long-term outcome of transoral organ-preserving pharyngeal endoscopic resection for superficial pharyngeal cancer","volume":"74","author":"Muto","year":"2011","journal-title":"Gastrointest. Endosc."},{"key":"2021102611231516100_CIT0007","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.gie.2015.06.021","article-title":"Endoscopic submucosal dissection as minimally invasive treatment for superficial pharyngeal cancer: a phase II study (with video)","volume":"82","author":"Hanaoka","year":"2015","journal-title":"Gastrointest. Endosc."},{"key":"2021102611231516100_CIT0008","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1002\/hed.24839","article-title":"Synopsis of transoral endoscopic laryngopharyngeal surgery for superficial pharyngeal cancers","volume":"39","author":"Watanabe","year":"2017","journal-title":"Head Neck"},{"key":"2021102611231516100_CIT0009","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/carcin\/22.3.433","article-title":"Alcohol and aldehyde dehydrogenase gene polymorphisms and oropharyngolaryngeal, esophageal and stomach cancers in Japanese alcoholics","volume":"22","author":"Yokoyama","year":"2001","journal-title":"Carcinogenesis"},{"key":"2021102611231516100_CIT0010","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1093\/carcin\/bgl206","article-title":"Genetic polymorphisms of alcohol and aldehyde dehydrogenases, and drinking, smoking and diet in Japanese men with oral and pharyngeal squamous cell carcinoma","volume":"28","author":"Asakage","year":"2007","journal-title":"Carcinogenesis"},{"key":"2021102611231516100_CIT0011","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/nrc2191","article-title":"Molecular mechanisms of alcohol-mediated carcinogenesis","volume":"7","author":"Seitz","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"2021102611231516100_CIT0012","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/em.21824","article-title":"Acetaldehyde and the genome: beyond nuclear DNA adducts and carcinogenesis","volume":"55","author":"Brooks","year":"2014","journal-title":"Environ. Mol. Mutagen."},{"key":"2021102611231516100_CIT0013","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/CEJ.0000000000000222","article-title":"Development of a prediction model and estimation of cumulative risk for upper aerodigestive tract cancer on the basis of the aldehyde dehydrogenase 2 genotype and alcohol consumption in a Japanese population","volume":"26","author":"Koyanagi","year":"2017","journal-title":"Eur. J. Cancer Prev."},{"key":"2021102611231516100_CIT0014","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1002\/ijc.28885","article-title":"The interplay between alcohol consumption, oral hygiene, ALDH2 and ADH1B in the risk of head and neck cancer","volume":"135","author":"Tsai","year":"2014","journal-title":"Int. J. Cancer"},{"key":"2021102611231516100_CIT0015","doi-asserted-by":"crossref","first-page":"e0175182","DOI":"10.1371\/journal.pone.0175182","article-title":"Alcohol abstinence and risk assessment for second esophageal cancer in Japanese men after mucosectomy for early esophageal cancer","volume":"12","author":"Yokoyama","year":"2017","journal-title":"PLoS One"},{"issue":"11 Pt 1","key":"2021102611231516100_CIT0016","first-page":"1227","article-title":"Alcohol flushing, alcohol and aldehyde dehydrogenase genotypes, and risk for esophageal squamous cell carcinoma in Japanese men","volume":"12","author":"Yokoyama","year":"2003","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"2021102611231516100_CIT0017","doi-asserted-by":"crossref","first-page":"427","DOI":"10.2116\/analsci.30.427","article-title":"Direct detection of single nucleotide polymorphism (SNP) by the TaqMan PCR assay using dried saliva on water-soluble paper and hair-roots, without DNA extraction","volume":"30","author":"Hayashida","year":"2014","journal-title":"Anal. Sci."},{"key":"2021102611231516100_CIT0018","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/1097-0142(195309)6:5<963::AID-CNCR2820060515>3.0.CO;2-Q","article-title":"Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin","volume":"6","author":"Slaughter","year":"1953","journal-title":"Cancer"},{"key":"2021102611231516100_CIT0019","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1055\/s-0029-1214477","article-title":"Metachronous multiple esophageal squamous cell carcinomas and Lugol-voiding lesions after endoscopic mucosal resection","volume":"41","author":"Urabe","year":"2009","journal-title":"Endoscopy"},{"key":"2021102611231516100_CIT0020","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s10388-018-0643-7","article-title":"Construction of a risk model for the development of metachronous squamous cell carcinoma after endoscopic resection of esopahageal squamous cell carcinoma","volume":"16","author":"Urabe","year":"2019","journal-title":"Esophagus"},{"key":"2021102611231516100_CIT0021","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1007\/s00535-018-1441-7","article-title":"Risk assessment of metachronous squamous cell carcinoma after endoscopic resection for esophageal carcinoma based on the genetic polymorphisms of alcoholdehydrogense-1B aldehyde dehydrogenase-2: temperance reduces the risk","volume":"53","author":"Abiko","year":"2018","journal-title":"J. Gastroenterol."},{"key":"2021102611231516100_CIT0022","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S1470-2045(07)70099-2","article-title":"Carcinogenicity of alcoholic beverages","volume":"8","author":"Baan","year":"2007","journal-title":"Lancet Oncol."},{"key":"2021102611231516100_CIT0023","first-page":"3","article-title":"Alcohol consumption and ethyl carbamate","volume":"96","author":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans","year":"2010","journal-title":"IARC Monogr. Eval. Carcinog. Risks Hum."},{"key":"2021102611231516100_CIT0024","first-page":"11","article-title":"Clinical outcome after endoscopic resection for superficial pharyngeal squamous cell carcinoma invading the subepithelial layer","volume":"47","author":"Satake","year":"2015","journal-title":"Endoscopy"},{"key":"2021102611231516100_CIT0025","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1053\/j.gastro.2016.07.040","article-title":"Alcohol consumption and multiple dysplastic lesions increase risk of squamous cell carcinoma in the esophagus, head, and neck","volume":"151","author":"Katada","year":"2016","journal-title":"Gastroenterology"},{"key":"2021102611231516100_CIT0026","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S1470-2045(10)70017-6","article-title":"HPV-associated head and neck cancer: a virus-related cancer epidemic","volume":"11","author":"Marur","year":"2010","journal-title":"Lancet Oncol."},{"key":"2021102611231516100_CIT0027","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1159\/000360991","article-title":"Prevalence of human papillomavirus in oropharyngeal cancer: a multicenter study in Japan","volume":"87","author":"Hama","year":"2014","journal-title":"Oncology"},{"issue":"Pt 3","key":"2021102611231516100_CIT0028","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1469-1809.2009.00517.x","article-title":"Refined geographic distribution of the oriental ALDH2*504Lys (nee 487Lys) variant","volume":"73","author":"Li","year":"2009","journal-title":"Ann. Hum. Genet."},{"key":"2021102611231516100_CIT0029","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1176\/ajp.152.8.1219","article-title":"Alcohol and aldehyde dehydrogenase polymorphisms and the risk for alcoholism","volume":"152","author":"Higuchi","year":"1995","journal-title":"Am. J. Psychiatry"}],"container-title":["Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/carcin\/advance-article-pdf\/doi\/10.1093\/carcin\/bgab085\/40492841\/bgab085.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/carcin\/article-pdf\/42\/10\/1232\/40858440\/bgab085.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/carcin\/article-pdf\/42\/10\/1232\/40858440\/bgab085.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T11:23:43Z","timestamp":1635247423000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/carcin\/article\/42\/10\/1232\/6373366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,21]]},"references-count":29,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,9,21]]},"published-print":{"date-parts":[[2021,10,26]]}},"URL":"https:\/\/doi.org\/10.1093\/carcin\/bgab085","relation":{},"ISSN":["0143-3334","1460-2180"],"issn-type":[{"value":"0143-3334","type":"print"},{"value":"1460-2180","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,10,1]]},"published":{"date-parts":[[2021,9,21]]}}}